Cover Page The handle
Hele tekst
(2) 6 The Protein-Tyrosine Phosphatase Family in *DVWUXODWLRQ&HOO0RYHPHQWVLQ=HEUD¿VK Vincent Runtuwene, Mark van Eekelen and Jeroen den Hertog. 139.
(3) !"#$%&'$ ϐ Ǥǡϐ ǡ ! Ǥϐ ! ǦǤ ǡ !"#$!$%Ǥʹ Ͷͺǡ ǦǤ
(4) ϐ ǡ ϐ ! Ǥ !"#&!'( Ǧ ǡ ϔ Ǥ. 140.
(5) !"#$%&'(#)%" Ǧ ǡ ! ȏͳǦ͵ȐǤ ! Ǧ ȋȌ ȋȌ ȏͶǦͻȐǤ ǡ Ǥ ǡϐ ǡǮ ǯǦ ǡ Ǥ ȋȌ ȏͳͲȐǤ ǡ! ǡ ǡǤǡ ! ȏͳͳȐǤ ǡ Ǧ Ǥ Ǧ ȀȏͳʹǦͳͷȐǤ! ϐȏͳȐǤ Ǥǡ ϐ ϐ Ǧ Ͷͺ Ǥ ȏͳȐǤ ǡ !"!#$ǡǡǡ!"!%&&ǡ!"!#'$ ϐȏͳͺǦʹͲȐǤǡ !"!%&(!"!%)* ȋ͵ǡȌǤ Ǥ ǡ! ǡ ȏͳͻȐǤ ! ǡ ! Ǧ
(6)
(7)
(8) ǡ Ǧ ǡ Ǥ 141. !.
(9) ǡȋȌ Ǥ ǡ Ǥ
(10) ǡ Ǥ ! ϐ ʹǤ
(11) Ͷͳ Ǥ
(12) ǡ ǣ !"# $!%& ϐ ! Ǥǡ ǡǤϐ Ǥ. !"#$%&#
(13) ! Ǥǡϐ ! ϐǤ ǡ ȋ ǤͳȌǤϐǡ Ǥ ϐ Ǧ ʹͶǡͶͺʹ ȋȌǤ ʹϐ ! Ǥǡͷ͵Ǧ Ǧ Ǧ Ǧ ϐ ͷ͵Ǧ Ǥ ǡ ! ͷ͵Ǧ ! ϐ Ǥ ϐ ϐǡͺǡ ȏͳǡʹʹȐǤ ǡ ǡ ǡ ǡ " ǡ Ǧ Ǧǡ ȏʹ͵ǦʹͷȐǤǡ ǡ ǡ ȏʹǡʹȐǤ
(14) 142.
(15) !. 143.
(16) !"#$%&'()'*+,&-./"+'01&%1"&2'03'/,&'4+%&&5'30%'6764'2"/,'.'%08&'"5'9:'-01&-&5/4)' ȋȌ ϐ ϐ ȋͺȌǤȋȌȋͲǤ͵ȂͷǤͲȀȌ ϐ! ǡϐ ͶͺǤϐʹǤ ϐ ͷ͵ǤȋȌʹ ϐ ϐ ͷ͵ǡ ϐ Ǥ
(17) Ǥ Ǥ. Ǥ Ǥǡ Ǧ ǡ Ǥ ǡ ȋʹͷǦȌ ! ȋǣȀȀǤǦǤ ȀȌȋͳȌǤ. !"#" ptprc ptprm ptprk ptprt ptprua ptprub ptprfa ptprfb ptprsa 144. $%& #'(" MO1* MO2 MO1* MO2 MO1* MO2 MO1 MO2 MO1* MO2* MO1 MO2 MO1 MO2* MO1* MO2 MO1. )"*+"#," ACAAAGCACAAACCTTATTTCCTTC CCCTATCTGTACCTGCAGTGGACCA TTGATGCTGCACCTTCTCCACAGCG ATTCTCCTGTACCTGCAGTGCACCA AAAATAATCTCACCCTCTCCAGAGT GGCCACACACACCTCGGTCTGTACC AAAGAGATTTTACCTTCTGTACAGT ATAGCAGCATACCTGCAGTGAACCA AGTCATCTCGTACCCGCTCCAGGGC GAAGCTCCATACCTGCAGTGCACCA TAACACACTTACCCGCTCCATGGCA AGTAATTTCTACCTGCAGTGGACAA GGAACTTTTTACCTTGTAAAGGGCA AACCGTACTCACCTGCAGTGCACTA GAACACACACACCTTGTAGAGAGCG GTCACGCTGTACCTGCAGTGCACCA TTGAAATCTTACCTTGTGCAAGGAG.
