(3) !"#$%& amp;/(%& amp;#234-'5&
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(2) )XQFWLRQDO&KDUDFWHUL]DWLRQRI3URWHLQ7\URVLQH3KRVSKDWDVHVLQ=HEUDÀVK'HYHORSPHQWXVLQJ,PDJH$QDO\VLV Vincent J. Runtuwene 2012. Functional Characterization of Protein 7\URVLQH3KRVSKDWDVHVLQ=HEUDÀVK Development using Image Analysis Vincent J. Runtuwene.
(3) !"#$%&'#()*+,(-($%.-&/(%&'#*'0*1-'%.ê-'5&#.* ϐ
(4) 6#()45&5 Vincent Jimmy Runtuwene.
(5)
(6) ǣͻͺǦͻͶǦͳͻͲǦͳ͵ͶǦ ǣ ǡǮ
(7) ϐ ϐ2 Ǧ ʹ Ǧǯ ǣǡǦ Ǧ ̹ʹͲͳʹ ǤǤ ǡ ǡ Ǥ.
(8) !"#$%&'(#)"*+,,+-##./(#+,/#01#2+3(,4'.
(9)
(10) !"#$%&'#()*+,(-($%.-&/(%&'#*'0*1-'%.द ϐ2 5.#%*"6*85(7.*9#()46&6 ÃǦ ȋȌ.
(11) ǡ ϐ ǤǤǤ Ǥ ͳʹʹͲͳʹ ͳͳͷ. . ȋ´Ȍ ͳͻͺʹ.
(12) !"#$#%&'(#$$&))&' !"#$#%#"*+ . ǤǤ . ǣ + ǤǤ Ǥȋ ǡ Ǧ Ȍ ǡ + ǤǤ Ǥ ȋ Ȍ ǡ. . ǤǤ ȋ ȌǦ ǡ + Ǥ ȋ Ȍ ǡ . . ǤǦ ǡ. . . Ǥ ǡ.
(13) ǡ ȋȌǡ ǡ ȋ Ȍ ǡ ǡǤ ȋ ȀǦǦʹͲͲǦͲ͵ͷͺ͵ͲȌǤ.
(14) !"#$%&'(&)'*+%*+, !"#$%&'()(((((((((*+,-./01,2.+((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((3 ʹȽɂ Ȁ͵ͳ ϐ ͵Ǧ ͷ Ͷ ǦǦ ͻͻ ϐ ͷǣͳͳͻ Ǧ ͳ͵ͻ ϐ ͳͳ ͳͳ ͳ͵ ͳͷ ͳ.
(15)
(16) 1 Introduction.
(17) ͷϔ ϐ ǡǡ ȏͳǦ͵ȐǤ ϐ Ǥ ǡϐǡ ȏʹǡͶȐǤ ǡ ǡ ǡ !"#$%!&'Ǥǡ ǡ Ǥǡȋ͵Ȍǡ ȏͶȐǤϐ ϐ ǡ ϐ Ǥ ȋȌ ϐ ȏͷȐǤ ǡ ǡ Ǧ ǡ ǡ Ǥ
(18)
(19) ȋ Ȍ ϐ ȏǡȐ ǡ Ǧϐ ϐ ȏͺȐǤ ǡǡ ϐϐȏͻȐǤ ϐ ϐ ϐǡ ǡ ȏͳͲǡͳͳȐǤ ǡ ϐ ȋȏͳʹȐȌǡ ȋ ȏͳ͵ȐȌǡ ǡ ǡ Ǥ
(20) ϐǦ ȋȌǤ ϔ Ǥ ǡ ȏͳͶȐǤ ǡϐ ǡ Ǥ Ǥ ǡ ϐ Ǥǡ 10.
