Cover Page The handle http://hdl.handle.net/1887/37228 holds various files of this Leiden University dissertation

Electroconvulsive therapy (ECT) is the transcutaneous application of small electrical stimuli to the brain to produce generalized seizure for the treatment of selected

The research presented in this thesis was performed at the Departments of Clinical Pharmacy and Toxicology of Leiden University Medical Center, Leiden, The Netherlands and

In chapter five, we explore the past and current knowledge of pharmacogenetics in electroconvulsive therapy and adjunctive medications whose applications might augment the response

The onset of skeletal muscle paralysis is achieved 30 to 60 seconds after administration of suxamethonium, and usually lasts between 5 to 10 min (5 min at the dose of 0.5 mg.kg -1

During each subsequent ECT treatment (two days apart), patients received a 10% higher (if insufficient paralysis) or lower (if sufficient or excessive paralysis) dose of the same

16 investigated the rocuronium neuromuscular blocking effect (a 5-min infusion) along with neostigmine for its reversal on twitch height in adductor pollicis and estimated the

To follow up on the role of dopamine D receptor gene in efficacy of ECT and evaluate the potential impact of dopamine D receptor gene (DRD3) variation on ECT outcome in

Hereby, we investigate the accumulation of aberrant CYP2D6 genotypes and predicted metabolizer phenotypes (UM, IM, and PM) potentially affecting the antidepressants treatment