Cover Page
The handle http://hdl.handle.net/1887/19078 holds various files of this Leiden University dissertation.
Author: Lampen, Margit H.
Title: Alternative HLA class-I peptide presentation in processing deficient tumors Date: 2012-06-13
Alternative HLA class-I peptide presentation in processing deficient tumors
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 13 Juni 2012
klokke 13.45 uur door Margit H. Lampen geboren te Utrecht in 1982
Promotie commissie:
Promotor Prof. Dr. S.H van der Burg Co-promotor Dr. T van Hall
Overige leden Prof. Dr. E.J.H.J Wiertz (UMC Utrecht)
Prof. Dr. S.M van Ham (Sanquin, AMC, Amsterdam) Dr. M.H.M Heemskerk
Prof. Dr. R Offringa (Heidelberg Universistät)
ISBN: 978-94-6182-098-3
Cover design: Margit Lampen, Rose in Regent Park England early in bloom in January 2012.
Lay-out: Margit Lampen and Duncan de Jong Priting: Off Page Amsterdam
Printing sponsored by: Dutch Cancer Society
The studies described in this thesis were performed in the department of Clinical Oncology at the Leiden University Medical Center and was funded by the Dutch Cancer Society (UL2007-3897).
Niets in deze uitgave mag worden verveelvoudigd en/of openbaar gemaakt worden zonder voorafgaande schriftelijke toestemming van de auteur.
No part of this thesis may be reproduced in any form without written permission from the author.
Table of Contents
Chapter | page
1. Introduction | 6
2. CD8+ T-cell responses against TAP-inhibited cells are readily detected
in the human population. | 22
3. Development of a target discovery approach for the identification of
human TEIPP antigens. | 38
4. Alternative peptide repertoire of HLA-E reveals a binding motif that
is strikingly similar to HLA-A2. | 50
5. HLA-E expression by gynecological cancers restrains
tumor-infiltrating CD8+ T lymphocytes. | 58
6. Promiscuous Binding of Invariant Chain-Derived CLIP Peptide to
Distinct HLA-I Molecules Revealed in Leukemic Cells. | 72
7. Discussion | 84
&. Nederlandse samenvatting | 100
Curriculum vitae | 104
Publications | 104
Equipped with his five senses, man explores the universe around him and calls the adventure Science.
Edwin Powell Hubble The Nature of Science, 1954