(18) ptprsb ptprda ptprdb ptprb ptprja ptprh ptprq ptpro ptpra ptprea ptpreb ptprga ptprgb ptprza ptprzb ptprr ptprna ptprnb. MO2 MO1* MO2* MO1* MO2* MO1 MO2 MO1 MO2 MO1 MO2 MO1 MO2 MO1 MO2 MO1* MO2* MO1* MO2* MO1* MO2* MO1* MO2* MO1 MO2 MO1* MO2* MO1* MO2 MO1 MO2 MO1 MO2* MO1 MO2 MO1 MO2. CAGATTTCAGACCTGCAGTGGGCGA GCACACACTCACCCTGGCGTCGGTG GTCGTGTTTTACCTCAGTCTGCACC CTGTTTGGTTACCTTAAAGAGGGCA GGTAATAGCTACCTGCAGTGGACCA CACCGCTCGTACCCTGGACCGCTCC TGAGAGTCAGACCTGCAGTGCACCA GACTCCACTTACGCATGATATTTTG TGTGACTCTTACCTCGGTTTGTACC TGAGGTTCTTACATGGCAGCACATT TGAGGTTCTTACATGGCAGCACATT ACATTGCCTTACCCTTCCACCCTCA GAAATGGCTTACATTTTTGACATTA GCATTGGTTTACCCGCTCCACTTTG GCGTCTGTGTACCTGCAGTGGACCA TGTTTTCCTCACGTATGCGAGTCTG GTTAGCACTGACCCTGCGGCGCTCG TTGCGGCGTTTACCTCTTTCCGCTC TGCCCTGGAGAAACGAAACCTGCAT AAGGGATGCTAACCTCTTTTCTCTC ATTAAGACTTACATATTGCACACAG TATCTTATCTCACCTCTTTTCTCTC CTGCAGTCTTACCTACAGTGCACTA AAACATTGTGTACCTTCTTTACTTT TGTGGGTTTTACCTGCAGTGTACAA ATGGATACTCACCCTGCCTTTCTCC GCTTTAACGCACCTTTTTCAGTTTG CTCAAAGCCTTACCCGGCCCTTCTC GTAACTGCTTACCTGCAGTGCACCA AAAATGTCTTACCCTTCCTTTCTCC AAATATTGATACCTTTTTTATGCTG ATCAGGACTTACTCGTATGTAGTTG TCAGATACTGACTTGGCAAAATGGT GGTTTTCAGTAGGTGCGGAAGTCCA AAGTTTGCTTACCTTTGGCCATGCG ATGTATGCAGTACCTGCGAAAGTCC TGAAGTGCTGACCTTTAGCCATGCG. !. 145.
(19) ptprn2. MO1 MO2* ptpn1 MO1 MO2 ptpn2 MO1* MO2 ptpn6 MO1 MO2* ptpn11a MO1* MO2* ptpn11b MO1 MO2 ptpn9a MO1 MO2 ptpn9b MO1 MO2* ptpn18 MO1 MO2 ptpn3 MO1 MO2* ptpn4a MO1 MO2 ptpn4b MO1* MO2 ptpn21 MO1 MO2* ptpn13 MO1* MO2* ptpn23a MO1 MO2 ptpn20 MO1* MO2 ptpn5 MO1 MO2*. TGTGGACACATACCTGCGGAAGTCC TGTGGTACTTGCCTGCAATGAACAA CAAGAGCCTCACCGACAGATTTTCC CCGTCATCTCACCAATAGAAGGCAG AATGTGACTCACCGTGCCTTTCTCT TTACATTCACACCTTGCCATTTTGA ACTCATTCCTTACCCGATGCGGAGC TTATTAAAGTACCTGCAGTGAATGA GAAACCCTTTACCTTTCCCCGTTCC GGTGGAACCACCTTCGGGATGTCAT GCATTGCTCTTACCCTGTCTAGACG CCTGGACCTTACCCGTCCTCTCTCC TATGATGTCGTACCTTGTTATCATG TTAGAAATGTACCTCAGTGTTGTGC TAACGAAACTAACCTTGTAGTCATA TAAGAAACTAACCTGAGTGTTGAAC TGAAACAGCTCACCTTAACATTATG GAAAACACTTACAGTTGAGACAGTA TGTTGTTGTTACCTGAGTGTTAGTG ACGAAGTTGTACCGATGTCTGAACC GTGATAAGCTCACCTCAATGTGAGT ATGTGGACTTACAGGCGTCTGAATC ATGCTTTTCATACCCGGCCCCGCTC TCCAGGCCTGACCTGCAGTGAACCA GTGCTGTACTTACAGAGAAAGCCTT TGCAGTGCATACCTCATTGTGTTCC CTCTCTCTCTCACCTGGACGTCTTT TGTGACACTTACATCTGCGTCTTTG AAAAGTCCCTTACAGTTCAGGCCAT TAAGTGGTTTACCTTTAGTGTAATG CATGCTCCTAACCTTTTTTTCCACC TAAATGACTCACACTGAGGTCTTTC AACTCAGACAGACCTTCACAGTGAA TAAAAATGTTACCTGCAGTGGACGA. !"#$%&'(&)!)&*%+%,&"+-&./012/$3+/&,%45%+6%,(& ȋͳȌȋʹȌ! ȋǡǡȌǤǡ ȋȗȌǤ 146.
