Adoptive transfer of tumor- and minor antigen-specific T cell reactivity in mouse models
Witte, M.A. de
Citation
Witte, M. A. de. (2008, May 29). Adoptive transfer of tumor- and minor antigen-specific T cell reactivity in mouse models. Retrieved from https://hdl.handle.net/1887/12870
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Adoptive transfer of
tumor- and minor antigen-specific
T cell reactivity in mouse models
Adoptive transfer of
tumor- and minor antigen-specific T cell reactivity in mouse models
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden,
volgens het besluit van het College voor Promoties te verdedigen op donderdag 29 mei 2008
klokke 13.45 door
Moniek Angenies de Witte geboren te Nijmegen
in 1976
Promotiecommissie:
Promotor: Prof. Dr. T.N.M. Schumacher Referent: Prof. Dr. J.H.F. Falkenburg
Overige leden: Prof. Dr. J. Borst (Universiteit van Amsterdam) Prof. Dr. M.H. van Oers (Universiteit van Amsterdam)
Prof. Dr. H.J. Stauss (University College London, United Kingdom) Prof. Dr. J.J. Neefjes
Het geluk zit in een klein boekje…
Aan mijn familie
The studies described in this thesis were performed at the Department of Immunology at the Netherlands Cancer Institute (NKI), Amsterdam.
This study was financially supported by grants from the Netherlands Organization for Scientific Research (NWO Pioneer grant 00-03) and the EU 6th Framework program (ATTACK).
The printing of this thesis was financially supported by:
- Stichting AMSTOL - BD Biosciences - Corning BV
Contents
Chapter 1: General introduction 9
Chapter 2: Feasibility of removal of MiHAg-specific T cell responses and consequences for Graft versus Host Disease.
Blood 109: 3830-8 (2007)
17
Chapter 3: Prospects and limitations of T cell receptor gene therapy.
Curr Gene Ther. 5: 583-93 (2005)
29
Chapter 4: Targeting self antigens through allogeneic TCR gene transfer.
Blood 108: 870-7 (2006)
43
Chapter 5: Assessing TCR gene therapy and vaccination in spontaneous prostate carcinoma in mice.
Journal of Immunology, accepted for publication
59
Chapter 6: Requirements for effective anti-tumor responses of TCR transduced T cells.
Submitted for publication
77
Chapter 7: An inducible caspase 9 safety switch can halt cell therapy- induced autoimmune disease.
Journal of Immunology, in press
97
Chapter 8: General discussion 115
Summary 133
Nederlandse samenvatting 135
Curriculum Vitae 139
List of publications 141
