Intracellular routing of β-catenin
Hendriksen, J.V.R.B.
Citation
Hendriksen, J. V. R. B. (2008, June 19). Intracellular routing of β-catenin.
Retrieved from https://hdl.handle.net/1887/12965
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Intracellular routing of ß-catenin
Jolita Hendriksen
On the cover: “routing in a mystical world” picture taken by author in Ngorongoro Crater, Tanzania
Intracellular routing of ß-catenin
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 19 juni 2008 klokke 15.00 uur
door
Jolita Valentina Rudolphine Barbara Hendriksen
geboren te Doetinchem in 1977
Promotiecommissie
Promoter: Prof. Dr. J.J. Neefjes Co-promoter: Dr. M. Fornerod
Nederlands Kanker Instituut, Amsterdam Referent: Prof. Dr. W. H. Moolenaar
Overige leden: Prof. Dr. R. Fodde
Erasmus Medisch Centrum, Rotterdam Prof. Dr. P. ten Dijke
Prof. Dr. J.N. Noordermeer
Printed by Gildeprint drukkerijen, Enschede, The Netherlands
The work described in this thesis was performed at the Department of Tu- mor Biology of the Netherlands Cancer Institute, Amsterdam, The Netherlands.
This work was supported by grants from the Netherlands Science Foundation Medical Sciences (901-020250) and the Dutch Cancer Foundation (NKB/KWF;
2004-3080). Publication of this thesis was financially supported by the Dutch Cancer Foundation (KWF).
© Hendriksen, J.
ISBN 978-90-9023155-6
“Een dag niet gelachen is een dag niet geleefd”
In liefdevolle herinnering aan mijn moeder Marian.
Contents
page
Chapter 1 General introduction and scope of this thesis 13
Chapter 2 RanBP3 enhances nuclear export of active 33 ß-catenin independently of CRM1
Chapter 3 Wnt stimulation-independent plasma membrane 57 localization of dephospho-ß-catenin
Chapter 4 Plasma membrane recruitment of 71 signaling-competent ß-catenin upon
activation of the Wnt pathway
Chapter 5 Rapid nuclear export of GFP-ß-catenin via a 89 facilitated mechanism independent of CRM1
Chapter 6 Summary and discussion 103
Nederlandse samenvatting 113
Curriculum Vitae 119
