Citation
Jordens, I. (2005, November 23). Transport of Lysosome-Related Organelles. Retrieved from https://hdl.handle.net/1887/4341
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4341
Transport of Lysosome-Related Organelles
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op woensdag 23 november 2005
te klokke 15.15 uur
door
Ingrid Jordens
Overige leden: Prof. dr. E.J.H.J. W iertz
Prof. dr. T.H.M. Ottenhof
Dr. P. van der Sluijs
Universitair Medisch Centrum Utrecht
Dr. A. M. Mommaas
Dr. E.A.J. Reits
Academisch Medisch Centrum, Amsterdam
Reproduction: Pons & Looijen BV, Wageningen
Contents
Chapter 1 Introduction
Scope of the thesis 9
Chaperoning antigen presentation by M HC class II molecules and 11 their role in oncogenesis.
Adv Cancer Res. 93:129-158 (2005)
Rab proteins,connecting transport and vesicle fusion 29 Traffic: In press (2005)
Chapter 2 Opposing motor activities of dynein and kinesin determine retention 43 and transport of M HC class II-containing compartments.
J. Cell. Sci. 112: 785 (1999)
Chapter 3 The Rab7 effector protein RILP controls lysosomaltransport by 65 inducing the recruiment of dynein-dynactin motors.
Curr. Biol. 11: 1680 (2001)
Chapter 4 A splice variant of the Rab7 effector RILP induces lysosomal 83 clustering without dynein motor recruitment.
Submitted (2005)
Chapter 5 Dynein-mediated vesicle transport controls intracellular Salmonella 101 replication.
Mol. Biol. cell. 15: 2954 (2004)
Chapter 6 Rab7 and Rab27a controltwo motor protein activities competing 121 in melanosomaltransport.
Resubmitted (2005)
Chapter 7 Summary and Discussion 139
Nederlandse Samenvatting 149
Curriculum Vitae 155
