Cover Page The handle https://hdl.handle.net/1887/3147161

Cover Page

The handle

https://hdl.handle.net/1887/3147161

holds various files of this Leiden

University dissertation.

Author: Molder, L. te

Title: Regulators of integrin

_{α6β4 function}

Issue Date: 2021-02-25

Regulators of integrin α6β4 function

Cover design & thesis layout: Vera van Ommeren | persoonlijkproefschrift.nl Printing: Ipskamp Printing | proefschriften.net

ISBN: 978-94-6421-193-1

© Lisa te Molder, 2021. All rights reserved. No part of this book may be reproduced in any form or by any means without permission of the author.

The research described in this thesis was performed at the Division of Cell Biology of the Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands. Financial support was provided by the Netherlands Organisation for Scientific Research (NWO) and the Dutch Cancer Society (KWF)

Regulators of integrin α6β4 function

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof.dr.ir. H. Bijl,

volgens besluit van het College voor Promoties te verdedigen op 25 februari 2021 klokke 11.15 uur door

Lisa te Molder

Promotor: Prof.dr. A. Sonnenberg

Promotiecommissie: Prof.dr. H. Irth (voorzitter) Prof.dr. J.A. Bouwstra (secretaris) Overige commissieleden: Prof.dr. A.B. van Spriel

Dr. C. Margadant Prof.dr. E.H.J. Danen Prof.dr. J.J. Neefjes

Table of Content

Chapter 1 General introduction and thesis overview 7

Chapter 2 The opposing roles of laminin-binding integrins in cancer 13

Chapter 3 PKD2 and RSK1 regulate integrin β4 phosphorylation at

threonine 1736

41

Chapter 4 EGFR-dependent tyrosine phosphorylation of integrin β4

is not required for downstream signaling events in cancer cells

65

Chapter 5 Tetraspanin CD151 and integrin α3β1 contribute to the

stabilization of integrin α6β4-containing cell-matrix adhesions

89

Chapter 6 Comparative interactomics analysis reveals potential

regulators of α6β4 distribution in keratinocytes

115

Chapter 7 Summary and General Discussion 133

Addendum 147

References

Nederlandse samenvatting voor leken Curriculum Vitae

List of Publications Dankwoord