Cover Page
The handle
https://hdl.handle.net/1887/3182527holds various files of this Leiden
University dissertation.
Author: Cioni, B.
Title: The complex interactions between the tumor microenvironment and prostate and
oropharyngeal cancer
THE COMPLEX INTERACTIONS BETWEEN
THE TUMOR MICROENVIRONMENT AND PROSTATE
AND OROPHARYNGEAL CANCER
ISBN XXX
Cover title: ‘The yin and yang of the tumor microenvironment’
Cover design: Paola Antón Vasquez (https://paolaantonvasquez.wordpress.com/) Layout and printing: Off Page (https://www.offpage.nl/)
Copyright 2021 of this thesis by Bianca Cioni. All rights reserved. No part of this book may be reproduced, stored in retrieval system, or transmitted in any form or by any means, without prior permission of the author.
The research described in this thesis was performed at the Division of Molecular Genetics and Division of Oncogenomics of the Netherlands Cancer Institute (The Netherlands) and was supported by a grant from the European Union (FP7 MCA-ITN 317445 TIMCC).
THE COMPLEX INTERACTIONS BETWEEN
THE TUMOR MICROENVIRONMENT AND PROSTATE
AND OROPHARYNGEAL CANCER
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden, op gezag van rector magnificus prof.dr.ir. H. Bijl,
volgens besluit van het college voor promoties te verdedigen op donderdag 3 juni 2021
klokke 11.15 uur
door
Bianca Cioni geboren te Pisa
Promotor: Prof. dr. J.B.A.G. Haanen
Co-promotors: Dr. A.M. Bergman and Dr. J.P. de Boer (Nederlands Kanker Instituut)
Promotiecommissie: Prof. dr. S.H. van der Burg
Prof. dr, S.C. Linn (Nederlands Kanker Instituut) Prof. dr. J.A. Schalken (Radboud UMC)
To my family, my beloved Carlo and to my son
TABLE OF CONTENTS
Chapter 1 General introduction and outline 9
Chapter 2 Androgen Receptor Moonlighting in 21
the Prostate Cancer Microenvironment
Endocr Relat Cancer. 2018 Jun;25(6):R331-R349
Chapter 3 Loss of Androgen Receptor Signaling in Prostate 51 Cancer-Associated Fibroblasts (CAFs) Promotes CCL2 and
CXCL8 Mediated Cancer Cell Migration
Mol Oncol. 2018 Aug;12(8):1308-1323
Chapter 4 Androgen Receptor Signalling in Macrophages 77 Promotes TREM-1-mediated Cancer Cell Line
Migration and Invasion
Nat Commun. 2020 Sep 9;11(1):4498
Chapter 5 Human Prostate Cancer-Associated Macrophage 131 Subtypes with Prognostic Potential Revealed by
Single-cell Transcriptomics
In revision
Chapter 6 HLA class II Expression on Tumor Cells and Low Numbers 163 of Tumor-Associated Macrophages Predict Clinical
Outcome in Oropharyngeal Cancer
Head Neck. 2019 Feb;41(2):463-478
Chapter 7 General Discussion 195
Appendices English summary 205
Nederlandse samenvatting 209
PhD Portfolio and publications 212
Curriculum vitae 214