(20) Ǧ . Ǥ
(21) ͲǤ͵ͷǤͲ ȀǡͷͲ ȋαͷͲȌǤ ! ͶͺͺͲΨ ! ȋ ǤʹȌǤǦǡ ǡʹȋ ǤʹȌǤ ϐ ʹǤ Ͷͳ ǡ ǣ!"!#$%ǡǡ !"!#&Ǥ ǡ '!"!#()ǡ!"!#)Ȁ" ȋ Ȍ ! Ǥ ϐ Ǥ Ǧǡ ǡ ǡ ǦǦ ϐ ȏʹͺǦ ͵ͲȐǤ ϐ ͷȀȏ͵ͳǦ͵͵ȐǤ
(22) ǡ ǡ ǡ ǡǦ Ǥ ǡ ͷȀǤ ǡ Ǧǡ Ǧ ϐ Ǥ Ǧ ϐ ǡ! ͷ͵Ǧ ϐ ǡ Ǧ! ϐ ͷ͵Ǧȏ͵ͶȐǤ Ǧ ͷ͵ǦǤ ǡ ȋ ǤʹȌǡ ϐ Ǥ ! ǡ ! Ǥ ǡ ǤǤ ȏͳͳȐǤǡ ! 147. !.
(23) Ǥ ǡ ǡ! Ǥ ǡ!"#$!%& ϐ ͺǦͳͲ '()*+, ǡǦ ȏͳͻǡ͵ͷǡ͵Ȑȋ Ǥ͵ȌǤ'()*+, ͵ͷǤ ǤǤ ϐ Ǥ '()*+, ϐ. !"#$%&'()'*+,-./,0+',1'2345'-6$5&5'6'57,%3&%'6+3&%",84,53&%",%'69"5)' ȋȌͶͺ ͳǦ -%Ǧ -($.ȋͳǡʹͷȌǡȋͳǡʹͷȌǡȋͳǡʹͷȌǡ-%-()ȋͳȌ-%-(&/ȋͳǡʹͷȌǡ-%-(/ȋͲǡ͵Ȍǡ Ȁ ȋ ʹǡͷ ʹǤͷ Ȍǡ -%-(/ ȋͲǡ͵ Ȍ -%-"00 ȋͳ ȌǤ
(24) ǤȋȌϐ ȋȌǤ
(25) ǡǤǤ ǡʹ
(26) ʹǦǦ Ǥ ϐ αͲǡͲͷ Ǧ ȋ
(27) ȌǤϐ Ǥ 148.
(28) ! "#$%&'()*(+,(-'.'/01(#2(343(526/5-6721*( ȋȌ ͳǦ !"!#()ȋͳǡʹͷȌǡ!"!#&'ȋͳǡʹͷȌǡ ȋͳǡʹͷȌǡȋͲǡʹͷȌǡ!"!#$ȋͳȌ!"!#)ȋͲǡ͵ȌǡȀȋʹǡͷ" ʹǡͷȌǡ!"!*++ȋͳȌǤϐͺǦͳͲ ,#$-./Ǧ Ǧ ϐ Ǥ ,#$-./ ͵ͷǤ ͳͺ ! Ǥ ǤȋȌ ȋȌǤ ʹǦ Ǧ Ǥϐ αͲǡͲͷ Ǧ Ǥϐ Ǥ. Ǥ ϐ !
