• No results found

Cover Page The handle

N/A
N/A
Info
Downloaden
Protected

Academic year: 2021

Share "Cover Page The handle"

Copied!
21
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Download het nu ( 21 pagina )

Hele tekst

(1)Cover Page. The handle http://hdl.handle.net/1887/19776 holds various files of this Leiden University dissertation. Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis Date: 2012-09-12.

(2) 5 !. Cell Outliner and Cell Roses: New Tools for Automated Cell Membrane Detection and Determination of Cell Polarity Vincent Runtuwene and Jeroen den Hertog. 119.

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•—Ž–‹‰‹ƒ —”ƒ–‡†‡–‡ –‹‘ƒ†”‡’”‡•‡–ƒ–‹‘‘ˆϐŽ—‘”‡• ‡– ‡ŽŽ‡„”ƒ‡•Ǥ @3()#*61/&%34)&,)2#,%9)15B(.%&'()#$-)#.."/#%(7)=(**)G1,(,)&,)#)6/#03&.#*)#00*&.#%&1$) %1)-(0&.%).(**),3#0()#$-)1/&($%#%&1$)&$)%3(),#4()6/#037)K,)0/112?12?0/&$.&0*(9)>() ,"..(,,2"**+)#00*&(-)%3(,()$(>)%11*,)&$)%3()#$#*+,&,)12)%3()0/(,14&%&.)4(,1-(/4) ‘ˆƒ‘™œ‡„”ƒϐ‹•Š ‘˜‡”‰‡ ‡ƒ†‡š–‡•‹‘—–ƒ–Ǥ @3()#$#*+,&,)12).(**),3#0()#$-)1/&($%#%&1$)&,)>&-(*+)",(-)%1)#,,(,,)-&22(/($.(,)&$) 4#$+)5&1*16&.#*)0/1.(,,(,7)L()(403#,&<()%3#%)%3(,()%11*,)#/()5+)$1)4(#$,)/(? •–”‹ –‡†–‘ƒƒŽ›•‹•‘ˆ‰ƒ•–”—Žƒ–‹‘ ‡ŽŽ‘˜‡‡–•‹œ‡„”ƒϐ‹•ŠǤ‘—†‡”Ž‹‡–Š‹•ǡ >()3#'()",(-)%3(,()%11*,)%1)41-(*).(**)&4#6(,)2/14)21"/)-&,%&$.%),1"/.(,7)L()3#'() 4#-()=(**)E"%*&$(/)#$-)=(**)G1,(,)#'#&*#5*()21/);"#$%&%#%&'()#$#*+,&,)12).(**),3#0() #$-)-&/(.%&1$)&$)#$+)HI)&4#6(7. 120.

(4) !"#$%&'(#)%". !"##$%&#'()*'+)&,$',-$-)(".+"-$."##$/)0('+)&,$'("$'+$+1"$2'3)3$&4$/',5$%(&6 ."33"3$),$"/2(5&,).$-"7"#&%/",+8$9&($%(&%"($-"3.()%+)&,$&4$."##$%&#'()*'+)&,$',-$ -)(".+)&,:$',-$+&$2"$'2#"$+&$;<',+)+'+)7"#5$-"+"(/),"$-)44"(",."3$),$+1"3"$%'('/6 "+"(3$ 2"+="",$ >0(&<%3$&4?$"/2(5&3:$)+$ )3$)/%"('+)7"$+&$'..<('+"#5$ /"'3<("$+1"$ ."##$31'%"$',-$-)(".+)&,$&4$."##38$9&($),3+',.":$+1"$"7&#<+)&,'(5$.&,3"(7"-$.&,6 ˜‡”‰‡ ‡ ƒ† ‡š–‡•‹‘ ȋȌ ‡ŽŽ ‘˜‡‡–• †—”‹‰ œ‡„”ƒϐ‹•Š ‰ƒ•–”—Žƒ–‹‘ ƒ”‡ Š‹‰ŠŽ› Šƒ”ƒ –‡”‹•–‹ ƒ†”‡‘†‡Ž–Š‡‡˜‹†‡–Ž›—†‹˜‡”•‹ϐ‹‡†œ‡„”ƒϐ‹•Š„Žƒ•–—Žƒ 3+'0"$"/2(5&$),+&$'$.&/%#"@$"#&,0'+"-$3+(<.+<("$.&,3)3+),0$&4$+1(""$0"(/$#'5"(3:$ ƒ† Ž‡ƒ”Ž›†‡ϐ‹‡†•–”— –—”‡•ƒŽ‘‰–Š‡ƒ–‡”‹‘”’‘•–‡”‹‘”ƒš‹•ȏͳȐǤ‡†‹‘ǦŽƒ–‡”ƒŽ ."##$"#&,0'+)&,$',-$&()",+'+)&,$<,-"(#)"$+1"3"$/&(%1&0","+).$/&7"/",+3$),$+1"$ †‘”•ƒŽ‡•‘†‡”ƒŽƒ†‡ –‘†‡”ƒŽ ‡ŽŽ•ȏʹǡ͵ǡͶǡͷǡ͸ȐǤŠ‡‘–›’‹ ƒŽƒƒŽ›•‹•‘ˆ ‡Ž6 #<#'($#'5"(3$),$!A$%1",&+5%"3$("#)"3$&,$;<',+)+'+)7"$),4&(/'+)&,$&4$),-)7)-<'#$."##3$ =)+1),$'$+)33<":$.&##".+"-$4(&/$/).(&3.&%).$)/'0"38$B1"$-"+".+)&,$&4$."##$2&<,-'(6 ‹‡•‹–Š‡•‡‹ƒ‰‡•‹•‘ˆ–‡ ƒ””‹‡†‘—–ƒ—ƒŽŽ›ȏʹǡͷǡ͹Ȑǡ™Š‹ Š‹•Žƒ„‘”‹–‡•‹˜‡ǡ "((&(6%(&,":$+)/"6.&,3</),0$',-$3<2C".+)7"8$B1"("4&(":$0("'+$%&+",+)'#$#)"3$),$'<6 +&/'+"-$)/'0"$','#53)3$4&($",1',.),0$("%(&-<.)2)#)+5:$'..<('.5:$3%""-$',-$&2C".6 +)7)+58$D".",+#5:$"44&(+3$1'7"$2"",$/'-"$+&$-"7"#&%$'<+&/'+"-$/).(&3.&%5$)/'0"$ ƒƒŽ›•‹•–‡ Š‹“—‡•ˆ‘ —•‡†‘†‡–‡ –‹‘‘ˆ ‡ŽŽ—Žƒ”ˆ‡ƒ–—”‡•ȏͺǡͻȐǤŠ‹Ž‡ƒ‰”‘™6 ),0$,</2"($&4$3+<-)"3$("%&(+$'#0&()+1/3$4&($#&.'#)*'+)&,:$-"+".+)&,:$',-$','#53)3$ &4$,<.#"):$&,#5$'$4"=$1'7"$2"",$-"3.()2"-$4&($."##$/"/2(',"38$B1"$("'3&,$4&($+1)3$ Ž‹‡•‹–Š‡‹Š‡”‡–†‹ˆˆ‡”‡ ‡„‡–™‡‡†‡–‡ –‹‘‘ˆϐŽ—‘”‡• ‡–— Ž‡ƒ”ƒ”‡”• .&/%'("-$+&$."##$/"/2(',"$/'(E"(38$9#<&("3.",+$,<.#"'($/'(E"(3$/'(E$'$7&#6 </"$=)+1),$+1"$."##8$F3$'$.&,3";<",.":$'$3)0,'#$4(&/$'$+1(""6-)/",3)&,'#$3&<(."$ ‹•‰‡‡”ƒ–‡†—’‘Žƒ•‡”Ǧ‡š ‹–ƒ–‹‘™Š‹ Š ƒ„‡•—ˆϐ‹ ‹‡–Ž›•ƒ’Ž‡†–‘ ”‡ƒ–‡ƒ ”‡Žƒ–‹˜‡Ž›™‡ŽŽǦ†‡ϐ‹‡†”‡’”‡•‡–ƒ–‹‘‘ˆ–Š‡— Ž‡—•‹–Š‡”‡•—Ž–‹‰‹ƒ‰‡ǡƒ6 ‹‰ — Ž‡‹ ”‡Žƒ–‹˜‡Ž› •–”ƒ‹‰Š–ˆ‘”™ƒ”† –‘ †‡–‡ – ȏͳͲȐǤ Š‡ •Š‡‡–ǦŽ‹‡ •–”— –—”‡ ‘ˆ +1"$."##$/"/2(',"$)3$/<.1$+1),,"($+1',$+1"$-)'/"+"($&4$+1"$,<.#"<38$G,$4'.+:$+1"$ ."##$/"/2(',"$)3$+1),,"($+1',$+1"$%&),+$3%("'-$4<,.+)&,$=1).1$/'(E3$+1"$("3&#<6 –‹‘‘ˆƒ•–ƒ†ƒ”†• ƒ‹‰’‘‹– ‘ˆ‘ ƒŽ‹ ”‘• ‘’‡ȏͳͳȐǤ‡–‡ –‹‘‘ˆƒϐŽ—‘6 ”‡• ‡–Ž›–ƒ‰‰‡†‡„”ƒ‡ ƒ‘Ž›”‡•—Ž–ˆ”‘•—ˆϐ‹ ‹‡–•ƒ’Ž‹‰ƒ†‹–‡”6 %&#'+)&,$&4$"/)++"-$#)01+$4(&/$,")012&(),0$/'(E"(3:$+1<3$.("'+),0$'$/&("$-)44<3"$ 2&<,-'(5$),$+1"$.&,4&.'#$)/'0"38$!&,3";<",+#5:$+1"$%)@"#$),+",3)+)"3$0","('+"-$25$ –Š‡‡„”ƒ‡•‹‰ƒŽϐŽ— –—ƒ–‡Ǥ•ƒ”‡•—Ž–ǡ–Š‡ϐŽ—‘”‡• ‡ ‡‹–‡•‹–›‘ˆ–Š‡ ‡ŽŽ /"/2(',"$ +1'+$ )3$ -"+".+"-$ )3$ 3<2C".+$ +&$ +1"$ %(&@)/)+5$ &4$ /"/2(',"$ C<,.+)&,3:$ ƒ†Œƒ ‡– ‡ŽŽ ‡„”ƒ‡•ǡ ƒ† ƒ”‡” ƒ‰‰”‡‰ƒ–‹‘• ȏͳͲȐǤ Š‡•‡ Šƒ”ƒ –‡”‹•–‹ • ƒ‡–Š‡†‡–‡ –‹‘‘ˆϐŽ—‘”‡• ‡–‡„”ƒ‡•‘”‡ —„‡”•‘‡Ǥ B1"$%(&2#"/$&4$'<+&/'+"-$3"0/",+'+)&,$&4$."##$/"/2(',"3$3<.1$'3$-"6 ’‹ –‡† ‹ ‹‰Ǥ ͳ Šƒ• „‡‡ ƒ††”‡••‡† „‡ˆ‘”‡Ǥ  ƒ‹•‘–”‘’‹  ’Žƒ–‡ †‹ˆˆ—•‹‘ ϐ‹Ž6 121. !.

