Cover Page
The handle http://hdl.handle.net/1887/37228 holds various files of this Leiden University dissertation
Author: Mirzakhani, Hooman
Title: The role of clinical pharmacology and pharmacogenetics in electroconvulsive therapy : from safety to efficacy
Issue Date: 2016-01-14
THE ROLE OF CLINICAL PHARMACOLOGY AND PHARMACOGENETICS IN ELECTROCONVULSIVE THERAPY
FROM SAFETY TO EFFICACY
Hooman Mirzakhani, M.D., MMSc.
The research presented in this thesis was performed at the Departments of Clinical Pharmacy and Toxicology of Leiden University Medical Center, Leiden, The Netherlands and Anesthesia, Critical Care and Pain Medicine of Massachusetts General Hospital, Boston, Massachusetts, United States.
Financial support for the publication of this thesis was provided by AZL Onderzoeks- en Ontwikkelings- krediet Apotheek.
Cover design Midas Mentink, Midas.Mentink.nl Layout Mentink, Midas.Mentink.nl Printed by Gildeprint, Enschede ISBN/EVA 978-94-92026-08-8
© 2016 Hooman Mirzakhani
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage or retrie- val system, without permission in writing from the author.
THE ROLE OF CLINICAL PHARMACOLOGY AND PHARMACOGENETICS IN ELECTROCONVULSIVE THERAPY
FROM SAFETY TO EFFICACY
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 14 januari 2016
klokke 16:15 uur door
Hooman Mirzakhani, M.D., MMSc.
geboren te Tehran
in 1970
Promotores Prof. dr. H.J. Guchelaar
Prof. dr. A. Dahan
Copromotor Dr. J.J. Swen
Leden promotiecommissie Prof. dr. A.C.G. Egberts, Universiteit Utrecht
Prof. dr. L.P.H.J. Aarts
Dr. H.G. Ruhé, Universiteit Groningen Dr. I.M. van Vliet
CONTENTS
Chapter 1 General Introduction
Chapter 2 Neuromuscular blocking agents for electroconvulsive therapy: A systematic review.
Chapter 3 Optimal Doses of Succinylcholine and Rocuronium during Electroconvulsive Therapy:
A prospective, randomized, crossover trial Chapter 4 Pharmacokinetics and Pharmacodynamics of
Succinylcholine and Rocuronium during Electroconvulsive Therapy.
Chapter 5 Pharmacogenetics in Electroconvulsive Therapy and
Adjunctive Medications.
Chapter 6 CYP2D6 metabolizer phenotypes in patients undergoing ECT after antidepressant therapy.
Chapter 7 Profound hypotension after anesthetic induction with propofol in patients treated with rifampin.
Chapter 8 Severe postoperative hemodynamic events after spinal anesthesia : a prospective observational study.
Chapter 9 General discussion and future directions Appendices Summary
Samenvatting Dankwoord
About the author List of publications
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“It’s not that I’m so smart, it’s just that I stay with problems longer.”
Albert Einstein
