Cover Page
The handle http://hdl.handle.net/1887/53234 holds various files of this Leiden University dissertation.
Author: Berg, R. van den
Title: Greased lighting : implications of circadian lipid metabolism for cardiometabolic health
Issue Date: 2017-10-12
implicationsofcircadianlipidmetabolism forcardiometabolichealth
Rosa van den Berg
GREASED LIGHTING
Greased lighting:
implications of circadian lipid metabolism for cardiometabolic health
© 2017, Rosa van den Berg
Layout & printing by Sidestone Press ISBN: 978-90-8890-542-1
All rights are reserved. No part of this publication may be transformed, reproduced or transmitted in any form and by any means without permission of the copyright owners
implicationsofcircadianlipidmetabolism forcardiometabolichealth
PROEFSCHRIFT
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. Mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 12 oktober 2017
klokke 16.15 uur
door
Rosa van den Berg Geboren te Voorburg
In 1985
implicationsofcircadianlipidmetabolism forcardiometabolichealth
GREASED LIGHTING
Promotor Prof. dr. P.C.N. Rensen Copromotor Dr. N.R. Biermasz Leden promotiecommissie
Prof. dr. A.M. Pereira Arias Prof. dr. J.H. Meijer
Prof. dr. J.A. Romijn (Amsterdam Medisch Centrum) Prof. dr. S. Kersten (Wageningen University & Research)
The work described in this thesis was performed at the department of Medicine, division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands, and at Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
TABLE OF CONTENTS
CHAPTER 1 7
General Introduction and outline
Part I : Circadian rhythms in animal models: regulation of brown fat activity and consequences for metabolic disease
CHAPTER 2 27
Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity
CHAPTER 3 49
Diurnal regulation of plasma lipid levels by brown adipose tissue
CHAPTER 4 79
Glucocorticoid rhythm regulates the diurnal activity of brown adipose tissue
CHAPTER 5 97
Effects of mistimed light exposure on atherosclerosis development in APOE*3-Leiden.CETP mice
Part II : Circadian rhythms in human studies: implications for metabolic health
CHAPTER 6 119
A single night of sleep curtailment increases plasma acylcarnitines: novel insights in the relationship between sleep and insulin resistance
CHAPTER 7 151
Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals
CHAPTER 8 171
General Discussion and Future Perspectives
ADDENDUM 189 Summary 191
Nederlandse samenvatting 195
List of Publications 199
Curriculum Vitae 201
Dankwoord 203
