Cover Page
The handle http://hdl.handle.net/1887/67427 holds various files of this Leiden University
dissertation.
Author: Jong, L.W. de
Title: Ventral striatal atrophy in Alzheimer's disease : exploring a potential new imaging
marker for early dementia
Ventral striatal atrophy in
Alzheimer’s disease:
Exploring a potential new imaging
marker for early dementia
c
Copyright L.W. de Jong, Leiden, The Netherlands, 2018. All rights reserved. The copyrights of the articles that have been published have been transferred to the re-spected journals. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without written permission of the author. ISBN: 978-94-6361-199-2
Cover by L.W. de Jong designed with Context Free Art Layout by L.W. de Jong and J.-S. Vidal composed with LATEX
Ventral striatal atrophy in Alzheimer’s disease:
Exploring a potential new imaging marker for early dementia
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op dinsdag 11 december 2018
klokke 13:45 uur
door
Laura Willemijn de Jong
Promotor Prof. Dr. M.A. van Buchem
Copromotor Dr. L.J. Launer, Laboratory of Epidemiology and Population Science, NIA/NIH, Bethesda, MD, VS
Promotiecommissie Prof. Dr. Ir. M.J.P. Van Osch
Prof. Dr. V. Gudnason, Icelandic Heart Association Prof. Dr. Ir. B.P.F. Lelieveldt
Prof. Dr. G. Blauw
Prof. Dr. W.M. van der Flier, VU Medisch Centrum Dr. M.W. Vernooij, Erasmus Medisch Centrum
The research described in this thesis was conducted at the Department of Radiology of the Leiden University Medical Center (Leiden, the Netherlands), at the Icelandic Heart Institute (Kópavogur, Iceland), and at the Laboratory of Epidemiology and Population Science of the National Institutes of Health (Bethesda, Maryland USA).
The research described in this thesis was supported by the National Institutes of Health (Cooperative agreements 5U01AG017155-09 and 5U01AG019349-08, and Contracts N01-AG-1-2100 and N01-AG-4-2149), the Intramural Research Program of the Na-tional Institute on Aging, the Hjartavernd (Icelandic Heart Association), and the Al-thingi (Icelandic Parliament).
Contents
1 General introduction 9
I
Ventral striatal atrophy in Alzheimer’s disease
27
2 Reduced volumes putamen and thalamus in AD 29
3 Shape abnormalities of the striatum in AD 49
4 Ventral striatal volume and cognitive decline 71
5 Atrophy rates of MTL and BG and vascular risk factors 89
II
Allometric scaling in brain development and degeneration
113
6 Allometric scaling of brain structures 115
7 Bigger brains atrophy faster in later life 145
8 Summary and general discussion 169
Appendix A Samenvatting 183
Appendix B List of publications 189
Appendix C Dankwoord 191
