Vos, J.B.
Citation
Vos, J. B. (2007, January 11). Molecular mechanisms of epithelial host defense in the
airways. Retrieved from https://hdl.handle.net/1887/9749
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in
the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/9749
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M OLECULAR M ECHANISMS OF E PITHELIAL H OST D EFENSE
IN THE A IRWAYS
J
OOSTB
ASTIAANV
OSISBN-13: 978-90-9021330-9
© J.B. Vos, 2007
M OLECULAR M ECHANISMS OF E PITHELIAL H OST D EFENSE
IN THE A IRWAYS
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnifi cus Dr.D.D.Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op donderdag 11 januari 2007
klokke 13.45 uur
door
JOOST BASTIAAN VOS
geboren te Haarlem in 1977
Promotores: Prof. Dr. P.S.Hiemstra Prof. Dr. K.F. Rabe
Co-promotor: Mw. Dr. N.A. Datson
Referent: Prof. Dr. J-M Sallenave (Pasteur Instituut, Parijs, Frankrijk)
Overige leden: Prof. Dr. J.Schalkwijk (Radboud Universiteit, Nijmegen) Dr. A.H. van Kampen (AMC, Amsterdam)
Prof. Dr. A.C. Kroes Prof. Dr. F.J. Walther
The research described in this thesis was performed at the department of Pulmonology and the department of Medical Pharmacology of the Leiden University Medical Center, The Netherlands and was supported by a program grant from Netherlands Organiza- tion for Scientifi c Research (NWO; grant 902-11-092). Printing of this thesis was fi nan- cially supported by (in alphabetical order): AstraZeneca B.V., Boehringer Ingelheim B.V., GlaxoSmithKline B.V., J.E. Jurriaanse Stichting, Numico Research B.V., Pfi zer B.V., Stichting Longziekten Research.
Waar een wil is…
CONTENTS
Chapter 1 General introduction and scope of the thesis 9
Chapter 2 Exploring host-pathogen interactions at the epithelial surface:
Application of transcriptomics in lung biology Am J Physiol Lung Cell Mol Physiol, in press
21
Chapter 3 The transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identifi cation of early mediators of host defense
Physiol Genomics. 2005 May 11;21(3):324-36.
47
Chapter 4 Pseudomonas aeruginosa rapidly induces a transient increase in expression of S100A8 and S100A9 in bronchial epithelial cells Submitted for publication
77
Chapter 5 Host defense eff ector molecules in mucosal secretions FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):151-8.
93
Chapter 6 A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes
BMC Genomics. 2006 Jan 18;7(1):9
111
Chapter 7 Summary and General Discussion 131
Chapter 8 Nederlandse Samenvatting 145
Dankwoord 153
Curriculum Vitae 155
Publications 157
