The handle
http://hdl.handle.net/1887/79824
holds various files of this Leiden University
dissertation.
Author: Salvagno, C.
IMMUNE CELL COMPLEXITY IN THE TUMOR
MICROENVIRONMENT OF BREAST CANCER
Cover concept: Camilla Salvagno and Giovanni Marinovich Cover design: Giovanni Marinovich
Lay-out and printing: ProefschriftMaken ISBN: 978-94-6380-439-4
The printing of this thesis was financially supported by the NKI-AvL.
© 2019 by Camilla Salvagno. All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without prior permission of the author and the publisher holding the copyright of the articles.
IMMUNE CELL COMPLEXITY IN THE TUMOR
MICROENVIRONMENT OF BREAST CANCER
Proefschrift
ter verkrijging van de graad van Doctor aan de
Universiteit Leiden
op gezag van
Rector Magnificus
Prof. Mr. C.J.J.M. Stolker
volgens besluit van het College voor Promoties
te verdedigen op dinsdag
22 oktober 2019 klokke 11:15 uur
Door
Camilla Salvagno
Geboren te Venetië
Promotiecommissie:
Prof.dr. J. Borst
Prof.dr. J. Jonkers
Table of Contents
Chapter 1 11
Scope of the thesis
Unpublished
Chapter 2 27
Purification of Immune Cell Populations from Freshly Isolated Murine Tumors and Organs by Consecutive Magnetic Cell Sorting and Multi-parameter Flow Cytometry-Based Sorting
Camilla Salvagno and Karin E. de Visser
Methods Mol Biol. 2016;1458:125-35
Chapter 3 41
Transcriptional signatures derived from murine tumor-associated macrophages predict outcome in breast cancer patients
Sander Tuit*, Camilla Salvagno*,Theodore S. Kapellos*, Cheei-Sing Hau, Lea Seep, Marie Oestereich, Kathrin Klee, Karin E. de Visser, Thomas Ulas and Joachim L. Schultze
* These authors contributed equally
Manuscript submitted for publication
Chapter 4 79
Exploiting the immunomodulatory properties of chemotherapeutic drugs to improve the success of cancer immunotherapy
Kelly Kersten†, Camilla Salvagno† and Karin E. de Visser †These authors contributed equally
Front Immunol. 2015 Oct 7;6:516.
Chapter 5 111
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
Camilla Salvagno, Metamia Ciampricotti*, Sander Tuit*, Cheei-Sing Hau, Antoinette van Weverwijk, Seth B. Coffelt, Kelly Kersten, Kim Vrijland, Kevin Kos, Thomas Ulas, Ji-Ying Song, Chia-Huey Ooi, Dominik Rüttinger, Philippe A. Cassier, Jos Jonkers, Joachim L. Schultze, Carola H. Ries and Karin E. de Visser
*These authors contributed equally