(5) !"#$%&'("!)*+'),-'.""%'/#*/*-"+0'1)$2)'+"!"2!-',%+'"%),%2"-'2"33'("(.#,%"-' 4-$%&',%'$(,&"'5"--$,%6-'"$&"%-7-!"(0'8*33*1"+'.7','+$884-$*%'!"%-*#0',//3$2,.3"' –‘ ‘ˆ‘ ƒŽ͵Ǧ†ƒ–ƒ•‡–•ȏͳͲȐǤ‘–Š‡”‡–Š‘†ƒ’’Ž‹‡•ƒ•‡”‹‡•‘ˆƒ”–‹ϐ‹ ‹ƒŽ‡—”ƒŽ %"!1*#9-'8*#'!)"'+"!"2!$*%'*8'%"4#*%,3'("(.#,%"-'$%':;'8*#'"3"2!#*%'($2#*-2*/7' ‹ƒ‰‡•ȏͳʹȐǤŠ‡—•‡‘ˆ„‘–Šƒ„‘˜‡‡–‹‘‡†‡–Š‘†•”‡“—‹”‡•‹–‡•‹˜‡ ‘< ’—–ƒ–‹‘ ’‘™‡”ǡ ‘™Ž‡†‰‡ ‘ˆ ‘’—–ƒ–‹‘ǡ ƒ† ‹ –Š‡ ƒ•‡ ‘ˆ ƒ”–‹ϐ‹ ‹ƒŽ ‡—”ƒŽ %"!1*#9-'-/"2$,3$="+'),#+1,#"0'(,9$%&'!)"$#'4-"'24##"%!37'4%8",-$.3"'8*#'(*-!' -!,%+,#+'.$*3*&$2,3'#"-",#2)'3,.->'?)"'4-"'*8'-$(/3"'(*#/)*3*&$2,3'*/"#,!*#-'),-' .""%'+"-2#$."+'!*'+"!"2!',%+'(*+"3'2"33'&"*("!#$"-'$%'",#37'-",'4#2)$%'"(.#7*-0' ™Š‹ ŠŠƒ˜‡–Š‡ƒ†˜ƒ–ƒ‰‡‘ˆ„‡‹‰Ž‡•• ‘’—–ƒ–‹‘ƒŽŽ›‹–‡•‹˜‡–‘‡š‡ —–‡ȏͳ͵ȐǤ ?)"'("!)*+'!,9"-',+@,%!,&"'*8'!)"'(*#"'2*%@"%$"%!37'+"!"2!,.3"'2"33'%423"$',%+' "A!#,/*3,!"-'!)"'3*2,!$*%'*8'!)"'2"33'("(.#,%"'.7',//37$%&'@*#*%*$'!"--"33,!$*%' ‘–Š‡— Ž‡ƒ” ‡–‡”’‘•‹–‹‘•ȏͳ͵ȐǤŠ‹•‡–Š‘†’‡”ˆ‘”•ƒ —”ƒ–‡Ž›™Š‡ƒ’< /3$"+'!*'#"3,!$@"37'2$#243,#'2"33-'$%'1)$2)'!)"'%423"4-'$-0'$%'8,2!0'$%'!)"'2"%!"#'*8'!)"' ‡ŽŽ ›–‘’Žƒ• ȋ•‡‡ ›‡ŽŽ‘™ ƒ””‘™Š‡ƒ† ‹ ‹‰Ǥ ͳȌǤ ‘™‡˜‡”ǡ ™‹Ž†–›’‡ œ‡„”ƒϐ‹•Š +*#-,3' ("-*+"#(,3' ,%+' "2!*+"#(,3' 2"33-' ,#"' "3*%&,!"+' +4#$%&' BC' (*@"("%!-' ,%+'!)"$#'%423"4-'$-'(*#"'*8!"%'!),%'%*!'.$,-"+'8#*('!)"'2"%!"#'*8'!)"'2"33'27!*< /3,-(>'D//37$%&'!)$-'("!)*+'*%'!)"-"'2"33-'#"-43!-'$%','(*+"3'$%'1)$2)'2"33'"3*%< &,!$*%'$-'4%+"#"-!$(,!"+0'(*+"3$%&'"3*%&,!"+'2"33-'23*-"#'!*','2$#243,#'-),/"'E-""' ”‡†ƒ””‘™Š‡ƒ†•‹ ‹‰ǤͳȌǤŠ‡’”‡•‡ ‡‘ˆ ‡ŽŽ•‹™Š‹ Š–Š‡— Ž‡—•†‘‡•‘– #"-$+"'$%'!)"'2"%!"#'*8'!)"'27!*/3,-('2,4-"-',%'$%,224#,!"'-)$8!'$%'!)"'"-!$(,!"+' /*-$!$*%'*8'!)"'2"33'("(.#,%"'$%'!)"'+$#"2!$*%'*8'!)"'%423"4-'E-""'.34"',##*1)",+' ‹ ‹‰ǤͳȌǤ. !"#$%&'()'*++,"-./"01'02'30%010"'/&44.,./"01'5&56%.1&'507&,,"1#'5&/807'6.4&7'01'7&/&-9 /"01'02'1$-,&.%'-&1/&%'+04"/"014:' ȋȌ ƒ™ ‘ˆ‘ ƒŽ ‹ƒ‰‡ ‘ˆ ’”‡•‘‹–‹  ‡•‘†‡” ‘ˆ ƒ ‡„”›‘ ‹ ”‘Ǧ‹Œ‡ –‡† ™‹–Š ʹͲ ’‰ ‘ˆ  Ǧǡƒ‡„”ƒ‡ƒ”‡”ǡƒ†ʹͲ’‰‘ˆ ʹǦŠ‡””›ǡƒ— Ž‡ƒ”ƒ”‡”ǤȋȌ ‘”‘‘‹†‹ƒ‰”ƒ„ƒ•‡†‘–Š‡— Ž‡ƒ”ϐŽ—‘”‡• ‡ ‡•—’‡”‹’‘•‡†‘–‘–Š‡”ƒ™‡„”ƒ‡ Šƒ< %"3>'?)"'7"33*1',##*1)",+'$%+$2,!"-','2$#243,#'2"33'-),/"'!),!'1,-',224#,!"37'-"&("%!"+>'?)"'#"+' ,##*1)",+-'$%+$2,!"':'2"33-'*8'1)$2)'!)"'(*+"3"+'("(.#,%"-'#"-43!'$%',%'4%+"#"-!$(,!$*%'*8'!)"' 2"33'/*3,#$=,!$*%>'?)"'.34"',##*1)",+'/*$%!-',!','2"33'$%'1)$2)'!)"'2"33'%423"4-'$-'*88-"!'8#*('!)"' 2"%!"#'*8'!)"'27!*-*3'#"-43!$%&'$%',%'$%,224#,!"'(*+"3$%&'*8'!)"'("(.#,%"'/*-$!$*%> 122.

(6)  ‡”‡ǡ™‡”‡’‘”–ƒ‡™‡–Š‘†ˆ‘”ƒƒŽ›œ‹‰ ‡ŽŽ’‘Žƒ”‹–›†—”‹‰œ‡„”ƒϐ‹•Š !"#$%&'$'()*+#,'#-.'/)'0#/#('1#!'22#34)25('.#/26%.5)7$#/*#/#82465(#9%.#:$/6';# 9%.# /4)%$/)'0# 0')'-)5%(# /(0# $%0'25(6# %9# -'22# $'$<./('*=# 175-7# '$82%>*# 5$? ƒ‰‡ϐ‹Ž–‡”‹‰ƒ†‘”’Š‘Ž‘‰‹ ƒŽ‘’‡”ƒ–‘”•‹‹ƒ‰‡•ƒ “—‹”‡†—•‹‰ƒ•–ƒ†ƒ”† *-/((5(6#8%5()#-%(9%-/2#$5-.%*-%8'+#@7'#8.%-'**#5*#9/*)#/(0#/--4./)'#/(0#4)525A'*# &%.%(%5# )'**'22/)5%(# </*'0# %(# )7'# 0')'-)5%(# %9# -'22# ->)%82/*$*# ./)7'.# )7/(# -'22# (4-2'5+#B005)5%(/22>=#1'#'$82%>'0#!'22#C%*'*#)%#.'8.'*'()#0/)/#%(#-'22#'2%(6/)5%(# /(0#%.5'()/)5%(#5(#)7'#*/$'#6./87+#@75*#-%$8%*5)'#6./87#*7%1*#)7'#-%..'2/)5%(# <')1''(# -'22# '2%(6/)5%(# /(0# %.5'()/)5%(# 5(# /# *5(62'# &5'1+# ,'# *4--'**9422># /(/? Ž›œ‡† –Š‡ ’”‡•‘‹–‹  ‡•‘†‡” ‹ œ‡„”ƒϐ‹•Š —–ƒ–•ǡ –Šƒ– Šƒ˜‡ ƒ ™‡ŽŽǦ•–—†‹‡† 0'9'-)#5(#!"#$%&'$'()*=#)%#&/250/)'#)7'#4*'#%9#!'22#34)25('.#/(0#!'22#C%*'*#/*#/# )%%2#9%.#87'(%)>85-/2#/(/2>*5*+#@75*#)%%2#-/(#<'#/0/8)'0#)%#/(>#D?E#5$/6'#%9#-'22*# 5(#175-7#)7'#-'22#$'$<./('#5*#75672567)'0#)%#/**'**#-'22#*7/8'#/(0#05.'-)5%(#5(#/(# /4)%$/)'0#$/(('.#/(0#1'#7/&'#/(/2>A'0#5$/6'*#9.%$#9%4.#05*)5(-)#%.565(*+ !"#$%&"'()"*+),$#-.+(. ‡„”ƒϔ‹•Šƒ‹–‡ƒ ‡ǡ‹˜‹–”‘–”ƒ• ”‹’–‹‘‘ˆǡƒ†‹Œ‡ –‹‘ ‡„”ƒϐ‹•Š™‡”‡‡’–ƒ†–Š‡‡„”›‘•™‡”‡•–ƒ‰‡†ƒ•†‡• ”‹„‡†„‡ˆ‘”‡ȏͳͶȐǤ Ž›™‹Ž†–›’‡‡„”›‘•—’–‘͵†’ˆ™‡”‡—•‡†ˆ‘”–Š‡•‡‡š’‡”‹‡–•ǡ™Š‹ Š†‘‡• (%)#.'F45.'#/88.%&/2#%9#)7'#/(5$/2#'G8'.5$'()*#-%$$5))''#/--%.05(6#)%#(/)5%(/2# ƒ†—”‘’‡ƒŽƒ™Ǥ•‹‰–Š‡‡••ƒ‰‡ƒ Š‹‡‹–ȋ„‹‘Ȍǡ™‡•›–Š‡•‹œ‡† ͷǯǦ ƒ’’‡†•‡•‡‡ ‘†‹‰‡„”ƒ‡ǦŽ‘ ƒŽ‹œ‡† ‹–”‹‡ȋƒ ˜ƒ”‹ƒ–™‹–Š ƒǦ–‡”‹ƒŽˆ—•‹‘‘ˆ–Š‡ƒ•‡„”ƒ‡Ž‘ ƒŽ‹œƒ–‹‘•‡“—‡ ‡ȏȐȌȋ‹†Ž› ’”‘˜‹†‡†„› ‡”‘‡—••ƒ‘ˆ–Š‡ —„”‡ Š–