(21) ! ͳʹͺǦ ǡ ǡȋ Ȍ Ͷ Ǥ ǡ ǡ Ǥ ͷͲΨ ǡ ȏͳͷȐǤ ǡϐ Ǧ ϐ Ǥ ǡ ǡ Ǧȋ ǤͳǦȌȏͳͶȐǤ ͷͲΨ ǡ ǡ ǡ Ǥ ǡϐ Ǥǡ ǡǡ ȋ ǤͳȌǤǡ ǡ ȋ ǤͳȌǤ Ͷ ǣ ǡ ǡ ȋ Ǥ ͳ Ǧ
(22) ȌǤ
(23) ȋ Ǥ ͳ ǡ Ȍ ǡ ȋ ǡ ǡ ȌǤ ȋ Ǥͳ ȌǤ ǡǯǡ ǡϐ Ǧȋ Ǥͳ ȌȏͳǦͳͺȐǤ ǡ ǡȋ Ǥͳ ǡ ȌǤ ǯ Ǥ ȋȌ ȋ Ȍ ȋȌȋ Ǥͳ Ǧ
(24) Ǣ ǡǢǡ ȌǤ Ǧ Ǧ Ǥ ǡ ȋ Ǥͳ ǡ ǢȌȏͳͻȐǤ 11.
(25) Ǥ ϐ Ǥ ǡ Ǧ ȏʹͲǦʹʹȐǤ Ǧǡ Ǥǡ Ǥ
(26) ǡ ǡ Ǥ ȋȌǡ ϐ Ǥ !"#$%&#"#'%&()*#+,-.-)/&+01&2) 34"5"/0'(&) 67(&#"8&5+749)) Ȁ ǡ ǡ ȏʹ͵ǦʹͺȐǤ ϐ5+4&:'56;5)<5+:6=,)>&#) ?"80)ȋ>Ȍ@)A4'BB(7C)<AB=ǡC'507>7(7C)<C50)C>(=ǡǡ5+&442)#'80+ȋ5+&#ȌȀϔ ȋA6'Ȍǡ/4'%D(7ȋ/DȌǡC'78")ȋC8"Ȍȏʹͻǡ͵ͲȐǤ ǡ ȏ͵ͳǦ͵͵ȐǤ 34"5"/0'(&) Ǧ ȋ ǤʹȌǤ
(27) ϐ ǡ Ǧ Ǥ Ǥ ǡ ȏ͵ͳǦ͵ͶȐǤ
(28) ǡ ǤE+:6)/D) ABǡC>(@)C8"ȋ ǤʹȌǤF6' ǤC&%05";5) ȋC5Ȍ))A";4$G"'#+7C)ȋϔȌϐǡ 12.
(29) !. 13.
(30) !"#$%&'()'*+,-%$.+-"/0',-+#&'1+-&'2+3,'+04'2/%35/#&0&-"6'2/7&2&0-,8ȋȌǡ ȋ ȌǡȋȌǡȋȌ Ǥ ǦǤǣͷͲΨȋͷȌǤ ǦǤ Ǥ ȏͳͲͷǦͳͳͲȐǤ ǡϐȏͳͳͳȐǤǣ ȋȌǡ ǡȏͳͳͳȐǤǦ ǤǣͻͲΨȋͻȌǤ Ǥ ȏͳͳʹȐǡϐȏͳͳͳȐǤǣȋͳͲȌǤ ȋ
(31) ǤȌǤϐȏͳͳͳȐǤ ǣ ʹͶ Ǥ ȋǡ Ǧ ǡǡǡǡ Ȍ ȋǦȌȏͳͷǡͳͲǡͳͳͲȐǤ Ǥ ǣ ͷͲΨǦ Ǥ ȋȌȋȌ Ǥ ǣ ǤȋȌǡ ȋȌȋȌ Ǥ ǣ ͻͲΨǤȋȌǡ Ǧ ȋȌȋȌ Ǥ
(32) ǣ Ǥ ȋȌȋȌ Ǥǣ ǡǢǡǢǡǢ ǡǢǡǢǡ Ǣǡ Ǣǡ ǢǡǢǡǢ ǡǤ. ȂǤ!"ǡ ϔȋ ǤʹȌ# !"$%&'ȋ$&Ȍǡ Ǥ ȋ ǤʹȌȏ͵ͷǡ͵ȐǤ'
(33) ǡ ȏ͵ͷǡ͵ȐǤ ȏ͵ͺȐǤ
(34) ǡ !()")*+,-% ' ǡ Ǥ !()")*+,-% ǡ Ǥ Ǥ Ǧǡ ȋ ǤʹȌǤ ȏʹͷǡ 14.