(29) ȋ Ǥ͵ȌǤ ϐ ȋ Ǥ͵ȌǤ ͶȀ !"!#$% ϐ ͺǦͳͲ ǡ !"!#&'ȋ Ǥ͵ȌǤ ǡ! Ǥ ! 149.
(30) ʹ ͵Ǥ
(31) ϐ ǡ ʹͲ ǦǤ ͳͲͲ ρ ǡ Ǥ ͳͶͲͲͲρ; Ǥ
(32) Ǧ ǡ Ǧ
(33) Ǧǡ ǡ ǡ ϐ ȋͷǡȌǤ ! ϐ ϐ Ǥ ǡ ǡǤǤ ǡ! ǡ ǤǤ Ǥ ǡ ! Ǧǡ Ǧ ! ǡ ȋ ǤͶȌȋͷǡȌǤ! ǡ
(34) ȋ ǤͶȌǤ!"!#$ǡȀǡ !"#$%&'()'!"#$%&'"*'%&+$"%&,'-.%'/.%012'#1*3%$213"./'4&22'0.5&0&/3*)' ȋȌ ͳǦ !"!#%$ȋͳǡʹͷȌǡ!"!#&'ȋͳǡʹͷȌǡ ȋͳǡʹͷȌǡȋͳǡʹͷȌǡ!"!#(ȋͳȌ!"!#$ȋͲǡ͵ȌǡȀȋʹǡͷ ʹǡͷȌǡ!"!)**ȋͳȌǤ Ǧȋʹͷ Ȍϐ Ǥ ǡͳͲͲɊǤȋȌ
(35) ʹǦ͵Ǥ ǡǡ
(36) ȋȌǤ
(37) ȋ ! ǡDzdzDzdzȌǤ
(38) ǡ
(39) ǤȋȌ Ǥ ͷΨȋ ȌͳͲΨȋ Ȍ Ǥ ǡ ǡ ȋ Ȍȋ ǡȌ ǤǦ ʹ ! Ǥ ǡȋȌ ȋȌ Ǥ ǡ ! Ǧ
(40) ǤȋȌ ȀǤ ʹǦǦ Ǥϐ ! αͲǡͲͷ Ǧ Ǥ ϐ Ǥ 150.
(41) !. 151.
(42) !"!#$%ǡ!"!&''Ǥ ! Ǧȋ ǤͶȌǤ ϐϐ ȋ ǤͶǡȌǤǡ!"!#$%!"!&''! ǡǡϐ !"!#$%" !"!&''Ǥ (!"!#$%(ϐ !"!#)*" ȋ ǤͶǡȌǤ! ǡ ϐ! ȋ ǤͶȌǤ ʹ!"!#)* Ǥ !!"!#&'! ϐ ȋ ǤͶǡȌǤǡϐ ǡ ! ǡ ȋ ǤͶȌǤ !"Ǧ Ǥ
(43) !"#$%&Ǧ ϐ ϐ ȋ ǤͶǡȌǤ ǡ ϐ ȋ ǤͶȌǤ ! ȋ ǤͶȌǤ. ! ǡ ! ʹ !"!#+ Ǥ !"!#(%!ϐ ȋ ǤͶǡȌǤǡ ϐ ǡ ǡ ȋ ǤͶȌǤ ǡ ʹ ǡ ϔ ǡǤ. 152.
(44) !"#$%##"&'
(45) ϔ ! Ǧ ǤǡϐǦ Ǥ Ǥϐ ǣ Ǥ Ͷͺǡ ȋ"#"$%ǡǡǡ"#"&''ǡ"#"$(%)!"#"&'*!!"#"&+,Ȍǡ ϐ! ϐ Ǥ -&!.-#( Ǧ ǡ! ϔ Ǥ ǡ Ǥ Ǥ ǡ ǡ ǤǤ ǡ Ǧ ϐ Ǧ ȏ͵ʹȐǤ ǣȋͳȌ ͷ ȏ͵ͳȐǢȋʹȌ Ǧ ϐǡ ϐ Ǣȋ͵Ȍ ! ͷ͵Ǧ ϐ Ǧ ϐ ͷ͵ǦǦȏ͵ͶȐǤ Ǧ ϐ ! ǡ ǡǦ ȋȌǤ
(46) Ǥ ǡ ǡ Ǥ ! Ǥ ȀǡȀȀ ǡ Ǥǡ "#"$.%ǡ ǡ 153. !.