(7) •–‹–—–‡Ȍ‘”‡ ȋ‹†Ž›’”‘? ˜‹†‡†„› ‡”‘‡ƒ‡”•‘ˆ–Š‡ —„”‡ Š–

(8) •–‹–—–‡ȌǤ‘ƒ Š‹‡˜‡—„‹“—‹–‘—•ϐŽ—‘? .'*-'()#$'$<./('#2/<'25(6=#)7'#'$<.>%*#1'.'#5(H'-)'0#/)#)7'#%('#-'22#*)/6'#15)7# ʹͲ’‰‘ˆ Ǧ‘”͵Ͳ’‰‘ˆ‡ Ǥ ‘ˆ‘ ƒŽ‹ ”‘• ‘’›ƒ†’‘•‹–‹‘‹‰ @%#&5*4/25A'#)7'#-'22#*7/8'#5(#)7'#8.'*%$5)5-#$'*%0'.$=#25&'#'$<.>%*#1'.'# ‘—–‡†‹ͲǤ͹ͷΨ•‘ˆ–ƒ‰ƒ”‘•‡ƒ––Š‡†‘”•ƒŽ•‹†‡‹‰Žƒ••„‘––‘‡†’‡–”‹†‹•Š‡•Ǥ •‹‰ƒʹ‡‹ ƒ‘ˆ‘ ƒŽ‹ ”‘• ‘’‡–Š‡’”‡•‘‹–‹ ‡•‘†‡”™ƒ•‹ƒ‰‡† —•‹‰ƒͶͲ‘‹Ž‘„Œ‡ –‹˜‡ǤʹǦ‹ƒ‰‡•ͷͳʹͷͳʹ™‡”‡ƒ “—‹”‡††—”‹‰–Š‡ʹ–‘͵ •‘‹–‡•–ƒ‰‡ͳͲͲρ’‘•–‡”‹‘”–‘–Š‡†‡˜‡Ž‘’‹‰•‘‹–‡•‹–Š‡’ƒ”ƒš‹ƒŽ‡•‘? †‡”ǡŽƒ–‡”ƒŽ–‘–Š‡‘–‘ Š‘”†ǤŽ–‡”ƒ–‹˜‡Ž›ǡ–Š‡‡’‹„Žƒ•–™ƒ•‹ƒ‰‡†ƒ–͹ͲΨ‡’‹? <%2>#*)/6'+#B22#5$/6'*#/(/2>A'0#<>#!'22#34)25('.#1'.'#0565)/22>#'(2/.6'0#)%#$/I'# –Š‡•—”ˆƒ ‡‘ —’‹‡†„›‘‡ ‡ŽŽƒ’’”‘š‹ƒ–‡Ž›ʹͲͲͲ’‹š‡Ž•ǡ™Š‹ Š‹•–Š‡‘’–‹ƒŽ *5A'#9%.#!'22#34)25('.+## 123. !.

(9) ‹ ‡ƒ†‹—‘•–ƒ‹‹‰• ŽŽ ‹ ‡ ™‡”‡ ‹ –Š‡ ͷ͹

(10) ͸ŒȀ ‹š‡† „ƒ ‰”‘—† ƒ† ™‡”‡ Š‘—•‡† ƒ ‘”†‹‰–‘ƒ–‹‘ƒŽƒ†‡—”‘’‡ƒŽƒ™ǡ—†‡”–Š‡Ž‹ ‡•‡•”‡“—‹”‡†‹–Š‡‡–Š! "#$%&'()*+,-"#./"&0(*1"#"*2%##."'*340*4&'"#*546#"270*8&(0.040"*$.2"&("*&4/6"#*

(11) ͳͲǤͲͳǤͲͷǤ „”›‘• ™‡”‡ †‹••‡ –‡† ƒ† ϐ‹š‡† ƒ ‘”†‹‰ –‘ ȏͳͷȐǤ ™‘ †‹•–‹ – ‘‘ Ž‘ƒŽ”ƒ–Ǧ ƒ†Š‡”‹ƒ–‹„‘†‹‡•ȋ˜‘‘”—Ž‹ȀǦƒ†Š‡”‹ˆ”‘‹‰ƒƒ† Ǧʹˆ”‘‹ŽŽ‹’‘”‡Ȍ™‡”‡—•‡†ƒ•’”‹ƒ”›ƒ–‹„‘†‹‡•ˆ‘”†‡–‡ –‹‘‘ˆ–Š‡ ‡ŽŽ •Šƒ’‡•„‘–Š‹ͳǣʹͷͲ†‹Ž—–‹‘Ǥ’’”‘’”‹ƒ–‡•‡ ‘†ƒ”›ƒ–‹„‘†‹‡•™‡”‡‘„–ƒ‹‡† ˆ”‘ ƒ •‘

(12) —‘”‡•‡ƒ” Šƒ†—•‡†‹ͳǣͷͲͲ†‹Ž—–‹‘Ǥ‡ˆ‘”‡‹ —„ƒ–‹‘™‹–Š ’”‹ƒ”›ƒ–‹„‘†‹‡•ǡ‡„”›‘•™‡”‡–”‡ƒ–‡†™‹–ŠͲǡͳΨ”‹–‘ǦͳͲͲˆ‘”ͳͲǦͳͷ‹! —–‡•ƒ†„Ž‘ ‡†‹ͳΨ•‘Ž—–‹‘ˆ‘”ͷŠ‘—”•ƒ–”‘‘–‡’‡”ƒ–—”‡Ǥ

(13)  —„ƒ! –‹‘™‹–Š’”‹ƒ”›ƒ–‹„‘†‹‡•™ƒ• ƒ””‹‡†‘—–ˆ‘”–Š”‡‡†ƒ›•ˆ‘ŽŽ‘™‡†„›ͺ™ƒ•Š‡• ȋ͵Ͳ‹—–‡•‡ƒ Šǡƒ–ͶιȌƒ†‘˜‡”‹‰Š–ˆ‘”•‡ ‘†ƒ”›ƒ–‹„‘†‹‡•ˆ‘ŽŽ‘™‡†„› 1%(7"()*+/6#93(*1"#"*%&%$9:"'*69*23&;32%$*$%("#*(2%&&.&<*/.2#3(23-")*. !"#$%&#. ‡ŽŽ—–Ž‹‡”ǣ—–‘ƒ–‡†•‡‰‡–ƒ–‹‘™‘”ϔŽ‘™ˆ‘” ‡ŽŽ‡„”ƒ‡”‡ ‘‰‹–‹‘ * 8&*3#'"#*03*=4%&0.0%0.>"$9*%&%$9:"*07"*-3$%#.:%0.3&*-#3-"#0."(*3;*07"*2"$$(* /%?.&<*4-*07"*-#"(3/.0.2*/"(3'"#/*.0*.(*&"2"((%#9*03*%2=4.#"*.&;3#/%0.3&*3;*%* Žƒ”‰‡—„‡”‘ˆ ‡ŽŽ•Ǥƒ—ƒŽƒƒŽ›•‹•‹•Žƒ„‘”Ǧ‹–‡•‹˜‡ǡ‡””‘”Ǧ’”‘‡ƒ†•—„Œ‡ ! 0.>")*@4%&0.0%0.>"*%&%$9(.(*-"#;3#/"'*69*/%07"/%0.2%$*%$<3#.07/(*.(*;%(0"#A*/3#"* %224#%0"* %&'* 36B"20.>")* 531">"#A* 07"* 6300$"&"2?* .&* 07.(* %--#3%27* $."(* .&* '"0"2! –‹‘ǡ‹Ǥ‡Ǥ•‡‰‡–ƒ–‹‘ǡ‘ˆ–Š‡ ‡ŽŽ•Šƒ’‡ǤŠ‡’”‘„Ž‡‹• ƒ—•‡†„›ϐŽ— –—ƒ–‹‘‹ –Š‡‹–‡•‹–›‘ˆ–Š‡†‡–‡ –‡†ϐŽ—‘”‡• ‡–•‹‰ƒŽ†—‡–‘‡ Šƒ‹ ƒŽ‘‹•‡‹Š‡”‡– –‘–Š‡ ‘ˆ‘ ƒŽ–‡ Š‹“—‡ƒ†„‹‘Ž‘‰‹ ƒŽϐŽ— –—ƒ–‹‘ǡ™Š‹ Š‹ Ž—†‡•„ƒ ‰”‘—† ϐŽ—‘”‡• ‡ ‡ǡ‘Ǧ—‹ˆ‘”†‹•–”‹„—–‹‘‘ˆƒ”‡”ǡƒ†ϐŽ— –—ƒ–‹‘•‹•‹‰ƒŽ†—‡ 03*07"*-#3,./.09*03*/"/6#%&"*B4&20.3&(A*%'B%2"&0*2"$$*/"/6#%&"(A*%&'*/%#?"#* %<<#"<%0.3&()* ‡ŽŽ—–Ž‹‡”™ƒ•†‡•‹‰‡†–‘ ‘’‡•ƒ–‡ˆ‘”‹–‡•‹–›ϐŽ— –—ƒ–‹‘•ǡ™Š‹ Š ‘ˆ–‡‘ —”‹„‹‘Ž‘‰‹ ƒŽ•ƒ’Ž‡•ǡˆƒ ‹Ž‹–ƒ–‹‰ƒ—–‘ƒ–‹ †‡–‡ –‹‘‘ˆϐŽ—‘”‡• ‡–Ž› /%#?"'*2"$$*/"/6#%&"()*C7"*%$<3#.07/*1%(*3-0./.:"'*;3#*./%<"(*3;*2"$$*-3-4$%! –‹‘• Ž‘•‡Ž› ‘’ƒ –‡†–‘‰‡–Š‡”ƒ”‡†„› ǦǤ‘”‡–ŠƒʹͲ•ƒ’Ž‡’‹ ! 04#"(*3;*-#"(3/.0.2*/"(3'"#/*3;*'.;;"#"&0*"/6#93(A*"%27*23&(0.040.&<*6"01""&* ͶͲƒ†͸Ͳ ‡ŽŽ•™‡”‡—•‡†–‘‘’–‹‹œ‡–Š‡™‘”ϐŽ‘™‘ˆ–Š‡ƒŽ‰‘”‹–ŠǤˆ–‡”•‡‰! /"&0%0.3&*07"*/3#-73$3<.2%$*.&;3#/%0.3&*2%&*6"*",0#%20"') C7"*/3(0*./-3#0%&0*(34#2"*3;*/"27%&.2%$*&3.("*.(*(730*&3.("A*17.27*2%&* 124.

