Cover Page
The handle http://hdl.handle.net/1887/19743 holds various files of this Leiden University dissertation.
Author: Paul, Petra
Title: The systems biology of MHC class II antigen presentation Date: 2012-09-06
The Systems Biology of MHC Class II Antigen Presentation
Petra Paul
The Systems Biology of
MHC Class II Antigen Presentation
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 6 september 2012 klokke 11.15 uur
door
Petra Paul
geboren te Wenen, Oostenrijk in 1980
Promotiecommissie
Promotor: Prof. Dr. J. J. Neefjes Referent: Prof. Dr. Tom H. M. Ottenhoff Overige leden: Prof. Dr. J. Borst
Universiteit van Amsterdam Prof. Dr. M. van Ham Universiteit van Amsterdam
Prof. Dr. H. Overkleeft Prof. Dr. E. J. H. J. Wiertz Universiteit Utrecht
© 2012 P. Paul
Cover and Art Work: Wilhelm Paul
The research described in this thesis was performed at the Department of Cell Biology II at the Netherlands Cancer Institute (Antoni van Leeuwenhoek Ziekenhuis, NKI/AvL) under the supervision of Prof. Dr. J. Neefjes and was supported by an EEC Marie Curie Research Training Network, an ERC program grant, the Dutch Cancer Society, NWO ALW and CW and the Center for Biomedical Genetics (CBG).
Financial support for the publication of this thesis was provided by: The Netherlands Cancer Institute and BD Biosciences.
Table of Contents
Introduction Towards a Systems Understanding of MHC Class II Antigen Presentation 7 Nature Reviews Immunology, 2011 Nov 11;11(12):823-3
Chapter 1 A Genome-wide Multi-Dimensional RNAi Screen Reveals Pathways controlling 19 MHC Class II Antigen Presentation
Cell. 2011 Apr 15;145(2):268-83
Chapter 2 Supplemental Data 39
Cell. 2011 Apr 15;145(2):268-83
Chapter 3 Routes to manipulate MHC Class II Antigen Presentation 55 Current Opinion in Immunology, 2011 Feb;23(1):88-95
Chapter 4 Studying MHC Class II Transport in Dendritic Cells 67 Methods in Molecular Biology, 2012 (in press)
Discussion Summary & Discussion 81
Nederlandse Samenvatting
Appendices Curriculum vitae 89
List of Publications Acknowledgements
6
