• No results found

%9;&amp amp;!")&&"#%&quot amp

N/A
N/A
Protected

Academic year: 2021

Share "%9;&amp amp;!")&&"#%&quot amp"

Copied!
31
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)Cover Page. The handle http://hdl.handle.net/1887/61622 holds various files of this Leiden University dissertation. Author: Glind, G.C. van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue Date: 2018-04-18.

(2)   . . C������. 5. C������. 5. L��6+ ���� ����� ��� ����� ������� �� ����� ��������� ����� �������� �� ��������� ���� ��������������, ��� ����� ������� �� ������� ���� ������. L��6+ ���� ����� ��� ����� ������� �� ����� ��������� ����� �������� �� ��������� ���� ��������������, ��� ����� ������� �� ������� ���� ������. �.�. ��� �� �����, �.�. �����, �.�. ���-�������, �.�. ������� �.�. ������, �.�. �� ������ ����������. 2016 ��� 27;7(52):86740-86754. �.�. ��� �� �����, �.�. �����, �.�. ���-�������, �.�. ������� �.�. ������, �.�. �� ������ ����������. 2016 ��� 27;7(52):86740-86754. . 15374-vdGlind_BNW.indd 101. 12-03-18 13:01. 15374-vdGlind_BNW.indd 101. 12-03-18 13:01.

(3)     8. 5.      8.

(4)  E     

(5)

(6)            . .

(7)     . %9;&)!!'&!")&&"#%"%'!1 9:;2&' &! "(& #% &/!)&'''%%&#"!&'"+#"&(%!    

(8) %!%&& !*'%'," !''!&"0"% , !( &! '( "%&/  ")%+#"&(% %& %9; & 1 ;2 %"  '!'%"(% #% &12-('0&'%*"(!!0',##%!',%#"#(''%" '% "&/!%&(0&(!(%!%"!+#"&(%- %9;&!'%#%"!,1 ;'% #(&"' "+!2 !&&'%"!,!'/'"('!'%0'( "%%, &"* %9 #%"!,- !"! " ' 0 "%  , !( '( "%& 1!<66 ! 75- %&#'),2 ##% '"  "! +#!&"!& " %9; &'  &. // !" %9; & "% #%"!,!'#%"%'!'( "%(/!!"%#%" "'% ','"!*"(!' '""(%&'"&',"%'&&''/   &(%,$ *&"(! '"   !& ! &! '( "%& 1&" !  '( "%& %"  *' ',# 2/  %'" " *&&!!',%(-#"!'!'"&&" %9;&%" '#%"%') #""/

(9) (% ' &"* '' %9; & % !"' "% '( "%0!''! & ! &! %!"!&&/. ;  ##'()"$()$""$##'#,)8(. %9;&)!!'&!")&&"#%"%'!1 9: ##*'$%##()'!%$%*!)$#(2 2&' &! "(& )##$#$#8"!#$"9(&*"$*(!!'#$"#(!!!'#$":# #% &/!)&'''%%&#"!&'"+#"&(%!    "!#$"( 

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

(11) 'E -%'"#)!( %&#'),2#'#$#((.-$##)(4 ##% '"  "! +#!&"!& " %9; &'  &. // !" %9; & "% I ()"!!('!$)#)()"*('$#$)'$!!!9 :1#)($*( #%"!,!'#%"%'!'( "%(/!!"%#%" "'% ','"!*"(!'

(12) 'E !#9:##)#)'$!!*!'%'"(9 :;E8H<4#%%'))!4#))(()" '""(%&'"&',"%'&&''/   &(%,$ *&"(! !!(#)( ##$*#))).'*#&*%$%*!)$##$)-%'((#BC$' @D '"   !& ! &! '( "%& 1&" !  '( "%& %"  *' ',# 2/  %'" " ; &%")' '#%"%') '(%)+ ;E<4*&&!!',%(-#"!'!'"&&" %9 

(13) 'EI !!( # ) 1 ()"*( #  ' ! )$ "#)# ; I !"' ($,# "% )) '( "%0!''! & ! # &! $"%')"#)( #""/

(14) (% ' # ) &"* !$#'' )'" %9 ;H<4  )& ,( % '#)!.

(15) 'E  !!( #'( #*"'( %!"!&&/ # )  $ " '$" ') )$ *!)$$ 9G , ( $ : ;H<4

(16)   )( "!. ""'(

(17) 'C#D1)

(18) 'E'%)$'9!*#8''%)8$#)##%'$)#8$*%!   '%)$'E:$#)#((+#)'#(""'#'$###)$$"#,)@B!*#8 ' '%)( ;@?<1 # )' ## 8(%$## ) # ## #$#! #)708)## (#!#;@@<4  + %'+$*(!. "$#()') )) -%'"#)!1 8#* (&*"$*( !! '#$"(9(:$'#)'$") ;@A2%)'A<4'#)()*.$$*'(;@B2%)' B<"%!)&*(#)()"!!(#8#*)*"$'#))$#4(!!(*"*!) # ')#  " 9.!$*)# %.'"# "'(: *'# !$, !+! '$#  -%$(*'1, #'(( )'(  $"*)#(( ,# )(!!( ' $' )$ +4 )$#!!.1 ) $#)#*$*(!. )+!. +#

(19) 'EI ()" !!( # )  ' ! !. 8 )')#)!!('$",(".$'#)4$#+()))(!))'%$((!). ,''$*)-%'"#)($#$,)(

(20) 'EI()"!!(#)'%'$#.'(%$#)$ ')$##,)').'+'#$#((4-))$'#$#((1)

(21) 'EI ()"!!(".)')#"!( #'#$#((1,,()*#)$#! -%'"#)(4 ()!("$!$''#$#((('$#-%$(*'$ 8@'!((" ;@C<4 )' !. #$)$- !!#( '$" (*8(*#*'#  $(( )( " +!$% (("!')$)$(#*"#(4()*"$'(#"'$'8(#)*'"*))$#(#  ("!' )$ )$( # ( # *"#( ;@D<4  ,!. *( "$! $' "! ( # '#$#((()),$8()"$!3(#!%%!)$#$#$)$-#)944F1@A8 ").!#/;<#)'#1 :#))()*"$'(#(*(&*#)'%)%%!)$#( $9#$#8#$)$-:'')#)9"$()$""$#!.@A88)'#$.!%$'$!8@B8))1:. . 5. . 546. 15374-vdGlind_BNW.indd 102. 546. 12-03-18 13:01. 15374-vdGlind_BNW.indd 102. @?B. 12-03-18 13:01.

(22)       8.

(23)  E     

(24)

(25)            .

(26)  E     

(27)

(28)            .

(29)     .