(35) ! ͵ͻǦͶ͵ȐǤ!"#$#%&'() ǡ *!"#$#%&'() ǣ ǡȋ ǤʹȌǤ ǡ Ǧ ȏͶͶȐǤ* +,-+,.*/0123*)45*56(1**56(7*ȏͶͷȐ Ǧ Ǥ Ǧ ǡ ǡ ͷͳͳ `< ȏͶǡͶȐǤͷͳͳ ǡ ͳ ȏͶͺǡ ͶͻȐǤ ͳ ǡ ǡ ǡ ʹȏͷͲǦͷʹȐǤǦ ǡ Ǧ ǡ ͳǡ Ǧ Ǧ ȋ Ȍȋ Ǥ͵Ȍȏͷ͵ǡͷͶȐǤ ǡ ǡǤǦ ȏͳͻȐǤ ǡ Ǧ ǡ ǡ ǡȋ ǤʹȌȏͳͻǡʹʹǡͷͷǦͷȐǤ ǡ ǡ ȏͷͺǦͲȐǤ ǡ Ǥ. 89&:"*%)9&;)<$ ͵Ǥ
(36) ͵Ǧ Ǧ ǡ Ǥ ȏͳȐǤ 15.
(37) !"#$%&' ()' *+,-,%' .&++' /0+,%"12' /,134,2Ǥ ǣ Ǧ ȋȌǤȋȌȋȌ Ǥǣ ȋȌǡ ȋȌǡ ȋ Ȍǡ ȋȌǡ ȋȌ ȋȌǡ Ǧ ȋ Ȍǡ ȋ ȌǤ ȋȌȋȌ Ǥǣ ȋ Ȍǡ ȋ Ȍ ǦǤ ȋȌȋȌ Ǥǣ ǡǡ ǡǡ Ǥǣ Ǧ ǡǡ ǡ ǤȋȌȋȌ Ǥ. Ǥ
(38) ǡ Ǥ ʹΪȀ Ǧ Ǧ ǡǤ Ȃ ȏʹȐǤ . ǡ Ǧ 16.
(39) ! "#$%&'( )*( +,-./0-,-#/01( 2-3( 4#$-01#-$( 5036708*ȋȀȌ Ǧ ͳͳȋȌǦ Ǥ Ǧ ʹ ͷȀǤ ͳ ͳǡ Ǧ Ǥ ʹ ͳ Ǧ ǡ Ǧ Ǥ. ȏ͵ǡ ͶȐǤ ȏͷȐǡ Ȁ ȏȐǡ Ǧͳ ȏȐǡ ȏͺȐǡ ȏͻȐǡ ʹȏͲȐǤ ͺϔ Ǧ ǡ ǡ ǡ ǡ ȏͳǦͶȐǤ ǡ ǦȋȌȋȌ ȏͷǦͺͲȐǤ ϐ ǡ Ǥ ϐ ǡ ȏͷȐǤǡ ϐ ȏͺͳȐǤ ǡ ͳȏͺʹȐǡϐϐ ȏͺ͵Ȑǡ ͳ ǡ ϐ ȏͺͶȐǤ ǡͳ 17.
(40) ǡʹͲͳ͵ǤͳǦͳ͵ǤʹȏͺͷȐǡϐ ȏͺȐǤǡ
(41)
(42)
(43) ǡ ȏͺȐǤǤ ϐ ǡ ϐǤ ȏͺȐǤ Ǥ ǡ!"#$%&'( Ǥ. ϐ ǡ ǡ ϐ Ǥǡ ϐ ϐ ϐ ȋͺȌǤ ǡ ϐ ȋ Ǥ ͶȌǤ ǡ ϐ ȏͺͺȐǤ ȏͺͻȐǤ ϐ Ǥ ǡ Ǧ Ͷͺ ϐ ǡ ȏͺͺȐǤ ǡ ǡ ȏͻͲȐǤ ǡ ϐ ϐǤ ϐ ϐ ͳǤ !"# )!)(# ͳʹͳ͵ ǡͳǡ ǡ ȏͻͳȐǤ
(44) ǡ ǡ *%+",-ϐǡ ȏͺͺȐǤ ǡ ǡ ǡ ǡǤ ǡ Ǥ ǡ Ȃ ȋȌǤ ` ǡ ǡ ϐ 18.
