University of Groningen Evidence-b(i)ased psychiatry de Vries, Ymkje Anna

Evidence-b(i)ased psychiatry

de Vries, Ymkje Anna

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Publication date: 2018

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de Vries, Y. A. (2018). Evidence-b(i)ased psychiatry. University of Groningen.

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Evidence-b(i)ased psychiatry

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 21 February 2018 at 14.30 hours

by

Ymkje Anna de Vries

born on 18 July 1988 in Kollumerland en Nieuwkruisland

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Evidence-b(i)ased psychiatry

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 21 February 2018 at 14.30 hours

by

Ymkje Anna de Vries

born on 18 July 1988 in Kollumerland en Nieuwkruisland

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HB;?i TQbBiBp2 `2bmHib r?BH2 M2;iBp2 `2bmHib Kv ;Q mMMQiB+2/X

qBi?BM i?2 HBi2`im`2 QM /2T`2bbBQM M/ MtB2iv /BbQ`/2`b-  HM/K`F bim/v rb Tm#HBb?2/ BM kyy3- b?QrBM; i?i M2;iBp2 i`BHb Q7 MiB/2T`2bbMib 7Q` J.. r2`2 Km+? H2bb HBF2Hv iQ #2 Tm#HBb?2/ i?M TQbBiBp2 i`BHb (RN)X 6m`i?2`KQ`2- r?2M i?2b2 M2;iBp2 i`BHb r2`2 Tm#HBb?2/- i?2v r2`2 Q7i2M Tm#HBb?2/ b B7 TQbBiBp2X AM i?Bb bim/v- 8RW Q7 HH i`BHb r2`2 TQbBiBp2- #mi BM b?`T +QMi`bi- N9W Q7 Tm#HBb?2/ i`BHb TT2`2/ iQ #2 TQbBiBp2- M/ i?2 2z2+i bBx2 Q7 MiB/2T`2bbMib rb Qp2`2biBKi2/ #v jkWX aim/v Tm#HB+iBQM #Bb Bb HbQ T`2b2Mi BM Tbv+?Qi?2`Tv i`BHbX qBi?BM  +Q?Q`i Q7 LiBQMH AMbiBimi2b Q7 >2Hi?@7mM/2/ Tbv+?Qi?2`Tv i`BHb- k9W Q7 HH BMBiBi2/ i`BHb `2KBM2/ mMTm#HBb?2/- M/ i?2 2z2+i bBx2 Q7 i?2b2 mMTm#HBb?2/ i`BHb rb K`F2/Hv HQr2` i?M i?i Q7 Tm#HBb?2/ i`BHb- +H2`Hv b?QrBM;  #Bb ;BMbi Tm#HBb?BM; mM7pQ`#H2 }M/BM;b (j8)X

q?BH2 KQbi `2b2`+? QM #Bb ?b 7Q+mb2/ QM i?2 2{++v Q7 i`2iK2Mib- bQK2 `2b2`+? ?b HbQ 2tKBM2/ b72ivX /p2`b2 2p2Mib `2 ``2Hv KQMBiQ`2/- H2i HQM2 `2TQ`i2/- BM Tbv+?Qi?2`Tv i`BHb (9d- 93- 9N)X *QMb2[m2MiHv- r2 FMQr p2`v HBiiH2 #Qmi i?2 TQbbB#H2 /p2`b2 2z2+ib Q7 Tbv+?Qi?2`Tv- Hi?Qm;? Bi Bb +H2` i?i Tbv+?Qi?2`Tv- HBF2 HH 2z2+iBp2 i`2iK2Mib- +M ?p2 M2;iBp2 b r2HH b TQbBiBp2 2z2+ib (8y- 8R- 8k)X /p2`b2 2p2Mib BM /`m; i`BHb- ?Qr2p2`- `2 mbmHHv 2ti2MbBp2Hv KQMBiQ`2/ #2+mb2 Q7 `2;mHiQ`v `2[mB`2K2Mib- #mi `2TQ`iBM; QM i?2b2 2p2Mib Bb HBKBi2/- #Qi? BM Tbv+?Bi`v (8j) M/ BM Qi?2` K2/B+H }2H/b (89- 88- 8e)X S`2pBQmb `2b2`+? QM irQ MiB/2T`2bbMib Ub2`i`HBM2 M/ /mHQt2iBM2V ?b bm;;2bi2/ i?i ?`K Qmi+QK2b `2 TQQ`Hv `2TQ`i2/ M/ b2`BQmb /p2`b2 2p2Mib BM T`iB+mH` `2 MQi Hrvb `2TQ`i2/ 7mHHv Q` ++m`i2Hv (8d- 83)X AM ;2M2`H- ?Qr2p2`- `2HiBp2Hv HBiiH2 ii2MiBQM ?b #22M /2pQi2/ iQ ?`K Qmi+QK2b +QKT`2/ iQ 2{++v Qmi+QK2bX