(30)    . ;  ##'()"$()$""$##'#,)8(. %9;&)!!'&!")&&"#%"%'!1 9: ##*'$%##()'!%$%*!)$#(2 2&' &! "(& )##$#$#8"!#$"9(&*"$*(!!'#$"#(!!!'#$":# #% &/!)&'''%%&#"!&'"+#"&(%!    "!#$"( 

(31) %!%&& ##'('(#;@1A<4-%$(*'%!.(#"%$')#)'$!#))$!$.$ !*'%'," !''!&"0"% , )(( !( ##'(;B1C<4#'("*!)()%%'$((9"*!)%!5)(6$'"*))$#(:)) &! '( "%&/  ")%+#"&(% %& %9; & 1 ;2 %"  '!'%"(% #% &12-('0&'%*"(!!0',##%!',%#"#(''%" '% +#)*!!.'(*!)(#"!##)!!(%'$*)##)$#'$*('$,);D<4#()"!!( "&/!%&(0&(!(%!%"!+#"&(%- %9;&!'%#%"!,1 ;'% '!$#'(#!!(1)(!!('%'"#)()$*"*!)$#$##( #(&"' "+!2 !&&'%"!,!'/'"('!'%0'( "%%, $+')"4#$)"$''#)!.#)()"!!%$%*!)$#(#)( #())$ I

(32) 'E !!(;E<4)'$'%$()&*()$#,)')(()"!!(')')# &"*. %9 #%"!,- !"! " ' 0 "%  , !( '( "%& 1!<66 ! 75- -%'"#)!( %&#'),2#'#$#((.-$##)(4 ##% '"  "! +#!&"!& " %9; &'  &. // !" %9; & "% I ()"!!('!$)#)()"*('$#$)'$!!!9 :1#)($*( #%"!,!'#%"%'!'( "%(/!!"%#%" "'% ','"!*"(!'

(33) 'E !#9:##)#)'$!!*!'%'"(9 :;E8H<4#%%'))!4#))(()" '""(%&'"&',"%'&&''/   &(%,$ *&"(! !!(#)( ##$*#))).'*#&*%$%*!)$##$)-%'((#BC$' @D '"   !& ! &! '( "%& 1&" !  '( "%& %"  *' ',# 2/  %'" " ; &%")' '#%"%') '(%)+ ;E<4*&&!!',%(-#"!'!'"&&" %9 

(34) 'EI !!( # ) 1 ()"*( #  ' ! )$ "#)# ; I !"' ($,# "% )) '( "%0!''! & ! # &! $"%')"#)( #""/

(35) (% ' # ) &"* !$#'' )'" %9 ;H<4  )& ,( % '#)!.

(36) 'E  !!( #'( #*"'( %!"!&&/ # )  $ " '$" ') )$ *!)$$ 9G , ( $ : ;H<4

(37)   )( "!. ""'(

(38) 'C#D1)

(39) 'E'%)$'9!*#8''%)8$#)##%'$)#8$*%!   '%)$'E:$#)#((+#)'#(""'#'$###)$$"#,)@B!*#8 ' '%)( ;@?<1 # )' ## 8(%$## ) # ## #$#! #)708)## (#!#;@@<4  + %'+$*(!. "$#()') )) -%'"#)!1 8#* (&*"$*( !! '#$"(9(:$'#)'$") ;@A2%)'A<4'#)()*.$$*'(;@B2%)' B<"%!)&*(#)()"!!(#8#*)*"$'#))$#4(!!(*"*!) # ')#  " 9.!$*)# %.'"# "'(: *'# !$, !+! '$#  -%$(*'1, #'(( )'(  $"*)#(( ,# )(!!( ' $' )$ +4 )$#!!.1 ) $#)#*$*(!. )+!. +#

(40) 'EI ()" !!( # )  ' ! !. 8 )')#)!!('$",(".$'#)4$#+()))(!))'%$((!). ,''$*)-%'"#)($#$,)(

(41) 'EI()"!!(#)'%'$#.'(%$#)$ ')$##,)').'+'#$#((4-))$'#$#((1)

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

(43) 'EI!!(;E<4)'$'%$()&*()$#,)')(()"!!(')')# -%'"#)!( #'#$#((.-$##)(4

(44) 'EI()"!!('!$)#)()"*('$#$)'$!!!9 :1#)($*( !#9:##)#)'$!!*!'%'"(9 :;E8H<4#%%'))!4#))(()" !!(#)( ##$*#))).'*#&*%$%*!)$##$)-%'((#BC$' @D ;E<4 

(45) 'EI !!( # ) 1 ()"*( #  ' ! )$ "#)# )' '(%)+ $"%')"#)( # ) !$# )'" ;H<4 ) ,( '#)!. ($,# ))

(46) 'EI !!( #'( # #*"'( # )  $ " '$" ') )$ *!)$$ 9G , ( $ : ;H<4

(47)   )( "!. ""'(

(48) 'C#D1)

(49) 'E'%)$'9!*#8''%)8$#)##%'$)#8$*%! '%)$'E:$#)#((+#)'#(""'#'$###)$$"#,)@B!*#8 ' '%)( ;@?<1 # )' ## 8(%$## ) # ## #$#! #)708)## (#!#;@@<4  + %'+$*(!. "$#()') )) -%'"#)!1 8#* (&*"$*( !! '#$"(9(:$'#)'$") ;@A2%)'A<4'#)()*.$$*'(;@B2%)' B<"%!)&*(#)()"!!(#8#*)*"$'#))$#4(!!(*"*!) # ')#  " 9.!$*)# %.'"# "'(: *'# !$, !+! '$#  -%$(*'1, #'(( )'(  $"*)#(( ,# )(!!( ' $' )$ +4 )$#!!.1 ) $#)#*$*(!. )+!. +#

(50) 'EI ()" !!( # )  ' ! !. 8 )')#)!!('$",(".$'#)4$#+()))(!))'%$((!). ,''$*)-%'"#)($#$,)(

(51) 'EI()"!!(#)'%'$#.'(%$#)$ ')$##,)').'+'#$#((4-))$'#$#((1)

(52) 'EI ()"!!(".)')#"!( #'#$#((1,,()*#)$#! -%'"#)(4 ()!("$!$''#$#((('$#-%$(*'$ 8@'!((" ;@C<4 )' !. #$)$- !!#( '$" (*8(*#*'#  $(( )( " +!$% (("!')$)$(#*"#(4()*"$'(#"'$'8(#)*'"*))$#(#  ("!' )$ )$( # ( # *"#( ;@D<4  ,!. *( "$! $' "! ( # '#$#((()),$8()"$!3(#!%%!)$#$#$)$-#)944F1@A8 ").!#/;<#)'#1 :#))()*"$'(#(*(&*#)'%)%%!)$#( $9#$#8#$)$-:'')#)9"$()$""$#!.@A88)'#$.!%$'$!8@B8))1:. 546. 15374-vdGlind_BNW.indd 103. 5. @?B. 5. @?B. 12-03-18 13:01. 15374-vdGlind_BNW.indd 103. 12-03-18 13:01.