(45) !. ͶǤϐǤ ϐǤ ϐϐ Ǥ DzdzDzdzǤ. ǡ `͵ǡ ǡ Ǥ `! ȏͻʹȐǤ !"!#$ǡ ȏͻ͵Ȑǡ ϐ ǡ ͵ȋȌǤ Ǥ
(46) ǡͷ ϐ ǡǡϐ ȏͻͶȐǤ%
(47) ʹǡ!"!#$% &'&%%ǡ ǡ Ǥ ! ("!#)$*% s!"!#)+ȏͺͺȐ Ǥ
(48) Ǥ !"!#)$ 19.
(49) Ȁ Ǥǡ!"#$!%&# '%'(&) ȏͻͷȐǤ
(50) ǡ ǡ '%'(&)Ǥ ϐ ʹǡ '%'"**)ǡ ȏͻȐǤǡ'%'"**+ǡϐȏͺͺȐǡ Ǥʹ ǡ!"#$!%&#Ǧ ϐ Ǥ ʹ ǡ. ǡ ʹ ȏͻȐǡ Ǥʹ Ǧǡ ǡ ǡ ȏͻȐǤʹ ȏͻͺǡͻͻȐǤ ǡ ǡ ǡ Ǥ
(51) ǡ ʹ ǡ ȏͻȐǤ ϐ Ǥ ͻ
(52) ! ϐ Ǥ ǡǡ ȏͳͲͲȐǤ ϐ Ǥǡ Ǧ ǡ͵ǦͶǦȋȌǤ Ǥ ǡ Ǧ Ǥ ǡǡ ǡ Ǥ ȏͳͲͲǦͳͲͶȐǡ Ȁ Ǥ . 20.
(53) ! Ȁ ȏͳͻȐǤ ǡ ǡ Ǥ ǡ ǡ Ǥ ǡ Ǧ ǡ Ǧǡ Ǥ
(54) ϐ ǡǤ ǡ ǡ Ǥ Ǥ ǡ Ǥ ǡ Ǧ ʹ͵Ǥ
(55) ϐ Ǥ
(56) Ͷǡ Ǧ ǦǦ !"#$ǤǦ ǡ Ǧ ϐǤ ǡ ǦǦ ȋ Ȍ ϐ Ǧ Ǥ
(57) ͷǡ ǡǡ Ǥ
(58) ǡ Ǥ ǡ ǡ%&'(%)* Ǧ ǡϔ Ǥ +)+&,,-''+)+.*-Ǥ 21.
(59) ͳǤ ǡ Ǥ Ǥ ǤǤ ǡ ǣ Ǧ ϐǤ ǡʹͲͲǤͺȋͷȌǣǤ͵ͷ͵ǦǤ ʹǤ ǡǤǡǤǡϐǣ Ǥ ǡʹͲͳͳǤͻ͵ȋʹȌǣǤ ͳͳͷǦ͵͵Ǥ ͵Ǥ ǡǤǤǤǡ ǡǡ ǣ ϐǤ ǡʹͲͳͳǤͻ͵ȋʹȌǣǤ ͳͻͶǦʹͲ͵Ǥ ͶǤ ǡ Ǥǡ ǣǡϐǤǡʹͲͲͲǤ ͳȋ͵ȌǣǤʹʹͷǦ͵ͳǤ ͷǤ ǡǤǤǤǡ Ǯ ǯ ϐǤ ǡʹͲͲͲǤʹȋʹȌǣǤʹͳǦʹͲǤ Ǥ ǡǤǡǤǡǦ ϐͳ Ǥ ǡʹͲͲʹǤʹͻȋͷͷͺȌǣǤͻͻǦͳͲʹǤ Ǥ ǡǤǡǤǡϐ Ǧ ϐǤ. ǡʹͲͲ͵Ǥͳ͵ȋͳʹȌǣǤʹͲͲǦǤ ͺǤ ǡǤǡǤǡ ϐ Ǧϐ Ǥ ǡʹͲͲͺǤʹȋȌǣǤͲʹǦͺǤ ͻǤ ǡǤǡǤǡʹͲͳͳǤ ǡʹͲͳͳǤ͵ͻȋ ȌǣǤͺͲͲǦǤ ͳͲǤ ǡ Ǥ Ǥ ǡ Ǧ Ǧ ϐǤ ǡʹͲͲͺǤͶͳǣǤͷʹͳǦ͵ͻǤ ͳͳǤ ǡǤ ǤǤǡǣ ǡ Ǧ ǡ ϐǤǡʹͲͲ͵ǤʹͷȋͳȌǣ ǤͳǦͳǤ ͳʹǤ ǡǤǤǡ ǣ ϐ Ǥ