S`2+BbBQM Tbv+?Bi`v, r?Q #2M2}ib 7`QK i`2iK2Mi\

h?2 `2b2`+? QM #Bb BM MiB/2T`2bbMi i`BHb ?b b?QrM i?i i?2b2 K2/B+iBQMb `2 H2bb 2z2+iBp2 M/ HbQ H2bb b72 i?M T`2pBQmbHv i?Qm;?i- T`iB+mH`Hv BM vQmM; T2QTH2X >Qr@ 2p2`- Hi?Qm;? MiB/2T`2bbMi 2{++v Kv- QM p2`;2- #2 KQ`2 KQ/2bi i?M 2tT2+i2/ Q` /2bB`2/- Bi Bb HBF2Hv i?i bQK2 T2QTH2 /Q 2tT2`B2M+2  `Q#mbi M/ +HBMB+HHv K2MBM;7mH `2bTQMb2 iQ MiB/2T`2bbMib- r?BH2 Qi?2`b 2tT2`B2M+2 p2`v HBiiH2- Q` MQ #2M2}i i HHX AM ;2M2`H- `QmM/ R8W KQ`2 T2QTH2 `2bTQM/ iQ MiB/2T`2bbMib i?M iQ TH+2#Q (8N)X *QMb2@ [m2MiHv- i?2`2 Bb ;`2i BMi2`2bi BM T`2/B+iBM; r?Q #2M2}ib 7`QK i`2iK2Mi- iQ /BbiBM;mBb? #2ir22M TiB2Mib r?Q rBHH `2+Qp2` 2p2M rBi?Qmi +iBp2 i`2iK2Mi- TiB2Mib r?Q rBHH #2M2}i bT2+B}+HHv 7`QK i?2 i`2iK2Mi- M/ TiB2Mib r?Q Kv M22/  /Bz2`2Mi Q` KQ`2 BMi2MbBp2 i`2iK2Mi iQ `2+Qp2`X

Jm+? 2zQ`i ?b #22M /2pQi2/ iQ 2tKBMBM; #BQHQ;B+H M/ ;2M2iB+ K`F2`b i?i +QmH/ #2 bbQ+Bi2/ rBi? MiB/2T`2bbMi `2bTQMb2X h?2`2 ?b HQM; #22M  T`iB+mH` BMi2`2bi BM i?2 b2`QiQMBM@i`MbTQ`i2`@HBMF2/ TQHvKQ`T?B+ `2;BQM U8@>hhGS_V- 7Q` BMbiM+2- #2+mb2 aa_Ab- i?2 KQbi +QKKQMHv mb2/ MiB/2T`2bbMib- BM?B#Bi i?2 `2mTiF2 Q7 b2`QiQMBM #v

Rk

#HQ+FBM; i?2 b2`QiQMBM i`MbTQ`i2`X J2i@MHvb2b QM i?Bb iQTB+- ?Qr2p2`- ?p2 +QK2 iQ /Bp2`;BM; +QM+HmbBQMb QM r?2i?2` 8@>hhGS_ Bb +imHHv bbQ+Bi2/ rBi? MiB/2T`2bbMi `2bTQMb2 (ey- eR)X