(53)     F. 5.       F. (*'%',+-*, *,-%'*.$'(%&,;'-,*'/, <=CG>6 ,-%'*+, ,.$'(*%!&$1 ((!$$'%+/!,  %-,,!'&+=CH4CI>&,'%- $++*0,&,+6 .-+ ',  %'$+ ,' !&.+,!, ,  *'$ ' *GN +,% $$+ & , !* (*'&1 !& +#!& *!&'&+!+6. & ,  (*+&, +,-1 / -+ !*$++ & + .& !* ,*'21'-+ ,*&+&!   

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

(55)          

(56) ;#!&!,'*'6 &+$.*+<&**('*,*   %! ; #+'& '*,'*!+4 * *'*4 < /* *'++ ,' !&'*('*, ,   *('*,* -&* ,  '&,*'$ ' ,  '+ ;  < (*'%',* '* $!& ,*!& -('& %!&!+,*!& ,%'0!&=G>6 + 

(57)    %!/*$+'#*'++!&,' !*$++ #*'-& -+!& *$5

(58) C:  !*$++ $!&' %! ; *$+ !.*4 -$2$4 *%&1<6 ', %$&%$%!&,*, 0(*!%&,+,G:CB/#+';'* ,!% ('!&, !& ,  1(*($+! & $,!'& 0(*!%&,+ &OE<6  1 /* #(, !&!.!-$$1 !& *'$'&,1(C+,DFPD?&'-,FBM -%!!,1!&CD '-*+$! ,:CD '-*+*# 1$ -*!& 0(*!%&,+6 *''%!&/ !  ,  %! /*#(, & 0(*!%&,+ /* (*'*% /+ !$$-%!&, 1 $-'*+&, ,-+ , , ! &', %!, &1  *!,!'&6 ,&*  '/ & ,( /,* /* .!$$  $!!,-%6 + $$$1 *)-!*4 $$ %'-+ 0(*!%&,+/*(*'*%/!, , ((*'.$',  !&&!.*+!,1!$&,*+7+ , !+'%%!,,;((*'.$&-%*CBDDJ<6  CBE. 15374-vdGlind_BNW.indd 104. # (*'%',+-*,  

(59)  *,-%'*.$'(%&,;'-,*'/, <=CG>6 ,-%'*+, ,.$'(*%!&$1 ((!$$'%+/!, .-+ ,&- (/+/  %-,,!'&+=CH4CI>&,'%- 0(-1)+ &'-, '%. '- &)($++*0,&,+6 '-,(& ' ,-+ '-&(1 ' N  +,% $$+ & , !* (*'&1 !& +#!& ',  %'$+ ,' !&.+,!, ,  *'$ ' *G '(-$ ',&)%, ,)+,'- '.))%&'-+2 .+G9C9 *!&'&+!+6  ,  (*+&, +,-1 / -+ !*$++ & + .& !* ,*'21'-+ ,*&+&!  # & !

(60) 

(61)  

(62)   

(63)    %!'&,!&!&  *('*,*'*$!&,*!&6  + / -+ 9)9 '#- (', ( -&(1 ' <G &: '#- ('6 GHFJ  &;%+ 6 *G:0(*++!&$$+/*N&4,*%!&!+,*!&,%'0!&4, (*'&1'-$ 0 #'+-6-+%',=(/+-+2,-(/-% '-+ '<

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

(65) 

(66)  ,*!$+ & , '+<6 !* & !*$++ %! +-", ,'  %!$ *!&'&+!+  *!.+!&$!&!,!$(($!,!'&'$$'/1(($!,!'&+,/!/#6 % ), 

(67) ;CD:FB -., 0+ &(.'- (/+ - , ' ,0 - (' ' ( .-(&%%2-(% /+ '-'(,,<(.-).-(GFN ' +,-! +#!& +%($+ ;*'++ +,!'&+4 / '$ %'-&,+';6DJB;ECG'&6'FHN & (!*%$ + ,+< & ,-%'* N ;6 ECG;FBB '&=9 '+ -,%&), - & +,%$$+&, ' &% &:+2-&% (,< = (+  !*(*'&1;8 *G(*'&19 +%($+,'!&.+,!,, *+('&+' *G D + '!/<)+/ (.,%2.'1)(,=,$ '0,-+& '-(KBB'GBB :& '* + '*,< ,' ,  $,!. & *!&'&! *!%&+ ;+ ,!% $!&+ (+ '* ,  !*&, '  +%,, & 6 +,)- /%29 ( '. 2)+)%, 6 &  0+ ++ -  %2 0 - 0(*!%&,+!&-(($%&,*1!-*F6C<6 C (+F;J0$,60  '.'(, '(,.'.+'<& )--(1)(,.+=9 ,  ,& (, 0, ., ' -  + '(', , 1)+ &'-,6 0+ &  0+  %2 

(68)       ++ -.'- %-2-%,--0(PF&&-.&(+,9+ '(', ,0,('%2)+(+&   0 - +%,,& <'OCE6G(++%2 '.- ('(% '-+ ''J(+%- '.- ('=, ,/'  + &  <GI

(69) H= ' (.+ %(+-(+2 ,-+- 0(.' ' -&,%/, 2 ,/+  

(70) ;#!&!,'*'6 &+$.*+<&**('*,*   %! ,+- '-+&('-,(+(' %%21)(,.+6(+/%() ''2,$, '-.&(+,>CK?9 ; #+'& '*,'*!+4 * *'*4 < /* *'++ ,' !&'*('*,   *('*,* (+-&* - (/+1)(,.+ 1)+ &'-, 0 .,   + (, -- 0, #.,- -(%+% <'( ,  '&,*'$ ' ,  '+ ;  < (*'%',* '* $!& ,*!& -('& %!&!+,*!& 0(.',=.-%+%2%--,%%2+(-) +& ,<(+ +& E9H ' ,%'0!&=G>6 + 

(71)    %!/*$+'#*'++!&,' D +,)99*. -, %+=9 !.*4 -$2$4 (+ +%,,& G 6E9D'D9G$ :& !*$++ #*'-& -+!& *$5

(72) C:  !*$++ /%27 $!&' %! ;&*$+  *%&1<6 # ', #

(73)  

(74) 

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

(76)  H     

(77)

(78)            . 15374-vdGlind_BNW.indd 104. CBG. 12-03-18 13:01.

(79)       F.

(80)  H     

(81)

(82)            .