(14) !. ‹‰—”‡ʹǣ‘”ϐŽ‘™‘ˆ–Š‡‡ŽŽ—–Ž‹‡”Ž‰‘”‹–Šˆ‘”†‡–‡ –‹‘ƒ†•—„•‡“—‡–‡ƒ•—”‡" #$%&'()'*$++',(+-./0-&/(%1' „”›‘•™‡”‡‹Œ‡ –‡†™‹–ŠʹͲ’‰‘ˆ Ǧƒ†–Š‡’”‡•‘‹–‹ ‡•‘†‡”™ƒ•‹ƒ‰‡† !"#$%&'#(%)&*+$%&!,"#)&%('-#./0123#4%5#!6%('#%"7#*')+$&#,8#&9'#:'$$#;+&$!"'*#%$(,*!&96#,8#%#*'<*'0 •‡–ƒ–‹˜‡‹ƒ‰‡‘ˆ–Š‡’”‡•‘‹–‹ ‡•‘†‡”ǤȋȌǡƒ”ƒ™ ‘ˆ‘ ƒŽ‹ƒ‰‡‹ͺǦ„‹– ‘Ž‘—”˜‡”•‹‘Ǥ ȋȌǡ–Š‡•‹‰ƒŽ‘ˆ–Š‡  ‘˜‡”–‡†–‘ͺǦ„‹–‰”ƒ›• ƒŽ‡ǤȋȌǡƒ‡†‹ƒ„Ž—”‘’‡”ƒ–‹‘ȋ”ƒ†‹—•αʹ’‹š0 '$)2#*'7+=')#)9,&#",!)'3#59!$'#<*')'*>!"(#&9'#'7(')#,8#)&*+=&+*')-#.?23#%<<$!=%&!,"#,8#%"#%7%<&!>'# &9*')9,$7!"(#<*,='7+*'#*')+$&)#!"#7'&'=&!,"#,8#&9'#%*'%#,8#&9'#='$$#6'6@*%"')-#.A23#%*&'8%=&)#('"0 ‡”ƒ–‡†„›–Š‡–Š”‡•Š‘Ž†‹‰’”‘ ‡†—”‡ƒ”‡”‡†— ‡†‰”‡ƒ–Ž›„›ƒ’’Ž›‹‰ƒ ƒ—••‹ƒ„Ž—”ȋ”ƒ†‹—•α͸ȌǤ ȋ Ȍǡ‹ƒ”‹œƒ–‹‘ǡ—•‹‰ƒ–Š”‡•Š‘Ž†‘ˆ‰”ƒ›˜ƒŽ—‡͸ͲǤȋ Ȍǡƒ†‰‡‘””‡ –‹‘•–‡’‹•ƒ’’Ž‹‡†ǡ™Š‹ Š =,">'*&)#%$$#'7('#<!B'$)#&,#@%=C(*,+"73#59!=9#!)#"'='))%*D#8,*#&9'#7'&'=&!,"#,8#'7('#,@E'=&)#$%&'*# !"#&9'#<*,='7+*'-#.F23#!">'*)!,"#,8#&9'#)!("%$#8*,6#.G2#('"'*%&')#%"#!6%('3#59'*'!"#&9'#8,*'(*,+"7# ,@E'=&)#*'<*')'"&#=D&,),$!=#)!("%$)-#.H23#&9')'#=D&,),$!=#)!("%$)#%*'#",5#+)'7#&,#<'*8,*6#I,*,",!# &'))%$%&!,"3#('"'*%&!"(#%#I,*,",!#7!%(*%63#!-'-#&9'#6,7'$'7#6'6@*%"')-#.123#&9'#<*,E'=&!,"#,8#&9'# 6,7'$$'7#6'6@*%"')#,"&,#&9'#*%5#=,"8,=%$#!6%('-#.J0K23#%"#'"$%*('7#)'=&!,"#,8#&9'#!6%('#!"#./3# ›‡ŽŽ‘™ „‘šȌǤ ǡ –Š‡ ”‡† ƒ””‘™Š‡ƒ† ‹†‹ ƒ–‡• ƒ •‹–‡ ‹ –Š‡ –Š”‡•Š‘Ž†‡† ‹ƒ‰‡ǡ ™Š‡”‡ ƒ ƒ„”—’– =9%"('#!"#!"&'")!&D#!"#&9'#*%5#!6%('#*')+$&'7#!"#%#7!)=,"&!"+!&D#!"#&9'#7'&'=&'7#6'6@*%"'#)!("%$-# K9'#D'$$,5#%**,59'%7#!"7!=%&')#&9'#$,=%&!,"#,8#%#*,+"7#)'(6'"&'7#,@E'=&3#=%+)'7#@D#&9'#<*')'"='# 125.

(15) ‘ˆƒϐŽ—‘”‡• ‡–˜‡•‹ —Žƒ”•–”— –—”‡’”‡•‡–‹–Š‡ ›–‘•‘ŽǤȋȌǡ„‘–Š–Š‡•‡‘„Œ‡ –•ƒ”‡‡Ž‹‹ƒ–‡† „›ƒ —ƒ••‹ƒŽ—”ȋ”ƒ†‹—•α͸Ȍƒ†•—„•‡“—‡–„‹ƒ”‹œƒ–‹‘ȋȌǡ‡†‰‡ ‘””‡ –‹‘ȋȌǡƒ†‘”‘‘‹ ,"11*+*,%.&#@IC)#!*1"(#.&#,-"#45,.2+*1$%4#1%0&*+1#@JC)#0"&"3*,"#*&#*44/3*,"#$.("+#.7#,-"#4"++#$"$; „”ƒ‡•ǤȋȌǡ’”‘Œ‡ –‹‘‘ˆ–Š‡„‡•–ϐ‹–‡ŽŽ‹’•‡•ǡ‹„Ž—‡ǡ‘–‘–Š‡’”‘Œ‡ –‹‘ȋȌǤȋȌǡ”‡’”‡•‡–ƒ–‹‘ ‘ˆ–Š‡ƒŒ‘”ȋ›‡ŽŽ‘™Ȍƒ†‹‘”ȋ”‡†Ȍƒš‹•‘ˆ–Š‡„‡•–ϐ‹–‡ŽŽ‹’•‡™Š‹ Š™‡”‡—•‡†–‘ ƒŽ —Žƒ–‡–Š‡ 4"++#"+.&0*,%.&#@*12"4,#3*,%.#.7#,-"#+"&0,-#.7#$*F.3#*&(#$%&.3#*?"1C#*&(#4"++#.3%"&,*,%.&#@,-"#*&0+"# .7#,-"#$*F.3#*?%1#.7#,-"#"++%21"#3"+*,%:"#,.#,-"#$"(%.;+*,"3*+#(%3"4,%.&)#=-%4-#%1#%&#*++#,-"1"#%$*0"1## ,-"#-.3%'.&,*+#*?%1C8. !"#$%&%$%'"()#*+,-./0-#%,1#23"1"&4"#%1#%&-"3"&,+5#+%&6"(#,.#,-"#2-51%4*+#23%&4%2+"# /1"(#!5#4.&7.4*+#$%43.14.2"18#9,#3"1/+,1#73.$#,-"#1,*,%1,%4*+#:*3%*,%.&#%&#,-"#&/$; „‡”‘ˆ†‡–‡ –‡†’Š‘–‘•ǡ™Š‹ Š ƒ„‡†‡• ”‹„‡†ƒ•ƒ‘‹••‘†‹•–”‹„—–‹‘ȏͳ͸ȐǤ <1#*&#%&%,%*+#1,"2#7.3#1"0$"&,*,%.&#*#‡†‹ƒϐ‹Ž–‡”#=%,-#3*(%/1#.7#>#2%?"+1#=*1# %$2+"$"&,"(#*1#%,#=*1#7./&(#,.#3"(/4"#&.%1"#03"*,+5#=%,-./,#*77"4,%&0#!.3("31# @A%08#><;BC8# D%:"&#,-"#4.$$.&#.44/33"&4"#.7#%&,"&1%,5#03*(%"&,1#%&#4.&7.4*+#%$*0"1)# 0+.!*+#,-3"1-.+(%&0#,"4-&%E/"1#.7,"&#0%:"#2..3#3"1/+,1#%&#1"2*3*,%&0#7.3"03./&(# 2%?"+1#@4"++#$"$!3*&"1C#73.$#,-"#!*4603./&(#@45,.1.+C8#D+.!*+#,-3"1-.+(%&0#/1"1# ƒϐ‹š‡†–Š”‡•Š‘Ž†ˆ‘”ƒŽŽ’‹š‡Ž•‹–Š‡‹ƒ‰‡Ǥ

(16) ––Š‡”‡ˆ‘”‡™‘”•‘Ž›‹ˆ–Š‡‹–‡; 1%,5#-%1,.03*$#.7#,-"#%&2/,#%$*0"#4.&,*%&1#&"*,+5#1"2*3*,"(#2"*61)#4.33"12.&(%&0# ,.#,-"#.!F"4,1#.7#%&,"3"1,8#G"&4")#%,#4*&&.,#("*+#=%,-#%$*0"1#4.&,*%&%&0#*#1,3.&0# %&,"&1%,5#03*(%"&,8#!"#$%&'()%*+(,*-."&/0ȋ ‹‰Ǥ͵Ȍ‹•ƒ‘”‡•‘’Š‹•–‹ ƒ–‡†–‡ Š; &%E/")#=-%4-#1"+"4,1#*&#%&(%:%(/*+#,-3"1-.+(#7.3#"*4-#2%?"+#!*1"(#.&#,-"#3*&0"#.7# %&,"&1%,5#:*+/"1#%&#%,1#+.4*+#&"%0-!.3-..()#3*,-"3#,-*&#,-"#"&,%3"#%$*0"8#H-%1#*+; Ž‘™•ˆ‘”–Š”‡•Š‘Ž†‹‰‘ˆƒ‹ƒ‰‡™‹–Šƒ‹–‡•‹–›‰”ƒ†‹‡–ȏͳ͹ȐǤŠ‹Ž‡ ‘’Ž‡š ˆ‘”—Žƒ•Šƒ˜‡„‡‡†‡˜‡Ž‘’‡†–‘†‡–‡”‹‡–Š‡•‡Ž‘ ƒŽ–Š”‡•Š‘Ž†•ȏͳͺǡͳͻǡʹͲȐǡ™‡ 7./&(#,-*,#%$2+"$"&,%&0#*#,-3"1-.+(#:*+/"#!*1"(#.&#,-"#$"(%*&#.7#,-"#%&,"&1%,5#. 1&02+()34)!"#$%&'()5*+(,*-."&/06) ȋȌǡƒ™ ‘ˆ‘ ƒŽ‹ƒ‰‡‘ˆ ‡ŽŽ‡„”ƒ‡•‘ˆƒ‡„”›‘‹Œ‡ –‡†™‹–ŠʹͲ’‰‘ˆ ǦǤ ȋȌǡƒ’”‘ϐ‹Ž‡’Ž‘–ƒŽ‘‰–Š‡”‡‰‹‘ƒ”‡†„›–Š‡›‡ŽŽ‘™Ž‹‡‹ȋȌǤŠ‡’‡ƒ•‹–Š‡’”‘ϐ‹Ž‡’Ž‘– 4+"*3+5#1-.=#,-"#3"0%.&1#.7#-%0-#$"$!3*&"#%&,"&1%,5#4.$2*3"(#,.#*#+.="3#45,.1.+%4#1%0&*+#%&#!"; –™‡‡ǤŠ‡’”‘ϐ‹Ž‡’Ž‘–‹••—„†‹˜‹†‡†‹†‹ˆˆ‡”‡–”‡‰‹‘•ǡ͵Ͳ’‹š‡Ž•™‹†‡ǡƒ”‡†„›–Š‡ƒŽ–‡”ƒ–; %&0#=-%,"#*&(#!+/"#*3"*18#K%,-%&#"*4-#.7#,-"1"#*3"*1#*#1"2*3*,"#,-3"1-.+(#%1#4*+4/+*,"(#!*1"(#.&# ,-"#$"(%*&#03*5#:*+/"#.7#,-"#*3"*)#=-%4-#=%++#!"#/1"(#7.3#(%14"3&%&0#,-"#$"$!3*&"#1%0&*+#73.$# ,-"#+.4*+#!*4603./&(8 126.

