The handle http://hdl.handle.net/1887/38042 holds various files of this Leiden University dissertation
Author: Isogai, Tadamoto
Title: Roles of mDia formins in actin-dependent and –independent processes
Issue Date: 2016-02-25
Roles of mDia Formins in actin-dependent and –independent processes
Tadamoto Isogai
the Netherlands Cancer Institute
Copyright @ 2016 by T. Isogai. All rights reserved. No part of this book may be reproduced, stored in retrieval system, or transmitted in any form or by any means, without prior permission of the author.
The research described in this thesis was performed at the Division of Cell Biology I and Division of Molecular Genetics of the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Financial support was provided by the Cancer Genomics Centre (CGC).
Roles of mDia Formins in actin-dependent and –independent processes
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties ter verdedigen op donderdag 25 februari 2016
klokke 15.00 uur door
Tadamoto Isogai geboren te Rotterdam
in 1984
Prof. Dr. B. van de Water Prof. Dr. J. Borst
Universiteit van Amsterdam Dr. E. H. Danen
To my mentor
Daisaku Ikeda
TABLE OF CONTENTS
Chapter 1 Introduction 9
Chapter 2 Initiation of lamellipodia and ruffles involves cooperation 43 between mDia1 and the Arp2/3 complex
Journal of Cell Science, 2015
Chapter 3 Proteomic analyses uncover a new function and mode 87 of action for mouse homolog of Diaphanous 2 (mDia2)
Molecular & Cellular Proteomics, 2015
Chapter 4 Quantitative proteomics illuminates a functional 131 Interaction between mouse homolog of diaphanous 2
(mDia2) and the proteasome Submitted, 2015
Chapter 5 SMIFH2 has effects on Formins and p53 that perturb 191 the cell cytoskeleton
Scientific Reports, 2015
Chapter 6 Summary and discussion 229
Appendices Nederlandse samenvatting 243
Curriculum Vitae 247
Publications 249 Acknowledgements 251