(83)  H     

(84)

(85)            . # (*'%',+-*,  

(86)  *,-%'*.$'(%&,;'-,*'/, <=CG>6 ,-%'*+, ,.$'(*%!&$1 ((!$$'%+/!, .-+ ,&- (/+/  %-,,!'&+=CH4CI>&,'%- 0(-1)+ &'-, '%. '- &)($++*0,&,+6 '-,(& ' ,-+ '-&(1 ' N  +,% $$+ & , !* (*'&1 !& +#!& ',  %'$+ ,' !&.+,!, ,  *'$ ' *G '(-$ ',&)%, ,)+,'- '.))%&'-+2 .+G9C9 *!&'&+!+6  ,  (*+&, +,-1 / -+ !*$++ & + .& !* ,*'21'-+ ,*&+&!  # & !

(87) 

(88)  

(89)   

(90)    %!'&,!&!&  *('*,*'*$!&,*!&6  + / -+ 9)9 '#- (', ( -&(1 ' <G &: '#- ('6 GHFJ  &;%+ 6 *G:0(*++!&$$+/*N&4,*%!&!+,*!&,%'0!&4, (*'&1'-$ 0 #'+-6-+%',=(/+-+2,-(/-% '-+ '<

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

(92) 

(93)  ,*!$+ & , '+<6 !* & !*$++ %! +-", ,'  %!$ *!&'&+!+  *!.+!&$!&!,!$(($!,!'&'$$'/1(($!,!'&+,/!/#6 % ), 

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

(95)       ++ -.'- %-2-%,--0(PF&&-.&(+,9+ '(', ,0,('%2)+(+&   0 - +%,,& <'OCE6G(++%2 '.- ('(% '-+ ''J(+%- '.- ('=, ,/'  + &  <GI

(96) H= ' (.+ %(+-(+2 ,-+- 0(.' ' -&,%/, 2 ,/+  

(97) ;#!&!,'*'6 &+$.*+<&**('*,*   %! ,+- '-+&('-,(+(' %%21)(,.+6(+/%() ''2,$, '-.&(+,>CK?9 ; #+'& '*,'*!+4 * *'*4 < /* *'++ ,' !&'*('*,   *('*,* (+-&* - (/+1)(,.+ 1)+ &'-, 0 .,   + (, -- 0, #.,- -(%+% <'( ,  '&,*'$ ' ,  '+ ;  < (*'%',* '* $!& ,*!& -('& %!&!+,*!& 0(.',=.-%+%2%--,%%2+(-) +& ,<(+ +& E9H ' ,%'0!&=G>6 + 

(98)    %!/*$+'#*'++!&,' D +,)99*. -, %+=9 !.*4 -$2$4 (+ +%,,& G 6E9D'D9G$ :& !*$++ #*'-& -+!& *$5

(99) C:  !*$++ /%27 $!&' %! ;&*$+  *%&1<6 # ', #

(100)  

(101) 

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vdGlind_BNW.indd 105. #  

(103)  ,&- (/+/ 0(-1)+ &'-, '%. '- &)( '-,(& ' ,-+ '-&(1 ' '(-$ ',&)%, ,)+,'- '.))%&'-+2 .+G9C9  # !

(104) 

(105)  

(106) . 5.  + / -+ 9)9 '#- (', ( -&(1 ' <G &: '#- ('6 GHFJ  &;%+ 6 0 #'+-6-+%',=(/+-+2,-(- /-% '-+ '<

(107) ;)+(. ' %%,= && -%2 )+ (+ -( - ,-+- ( - %- (' ' 2)+)%,  1)+ &'-,9 ' - -.&(+ ', , 1)+ &'-, &  0+  /  '-( -0( +(.),8 (' +(.) + / -&(1 ' '#- (',--,-+-(-1)+ &'-6(+-+ '(' + &'6' -(-++(.)+ /-&(1 ' '#- (',0'-0(-.&(+,PF&&/%()9 &  '- ,%,-+(.)0+,+  D;E0$,-+- /- ('(% '-+ '9  # " 

(108) 

(109) . 5.  % ), 

(110) ;CD:FB -., 0+ &(.'- (/+ - , ' ,0 - (' ' ( .-(&- %%2-(% /+ '-'(,,<(.-).-(GFN ';6DJB;ECG'&6'FHN ' ;6 ECG;FBB '&=9 '+ -,%&), - & ' &% &:+2-&% (,< = (+  '!/<)+/ (.,%2.'1)(,=,$ '0,-+& '-(KBB'GBB :&D(+ + '  +%,, & 6 +,)- /%29 ( '. 2)+)%, 6 &  0+ ++ -  %2 0 - C (+F;J0$,60  '.'(, '(,.'.+'<& )--(1)(,.+=9 , ,& (, 0, ., ' -  + '(', , 1)+ &'-,6 0+ &  0+  %2 ++ -.'- %-2-%,--0(PF&&-.&(+,9+ '(', ,0,('%2)+(+& 0 - +%,,& <'OCE6G(++%2 '.- ('(% '-+ ''J(+%- '.- ('=, ,/'  + &  <GI

(111) H= ' (.+ %(+-(+2 ,-+- 0(.' ' -&,%/, 2 ,/+ ,+- '-+&('-,(+(' %%21)(,.+6(+/%() ''2,$ '-.&(+,>CK?9 (+ - (/+1)(,.+ 1)+ &'-, 0 .,   + (, -- 0, #.,- -(%+% <'( 0(.',=.-%+%2%--,%%2+(-) +& ,<(+ +& E9H ' (+ +%,,& G 6E9D'D9G$ :&D+,)- /%27 99*. -, & %+=9  # #

(112)  

(113) 

(114)  (+& %+ '(', ,& < +8'OF(++%2 '.- ('(% '-+ '''OH (+%- '.- ('7  +%,, 'OG (++%2 '.- (' ' 'OF (+%- '.- ('=+ /  ))% - ('<CBBQ6I6CD; &-2%'3>?'-+'6EDGF6 &;%+ =6('2 C ' +(& 2 J ('0+  -+-&'-<CD;;--+'(2%)(+(%;CE;--6 JCEK6  &;%+ = -0   0$ .'- % - %,- -0( P F && -.&(+, /%()9  -  ))% - ('6CBQ 'CBBQ%-('0,))% ('))+(1 &-%2H&D((+,%,$ ' ., ' '+.,9  +& 0+)+ (+%2,/'-(+&(/ +(/+ '-(+,%,$ '9 . CBG. CBG. 12-03-18 13:01. 15374-vdGlind_BNW.indd 105. 12-03-18 13:01.

