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The handle http://hdl.handle.net/1887/19774 holds various files of this Leiden University dissertation.

Author: Snoeck-Stroband, Jiska Bouwien

Title: Towards clinical phenotyping of COPD : effects of inhaled corticosteroide in the GLUCOLD study

Date: 2012-09-12

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TOWARDS

CLINICAL PHENOTYPING IN COPD

Effects of inhaled corticosteroids in the GLUCOLD study

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Thesis, Leiden University Medical Center, 2012

© Copyright Jiska Snoeck-Stroband

Printing: Drukkerij Brügemann, Hilversum Lay-out: M.F. Stroband, Amsterdam

The studies in this thesis were performed at the departments of Medical Decision Making, Public health and Primary care and Pulmonology, Leiden University Medical Center (LUMC), Leiden and at the departments of Pulmonology and General Practice, University Medical Center Groningen (UMCG).

The studies in this thesis were financially supported by grants from the Netherlands Organization for Scientific Research (NWO), Netherlands Asthma Foundation (NAF), GlaxoSmithKline (GSK NL), Leiden University Medical Center (LUMC), University Medical Center Groningen (UMCG).

All rights reserved. No part of this publication may be reproduced in any form or means by photocopying, recording or otherwise, without written permission of the author and the publishers of the articles concerned.

Publication of this thesis was generously supported by:

SBOH, Afdelingen Medische Besliskunde, Longziekten en Public health en

Eerstelijnsgeneeskunde (LUMC), COPD en Astma Huisartsen Advies Groep (CAHAG), KSYOS TeleMedisch Centrum, Apotheken Akelei, Bohemenwijk en van Laaren Den haag,

Huisartsenpraktijk Akelei Den Haag, MediPC bv, Eerstelijns Zorggroep Haaglanden (ELZHA)

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TOWARDS

CLINICAL PHENOTYPING IN COPD

Effects of inhaled corticosteroids in the GLUCOLD study

Proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op woensdag 12 september 2012

klokke 15.00 uur

door

Jiska Bouwien Snoeck-Stroband geboren op 5 oktober 1971

te Delft

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Promotiecommisies

Promotores Prof. dr. P.J. Sterk

Prof. dr. D.S. Postma, Universitair Medisch Centrum Groningen Prof. dr. P.S. Hiemstra

Copromotor Dr. J.K. Sont

Overige leden

Prof. dr. W.J.J. Assendelft

Prof. dr. G.G. Brusselle, Universitair Ziekenhuis Gent, België

Prof. dr. E.F.M. Wouters, Maastricht Universitair Medisch Centrum

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Wat niemand zoekt wordt zelden gevonden

Johann Heinrich Pestalozzi

Voor Sebastiaan, Duco en Philippine

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Contents

Chapter 1 General introduction

Chapter 2 Dissociation of lung function and airway inflammation in Chronic Obstructive Pulmonary Disease (COPD)

Chapter 3 Airway inflammation contributes to health status in COPD: a cross-sectional study

Chapter 4 Chronic bronchitis sub-phenotype within COPD:

inflammation in sputum and biopsies

Chapter 5 Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomised, controlled trial

Chapter 6 Towards predicting long-term benefits of inhaled steroids by phenotypic markers in moderate to severe COPD: a randomized controlled trial

Chapter 7 Self-monitoring day-to-day health status and

peak-flow: effect of long-term treatment with inhaled corticosteroids and long-acting ß

2

-agonists in COPD Chapter 8 Conclusions, general discussion and implications Chapter 9 Nederlandse samenvatting (Dutch)

Curriculum Vitae Dankwoord Bibliography

The GLUCOLD study group

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56

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