(17) !"#$%&#'()&*+#(,#$%&#(--&.(/$&#+011!0,.(,2+#2/3&#$%&#4&+$#1&+0*$+5#6#*!7/*#&,3(1!,8 ‡–‘ˆ͵Ͳ͵Ͳ’‹š‡Žƒ”‡ƒƒ”‘—†–Š‡ƒƒŽ›œ‡†’‹š‡Ž™ƒ•ˆ‘—†–‘„‡‘’–‹ƒŽȋ ‹‰Ǥ 9:;5 Š‹Ž‡ –Š‹• ‡–Š‘† ’”‘˜‡† –‘ „‡ Š‹‰ŠŽ› ‡ˆϐ‹ ‹‡– ‹ •‡’ƒ”ƒ–‹‰ –Š‡ ‡8 „”ƒ‡•‹‰ƒŽǡ–™‘•‘—” ‡•‘ˆ‡””‘”‡‡†‡†–‘„‡‹‹‹œ‡†Ǥ ‹”•–ǡϐŽ—‘”‡• ‡–˜‡8 +(70*/1# +$107$01&+# <($%(,# $%&# 7=$!+!*# !77/+(!,/**=# 71&/$&# 1!0,.># +&2-&,$&.# !48 Œ‡ –•ȋ›‡ŽŽ‘™ƒ””‘™Š‡ƒ†‹ ‹‰ǤʹȌǤ”‡•‡ ‡‘ˆ–Š‡•‡•–”— –—”‡•‹•—ƒ˜‘‹†ƒ„Ž‡ +(,7&#$%&+&#3&+(7*&+#/1&#'/1$#!"#$%&#&,.!-&-41/,&#+=+$&->#<%(7%#(+#0+&.#$!#$1/"8 ϐ‹ Ǧ–ƒ‰‰‡†’”‘–‡‹•–‘–Š‡’Žƒ•ƒ‡„”ƒ‡ȏʹͳȐǤ‡ ‘†ǡƒ„”—’– Šƒ‰‡• (,#-&-41/,&#(,$&,+($=#<%(7%#!"$&,#!7701#(,#4(!*!2(7/*#+/-'*&+>#7/,#7/0+&#+($&+# ™Š‡”‡ –Š‡ ‡„”ƒ‡ ‹• ‘– †‡–‡ –‡† ȋ”‡† ƒ””‘™Š‡ƒ† ‹ ‹‰Ǥ ʹȌǤ ‡ ˆ‘—† ƒ. ƒ—••‹ƒϐ‹Ž–‡”#?@(25#9A;#<($%#/#1/.(0+#!"#+()#'()&*+#"!**!<&.#4=#/#"#$%&#'%(#)$*# ™Š‹ Šƒ’’Ž‹‡†ƒ‰Ž‘„ƒŽ–Š”‡•Š‘Ž†‘ˆ‰”ƒ›˜ƒŽ—‡͸Ͳ–‘„‡Š‹‰ŠŽ›‡ˆϐ‹ ‹‡–‹‹‹8 -(B(,2#$%&+&#+!017&+#!"#&11!1#?@(25#9@;5 C%&#1&+0*$(,2#(-/2&#</+#"01$%&1#'1!7&++&.#4=#/,#+,-+./)&&+/(#)$#7!,8 3&1$(,2#/**#'()&*+#/$#$%&#&.2&#!"#$%&#(-/2&#$!#4/7D21!0,.#?@(25#9E;5#0$1+&2#)$.!"# $%(+#(-/2&#1&+0*$&.#(,#/#+&2-&,$&.#(-/2&#(,#<%(7%#$%&#&.2&#!"#$%&#(-/2&#/,.#$%&# 7=$!'*/+-+# /1&# "!1&21!0,.# !4F&7$+# ?@(25# 9G;5# C%&# &.2&# 7!11&7$(!,# (+# ,&&.&.# $!# (,7*0.&#7&**+#!"#<%(7%#$%&#-&-41/,&#(+#7*!+&#$!#$%&#&.2&#!"#$%&#(-/2&#(,#$%&#/,/*=8 •‹•ǤŠ‡”‡ƒ•‘ˆ‘”–Š‹•Ž‹‡•‹–Š‡‡š–’”‘ ‡••‹‰•–‡’ǣ ‡‡”ƒ–‹‘‘ˆƒ3)&)$)## ,#%-&%45# C%(+# .(3(.&+# /,# (-/2&# (,$!# 1&2(!,+# 4=# .1/<(,2# '!(,$+# /$# 7!!1.(,/$&+# ™Š‹ Šƒ”‡‡“—‹†‹•–ƒ–ˆ”‘–Š‡ Ž‘•‡•–•—””‘—†‹‰‘„Œ‡ –•ȏʹʹȐǤ

(18) ‘–Š‡”™‘”†•ǡ ($# +04.(3(.&+# $%&# 4(,/1=# (-/2&# (,$!# 1&2(!,+# +07%# $%/$# $%&# H!1!,!(# 1&2(!,# !"# /,# !4F&7$# (+# $%&# 7*0+$&1# !"# '!(,$+# ?+01"/7&;# *!7/$&.# 7*!+&+$# $!# $%(+# !4F&7$5# C%(+# !'8 ‡”ƒ–‹‘‹• ƒŽŽ‡†‘”‘‘‹–‡••ƒŽƒ–‹‘Ǥ›ƒ‹‰–Š‡‡†‰‡’ƒ”–‹ Ž‡•ƒ•™‡ŽŽƒ•–Š‡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ˆϔ‹ ‹‡–•‡‰‡–ƒ–‹‘‘ˆ‡„”ƒ‡• ‘†‡–‡”‹‡–Š‡‡ˆϐ‹ ‹‡ ›‘ˆ‡ŽŽ—–Ž‹‡”ˆ‘”‡„”ƒ‡•‡‰‡–ƒ–‹‘ǡ –Š‡‰‡‡”ƒ–‡†‡„”ƒ‡‘†‡Ž•™‡”‡˜‡”‹ϐ‹‡†„›ƒ—ƒŽ ‘’ƒ”‹•‘–‘–Š‡”ƒ™ ‘ˆ‘ ƒŽ‹ƒ‰‡•Ǥ‡—•‡†•ƒ’Ž‡•ƒ “—‹”‡†ˆ”‘–Š‡’”‡•‘‹–‹ ‡•‘†‡”‘ˆͳͲ &-41=!+#/,.#/**#(-/2&+#<&1&#/,/*=B&.#/0$!-/$(7/**=#4=#K&**#M0$*(,&15#C%&#'1!8 21/-#71&/$&+#/#+&7!,.#(-/2&#(,#<%(7%#/#-!.&*#!"#$%&#-&-41/,&+#(+#2&,&1/$&.# "1!-#$%&#1/<#./$/>#/,.#/#$%(1.#(-/2&#(,#<%(7%#$%&#.&$&7$&.#7&**+#/1&#,0-4&1&.# 127. !.

(19) !"#$ %&'()*+',%(#$ ,"$ -.($ ,)*/*"!0$ )!1$ *+!/(2$ 3"$ ,)#()$ -,$ 4!0*#!-($ -.($ +(-.,#$ —•‡†„›‡ŽŽ—–Ž‹‡”ǡ–Š‡‰‡‡”ƒ–‡†‘„Œ‡ –•™‡”‡˜‡”‹ϐ‹‡†‘‡„›‘‡„› ‘’ƒ”‹5 •‘‘ˆ–Š‡†‡–‡ –‡†Ȁ‰‡‡”ƒ–‡† ‡ŽŽ‡„”ƒ‡•‹–Š‡‘†‡Ž–‘–Š‡‹” ‘’Ž‡‡– *"$-.($)!1$*+!/(%2