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

(116) @ECAG@?5( *%5++5 #*/*.#*+I*-*  ''0./-/*-I)- +. )//$1 . .- +- . )/ $) .0'/.9 , *$&+;&%!&(*!&7 '$%'-&,+#!&!'(+!+'*

(117) $!&,*!&  /* -, !&,' (!+ ' D0D %% & !&-, !& A? %   :#*5 .&,*5   ! , *$&+;!&8,BF<7 &0,15, 1/*/+ /!, 5!0!&9. ! /* +*!! 1 A +( 10!,!'&7 '*+$ & .&,*$ +#!& /+ 0!+ & +%&,'*-+!&!*&, !+,' %!$+,!&!&+7%($+'*, &,!9+(+9B& 39$,'+!++,!&!&/*%!&!++-9,#5+&(*'2&!&$!)-!&!,*'&& +,'*,9G?<-&,!$+,!'&!&&+,!&!&7%($+'*, &,!9+,!&!&/*!0 '.*&! ,!&9-*CK'*%$ 1+'$-,!'&:

(118) @ECAG@?5( *%5++5  , *$&+;&%!&(*!&7 '$%'-&,+#!&!'(+!+'*

(119) $!&,*!& /* -, !&,' (!+ ' D0D %% & !&-, !& A? %   :#*5 .&,*5   , *$&+;!&8,BF<7 &0,15, 1/*/+ /!, 5!0!&9 -* CK '*%$ 1 +'$-,!'& '* D %!& & !&-, 8 /!,  9$ +'$-,!'& :@ %8%$ 9$5 D %  **', !'1&!5 D %  **!, !'1&!5 A %  $A !& ;7 ,* !&-,!'&, 1/*%!& !+*+$1*!&7(!*%$+ ,+'*

(120) +,!&!&/* ,*, +!%!$* ,' ,  / '$ %'-&,+7 #!& /+ 0!+5 ,,1 ,!++- /+ *%'.5 & +%($+ /* +-%* '* A *+ !& A? %   !&  , BF<7 ,* !&-,!'& ,  (!*%$+ ,/+($*'%, *%!+&/+!0'*D%!&!&9-*CK '*%$ 1+'$-,!'&&+,!&'*!&,', (*',''$', / '$%'-&,!'(+!+7 $-+,*+'

(121) ('+!,!.$$+!&&(!*%$+ ,/*'-&,!&@?%!*'+'(!*%+ ,@?'",!.:A%%*'+++,!'&;7 -%'*+/*!, *+&(*'2&!&$!)-!&!,*'&'*!0!&9-*CK'*%$ 1 +'$-,!'&&%!&(*!&7  "  . 5. P   ''. -(' .#8 /./!, 2 - 9$  +- + 4 :@ '*%$ *! 1 +'$-,!'& D %!& &+$ !&-, +'$-,!'& *--* *)!*'CK ($-*.*+4 !'0*. )/'*  $)0/$)".&$)!*-E#-.$)EC(>& -7**!, 1 )/!'1&!5 -7#  /# -').?$)/FJ@9 %8%$ 9$5 D %  **', !'1&!5 D %  A %  $A !& ;7 ,* !/!&-,!'&, - $)0/$*)1/*%!& !+*+$1*!&7(!*%$+ /#  +$ -($. )  -($. 2 -  . +-/ 9 #  ,+'*

(122) +,!&!&/* +$ -($. 2. !$3  !*- ,*, +!%!$* ,' ,  /#4 '$%'-&,+7 ,!++- /+ *%'.5 & DC($) $) GO +-!*-(' ) (#!&  /+  $)0!+5  /.#$ ,,1 ' *)/$)$)"   > DECC7 +%($+ /* +-%* '*799?9$/0A *+ !& A? %   !&  , BF<7 JCC*)!*' ,* !&-,!'& ,   /*- *-/*-$ .70-'$)"( .2 - /& )0.$)"/# (!*%$+ ,/+($*'%, *%!+&/+!0'*D%!&!&9-*CK ($-*.*+ > $..?2$/#/#   ')< *!'0-EH3*% /$1 ;C9K ((

(123) *-- EJ9 P  ''.2.'0'/ 0.$)"/#  /) (" 9'$%'-&,!'(+!+7 ( .0- /#  1+'$-,!'&&+,!&'*!&,', (*',''$', / # '*%$ - *! P )$)"/# )0' -!'0*- . ) /*- /  - $-+,*+'

(124) ('+!,!.$$+!&&(!*%$+ >)0( -*!+$3 '.?*!  ''.>!/ -.(**/#,/*'-&,!&@?%!*'+'(!*%+ *)/$"0*0.*! P ''.?$)5<./&+') )/# - *!P ''.$)/# .(  ,@?'",!.:A%%*'+++,!'&;7 +')  !*- (0'/$+'  .(+' .;!-( . !-*( E<F ($ 9 -*( /#*.  / 2  '0'/  /# 1  -%'*+/*!, *+&(*'2&!&$!)-!&!,*'&'*!0!&9-*CK'*%$ + - )/" *!/# /*/'- /#/2.P9 +'$-,!'&&%!&(*!&7   " 

(125)          "  .  2. $.*'/  !-*( !-*5 ) /$..0  0.$)" /#   !#&++&!&-,,E?<87 .4 &$/ >$" )7 $' )7  -()4?   7*!&+%($+/*-,,D4%, *-$)"/*()0!/0*)1 -.$*)2.+ -!*-( *)DQ" &0, 15 , 1 /* -:.+-*/**'9$.0'+#$/  1*, & &,!& *,*!.$ /+ (*'*% /!,  &,!& 0.$)"/# ( /#4'/$*)&$/>4(* . -#7-)" 7?9$.0'+#$/ +-$( -. ,0 ) . -&%+#!&+'$-,!'&: 9BB??5,'*

(126) '*,'*!+5 &-*$!&%5;!&(*++-*''#* 2 '*D%!&7'&9+(!!!&!&/+$'#/!, -  .$") /*(+'$!4+-/*!/# +$.')'*/ $)/# " ) *4*!  PEGH/* 8?7@K/&8@K'*A '$$'/ PFJD+*2)./(*!/# >=CCDCFFGCL9F?-$( -.2 -  1 '*+ 1 !&-,!'& /!,  &,!9 :@6A??5 @BH?F?5 %5 %*!5  ;$).0#24 , C< 87   /#/*/#( /#4'/ .2 ''.0)( /#4'/ . ,0 ) .2 - (+'$!$!#&CGG:@6AD?5

(127) ! 0.$)"/# .(  +,!'&+/*!&-,/!, +'&*1&,!'1$0',&,!9 $.0'+#$/ </- /   .  / (+'/  >0++' )/-4/* ' +,!&  H9D?9 /!, (+'$!$/$*) , &'$'!+5 $!+/!"#5  , *$&+; &(&-$!  (! '*2. D %!& + -!*-(  2$/# $  - ) 0+ -($3 , *)  FKG *0#  '<$(    / /$*)  :@6B???5@B?E5 &.!,*'&5$!+/!"#5 *$&+;7 +,!'&+/*%'-&,/!, 4./,+ (>$*<7 ) )'7#  '* /# -').?0.$)"/*0#*2)+-*/**'2$/#/#  !$ %'-&,!& %!-% $-'*+& : 9@???5 ,'*