(47) Ǥ! ǡ Ǥ ȀȀ! ǡ ȏͳȐǤ
(48) ǡ! Ǥ ! ǡ ȏͳȐǤ Ǥ ! ! ǡ Ȁ Ȁ Ǥ
(49) Ȁ Ȁ ǡ ! ǡ Ǥ
(50) !"!#$% !"!#$&ǡ ǡ Ǥ
(51) ! Ǥ . ! Ǥ ϐ Ǥ !"#$%&
(52)
(53) Ǧȏͳǡʹ͵ȐǤ ϐ ǡ Ǥ Ǧ ǡ ȏ͵ȐǤ ǡ ǡǡ ǡ ȏ͵ͺȐǤ ϐ Ǥ !"#$'()
(54)
(55) Ǧǡ ȏͳǡ͵ͻȐǤ ϐ Ǥǡ ȏ͵ȐǤ Ǧϐ ! ȏͶͲȐǤϐ Ǧ ǡ Ǧ ϐǡ ϐǤ 154.
(56) ϐ"#$%&ǡǡ'
(57)
(58)
(59) ! Ǧǡ ͺ
(60)
(61)
(62) ȏͳǡ Ͷͳǡ ͶʹȐǤ ϐ !"!#$ Ǥ !"!#$Ǧϐ Ǥ ϐ ! Ǧ ! ϐȏͶ͵ȐǤ Ǧ ȏͶͶȐǤ Ǧ ǡϐϐ Ǥ "#$%()ǡ Ǧ ȏͳǡͶͷȐǤ ǡ Ǥ % Ǥ Ǧ ȏͶȐǤ ǡ ! ϐ Ǥ Ͷͺ ϐǤ ! ǡϐ! ǡ Ǥ
(63) ǦǡǦ Ǥ
(64) ǡ Ǧ ϐ Ǥ. *+#,%-+./'+01'2,#3&1/ ϔ " ϐ ! ȏͶȐǤ &'% ()"* ȏͶͺȐ " αǦ ϐ +#$,-.Ǥ ǡ ! ȋ! 155. !.
(65) ǡǡȌǤ ȋȌǡͷǯ ȋ Ǧ ȏȐȌǤ Ǥ ǡ ǡ ͲǤͷΨ Ǥʹ ͶͲ ǤʹǦ ! ʹ ͵ ͳͲͲ ρ ǡ Ǥ! ͷǤ !"#"$"%&"' ͳǤ. ǡǤǡǣǦ ǤǡͳͻͻͷǤ"#ȋʹȌǣǤʹʹͷǦ͵Ǥ. ʹǤ. ǡǤǡǤ ǡǤǤǡ Ǧ Ǥ ǡ ͳͻͻͶǤ$#ǣǤʹͷͳǦ͵͵Ǥ. ͵Ǥ. ǡǤǡǤǤǯǡǤ Ǥǡ Ǥ ǡͳͻͻͺǤ"ȋͳȌǣǤͳͳʹǦʹǤ. ͶǤ. ǡ Ǥǡ Ǧ Ǥ ǡͳͻͻͻǤ"%ȋͳǦʹȌǣǤ͵ǦͳͶǤ. ͷǤ. ǡǤǡǤǡǤ" ǡʹͲͲͶǤ$$&ȋȌǣǤͻͻǦͳͳǤ. Ǥ. ǡ Ǥ Ǥǡ Ǥǡ ǣ Ǧ Ǥ ǡʹͲͲͺǤ'&%ȋͷȌǣǤ ͺͳǦ͵ͲǤ. Ǥ. ǡǤǡǤǡ Ǧ ͷǤ" ǡͳͻͻͳǤ""ȋͳͳȌǣǤͷͲ͵ǦͶͲǤ. ͺǤ. ǡǤǡǤǡͷͷǡ Ǧǡ Ǥ ǡʹͲͲͳǤ'(ȋͶȌǣ. 156.