(20) –‘–ƒŽ͸͸ͳ ‡ŽŽ•‘ˆ Ǧ‹Œ‡ –‡†‡„”›‘•™‡”‡ƒƒŽ›œ‡†ƒ† 4!0*#!-(#2$6*"7($8(00$9&-0*"()$*%$:!%(#$,"$-.($*"#*)(7-$#(-(7-*,"$,;$7<-,%,0%=$!$;!0%($ ’‘•‹–‹˜‡‹•†‡ϐ‹‡†ƒ•ƒ•‹‰Ž‡ ›–‘•‘Ž–Šƒ–Šƒ•„‡‡†‡–‡ –‡†ƒ•—Ž–‹’Ž‡ ›–‘•‘Ž•Ǥ ˆƒŽ•‡‡‰ƒ–‹˜‡‹•†‡ϐ‹‡†ƒ•ƒ—†‡–‡ –‡† ›–‘•‘ŽǤ‡ŽŽ—–Ž‹‡”•Š‘™‡†˜‡”› Š‹‰Š‡ˆϐ‹ ‹‡ ›ǣͻ͸ǡͺͻΨ‘ˆ–Š‡ ›–‘•‘Ž•™ƒ•†‡–‡ –‡† ‘””‡ –Ž›ǤŠ‡‡””‘””ƒ‰‡ ‘•‹•–‡†‘ˆʹǤ͸ͻΨˆƒŽ•‡’‘•‹–‹˜‡•ƒ†͵ǤͳͲΨˆƒŽ•‡‡‰ƒ–‹˜‡•ǤŠ‡ƒ‹•‘—” ‡ ‘ˆˆƒŽ•‡’‘•‹–‹˜‡•ƒ”‡”‘™•‘ˆ•ƒŽŽǡϐŽ—‘”‡• ‡–ǡ˜‡•‹ —Žƒ”•–”— –—”‡•™Š‹ Š‘ —” ,77!%*,"!00<$1*-.*"$-.($7<-,%,0$!"#$.*/.$*"-("%*-<$7<-,%,0*7$%*/"!0%$1.*7.$)(%&0-$ ;),+$7(00$+(+:)!"(%$0<*"/$*"$!"#$'!)!00(0$-,$-.($7,";,7!0$'0!"(2$>!0%($"(/!-*4(%$ ,77&)$1.("$-.($4*%*:0($7<-,%,0$*%$4()<$"!)),1=$*2(2$,"0<$!$%+!00$'!)-$,;$-.($7<-,%,0$ ,;$-.($7(00$1!%$4*%*:0($*"$-.($7,";,7!0$'0!"($1.*0($-.($:&0?$,;$-.($7(00$)(%*#(#$(*5 -.()$70,%()$-,$-.($%&);!7($,)$#(('()$1*-.*"$-.($-*%%&(2$ ‡ŽŽ—–Ž‹‡”™ƒ•‹‹–‹ƒŽŽ›†‡•‹‰‡†ƒ†‘’–‹‹œ‡†–‘†‡–‡ – Ǧ‹ Ž‹˜‹‰œ‡„”ƒϐ‹•Š‡„”›‘•Ǥ ‘™‡˜‡”ǡ‹–™ƒ•Š‹‰ŠŽ›Ž‹‡Ž›–Šƒ–‹– ‘—Ž†ƒŽ•‘„‡ƒ’’Ž‹‡† –‘†‡–‡ –ϐŽ—‘”‡• ‡– ‡ŽŽ‡„”ƒ‡•‹†‹ˆˆ‡”‡–•ƒ’Ž‡•Ǥ‘–‡•––Š‹•ǡ™‡†‡–‡”5 ‹‡†‹–•‡ˆϐ‹ ‹‡ ›™Š‡—•‹‰†ƒ–ƒˆ”‘Ž‹˜‡‹ƒ‰‹‰‘ˆ‰ƒ•–”—Žƒ•–ƒ‰‡œ‡„”ƒϐ‹•Š ‡„”›‘•‹Œ‡ –‡†™‹–Š‘ˆ‡ ǡƒ Š‹‡”‹ ’”‘–‡‹ ‘–ƒ‹‹‰–Š‡ͳͲ Ǧ–‡”‹ƒŽƒ‹‘ƒ ‹†•‘ˆ Ͷ͵ˆ—•‡†–‘Ǧ–‡”‹—•‘ˆ Ǥ‘”‡‘˜‡”ǡ™‡—•‡† ‹ƒ‰‡•‘ˆŽƒ–‡”ƒŽ‡•‘†‡”ˆ”‘ϐ‹š‡†ͶǦ•‘‹–‡•–ƒ‰‡‘—•‡‡„”›‘•–Šƒ–™‡”‡ Žƒ„‡Ž‡†™‹–Šʹ†‹ˆˆ‡”‡–‘‘ Ž‘ƒŽ”ƒ–ƒ–‹„‘†‹‡•ˆ‘”Ǧƒ†Š‡”‹ǡ˜‘‘”—Ž‹Ȁ Ǧƒ†Š‡”‹ƒ–‹„‘†›‘”Ǧʹȋ ‹‰ǤͶȌǤ‡ŽŽ—–Ž‹‡”™ƒ••Š‘™–‘Šƒ˜‡ƒ˜‡”› Š‹‰Š‡ˆϐ‹ ‹‡ ›ˆ‘”ƒŽŽƒ”‡”•ƒ† ‡ŽŽ–›’‡•ȋεͻͷΨȌ™‹–ŠƒŽ‘™‹ ‹†‡ ‡‘ˆ „‘–ŠˆƒŽ•‡’‘•‹–‹˜‡•ȋδʹǡ͸ͻΨȌƒ†‡‰ƒ–‹˜‡•ȋδͶǡͲ͸ΨȌǤ‡ŽŽ—–Ž‹‡”™ƒ•ƒ„Ž‡–‘ 7,))(7-0<$*#("-*;<$,:@(7-%$*"$*+!/(%$1*-.$*"-("%*-<$/)!#*("-%$!"#$*+!/(%$1*-.$0,1$ ‹–‡•‹–›™‡”‡ƒŽ•‘’”‘ ‡••‡†™‹–ŠŠ‹‰Š‡ˆϐ‹ ‹‡ ›™Š‡–Š‡‡„”ƒ‡•™‹–Š‹ -.($*+!/(%$#*#$",-$!''(!)$-,$:($*"-())&'-(#2$3+!/(%$1*-.$0,1$*"-("%*-<$*"$1.*7.$ –Š‡ ‡ŽŽ•™‡”‡’‘‘”Ž›†‡ϐ‹‡†™‡”‡‘–’”‘ ‡••‡†™‡ŽŽƒ†•Š‘—Ž†„‡†‹• ƒ”†‡†Ǥ 8(00$ 9&-0*"()$ ;&"7-*,"%$ 7,"%*%-("-0<$ !%$ *-$ !01!<%$ /("()!-(%$ -.($ %!+($ +,#(0$ ;,)$ !$ /*4("$ %!+'0(2$ A*4("$ -.($ ,:@(7-*4*-<$ !"#$ 7,"%*%-("7<$ ,;$ -.*%$ +(-.,#=$ +&0-*'0($ %!+'0(%$7!"$:($!"!0<B(#$!"#$7,+'!)(#$-,$(!7.,-.()$#*)(7-0<2$C.(%($)(%&0-%$%.,1$ –Šƒ–‡ŽŽ—–Ž‹‡”‹•ƒ„”‘ƒ†Ž›ƒ’’Ž‹ ƒ„Ž‡ǡŠ‹‰ŠŽ›‡ˆϐ‹ ‹‡–ǡƒ† ‘•‹•–‡–‡–Š‘† -,$+,#(0$7(00$+(+:)!"(%2. ‘’—–ƒ–‹‘ƒŽ ‡ŽŽ‡ƒ•—”‡‡–ƒ††ƒ–ƒ”‡’”‡•‡–ƒ–‹‘ 128.

(21) !. ‹‰—”‡Ͷǣ‡ŽŽ—–Ž‹‡”‡ˆϐ‹ ‹‡–Ž›†‡–‡ –• ‡ŽŽ‡„”ƒ‡•‹†‹•–‹ –‹ƒ‰‡•Ǥ ‡„”ƒϐ‹•Š™‡”‡‹Œ‡ –‡†™‹–ŠʹͲ’‰‘ˆ Ǧƒ†™‡”‡‹ƒ‰‡†ƒ––Š‡ʹǦ͵•‘‹–‡•–ƒ‰‡ ‘”͵Ͳ’‰‘ˆ‡„”ƒ‡Ǧ ȋ‡ Ȍƒ†™‡”‡‹ƒ‰‡†ƒ–͹ͲΨ‡’‹„‘Ž›Ǥ‹ ‡™‡”‡ϐ‹š‡†ƒ– Ͷ•‘‹–‡•–ƒ‰‡ƒ†Žƒ„‡Ž‡†™‹–Š‘‡‘ˆʹ‘‘ Ž‘ƒŽƒ–‹Ǧ ƒ†Š‡”‹”ƒ–ƒ–‹„‘†‹‡•Ǣ˜‘‘”—Ž‹Ȁ K:7)4.*3#$&<3&K77G:D>&G*-*/-#<$&<@&5<-.&)$-#5<4#*"&2)"&4<$*&2#-.&)&C'J7&0)5*0*4&"*/<$4)36&)$: –‹„‘†›Ǥ

(22) ƒ‰‹‰™ƒ•’‡”ˆ‘”‡†ǡˆ‘ —•‹‰‘‘—•‡Žƒ–‡”ƒŽ‡•‘†‡”ƒ†œ‡„”ƒϐ‹•Š’”‡•‘‹–‹  (*"<4*3(>& 7<$@</)0& #()%*"& 2*3*& /<00*/-*4& )$4& )$)06L*4& 56& 7*00& 89-0#$*3,& @<00<2*4& 56& ()$9)0& ‘’ƒ”‹•‘‘ˆ–Š‡•‡‰‡–‘ˆ ‡ŽŽ‡„”ƒ‡•ǤˆƒŽ•‡’‘•‹–‹˜‡‹•†‡ϐ‹‡†ƒ•ƒ•‹‰Ž‡ ›–‘•‘Žǡ™Š‹ Š ‹•†‡–‡ –‡†ƒ•ȋ†‹˜‹†‡†‹Ȍ—Ž–‹’Ž‡ ›–‘•‘Ž•ǤˆƒŽ•‡‡‰ƒ–‹˜‡‹•†‡ϐ‹‡†ƒ•ƒ—†‡–‡ –‡† ›–‘•‘ŽǤ G)-)&@3<(&)-&0*)"-&-2<&#$4*1*$4*$-&*=1*3#(*$-"&2)"&)$)06L*4&)$4&#"&13*"*$-*4&.*3*>. !"#$%&'()%*+,&-.*&/*00&".)1*"&-.)-&2*3*&4*-*3(#$*4&56&7*00&89-0#$*3&2*3*& ƒƒŽ›œ‡†„›†‡–‡”‹‹‰ƒ„‡•–ϐ‹–‡ŽŽ‹’•‡‘–‘–Š‡•‡‰‡–‡† ‡ŽŽ•Šƒ’‡•ȋ ‹‰Ǥ ʹȌǤ Š‡ Ž‡‰–Š ‘ˆ –Š‡ ƒŒ‘” ƒ† ‹‘” ƒš‹• ‘ˆ –Š‡•‡ „‡•– ϐ‹– ‡ŽŽ‹’•‡• ™‡”‡ †‡: –‡”‹‡†–‘ ƒŽ —Žƒ–‡–Š‡‡Ž‘‰ƒ–‹‘‘ˆ ‡ŽŽ•ǡ†‡ϐ‹‡†ƒ•–Š‡”ƒ–‹‘‘ˆ–Š‡Ž‡‰–Š‘ˆ ();<3&)$4&(#$<3&)=#">&?44#-#<$)006,&-.*&<3#*$-)-#<$&<@&-.*&();<3&)=#"&<@&-.*&/*00"& 2)"&4*-*3(#$*4&)"&-.*&)$%0*&-.#"&)=#"&()A*"&-<2)34"&-.*&(*4#<:0)-*3)0&4#3*/-#<$& BC#%>&DEF>&G)-)&4*"/3#5#$%&/*00&*0<$%)-#<$&)$4&<3#*$-)-#<$&#$&4*H*0<1#$%&*(536<"& ‹• ‘˜‡–‹‘ƒŽŽ› ’”‡•‡–‡†‘•‡’ƒ”ƒ–‡’Ž‘–• ȏͷǡ͸ǡʹ͵ȐǤ”‡•‡–‹‰–Š‡•‡˜ƒŽ—‡• <$&"*1)3)-*&4#)%3)("&(#%.-&<5"/93*&1<-*$-#)006&H)09)50*&#$@<3()-#<$&3*%)34#$%& –Š‡‹” ‘””‡Žƒ–‹‘Ǥ•‹‰–Š‡’”‹ ‹’Ž‡‘ˆƒ™‹†”‘•‡ȏʹͶȐǡ„‘–Š‡Ž‘‰ƒ–‹‘ƒ†‘”‹: *$-)-#<$&)3*&13*"*$-*4&<$&)&7*00&I<"*>&J.#"&-61*&<@&10<-&(#%.-&3*H*)0&4#@@*3*$/*"& 129.