(128) '*,'*!+5 &7 -*$!&%5;7 !*''*2$)" +-( / -.8  )/0-$)" / LH°!*- FC . *). >-(+ -/  / E° + - . *)?7  !*''*2 4J4' .*!)) '$)"/IH°/*HK°!*-GC. *).>2$/#D° - ( )/+ -   

(129)    *1'+,!'&+/*-,,EL%, !#&++&!0/!, CK 4' ? ) 3/ ).$*) / JE° !*- GC . *).9 *- /#  !*''*2$)" FF 4' . )) '$)" 2.  !&/IC°9#  :EC@G5 !% 5 ,!& !%5 *%&1; %!& , 7.9*''*2$)" ,!'&+ /* + -!*-( './ $*! 3/ ).$*)./ +/JE°2. 3/ '* ) @? /*F($)0/ 5?5?@KC?!&;&!&-, /+ /!, &/!, !&++'$-,!'&:A%  $ (+'$!$/$*)7 ( '/$)" 0-1 . 2 -  ,0$-  0-$)"  '$)A - / (+ -/0-  /-).$/$*) !-*( •B A5 8,BF</!, 39$,'+!++,!&!&+'$-,!'&:D%  B:; C:;E!*- IH/*LC°2$/#$)( )/.*!C9E°+ -DC. *).9$.0'!$/ +-$( -.E5D%  /.2 - 1'$/ 9$ !& !&+ ,!'&+ /*  -.' /!,   *!&+ " )@  %8%$ .+ $!$$/4 *) $.0'!$/  /- +'$-,!'&;7 /  ( /#4'/  + )*(/+  )$1 /#4'/+'$-,!'&  *0. & .  7*!&+%($+/*-,,D4%, !#&++&!&-,,E?<87  &0, 15 , 1 /*  1*, & &,!& *,*!.$ /+ (*'*% /!,  &,!& -&%+#!&+'$-,!'&: 9BB??5,'*

(130) '*,'*!+5 &-*$!&%5;!&(*++-*''#* '*D%!&7'&9+(!!!&!&/+$'#/!, 8?7@K/&8@K'*A '$$'/ 1 !&-,!'& /!,  &,!9 :@6A??5 @BH?F?5 %5 %*!5  ; , C< 87   +,!'&+/*!&-,/!, +'&*1&,!'1$0',&,!9 !#&CGG:@6AD?5

(131) ! , &'$'!+5 $!+/!"#5   , *$&+; & &-$! /* +,!& /!,  (! '* D %!& :@6B???5@B?E5 &.!,*'&5$!+/!"#5 , *$&+;7 +,!'&+/*%'-&,/!,  ,+ !$ %'-&,!& %!-% '* $-'*+& : 9@???5 ,'*

(132) '*,'*!+5 &7 -*$!&%5;7    

(133)    *1'+,!'&+/*-,,EL%, !#&++&!0/!, CK  !&  :EC@G5 !% $*! 5 ,!& !%5 *%&1; '* @? %!& , 7 ,!'&+ /* /+ /!, &/!, !&++'$-,!'&:A%  $A5?5?@KC?!&;&!&-, 8,BF</!, 39$,'+!++,!&!&+'$-,!'&:D%  B:;E5D%  C:;E•B A5 @ %8%$ 9$ !& !&+ +'$-,!'&;7 ,!'&+ /* /+  /!,  *!&+ +'$-,!'& & @?E. 15374-vdGlind_BNW.indd 106.  I                 . @?E. 12-03-18 13:01. 15374-vdGlind_BNW.indd 106. DCJ. 12-03-18 13:01.

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

(135) @ECAG@?5( *%5++5 #*/*.#*+I*-*  ''0./-/*-I)- +. )//$1 . .- +- . )/ $) .0'/.9 , *$&+;&%!&(*!&7 '$%'-&,+#!&!'(+!+'*

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

(137) +,!&!&/* +$ -($. 2. !$3  !*- ,*, +!%!$* ,' ,  /#4 '$%'-&,+7 ,!++- /+ *%'.5 & DC($) $) GO +-!*-(' ) (#!&  /+  $)0!+5  /.#$ ,,1 ' *)/$)$)"   > DECC7 +%($+ /* +-%* '*799?9$/0A *+ !& A? %   !&  , BF<7 JCC*)!*' ,* !&-,!'& ,   /*- *-/*-$ .70-'$)"( .2 - /& )0.$)"/# (!*%$+ ,/+($*'%, *%!+&/+!0'*D%!&!&9-*CK ($-*.*+ > $..?2$/#/#   ')< *!'0-EH3*% /$1 ;C9K ((

(138) *-- EJ9 P  ''.2.'0'/ 0.$)"/#  /) (" 9'$%'-&,!'(+!+7 ( .0- /#  1+'$-,!'&&+,!&'*!&,', (*',''$', / # '*%$ - *! P )$)"/# )0' -!'0*- . ) /*- /  - $-+,*+'

(139) ('+!,!.$$+!&&(!*%$+ >)0( -*!+$3 '.?*!  ''.>!/ -.(**/#,/*'-&,!&@?%!*'+'(!*%+ *)/$"0*0.*! P ''.?$)5<./&+') )/# - *!P ''.$)/# .(  ,@?'",!.:A%%*'+++,!'&;7 +')  !*- (0'/$+'  .(+' .;!-( . !-*( E<F ($ 9 -*( /#*.  / 2  '0'/  /# 1  -%'*+/*!, *+&(*'2&!&$!)-!&!,*'&'*!0!&9-*CK'*%$ + - )/" *!/# /*/'- /#/2.P9 +'$-,!'&&%!&(*!&7   " 

(140)          "  . *- *)!*' ($-*.*+4 *! !'0*- . )/ P  ''. +$ -(' .# /. 2 -  +- +-  4 $)0/$)".&$)!*-E#-.$)EC(>& -7 1 )/ -7#  /# -').?$)/FJ@9 !/ - $)0/$*) /#  +$ -($. )  -($. 2 -  . +-/ 9 #  +$ -($. 2. !$3  !*- DC($) $) GO +-!*-(' #4  ) (   $)  /.#$ ' *)/$)$)"   > DECC7  /*- *-/*-$ .70-'$)"( 799?9$/0- .2 - /& )0.$)"/#  JCC*)!*' ($-*.*+ > $..?2$/#/#   ')< *!'0-EH3*% /$1 ;C9K ((

(141) *-- EJ9 # - *!P ''.2.'0'/ 0.$)"/#  /) (" 9 ( .0- /#  - >)0( -*!+$3 '.?*! P ''.>!/ -.(**/# )$)"/# )0' -!'0*- . ) /*- /  *)/$"0*0.- *! P ''.?$)5<./&+') )/# - *!P ''.$)/# .(  +')  !*- (0'/$+'  .(+' .;!-( . !-*( E<F ($ 9 -*( /#*.  / 2  '0'/  /#  + - )/" *!/# /*/'- /#/2.P9  " 