AM ;2M2`H- +M/B/i2 ;2M2 bim/B2b HBF2 i?2b2 UBM r?B+?  bT2+B}+ ;2M2 Q7 BMi2`2bi Bb bim/B2/V ?p2 T`Qp2M mMHBF2Hv iQ `2THB+i2 `2HB#Hv (ek- ej)- /m2 iQ i?2 mM7Q`imMi2 +QK#BMiBQM Q7 p2`v bKHH bKTH2 bBx2b UBM+`2bBM; i?2 HBF2HB?QQ/ i?i Mv biiBbiB+HHv bB;MB}+Mi }M/BM; Bb  7Hb2 TQbBiBp2V- MHviB+H ~2tB#BHBiv UT`QpB/BM; i?2 TQbbB#BHBiv Q7 b2H2+iBM; i?2 MHvbBb Q` Qmi+QK2 i?i rQ`F2/ dz#2biǴ- i?i Bb- vB2H/2/  biiBbiB+HHv bB;MB}+Mi `2bmHi (e9)V- M/ `2TQ`iBM; #BbX 6Q` i?i `2bQM- i?2 }2H/ Q7 ;2M2iB+b ?b H`;2Hv #M/QM2/ +M/B/i2 ;2M2 bim/B2b BM 7pQ` Q7 ;2MQK2@rB/2 bbQ+BiBQM bim/B2b U:qaV- r?B+? ?p2 T`Qp2M iQ #2 Km+? KQ`2 `2HB#H2 (e8)X

AM i?2 Tbi /2+/2- :qa ?p2 /2KQMbi`i2/ i?i ;2M2iB+ 2z2+ib `2 mbmHHv 2ti`2K2Hv bKHH M/ p2`v H`;2 bKTH2 bBx2b `2 `2[mB`2/ iQ /2i2+i i?2b2 2z2+ib (ek)X P#iBMBM; bm+? bKTH2 bBx2b rBi?BM i?2 +QMi2ti Q7  i`2iK2Mi i`BH Bb  KDQ` +?HH2M;2X  `2+2Mi K2i@ MHvbBb Q7 MiB/2T`2bbMi T?`K+Q;2M2iB+b i`BHb- r?B+? BM+Hm/2/ k-k8e T`iB+BTMib-7QmM/ QMHv QM2 ;2MQK2@rB/2 bB;MB}+Mi bbQ+BiBQMc  TQHv;2MB+ `BbF b+Q`2 ++QmMi2/ 7Q` QMHv #Qmi RW Q7 i?2 p`BM+2 BM i`2iK2Mi Qmi+QK2b (ee)X >2M+2- Bi b22Kb mMHBF2Hv i?i ;2M2iB+ `2b2`+? rBHH bQQM /2HBp2`  KDQ` +QMi`B#miBQM iQ i?2 T`2/B+iBQM Q7 MiB/2T`2bbMi `2bTQMb2X

Pi?2` #BQHQ;B+H K`F2`b Kv ?p2 KQ`2 TQi2MiBH- #mi bQ 7` /2+/2b Q7 `2b2`+? ?p2 MQi `2bmHi2/ BM Mv K`F2`b i?i `2 bm{+B2MiHv T`2/B+iBp2 iQ #2 mb27mH (ed)X "BQHQ;B+H K`F2`b #b2/ QM 2H2+i`Q2M+2T?HQ;`Kb U11:V- 7mM+iBQMH K;M2iB+ `2bQMM+2 BK;BM; U7J_AV-Q` i?2 HBF2 `2 HbQ mMHBF2Hv iQ #2 72bB#H2 BM `QmiBM2 +HBMB+H T`+iB+2X J`F2`b i?i +M #2 /2`Bp2/ 7`QK #HQQ/ Q` bHBp i2bib Kv #2 KQ`2 72bB#H2- #mi biBHH `2[mB`2 //BiBQMH bi2Tb i?i `2 b2H/QK T2`7Q`K2/ BM +HBMB+H T`+iB+2X *QMb2[m2MiHv- i?2 `2[mB`2K2Mib Q7 72bB#BHBiv /B+ii2 i?i `QmiBM2Hv Q#iBM2/ M/ `2/BHv pBH#H2 +HBMB+H BM7Q`KiBQM b?QmH/ #2 mb2/ r?2M2p2` TQbbB#H2- BM T`272`2M+2 Qp2` Km+? H2bb 2{+B2Mi Hi2`MiBp2b HBF2 M2m`QBK;BM;- mMH2bb i?Bb Bb b?QrM iQ #2 Km+? KQ`2 ++m`i2 (e3)X