(60) ȋȌǡʹͲͳͲǤʹȋʹǦ͵ȌǣǤǦͻ͵Ǥ ͳ͵Ǥ ǡǤ ǤǤǤ ǡ
(61) ǤǡʹͲͲǤ ͳ͵ͲȋͷȌǣǤͺͶǦͻͷǤ ͳͶǤ ǡ ǤǤ ǤǤ ǡ ǤǡʹͲͲͲǤͳ͵ͷǣǤͳͳ͵ǦʹͷǤ ͳͷǤ ǡǤǤǡǤǡ ϐǤ ǡͳͻͻͷǤʹͲ͵ȋ͵ȌǣǤʹͷ͵Ǧ͵ͳͲǤ ͳǤ ǡǤǤǤǤǡǦ ϐǤǡͳͻͻͲǤͳͲͺȋͶȌǣǤͷͻǦͺͲǤ ͳǤ ǡ ǤǤǡǤǡϐǦ ǤǡʹͲͲͷǤͳ͵ʹȋȌǣǤͳͳͺǦͻͺǤ 22.
(62) ! ͳͺǤ ǡ ǤǤǤǤ ǡ ǣ ǤǡʹͲͲͶǤͳͶȋͳͳȌǣǤʹͲǦǤ ͳͻǤ ǡ ǤǤǡ ǤǤ ǡ Ǥ Ǧǡ Ǧ ǣ ǫ ǡʹͲͲʹǤͳͺȋͻȌǣǤͶͶǦͷͷǤ ʹͲǤ ǡǤǤǤ Ǥǡ Ǧ ϐǣǦǤǦ ǡͳͻͻͺǤͳʹͷȋȌǣǤͻͺ͵ǦͻͶǤ ʹͳǤ ǡǤǤǡǤǤ ǡǤ Ǧǡ ϐǤǡʹͲͲʹǤ ʹͶ͵ȋͳȌǣǤͺͳǦͻͺǤ ʹʹǤ ǡ ǤǡǤǡϐ Ǧ ǤǡʹͲͲͳǤ ͳȋʹȌǣǤʹͷͳǦͶǤ ʹ͵Ǥ ǡ Ǥǡ Ǥǡ ǡ Ǧ ǡ Ǥ ǡʹͲͲͳǤͳͳȋͳͳȌǣǤͺͷͻǦ͵Ǥ ʹͶǤ ǡǤǤǡ ǤǤǡǤǤǡ Ǥ Ǧ ǦǤǡʹͲͲ͵Ǥ ͷȋ͵ȌǣǤ͵ǦǤ ʹͷǤ ǡ Ǥǡ ǣǤ ǡʹͲͳͲǤʹȋʹȌǣǤͲͲ͵͵Ǥ ʹǤ ǡǤǤ Ǧǡ Ǥ Ǧ ǡͳͻͺʹǤͺǣǤ͵ǦͷǤ ʹǤ ǡ Ǥǡ Ǥǡ Ǧ ǤǡͳͻͻͻǤͳʹȋʹ͵ȌǣǤ ͷͶʹͳǦͻǤ ʹͺǤ ǡ ǤǡǤǡ ǣǤ Ǧ ǡͳͻͻͺǤͳͷͲȋͳȌǣǤͳͻͻǦʹͳͲǤ ʹͻǤ ǡ Ǥ Ǥ ǡ ϐ Ǥ ǡʹͲͲͶǤͳͳȋͶȌǣǤͷʹǦ͵͵Ǥ ͵ͲǤ ǡ ǤǡǤǡ Ǧ ǤǡʹͲͲͳǤͳȋͳȌǣǤͻ͵ǦͳͲͳǤ ͵ͳǤ ǡǤǡǤǡǤǡ ͳ Ͷʹ Ǥ ǡͳͻͻǤ ͳ͵ͷȋͷȌǣǤͳʹǦͺͻǤ ͵ʹǤ ǡǤ
(63) ǤǡǤǡǤǡǦ ǤǡͳͻͻǤ͵ͺȋ͵ͲȌǣǤʹͻʹǦͷǤ ͵͵Ǥ ǡǤ ǤǡǤǡǦ ȋȌ Ǧ Ǧ Ǥ ǡ ʹͲͲͳǤͳͲͷȋͳȌǣǤͺͳǦͻͳǤ 23.