(142)         . 5.  2. $.*'/  !-*( !-*5 ) /$..0  0.$)" /#   !#&++&!&-,,E?<87 .4 &$/ >$" )7 $' )7  -()4?   7*!&+%($+/*-,,D4%, *-$)"/*()0!/0*)1 -.$*)2.+ -!*-( *)DQ" &0, 15 , 1 /* -:.+-*/**'9$.0'+#$/  1*, & &,!& *,*!.$ /+ (*'*% /!,  &,!& 0.$)"/# ( /#4'/$*)&$/>4(* . -#7-)" 7?9$.0'+#$/ +-$( -. ,0 ) . -&%+#!&+'$-,!'&: 9BB??5,'*

(143) '*,'*!+5 &-*$!&%5;!&(*++-*''#* 2 '*D%!&7'&9+(!!!&!&/+$'#/!, -  .$") /*(+'$!4+-/*!/# +$.')'*/ $)/# " ) *4*!  PEGH/* 8?7@K/&8@K'*A '$$'/ PFJD+*2)./(*!/# >=CCDCFFGCL9F?-$( -.2 -  1 '*+ 1 !&-,!'& /!,  &,!9 :@6A??5 @BH?F?5 %5 %*!5  ;$).0#24 , C< 87   /#/*/#( /#4'/ .2 ''.0)( /#4'/ . ,0 ) .2 - (+'$!$!#&CGG:@6AD?5

(144) ! 0.$)"/# .(  +,!'&+/*!&-,/!, +'&*1&,!'1$0',&,!9 $.0'+#$/ </- /   .  / (+'/  >0++' )/-4/* ' +,!&  H9D?9 /!, (+'$!$/$*) , &'$'!+5 $!+/!"#5  , *$&+; &(&-$!  (! '*2. D %!& + -!*-(  2$/# $  - ) 0+ -($3 , *)  FKG *0#  '<$(    / /$*)  :@6B???5@B?E5 &.!,*'&5$!+/!"#5 *$&+;7 +,!'&+/*%'-&,/!, 4./,+ (>$*<7 ) )'7#  '* /# -').?0.$)"/*0#*2)+-*/**'2$/#/#  !$ %'-&,!& %!-% $-'*+& : 9@???5 ,'*

(145) '*,'*!+5 &7 -*$!&%5;7 !*''*2$)" +-( / -.8  )/0-$)" / LH°!*- FC . *). >-(+ -/  / E° + - . *)?7  !*''*2 4J4' .*!)) '$)"/IH°/*HK°!*-GC. *).>2$/#D° - ( )/+ -   

(146)    *1'+,!'&+/*-,,EL%, !#&++&!0/!, CK 4' ? ) 3/ ).$*) / JE° !*- GC . *).9 *- /#  !*''*2$)" FF 4' . )) '$)" 2.  !&/IC°9#  :EC@G5 !% 5 ,!& !%5 *%&1; %!& , 7.9*''*2$)" ,!'&+ /* + -!*-( './ $*! 3/ ).$*)./ +/JE°2. 3/ '* ) @? /*F($)0/ 5?5?@KC?!&;&!&-, /+ /!, &/!, !&++'$-,!'&:A%  $ (+'$!$/$*)7 ( '/$)" 0-1 . 2 -  ,0$-  0-$)"  '$)A - / (+ -/0-  /-).$/$*) !-*( •B A5 8,BF</!, 39$,'+!++,!&!&+'$-,!'&:D%  B:; C:;E!*- IH/*LC°2$/#$)( )/.*!C9E°+ -DC. *).9$.0'!$/ +-$( -.E5D%  /.2 - 1'$/ 9$ !& !&+ ,!'&+ /*  -.' /!,   *!&+ " )@  %8%$ .+ $!$$/4 *) $.0'!$/  /- +'$-,!'&;7 /  ( /#4'/  + )*(/+  )$1 /#4'/+'$-,!'&  *0. &  @?E. 15374-vdGlind_BNW.indd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°!*- FC . *). >-(+ -/  / E° + - . *)?7 !*''*2 4J4' .*!)) '$)"/IH°/*HK°!*-GC. *).>2$/#D° - ( )/+ - 4' ? ) 3/ ).$*) / JE° !*- GC . *).9 *- /#  !*''*2$)" FF 4' . )) '$)" 2. + -!*-( /IC°9# './ 3/ ).$*)./ +/JE°2. 3/ ) /*F($)0/ .9*''*2$)" (+'$!$/$*)7 ( '/$)" 0-1 . 2 -  ,0$-  0-$)"  '$) - / (+ -/0-  /-).$/$*) !-*( IH/*LC°2$/#$)- ( )/.*!C9E°+ -DC. *).9$.0'!$/ +-$( -. /.2 - 1'$/ !*- " )  .+ $!$$/4 *) $.0'!$/  /- /  ( /#4'/  + )*(  )$1 -.'  /#4'/  *0. . DCJ. DCJ. 12-03-18 13:01. 15374-vdGlind_BNW.indd 107. 12-03-18 13:01.

(147)     G.       G .  +%) ; !##!'&)4 $*+)$4   + )#%*< % ,%$+ 0#+ .+ GI

(148) 9H $!  * ))% &%+)&# *$'#7   ')*% & $+ 0#+  .* ++ + )&, $#+!%'"*.!+  ! )$#+!%,)-+$')+,)*&$')+&,%$+ 0#+ *&+!%)&$+ ))%&%+)&#*$'#*7 #+!%'"*.)++0 $%) E7C *&+.) ;!&:< % -) $#+!% +$')+,)* .) #,#+ &) + *)&%!1 '"*7  ')&$&+) .* &%*!)$+ 0#+ ! $#+!% +$')+,)* .) /!% # & +  $/!$,$ +$')+,) !)% * +)$!% &) +  ))%&%+)&#*$'#*7 ,#*#)(# !%  &  '. 5.  +%) ; !##!'&)4 $*+)$4   + )#%*< % ,%$+ 0#+ .+ GI

(149) 9H $!  * ))% &%+)&# *$'#7   ')*% & $+ 0#+  .* ++ + )&, $#+!%'"*.!+  ! )$#+!%,)-+$')+,)*&$')+&,%$+ 0#+ *&+!%)&$+ ))%&%+)&#*$'#*7 #+!%'"*.)++0 $%) E7C *&+.) ;!&:< % -) $#+!% +$')+,)* .) #,#+ &) + *)&%!1 '"*7  ')&$&+) .* &%*!)$+ 0#+ ! $#+!% +$')+,)* .) /!% # & +  $/!$,$ +$')+,) !)% * +)$!% &) +  ))%&%+)&#*$'#*7 ,#*#)(# !%  &  '. &+#  .* !*&#+ )&$ )&1% *"!% % +,$&)* ,*!% +  *0 $!%! "!+ ;IFCBH4 !%4 !#%4 )$%0< !%#,!% &%:&#,$% * +)+$%+7  .* *0%+ *!1 )&$CN+&+#,*!%+ !)!'+ 0%+ *!* !+;CIB:JJKC4!&)4%%#4   + )#%*< &)!% +& $%,+,))8* !%*+),+!&%*7 ( &)