(66) ǤͶͷǦͺǤ ͻǤ. ǡǤǡǤǡ Ǧ Ǥ ǡʹͲͲͶǤ"#$ȋͷͶȌǣǤͳͳͶǦǤ. ͳͲǤ. ǡ
(67) ǤǡǤǡǤ Ǧǡ Ȁ ǤǡʹͲͲͻǤ%#ȋͺȌǣǤͻͺǦͻǤ. ͳͳǤ. ǡǤǤǤǤǡǦ ϔǤǡͳͻͻͲǤ&#'ȋͶȌǣǤͷͻǦͺͲǤ. ͳʹǤ. ǡǤǤǡǤǡ Ȁͷͷ ϔǤǡʹͲͲͲǤ$#(ȋͺʹȌǣǤ ǦͺͳǤ. ͳ͵Ǥ. ǡ ǤǤǡǤǡϔϔ ǤǡʹͲͲʹǤ$ȋͺȌǣǤ ͳͲǦͷǤ. ͳͶǤ. ǡ ǤǤǡ Ǥǡ ϔ Ǥ ǡʹͲͲͲǤ%)ȋͶȌǣǤͳͷͻǦ ͵Ǥ. ͳͷǤ. ǡ ǤǡǤǡϔ Ǧ Ǥ ǡ ʹͲͲͳǤ&ȋʹȌǣǤʹͷͳǦͶǤ. ͳǤ. ǦǡǤǡ ϔǦǦǫ! ǡʹͲͲǤ&!ȋͶȌǣǤͶ͵͵ǦͶͳǤ. ͳǤ. ǡǤǡǤǡ
(68) ϔ Ǧ ǦϔǤǡʹͲͳͲǤ(ȋͻȌǣ Ǥͳʹͷ͵Ǥ. ͳͺǤ. ǡǤǡǤ ǡ Ǥ ǡ Ǧ ȀǦ Ǥ ǡ ʹͲͲǤ"ȋͳʹȌǣǤʹʹͷǤ. ͳͻǤ. ǡǤǡǤǡ Ȁ ϔ Ǧ ǤǡʹͲͳͲǤ"$#ȋʹȌǣǤʹǦ͵ͻǤ. ʹͲǤ. ǡǤǤ
(69) Ǧ ǡ Ǧ Ȁ Ǧ ǤǡʹͲͲͶǤ&"&ȋͳͶȌǣǤ͵͵ͻͳǦͻǤ 157. !.
(70) ʹͳǤ. ǡǤǡǡǤǡǡǤǡ ǡ Ǥǡ Ǧ ǤǤ. ʹʹǤ. ǡ Ǥǡ Ǥǡ ǯ ͷͶ Ǥ ǡ ʹͲͳͲǤ !"ȋȌǣǤͷͷǦʹǤ. ʹ͵Ǥ. ǡǤǡǤǡȀȀǦ ǦǦǣǡǡ Ǧ ϔ Ǧ
(71) ǤͷǤ ǡͳͻͻͷǤ#$ȋʹͷȌǣǤͳͳͺǦͻͲǤ. ʹͶǤ. ǡǤǤǤ ǡ ǡͺͻǤǡʹͲͳͲǤ $$ȋ͵ȌǣǤ͵͵ͻǦͶͺǤ. ʹͷǤ. ǡ ǤǤǡ Ǥǡ ǣ Ǧ Ǧ ͶȀ ͷ Ǥ! ǡͳͻͻͻǤ#%ȋȌǣǤʹͶͲ͵Ǧͳ͵Ǥ. ʹǤ. ǡǤǤǡǦǤ ϔ Ǧ Ǧ Ǥ ǡͳͻͻͷǤ$&'ȋͶͶȌǣǤʹͳͳǦʹʹǤ. ʹǤ. ǡǤǡǤǡ Ǧ Ǧ ǡ Ǧ ϔ Ǥ ǡʹͲͲ͵Ǥ$&"ȋͶͷȌǣǤͶͶʹ͵ǦͺͲǤ. ʹͺǤ.
(72) ǡ Ǥ ǤǤ ǡ Ȁ ͽȀǤ ǡʹͲͲͳǤ!'ȋ͵ȌǣǤͳͲǦ͵Ǥ. ʹͻǤ. ǡǤǤǡǤǡϔ Ǥ ǡʹͲͲͳǤ!'ȋ͵Ȍǣ Ǥͳͺ͵ǦͷǤ. ͵ͲǤ. ǡǤǡ ǤǡǤ ǡ ǡǡǡϔǡ ǡǦ !"!#$%&' ǡʹͲͲͳǤ!'ȋ͵ȌǣǤͳͻͲǦͶǤ. ͵ͳǤ. ǡǤǤ ǤǤǡ Ǧ Ǥ ǡʹͲͲͳǤ!'ȋ͵ȌǣǤͺͻǦͻ͵Ǥ. ͵ʹǤ. ǡ Ǥǡ ǣ ǫ ǡ ʹͲͲʹǤ$%!ȋʹȌǣǤʹͲͻǦͳͶǤ. 158.