PM2 Q#pBQmb +HBMB+H +?`+i2`BbiB+ Bb /BbQ`/2` b2p2`BivX  kyy3 K2i@MHvbBb bm;;2bi2/ i?i BMBiBH b2p2`Biv Q7 /2T`2bbBp2 bvKTiQKb rb bbQ+Bi2/ rBi? MiB/2T`2bbMi `2bTQMb2-bm+? i?i T2QTH2 rBi? KBH/2` /2T`2bbBQM 2tT2`B2M+2/ HBiiH2 #2M2}i 7`QK iFBM; MiB/2T`2b@ bMib +QKT`2/ iQ TH+2#Q (eN)X Pi?2` `2b2`+? TT2`2/ iQ +QM}`K i?Bb (dy- dR- dk)- M/ +HBMB+H ;mB/2HBM2b r2`2 mT/i2/ iQ `2~2+i i?Bb }M/BM; M/ iQ `2+QKK2M/ ;BMbi i?2 mb2 Q7 MiB/2T`2bbMib b  }`bi@HBM2 i`2iK2Mi 7Q` KBH/ /2T`2bbBQM (dj- d9)X JQ`2 `2+2MiHv-?Qr2p2`- irQ H`;2 bim/B2b /B/ MQi `2THB+i2 i?Bb bbQ+BiBQM (d8- de)- +biBM; /Qm#i mTQM i?Bb }M/BM;X

Hi?Qm;? MiB/2T`2bbMib `2 HbQ +QKKQMHv mb2/ 7Q` MtB2iv /BbQ`/2`b- i?2 2pB/2M+2 rBi? `2;`/ iQ b2p2`Biv M/ MiB/2T`2bbMi 2{++v 7Q` MtB2iv Bb p2`v HBKBi2/- Hi?Qm;? bQK2 bKHH bim/B2b ?p2 bm;;2bi2/ i?i i?2`2 Bb MQ bbQ+BiBQM #2ir22M BMBiBH b2p2`Biv M/

1

HB;?i TQbBiBp2 `2bmHib r?BH2 M2;iBp2 `2bmHib Kv ;Q mMMQiB+2/X

qBi?BM i?2 HBi2`im`2 QM /2T`2bbBQM M/ MtB2iv /BbQ`/2`b-  HM/K`F bim/v rb Tm#HBb?2/ BM kyy3- b?QrBM; i?i M2;iBp2 i`BHb Q7 MiB/2T`2bbMib 7Q` J.. r2`2 Km+? H2bb HBF2Hv iQ #2 Tm#HBb?2/ i?M TQbBiBp2 i`BHb (RN)X 6m`i?2`KQ`2- r?2M i?2b2 M2;iBp2 i`BHb r2`2 Tm#HBb?2/- i?2v r2`2 Q7i2M Tm#HBb?2/ b B7 TQbBiBp2X AM i?Bb bim/v- 8RW Q7 HH i`BHb r2`2 TQbBiBp2- #mi BM b?`T +QMi`bi- N9W Q7 Tm#HBb?2/ i`BHb TT2`2/ iQ #2 TQbBiBp2- M/ i?2 2z2+i bBx2 Q7 MiB/2T`2bbMib rb Qp2`2biBKi2/ #v jkWX aim/v Tm#HB+iBQM #Bb Bb HbQ T`2b2Mi BM Tbv+?Qi?2`Tv i`BHbX qBi?BM  +Q?Q`i Q7 LiBQMH AMbiBimi2b Q7 >2Hi?@7mM/2/ Tbv+?Qi?2`Tv i`BHb- k9W Q7 HH BMBiBi2/ i`BHb `2KBM2/ mMTm#HBb?2/- M/ i?2 2z2+i bBx2 Q7 i?2b2 mMTm#HBb?2/ i`BHb rb K`F2/Hv HQr2` i?M i?i Q7 Tm#HBb?2/ i`BHb- +H2`Hv b?QrBM;  #Bb ;BMbi Tm#HBb?BM; mM7pQ`#H2 }M/BM;b (j8)X