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

(151) )HL*+$##*.)')*%+!%+ '!)$!*&;+)%*%!< !)#**$!;*!,)G7C4#*&&)&$')!*&%.!+  !)$!<7&+ !*%4 !)-%  %%

(152) *$ *- %  $! .) ")&** !%+&  !)#** ")&,% ,*!% #!%& :C$!7 ')&%0.*-!#%!%&+* &.*'!!' %&+0'7*!%  :C $!4 * !% !)#** -% %%

(153) *$ *- %  $! '') +&  ))*+ !% +%7  )$%%+* .) &%%+ +& ':*+ 0*+* !% +  )$!* ;')*,$,#)$%%+*<=CD5 '+)D>7

(154) )H:/')**!%*+$##*;L!%!,)G7C< .)')*%+!%+  %%)+ &++&$& )$%%+*;)!&%&*&,*#%*<7

(155) )H')&%0;

(156) L<.*&,%!%+ #&.)')+&+  )$%%+;*!,)G7C<7 #*&&,%

(157) )H*+$##')&%0;

(158) L<!%+  ;*!,)G7CLG7C<7 CBJ. 15374-vdGlind_BNW.indd 108.

(159)  A     

(160)

(161)            . &+#  .* !*&#+ )&$ )&1% *"!% % +,$&)* ,*!% +  *0 $!%! "!+ ;IFCBH4 !%4 !#%4 )$%0< !%#,!% &%:&#,$% * +)+$%+7  .* *0%+ *!1  *!* !+;CIB:JJKC4!&)4%%#4 )&$CN+&+#,*!%+ !)!'+ 0%+   $%#%)*) )

(162) (AE)*#"")$* (&(%$/(&()$* $*"%-(&(*%*    + )#%*< &)!% +&657$ $%,+,))8* ( &)

(163) )H $ $ .* (#$$*)$ $* % ("))# $* !%*+),+!&%*7 )*#+)$ % (# 6573! E)*#"")  )*')&)$ %$)%($$$ %# %( $ # -()* $%(*%**

(164) (A ,*!% +   )% ,')$!/ ;!&:< &% +  EJF  )#:+!$  6E1((%-)73! $-%"#%+$*)6E2 %(  )%$*%+( $71(%)))* %$)6E7$& (#" ++!&% *0*+$ ;!&)<7 0# ')$+)* .) * &##&.*6 &+ *+)+ &) E $!%,+* + )*)6 $)(* (#$$* $7-()* $6"+7%(

(165) .&()) %$6C5D-!)*(*#%. $7*% KG?5%+,)+!&%&)CG*&%*+KG?4%%#!%%/+%*!&%&)EB*&%*+HB? **

(166) (A&(%$/3"( $F=<<G#1)"( $11FB@G#1)"( $EF@<G# &)FB0#*7'!!!+0&+ ')&,+*.*&%!)$0$#+!%,)-%#0*!*7+ '"&"%"()!

(167)  .*%&)$#!1!%*+))%%*0C%/GD;*,''#$%+)0#G7E&)   ')!$)*,*<,*!%+ 22($+ &=DB>%!*')*%+*)#+!-$/')**!&%7 "*"(&(*%*& (#")""/(+) $*%"("%,(.&%)+(6?3> ,#*#))#" $>3@! 4#>%( ($ ("))# 1()&* ,"/2) *( "$ *%)73 ) L )*%!%$/')**!&%.)+)$!% ++!*+!#*!%!!%+!)%*!% %) $+#)) ,&%&*%) ) $)""")+*"**%,("/ $"""/() $**8=>2 E 0+  %%: !+%0+*+;!%)' ')!*$H<7++!*+!#*!%!!%.**++'MB7BG7 &*(>93)* $%(

(168) (A )*#"")1+) $$$* 5$* %/1 $)! $)#&") %*.)!-%.!+ *+%)))&)&+ $%; <,%#**&+ ).!**++7)' *!$* ($** #&% $*)*(%,(.&%)+(2) +()@3>$@3?5 %( (")) * .)%)+!%)' ')!*$H%&)$++!%& ##,*+)+&)H7 $  ( # 1 ()&* ,"/3 5.&()) %$ -) #+ ")) &(,"$* +* )* "" -!"/ &()$* $*&%&*%* )""/(%* =/*(%,(.&%)+(%* $ (.   $ ("))# 3 %-,(1?/)*(%,(.&%)+(* $%"%$()%-$/ E .&()). %$3(%#=-!*(%,(.&%)+(%$-(5.&()) $

(169) (AE"")  ,#+#)#(%+(( $ * 3 $ *%$*(%"L)#&") **   $%*( ,   %,(.&%)+( - !)*+*)+!%. + )

(170) )H *+$##*.)')*%+!%+ '!)$!*&;+)%*%!< %+$E"") $* '+""/*""* #&% $*)6 +()@3>$@3?573E !)#**$!;*!,)G7C4#*&&)&$')!*&%.!+  !)$!<7&+ !*%4 !)-% "") $* )*#+)% (# $ $ (#$$*)% ("))# -(&()$**""  %%

(171) *$ *- %  $! .) ")&** !%+&  !)#** ")&,% ,*!% * #&% $*)$ $%*&&(*% $"+$/*%,(.&%)+(3")%1

(172) (A&(%$/ #!%& :C$!7 ')&%0.*-!#%!%&+* &.*'!!' %&+0'7*!% 6

Referenties

GERELATEERDE DOCUMENTEN

[r]

68 67888942 WXYZ[Y\]Y^_YZ]\Y`aYb_cZ\Y`dYe_ZbfZg`hbiYeZjklcZ^gghZfgZ]mZ_YZ^YdYe_YZagf_Yebf^YfZ]mZYnoe]bhghbYZ

68 67888942 WXYZ[Y\]Y^_YZ]\Y`aYb_cZ\Y`dYe_ZbfZg`hbiYeZjklcZ^gghZfgZ]mZ_YZ^YdYe_YZagf_Yebf^YfZ]mZYnoe]bhghbYZ

[r]

[r]

[r]

RSTTUVWXVYZVX[W\W]^VT_XV`ZVaZ]VbWZ]V\ZY]Vc[VYW]VUTb]cc\dVeZbV`ZVbWZ]

[r]