(73) ͵͵Ǥ. ǡ ǤǤǡ ϔ Ǧ ǤǡʹͲͲͶǤ""ǣǤͳʹͳǦ͵Ǥ. ͵ͶǤ. ǡǤǤǡǤǡͻ Ǥ ! ǡʹͲͲǤ#ȋͷȌǣǤͺǤ. ͵ͷǤ. ǡ Ǥǡ Ǥǡ ǦͷͷȀ
(74) Ǧ Ǧ ϔ Ǥ ǡ ʹͲͲͺǤ $ȋ͵Ȍǣ Ǥ ͳͲͲͲͲͶͶǤ. ͵Ǥ. ǡǤǡǤǡǦǦ ϔ Ǥ ǡʹͲͳͳǤ$ȋ͵Ȍǣ Ǥ͵ͻ͵ǦͻǤ. ͵Ǥ. ǡǤ ǤǡǤǡǤǤǡ ϔ Ǥ ǡʹͲͲͶǤ%&ȋȌǣǤͶǦͷǤ. ͵ͺǤ. ǡ Ǥǡ Ǥǡ Ǥ ǡͳͻͻͻǤ&'ȋ͵ȌǣǤ͵͵ͲǦ͵Ǥ. ͵ͻǤ. ǡǤǡǤǡ Ǧ Ǧ Ǥ Ǧ ϔ ǦǦ Ǥ ǡͳͻͻͷǤ&"(ȋͳʹȌǣǤʹʹǦͺǤ. ͶͲǤ. ǡǤǡǤǡ
(75) Ǧ Ǧϔ Ǥ ǡʹͲͲͲǤ')ȋͳʹȌǣǤ ʹͷǦͺͷǤ. ͶͳǤ. ǡ Ǥǡ Ǥǡ ǡ ȋǦȌ Ǧ Ǥ ǡ ͳͻͻͷǤ '(ȋͻȌǣ Ǥ ͳ͵ͳǦͺǤ. ͶʹǤ. ǡ ǤǤǡ Ǥǡ . ͷǡ ǣ ͷ ͷ ͷͷǦͷǤ ǡͳͻͻͷǤ &"ȋͳȌǣǤͳͶǦͺͳǤ. Ͷ͵Ǥ. ǡǤǤǡǤǡ ͷȋȌǦǦ ϔ ϔ Ǥ
(76) ǡʹͲͲͲǤ'(!ȋͳͲȌǣǤͳʹͺͳǦͻͲǤ 159. !.
(77) ͶͶǤ. ǦǡǤǤ ǤǤǡ Ǧ Ǥ ǡʹͲͲͻǤ!"ȋͶȌǣǤͶͷͺǦͷǤ. ͶͷǤ. ǡ ǤǡǤǡ
(78) ϔ Ǧ ϔǦ Ǥǡͳͻͻ͵Ǥ#$ȋ͵ȌǣǤͳͶͻǦͷͲǤ. ͶǤ. ǡ Ǥǡ Ǥǡ Ǧ ǤǡʹͲͲǤ "%ȋͳ͵ȌǣǤͷͳͲǦͳͻǤ. ͶǤ. ϐǡϔǤͳͻͻͷǣǡ! ǡǤ. ͶͺǤ. ǡǤǡǤǡ ϔͷǦ ǦǡǤǡ ͳͻͻ͵Ǥ##&ȋͶȌǣǤͳʹͲ͵ǦͳͷǤ. 160.
(79)
GERELATEERDE DOCUMENTEN
Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis Date: 2012-09-12...
Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis
36 Chapter 1 ŔeForm SUBCONSCIOUS (Muddled Thinking) Internal Colonization Unrealistic Dreamer American Walden (Sub-)Consciousness Enclosed Garden. Asocialen –
To give one example, I approached this by compressing dirt, plant fragments and building debris, collect- ed on the ruins of an early 20th century socialist commune in the
Asocialen-Private Prophesy-Detox, performance and installation, Ruchama Noorda, Diepenheim, 2012..
Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.
Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.
Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.