Physical activity, immobilization and the risk of venous thrombosis
Stralen, K.J. van
Citation
Stralen, K. J. van. (2008, April 3). Physical activity, immobilization and the risk of venous thrombosis. Retrieved from https://hdl.handle.net/1887/12666
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12666
Note: To cite this publication please use the final published version (if applicable).
Physical activity, immobilization and
the risk of venous thrombosis
Cover: Motionless water in a pool made for physical activity Cover design: K.J. van Stralen & J. van der Ahé
© 2008 K.J. van Stralen
Lay-Out: Y. Souverein
ISBN: 978-90-9022857-0
Printed by Gildeprint, Enschede, the Netherlands
Physical activity, immobilization and
the risk of venous thrombosis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 3 april 2008 klokke 15.00 uur door
Karlijn Janneke van Stralen
geboren te Delft in 1980
Promotiecommissie
Promotor: Prof. Dr. F.R. Rosendaal
Copromotor: Dr. C.J.M. Doggen
Referent: Prof. Dr. B.M. Psaty (University of Washington, Seattle, USA)
Overige leden: Prof. Dr. J.P. Vandenbroucke
Prof. Dr. H.R. Büller (University of Amsterdam)
Dr. S. Le Cessie
The work described in this thesis was performed at the department of clinical epidemiology, Leiden University Medical Center, Leiden, the Netherlands, and the Cardiovascular Health and Research Unit, University of Washington, Seattle, USA.
This research was supported by the Netherlands Organization for Scientific Research (912-033| 2003) and the Leducq foundation, Paris, France for the development of transatlantic networks of excellence in cardiovascular research.
Financial support by the Netherlands Heart Foundation and the J.E. Jurriaanse Stichting for the publication of this thesis is gratefully acknowledged.
Additional support was kindly provided by Bayer Health Care and Roche Diagnostics.
Table of Contents Page
Chapter 1 7
Introduction
Chapter 2 15
The tortuous history of the implementation of early ambulation after delivery
Chapter 3 31
Regular sports activities decrease the risk of venous thrombosis
Chapter 4 49
The relationship between exercise and risk of venous thrombosis in elderly people
Chapter 5 65
Strenuous sport activities involving the upper extremities increase the risk of venous thrombosis of the arm
Chapter 6 73
Minor injuries as a risk factor for venous thrombosis
Chapter 7 89
Mechanisms of the factor V Leiden paradox
Chapter 8
Discussion & Summary 105
Samenvatting 117
Dankwoord 125
Curriculum Vitae 127