(23) !"#$%&#'())&*+$!("#,&$-&&"#'&**#()!&"$+$!("#+".#&*("/+$!("#-%&"#+"+*01!"/#2%&3 ‘–›’‡•Ǥ ‘ –Š‹• ‡†ǡ ™‡ ƒ†Œ—•–‡† ƒ ™‹†”‘•‡Ǧ’Ž—‰‹ ȋŠ––’ǣȀȀ™™™Ǥƒ–Š™‘”•Ǥ '(45#6()#4+$*+,#$(#/&"&)+$&#7&**#8(9&9#)&2)&9&"$!"/#,($%#$%&#.!9$)!,:$!("#(6#2(3 Žƒ”‹œƒ–‹‘†‹”‡ –‹‘•ƒ†‹–‡•‹–‹‡•ȋŠ‡”‡†‡ϐ‹‡†ƒ•ƒ•’‡ –”ƒ–‹‘‘ˆ–Š‡„‡•–ϐ‹– ‡ŽŽ‹’•‡–‘–Š‡ ‡ŽŽ•Šƒ’‡Ȍ‹ƒ ‘Ž‘—” ‘†‡†”ƒ†‹ƒŽŠ‹•–‘‰”ƒǤ‡ƒ•—”‡‡–•‘ˆ–Š‡ †‹”‡ –‹‘‘ˆ‘”‹‡–ƒ–‹‘™‡”‡‰”‘—’‡†‹–‘ͳͲι„‹•ƒ†’Ž‘––‡†ƒ•ƒ”ƒ†‹ƒŽŠ‹•3 $(/)+4;#<!$%!"#$%!9#%!9$(/)+4=#$%&#+)&+#(6#&+'%#9&'$()#!9#2)(2()$!("+*#$(#!$9#)&*+3 $!>&#6)&?:&"'0#@)+.!:9#2)(2()$!("+*#$(#$%&#9?:+)&#)(($#(6#6)&?:&"'05;#A%&#*&"/$%# –‘ ™‹†–Š ”ƒ–‹‘• ‘ˆ –Š‡ „‡•– ϐ‹– ‡ŽŽ‹’•‡• ƒ”‡ ƒŽ —Žƒ–‡† —•‹‰ ‹ ”‘•‘ˆ– š ‡Ž ƒ† ‰”‘—’‡†‹–‘ͲǤʹ—‹–„‹•Ǥƒ Š•‡ –‘”‘ˆ–Š‡”ƒ†‹ƒŽŠ‹•–‘‰”ƒ‹••—„†‹˜‹†‡†‹–‘ 94+**&)#'(*(:)#'(.&.#1("&9;#A%&#+)&+#(6#&+'%#'(*(:)#'(.&.#1("&#!9#2)(2()$!("+*# $(#$%&#)&*+$!>&#6)&?:&"'0#(6#&*("/+$!("#>+*:&9#-!$%!"#$%!9#9&'$();#A%&#'(*(:)#'(.&# ‹•‹†‹ ƒ–‡†‹–Š‡Ž‡‰‡†‘ˆ ‹‰ǤͷǤ–ƒ–‹•–‹ ƒŽƒƒŽ›•‹•‘ˆ–Š‡Ž‡‰–Š–‘™‹†–Š”ƒ–‹‘ -+9#.("&#,0#$%&#9$:.&"$#$3$&9$#+99:4!"/#:"&?:+*#>+)!+"'&9;#B$+$!9$!'+*#+"+*09!9#(6# $%&#'&**#()!&"$+$!("#.+$+#-+9#2&)6()4&.#:9!"/#<+$9("C9#DE•“—ƒ”‡–‡•–•ˆ‘”•‹‰‹ϐ‹3 ƒ ‡‹ƒ–Žƒ„Ǥ ‡ŽŽ—–Ž‹‡”ƒ†‡ŽŽ‘•‡• ƒ„‡—•‡†–‘ƒƒŽ›œ‡ ‡ŽŽ’‘Žƒ”‹œƒ–‹‘†‡ˆ‡ –• F"#().&)#$(#$&9$#$%&#>+*:&#(6#7&**#G:$*!"&)#+".#7&**#8(9&9#!"#$%&#.&$&)4!3 "+$!("# (6# '&**# 2(*+)!1+$!("# .&6&'$9# -&# +"+*01&.# -!*.$02&# +".# 4:$+"$# &4,)0(9=# -!$%# +# H"(-"# 7I# .&6&'$;# –’”ƒ# &"'(.&9# +# )&'&2$()# *!H&# 2)($&!"3$0)(9!"&# 2%(93 ’Šƒ–ƒ•‡™Š‹ ŠŠƒ•ƒ‡••‡–‹ƒŽ”‘Ž‡‹‘˜‡‡–•†—”‹‰‰ƒ•–”—Žƒ–‹‘ȏʹ͵ȐǤ –’”ƒǦȀǦ—–ƒ–œ‡„”ƒϐ‹•Š‡„”›‘•Šƒ˜‡†‡ˆ‡ –•‹‡†‹‘ǦŽƒ–‡”ƒŽ‡Ž‘‰ƒ–‹‘ƒ† ()!&"$+$!("#(6#4&9&".(.&)4+*#'&**9;#J&$&)(10/(:9#’–’”ƒΪȀǦϐ‹•Š™‡”‡‹ ”‘••‡† +".#$%&#2)&9(4!$!'#4&9(.&)4#(6#$%&#&4,)0(9#-+9#!4+/&.#+$#*+$&#/+9$):*+$!(";# B:,9&?:&"$*0=#$%&#!4+/&9#-&)&#+"+*01&.#:9!"/#7&**#G:$*!"&)#+".#7&**#8(9&9;#<&# ‘•‹•–‡–Ž›ˆ‘—†ƒ•‹‰‹ϐ‹ ƒ–Ž‘••‘ˆ‡†‹‘ǦŽƒ–‡”ƒŽ‡Ž‘‰ƒ–‹‘ƒ†ƒ‘”‡”ƒ3 .(4*0#.!9$)!,:$&.#'&**#()!&"$+$!("#6()#%(4(10/(:9#’–’”ƒǦȀǦ—–ƒ–• ‘’ƒ”‡†–‘ ™‹Ž†–›’‡•‹„Ž‹‰•ȋ ‹‰ǤͷȌǡ ‘•‹•–‡–™‹–Š ‡ŽŽ’‘Žƒ”‹œƒ–‹‘†‡ˆ‡ –•‹–Š‡—–ƒ–•Ǥ A%&#&4,)0(9#-&)&#9&?:&"'&.#6(**(-!"/#!4+/!"/#!"#().&)#$(#.&$&)4!"&#$%&!)#/&"3 ($02&;#F"#$%)&&#!".&2&".&"$#&K2&)!4&"$9#+#'*&+)#.&6&'$#!"#'&**#2(*+)!1+$!("#+".# ()!&"$+$!("# !"# $%&# 4&.!(3*+$&)+*# .!)&'$!("# -+9# +22+)&"$=# +*,&!$# 9(4&# >+)!+$!("# ™ƒ•‡˜‹†‡–ˆ”‘‡š’‡”‹‡––‘‡š’‡”‹‡–ȋ ‹‰ǤͷȌǤ‡–ǡ–Š‡”‡™ƒ•‘•‹‰‹ϐ‹ ƒ– .!66&)&"'&#+4("/#$%&#-!*.$02&#9+42*&9#6)(4#$%)&&#!".&2&".&"$#&K2&)!4&"$9#6(*3 *(-!"/#+"+*09!9#:9!"/#$%&#9$:.&"$#$3$&9$#-!$%#:"&?:+*#>+)!+"'&9#6()#'&**#&*("/+3 $!("# +".# $%&# <+$9("# DL# $&9$# 6()# ()!&"$+$!(";# A%&# '(*(:)# '(.&# (6# $%&# 7&**# 8(9&9# 9%(-&.#$%+$#$%&#*(-#2&)'&"$+/&#(6#-!*.$02&#'&**9#(6#-%!'%#$%&#()!&"$+$!("#.&>!3 +$&9#9$)("/*0#6)(4#$%&#4&.!(3*+$&)+*#.!)&'$!("#.!.#"($#9%(-#+#9$)("/#&*("/+$!("# ȋ ‹‰ǤͷȌǤŠ‹•‹• ƒ—•‡†‹’ƒ”–„›‹–‘–‹  ‡ŽŽ•ǡ™Š‹ Šƒ†‘’–ƒ‘”‡•’Š‡”‹ ƒŽ•Šƒ’‡ +".#.!92*+0#"(#9$)("/#2)&6&)&"$!+*#()!&"$+$!(";#A+H&"#$(/&$%&)=#$%&9&#.+$+#9%(-# $%+$#7&**#G:$*!"&)#+".#7&**#8(9&9#+)&#2(-&)6:*#$((*9#$(#+"+*01&#'&**#2(*+)!1+$!("# .&6&'$9#-!$%#)&92&'$#$(#&*("/+$!("#+".#.!)&'$!(";## 130.

(24) !. 131.

(25) ‹‰—”‡ͷǣ‡ŽŽ‘•‡•ƒ”‡‡ˆˆ‡ –‹˜‡–‘‘Ž•–‘ ‘’ƒ”‡ǡƒƒŽ›œ‡ƒ††‡–‡”‹‡ ‡ŽŽ’‘Žƒ”‹œƒ–‹‘ !"#"$%&'$

(26) ͵‹†‡’‡†‡–‡š’‡”‹‡–•Š‡–‡”‘œ›‰‘—•’–’”ƒΪȀǦϐ‹•Š™‡”‡‹ ”‘••‡†ƒ†–Š‡‹”‘ˆˆ•’”‹‰™ƒ• ‹Œ‡ –‡†™‹–ŠʹͲ’‰ ǦǤŠ‡‡„”›‘•™‡”‡‹ƒ‰‡†ƒ––Š‡ʹǦ͵•‘‹–‡•–ƒ‰‡ƒ†•—„7 -"6&")'#=<$/")0'=4".$3=$-"6&")1()/9$>5"$*"-&#'()/$(2,/"-$+"*"$4*01"--".$3=$!"##$%&'#()"*$,).$ '5"$*"-&#'()/$.,',$+,-$4#0''".$&-()/$!"##$H0-"-9$>5"-"$/*,45-$-50+$'5"$.(-'*(3&'(0)$08$'5"$0*(")7 ','(0)-$08$'5"$1"##-$()$'5"$4*"-02('(1$2"-0."*2$()$*,.(,#$5(-'0/*,2-9$>+0$1(*1#"-$0)$'5"$/*,45-$ ”‡’”‡•‡––Š‡ͷΨȋ‹‡” ‹” Ž‡Ȍƒ†ͳͲΨȋ‘—–‡” ‹” Ž‡Ȍ’‘’—Žƒ–‹‘ˆ”ƒ –‹‘ƒ”‡”•ˆ‘”–Š‡”ƒ†‹ƒŽ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‡ŽŽ†‡•‹–›ǡƒ”‡†™‹–ŠϐŽ—‘”‡• ‡–‡„”ƒ‡ƒ”‡”•ǡ,16&(*".$'5*0&/5$10)7 801,#$(2,/()/9$:'$5,-$3"")$;,#(.,'".$‹˜‹˜‘‹œ‡„”ƒϐ‹•Š‡„”›‘•ˆ‘”–Š‡‡„”ƒ‡ ƒ”‡”•  Ǧǡ ‹ ™Š‹ Š –Š‡ Ǧ–‡”‹ƒŽ Ǧ‘–‹ˆ ‡†‹ƒ–‡• ƒ••‘ ‹ƒ–‹‘ ™‹–Š–Š‡ ‡ŽŽ‡„”ƒ‡ȏʹͳȐǡƒ†‡ ǡ ‘–ƒ‹‹‰–Š‡Ǧ–‡”‹ƒŽ•‡“—‡ ‡ ‘ˆ Ͷ͵ǡ™Š‹ Š‡†‹ƒ–‡•ƒ••‘ ‹ƒ–‹‘™‹–Š–Š‡ ‡ŽŽ‡„”ƒ‡ȏʹͷǡʹ͸ȐǤ

