The handle http://hdl.handle.net/1887/3135058 holds various files of this Leiden
University dissertation.
Author: Zanden, S.Y. van der
Title: Novel insights into old anticancer drugs
Issue date: 2021-03-02
Novel insights into old anticancer drugs
Institute and Leiden University Medical Center. Print: Ridderprint | www.ridderprint.nl
The research described in this thesis was performed at the Department of Cell Biology at the Netherlands Cancer Institute in Amsterdam, The Netherlands, as well as at the Department of Chemical Immunology and the Department of Cell and Chemical Biology at Leiden University Medical Center in Leiden, The Netherlands. The work was financially supported by the Institute for Chemical Immunology and Oncode Institute.
Copyright © 2021 by Sabina Y. van der Zanden. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without prior written permission of the authors, or where appropriate, of the publisher of the articles.
Novel insights into old anticancer drugs
Proefschriftter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. dr. ir. H. Bijl,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 2 maart 2021
klokke 15:00 uur door
Sabina Yasmin van der Zanden
Geboren te Haarlem op 15 oktober 1989
Promotiecommissie
Prof. dr. P. Baas – Nederlands Kanker Instituut Prof. dr. J.G. Borst
Prof. dr. R.C. Hoeben Prof. dr. C.L. Mummery
Prof. dr. E.A.J. Reits – Universiteit van Amsterdam Prof. dr. W.T. Zwart – Nederlands Kanker Instituut
“what we know is a drop, what we don’t know is an ocean” Isaac Newton
-TABLE OF CONTENTS Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Appendices 9 35 63 103 141 163 185 205 235 245 256 258 259 New insights into the activities and toxicities of the old anti-cancer drugs doxorubicin
FEBS Journal (2020)
Genome-wide identification and characterization of novel factors conferring resistance to topoisomerase II poisons in cancer
Cancer Research (2015)
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin
PNAS (2020)
Doxorubicin and aclarubicin: shuffling anthracycline glycans for improved anticancer agents
Journal of Medicinal Chemistry (2020)
Synthetic (N,N-dimethyl)doxorubicin glycosyl diastereomers to dissect modes of action of anthracycline anticancer drugs Exploring the chemical space around the 3’ amine of doxo-rubicin for improved cytotoxic drugs with different genomic specificity
Nuclear DNA sensors re-localize upon chromatin damage; do they play a role in anthracycline induced cell death? Opportunities for small molecules in cancer immunotherapy Trends in Immunology (2020)
Summary and future prospects Nederlandse samenvatting List of publications
Curriculum vitae Acknowledgements
