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University of Groningen

Programming of adult metabolic health Lohuis, Mirjam Agnes Maria

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Lohuis, M. A. M. (2019). Programming of adult metabolic health: the roles of dietary cholesterol and microbiota in early life. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

Download date: 28-06-2021

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PROGRAMMING OF ADULT METABOLIC HEALTH

THE ROLES OF DIETARY CHOLESTEROL MICROBIOTA AND IN EARLY LIFE

Mirjam A.M. Lohuis

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The research described in this thesis was performed at the Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

This work is part of the research programme “You are what you ate: metabolic programming by early nutrition” with project number 11675, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO).

Printing of this thesis was financially supported by :

• the University of Groningen,

• the University Medical Center Groningen

• the Graduate School of Medical Sciences (GSMS), the Groningen University Institute for Drug Exploration (GUIDE).

PhD dissertation, University of Groningen, The Netherlands

Cover design: Siny Lohuis Layout by: Mirjam Lohuis Printed by: Ipskamp Printing

(Everprint Premium paper, 100% recycled)

ISBN: 978-94-034-1779-0 (printed) ISBN: 978-94-034-1778-3 (digital)

© Mirjam A.M. Lohuis | 2019

All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without prior permission of the author.

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Programming of adult metabolic health

The roles of dietary cholesterol and microbiota in early life

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 10 Juli 2019 om 11:00 uur

door

Mirjam Agnes Maria Lohuis

geboren op 30 November 1989

te Denekamp

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Promotores

Prof. dr. H.J. Verkade Prof. dr. U.J.F. Tietge

Beoordelingscommissie

Prof. dr. S.A. Scherjon Prof. dr. E.M. van der Beek Prof. dr. A.B.J. Prakken

Paranimfen

Nicole S. Noordhof Raphael Fagundes Rosa

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General Introduction

&

Scope of this thesis

7

Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-

induced hypercholesterolaemia

21

Programming of intestinal cholesterol absorption in mice: sensitive window of ezetimibe treatment

37

Plasma bile acid dynamics after conventionalization of germ-free mice with opposite sex microbiota

51

Absence of intestinal microbiota during gestation and lactation does not alter the metabolic response to a Western-type diet in adulthood

67

General Discussion

Conclusions

89

Chapter 7 References English Summary

Nederlandse Samenvatting Dankwoord / Acknowledgements Curriculum vitae

101 102 116 122 129 136

CONTENT

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