(64) ͵ͶǤ ǡǤǤǤǤǡ Ǥ ǡ ͳͻͻ͵Ǥͳʹ͵ȋͳȌǣǤʹͲͻǦʹͳǤ ͵ͷǤ ǡǤǡǤǡ ǤǡʹͲͲ͵Ǥ ͶʹͳȋͻʹʹȌǣǤͷͶ͵ǦǤ ͵Ǥ ǡǤ ǤǡǤǤǡ Ǥ ǡ ϐǤǡͳͻͻͻǤͳʹȋʹͶȌǣǤͷͺͷǦǤ ͵Ǥ ǡǤ Ǥǡ ǤǤǡǤǤǡ Ǧ ǤǡʹͲͲʹǤͳͲͺȋͷȌǣǤͷǦͺͺǤ ͵ͺǤ
(65) ǡ ǤǤǡ Ǥǡ Ǧ Ǧ Ǥ ǡʹͲͲͺǤ͵ʹͳȋͷͺͺȌǣǤͶͲͳǦͶǤ ͵ͻǤ ǡǤǤǡǤ ǡ ǤǤǡ ǣ ǯ Ǥ ǡʹͲͲͻǤͳȋ͵ȌǣǤ ͲͲʹͻͶǤ ͶͲǤ ǡǤǤǡ Ǥ
(66) ǡʹͲͲǤͷͳȋǦȌǣǤͷ͵ͷǦͶǤ ͶͳǤ ǡǤǡǤ ǡ Ǥǡ ͵ Ǧ Ǥ ǡʹͲͲǤʹȋͺȌǣǤʹͳͶǦͷǤ ͶʹǤ ǡ Ǥǡ Ǥǡ ǤǦ ǡʹͲͲǤͳ͵͵ȋͻȌǣǤͳǦͺǤ Ͷ͵Ǥ ǡ ǤǤǡ Ǥǡ ͵ ͳʹ ϐ ǡ ǡ Ǥ ǡʹͲͲͺǤͶȋͳͳȌǣǤͳͲͲͲʹͷͻǤ ͶͶǤ ǡ Ǥ Ǥ ǡ ǤǡʹͲͳͳǤʹͶͲȋ͵ȌǣǤͳǦʹǤ ͶͷǤ ǡ ǤǡǤǡ Ǧ Ǥ ǡʹͲͲͷǤ͵ȋͻȌǣǤ ͻͺͲǦͷǤ ͶǤ ǡ Ǥǡ Ǥǡ Ǧ Ǥ ǡ ͳͻͻͺǤ ͻͶȋͳȌǣǤͳͲͻǦͳͺǤ ͶǤ ǡǤǤǡǤǡǦͷǣ Ǥǡ ͳͻͻ͵ǤͳͳͻȋͳȌǣǤͻǦͳͳͳǤ ͶͺǤ ǡ ǤǤǡǤǡ Ǧ Ǥǡ ʹͲͲ͵ǤͳʹȋͷȌǣǤͳʹͷͳǦͲǤ ͶͻǤ ǡǤǡǤǡ ϐ 24.
(67) ! Ǧϐ Ǧ Ǥ ǡʹͲͲͻǤͳͺȋͷȌǣǤͻͻͶǦͳͲͲʹǤ ͷͲǤ ǡ ǤǤǡ Ǧ Ǥ ǡʹͲͲʹǤͳʹȋʹ͵ȌǣǤͻǤ ͷͳǤ ǡ ǤǤǡ ǣǦ ǤǦ ǡʹͲͲͷǤ͵ͲȋȌǣǤ͵ͶʹǦͷ͵Ǥ ͷʹǤ ǡǤǡǤǡ ͳǤ ǡʹͲͲͺǤͳͲͷȋͳȌǣǤʹͳͲǦͷǤ ͷ͵Ǥ ǡǤǤǡǤǡǡ Ǧ Ǥ ǡʹͲͲͷǤͺȋͳȌǣǤ͵ͶǦͶʹǤ ͷͶǤ ǡǤǡ
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