q?BH2 KQbi `2b2`+? QM #Bb ?b 7Q+mb2/ QM i?2 2{++v Q7 i`2iK2Mib- bQK2 `2b2`+? ?b HbQ 2tKBM2/ b72ivX /p2`b2 2p2Mib `2 ``2Hv KQMBiQ`2/- H2i HQM2 `2TQ`i2/- BM Tbv+?Qi?2`Tv i`BHb (9d- 93- 9N)X *QMb2[m2MiHv- r2 FMQr p2`v HBiiH2 #Qmi i?2 TQbbB#H2 /p2`b2 2z2+ib Q7 Tbv+?Qi?2`Tv- Hi?Qm;? Bi Bb +H2` i?i Tbv+?Qi?2`Tv- HBF2 HH 2z2+iBp2 i`2iK2Mib- +M ?p2 M2;iBp2 b r2HH b TQbBiBp2 2z2+ib (8y- 8R- 8k)X /p2`b2 2p2Mib BM /`m; i`BHb- ?Qr2p2`- `2 mbmHHv 2ti2MbBp2Hv KQMBiQ`2/ #2+mb2 Q7 `2;mHiQ`v `2[mB`2K2Mib- #mi `2TQ`iBM; QM i?2b2 2p2Mib Bb HBKBi2/- #Qi? BM Tbv+?Bi`v (8j) M/ BM Qi?2` K2/B+H }2H/b (89- 88- 8e)X S`2pBQmb `2b2`+? QM irQ MiB/2T`2bbMib Ub2`i`HBM2 M/ /mHQt2iBM2V ?b bm;;2bi2/ i?i ?`K Qmi+QK2b `2 TQQ`Hv `2TQ`i2/ M/ b2`BQmb /p2`b2 2p2Mib BM T`iB+mH` `2 MQi Hrvb `2TQ`i2/ 7mHHv Q` ++m`i2Hv (8d- 83)X AM ;2M2`H- ?Qr2p2`- `2HiBp2Hv HBiiH2 ii2MiBQM ?b #22M /2pQi2/ iQ ?`K Qmi+QK2b +QKT`2/ iQ 2{++v Qmi+QK2bX

S`2+BbBQM Tbv+?Bi`v, r?Q #2M2}ib 7`QK i`2iK2Mi\

h?2 `2b2`+? QM #Bb BM MiB/2T`2bbMi i`BHb ?b b?QrM i?i i?2b2 K2/B+iBQMb `2 H2bb 2z2+iBp2 M/ HbQ H2bb b72 i?M T`2pBQmbHv i?Qm;?i- T`iB+mH`Hv BM vQmM; T2QTH2X >Qr@ 2p2`- Hi?Qm;? MiB/2T`2bbMi 2{++v Kv- QM p2`;2- #2 KQ`2 KQ/2bi i?M 2tT2+i2/ Q` /2bB`2/- Bi Bb HBF2Hv i?i bQK2 T2QTH2 /Q 2tT2`B2M+2  `Q#mbi M/ +HBMB+HHv K2MBM;7mH `2bTQMb2 iQ MiB/2T`2bbMib- r?BH2 Qi?2`b 2tT2`B2M+2 p2`v HBiiH2- Q` MQ #2M2}i i HHX AM ;2M2`H- `QmM/ R8W KQ`2 T2QTH2 `2bTQM/ iQ MiB/2T`2bbMib i?M iQ TH+2#Q (8N)X *QMb2@ [m2MiHv- i?2`2 Bb ;`2i BMi2`2bi BM T`2/B+iBM; r?Q #2M2}ib 7`QK i`2iK2Mi- iQ /BbiBM;mBb? #2ir22M TiB2Mib r?Q rBHH `2+Qp2` 2p2M rBi?Qmi +iBp2 i`2iK2Mi- TiB2Mib r?Q rBHH #2M2}i bT2+B}+HHv 7`QK i?2 i`2iK2Mi- M/ TiB2Mib r?Q Kv M22/  /Bz2`2Mi Q` KQ`2 BMi2MbBp2 i`2iK2Mi iQ `2+Qp2`X

Jm+? 2zQ`i ?b #22M /2pQi2/ iQ 2tKBMBM; #BQHQ;B+H M/ ;2M2iB+ K`F2`b i?i +QmH/ #2 bbQ+Bi2/ rBi? MiB/2T`2bbMi `2bTQMb2X h?2`2 ?b HQM; #22M  T`iB+mH` BMi2`2bi BM i?2 b2`QiQMBM@i`MbTQ`i2`@HBMF2/ TQHvKQ`T?B+ `2;BQM U8@>hhGS_V- 7Q` BMbiM+2- #2+mb2 aa_Ab- i?2 KQbi +QKKQMHv mb2/ MiB/2T`2bbMib- BM?B#Bi i?2 `2mTiF2 Q7 b2`QiQMBM #v

Rk

#HQ+FBM; i?2 b2`QiQMBM i`MbTQ`i2`X J2i@MHvb2b QM i?Bb iQTB+- ?Qr2p2`- ?p2 +QK2 iQ /Bp2`;BM; +QM+HmbBQMb QM r?2i?2` 8@>hhGS_ Bb +imHHv bbQ+Bi2/ rBi? MiB/2T`2bbMi `2bTQMb2 (ey- eR)X

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R9

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