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University of Groningen Characterization of a Drosophila model for Chorea‐Acanthocytosis Vonk, Jan

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University of Groningen

Characterization of a Drosophila model for Chorea‐Acanthocytosis

Vonk, Jan

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Vonk, J. (2017). Characterization of a Drosophila model for Chorea‐Acanthocytosis. University of

Groningen.

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CHARACTERIZATION OF A DROSOPHILA

MODEL FOR CHOREA-ACANTHOCYTOSIS

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ISBN: 978-90-367-9868-6 Ebook ISBN: 978-90-367-9867-9 Cover and layout design by ThesisExpert.nl Printed by Gildeprint, Enschede, the Netherlands.

Printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen and The Graduate School of Medical Sciences, Groningen.

The research described in this thesis was performed at the Department of Cell Biology of the University Medical Center Groningen, the Netherlands.

Copyright © 2017 J.J.Vonk, Groningen, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without prior written permission of the author.

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CHARACTERIZATION OF A DROSOPHILA

MODEL FOR CHOREA-ACANTHOCYTOSIS

PHD THESIS

To obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus Prof. E. Sterken

and in accordance with

the decision by the college of Deans.

This thesis will be defended in public on

Monday 3 July 2017 at 14.30 hours

by

JAN JOHANNES VONK

born on 9 January 1987

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Supervisor

Prof. O.C.M. Sibon

Assessment committee

Prof. J.C. Billeter

Prof. H. van Bokhoven

Prof. M.A. de Koning-Tijssen

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TABLE OF CONTENTS

Chapter 1

Introduction and aim of the thesis

8

Chapter 2

Brain, blood and iron: Perspectives on the roles of erythrocytes

20

and

iron

in

neurodegeneration

Chapter 3

Drosophila Vps13 is required for protein homeostasis in the brain

56

Chapter 4

Drosophila Vps13 mutants show overgrowth of larval

84

neuromuscular

junctions

Chapter 5

Summarizing discussion and future perspectives

98

Appendices

Nederlandse samenvatting

111

Acknowledgements

113

Curriculum vitae

115

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