(27) ƒ‰‹‰ ‘ˆœ‡„”ƒϐ‹•Š‡„”›‘•™‹–Š—„‹“—‹–‘—•‡š’”‡••‹‘‘ˆ–Š‡•‡ƒ”‡”•›‹‡Ž†‡†‹ƒ‰7 ‡•‘ˆ ‡ŽŽ•Š‡‡–•™‹–ŠŠ‹‰Š†‡•‹–›ƒ†ƒŠ‹‰ŠϐŽ—‘”‡• ‡ ‡‹–‡•‹–›•‹‰ƒŽƒ––Š‡ 1"##$2"23*,)"<$,).$011,-(0),##=$#0+$()'")-('=$;"-(1&#,*$-'*&1'&*"-$()$'5"$1='0-0#9$ ‘‡‹ƒ‰‡•ǡ—•‡†ˆ‘”ƒƒŽ›•‹•ǡ ‘–ƒ‹‡†ϐŽ— –—ƒ–‹‘‘ˆ•‹‰ƒŽ‹–‡•‹–›™‹–Š‹ƒ 2"23*,)"$-"/2")'$0*$,$/#03,#$()'")-('=$/*,.(")'9$>5"$2"'50.$5,-$-50+)$'0$3"$ *03&-'$()$5,).#()/$/*,.&,#$()'")-('=$15,)/"-$,).$5,-$-50+)$'0$3"$,3#"$'0$1027 4")-,'"$80*$-2,##$,3*&4'$15,)/"-$08$()'")-('=<$4*0.&1()/$;"*=$,11&*,'"$*"-&#'-$80*$ '5"-"$2,*?"*-9$ ‡ƒŽ•‘•Š‘™‡†–Š‡‡–Š‘†–‘„‡‡ˆˆ‡ –‹˜‡‹ϐ‹š‡†Ͷ•‘‹–‡•–ƒ‰‡‘—•‡ "23*=0-$ #,3"#".$ +('5$ @$ ,)'(30.("-$ 80*$ A71,.5"*()<$ ."20)-'*,'()/$ ,$ +(."$ 1027 4,'(3(#('=$,).$,44#(1,3(#('=9$!"##$%&'#()"*$1,)$()$4*()1(4#"$3"$&-".$()$0'5"*$20."#$ 0*/,)(-2-$0*$,)=$‹˜‹˜‘$0*$‹˜‹–”‘$20."#$=("#.()/$(2,/"-$."-1*(3()/$.,',$()$@B$ ,**,=$80*2,'$()$+5(15$'5"$1"##$2"23*,)"-$,*"$#,3"#".9$!"##$%&'#()"*$2,=$3"$,44#(7 ƒ„Ž‡ˆ‘”ƒŽ–‡”ƒ–‹˜‡’—”’‘•‡•ƒ•™‡ŽŽǤ ‘™‡˜‡”ǡ‹–‹•‡••‡–‹ƒŽ–‘ ‘ϐ‹”–Šƒ––Š‡ 03C"1'-$08$()'"*"-'$,*"$08$1024,*,3#"$-(D"$E()$4(F"#-G$'0$'5"$1"##-$('$+,-$."-(/)".$'0$ 20."#$-()1"$'5"$)&2"*(1,#$;,#&"-$&-".$()$'5"$,#/0*('52$+"*"$04'(2(D".$80*$'5(-$ 4&*40-"9$ Š‡†‡ϐ‹‹‰’ƒ”ƒ‡–‡”•ˆ‘”–Š‡†‡–‡”‹ƒ–‹‘‘ˆ ‡ŽŽ’‘Žƒ”‹œƒ–‹‘†‡ˆ‡ –• ƒ”‡“—ƒ–‹ϐ‹ ƒ–‹‘•‘ˆ ‡ŽŽ‡Ž‘‰ƒ–‹‘ƒ†‡†‹‘ǦŽƒ–‡”ƒŽ‘”‹‡–ƒ–‹‘Ǥ‘˜‡–‹‘7 ,##=<$'5"-"$,*"$,),#=D".$,).$*"4*"-")'".$-"4,*,'"#=9$:)$.0()/$-0<$'5"*"$(-$,$40'")7 '(,#$#0--$08$()80*2,'(0)$,30&'$'5"$10**"#,'(0)$3"'+"")$'5"$,80*"2")'(0)".$4,*,27 132.

(28) ‡–‡”•Ǥ›”‡’”‡•‡–‹‰„‘–Š‘ƒ‡ŽŽ‘•‡ǡ–Š‡™‡ŽŽǦ•–—†‹‡† ‘””‡Žƒ–‹‘„‡–™‡‡ !"#$%&'()"*('+"'%,-()$%,+(,#+%*$",)()$%,+%.+)/"+0*"1%!$)$2+!"1%#"*!+3(1+2'"(*+ .%*+ )/"+ 3$'#)40"+ 1(!0'"15+ 6"+ #"!%,1)*()"#+ )/"+ 2%!7$,"#+ 81"+ %.+ 9"''+ :8)'$,"*+ (,#+9"''+;%1"1+.%*+(,('4<$,-+)/"+!8)(,)+0/",%)40"+%.+”’–’ƒ+$,+)/"+0*"1%!$)$2+!"& •‘†‡”‘ˆœ‡„”ƒϐ‹•Š‡„”›‘•ǤŠ‡ ‡ŽŽ”‘•‡• Ž‡ƒ”Ž›•Š‘™‡†–Š‡ ‘ ‘‹–ƒ–Ž‘•• %.+"'%,-()$%,+(,#+!"#$%&'()"*('+%*$",)()$%,+%.+)/"+2"''1+$,+)/"+!8)(,)5+ !""#$%&'$()*&)+*,()%#-.$() =/"+,"2"11$)4+%.+#")"*!$,$,-+(,#+12%*$,-+$,#$>$#8('+2"''+7"/(>$%8*1+(,#+ 0%'(*$)4+(1+0(*)+%.+(+0%08'()$%,+%*+)$118"+$1+,%)+*"1)*$2)"#+)%+)/"+1)8#4+%.+-(1)*8'(& )$%,5+?,+#">"'%0!",)+('%,"+,8!"*%81+"@(!0'"1+2(,+7"+.%8,#+$,+3/$2/+0%'(*$)4+ ƒ†–‹••—‡‹‰”ƒ–‹‘ƒ”‡‡›ˆƒ –‘”•ǡŽ‹‡‹ƒ‰‹‘‰‡‡•‹•ȏʹ͹Ȑƒ†–Š‡‡•–ƒ„Ž‹•Š& ‡–‘ˆ–Š‡Š‹‰ŠŽ›‘”‰ƒ‹œ‡†•–”— –—”‡‘ˆƒ—†‹–‘”›ƒ†˜‡•–‹„—Žƒ”‡’‹–Š‡Ž‹ƒȏʹͺȐǤ ‘ŽŽ‡ –‹˜‡–‹••—‡‹‰”ƒ–‹‘ƒŽ•‘—†‡”Ž‹‡•™‘—†Š‡ƒŽ‹‰Ǣ–Š‡„ƒ•ƒŽ”ƒ†‘‹& #$>$#8('+!%>"!",)1+%.+)/"+",#%)/"'$('+2"''1+(*"+*"%*$",)"#+)%+2%''"2)$>"'4+0%'(*& $<"#+!$-*()$%,+74+!%#8'(*+2%,)*%'A+$,#"0",#",)+.*%!+-*%3)/+.(2)%*1A+80%,+)/"+ ƒ’’‡ƒ”ƒ ‡‘ˆ ‡ŽŽˆ”‡‡•’ƒ ‡ȏʹͻȐǤ‹‹Žƒ” ‡ŽŽ„‡Šƒ˜‹‘”•Šƒ˜‡ƒŽ•‘„‡‡‘„•‡”˜‡† ‹‡–ƒ•–ƒ–‹ ’”‘ ‡••‡•‹‘—•‡ƒƒ”›–‹••—‡ȏ͵ͲȐǤŠ‡ƒ†˜‡–‘ˆ‘”‡•‘& 0/$1)$2()"#+$!(-$,-+)"2/,%'%-4A+$,2'8#$,-+/(*#3(*"+(,#+(+0'")/%*(+%.+/$-/'4+1",& •‹–‹˜‡ƒ†•’‡ ‹ϐ‹ ϐŽ—‘”‡• ‡–’”‘„‡•ǡƒŽŽ‘™•–Š‡˜‹•—ƒŽ‹œƒ–‹‘‘ˆ–Š‡•‡„‹‘Ž‘‰‹& 2('+0*%2"11"1+$,+8,0*"2"#",)"#+#")($'5+B()(+(,('41$1+%.+)/"1"+/8-"+#()(+1")1+.%*+ !%*0/%'%-$2('+."()8*"1+2(,+7"+-*"()'4+.(2$'$)()"#+74+)/"+81"+%.+('-%*$)/!1+'$C"+9"''+ :8)'$,"*5+ ‡ŽŽ—–Ž‹‡”‹•ƒˆ”‡‡Ž›ƒ˜ƒ‹Žƒ„Ž‡

(29) ƒ‰‡ ’Ž—‰Ǧ‹ȋŠ––’ǣȀȀ”•„™‡„Ǥ‹ŠǤ‰‘˜Ȁ ‹ŒȀ’Ž—‰‹•ȀȌǡ™Š‹ Š™‘”•™‹–Š

(30) ƒ‰‡ ˜‡”•‹‘ͳǤͶͷŠ‘”Š‹‰Š‡”ǤŠ‡ƒ’’Ž‹ ƒ–‹‘ ‹•˜‡”›•‹’Ž‡ǣ‹•–ƒŽŽƒ•ƒ

(31) ƒ‰‡ ’Ž—‰‹ǡƒ†–Š‡ƒ’’Ž‹ ƒ–‹‘™‹ŽŽƒ’’‡ƒ”‹–Š‡ • ”‘ŽŽǦ†‘™‡—™‹–Š‹–Š‡

(32) ƒ‰‡ ’”‘‰”ƒǤ’’Ž›–‘ƒͺǦ„‹–‹ƒ‰‡ȋ‘”•–ƒ  ‘ˆ‹ƒ‰‡•Ȍ”‡’”‡•‡–‹‰–Š‡ ‡ŽŽ‡„”ƒ‡•ǣ–Š‡‘—–’—– ‘–ƒ‹•–Š‡‘”‹‰‹ƒŽ‹& (-"A+(,+$!(-"+%.+)/"+-","*()"#+!%#"'A+(+0*%D"2)$%,+%.+)/"+#")"2)"#+%7D"2)1+%,)%+ )/"+%*$-$,('+$!(-"+(,#+(+)(7'"+3$)/+)/"+#()(+%.+)/"+(,('4<"#+2"''15+=/"+!")/%#+ "'$!$,()"1+)/"+,""#+.%*+2%,>",)$%,('A+'(7%*&$,)",1$>"A+!(,8('+(,,%)()$%,+%.+)/"+ !"!7*(,"1+(,#+$1+"@)*"!"'4+.(1)A+%7D"2)$>"A+*"'$(7'"A+(,#+*"0*%#82$7'"5+E$,2"+9"''+ :8)'$,"*+.(2$'$)()"1+)/"+2%''"2)$%,+%.+$,.%*!()$%,+*"-(*#$,-+(+2%!!%,'4+81"#+0/"& ,%)40$2+0(*(!")"*+'$C"+2"''+1/(0"A+$)+2(,+7"+(00'$"#+)%+(+3$#"+*(,-"+%.+0/",%)40"1+ ƒ†‹• ‡”–ƒ‹Ž›‘–Ž‹‹–‡†–‘–Š‡œ‡„”ƒϐ‹•Š‘”‘—•‡‘†‡ŽǤ ‡ŽŽ‘•‡•‹•ƒˆ”‡‡Ž›ƒ˜ƒ‹Žƒ„Ž‡’Ž—‰‹ȋ—’‘”‡“—‡•–Ȍˆ‘”ƒ–Žƒ„ǡ™Š‹ Š ƒ 7"+81"#+)%+0'%)+)/"+%8)08)+%.+9"''+:8)'$,"*5+=/"+#()(+-","*()"#+74+9"''+:8)'$,"*A+ ™Š‹ Š‹•‹ƒ‡š ‡Žˆ‘”ƒ–ǡ ƒ„‡‹’‘”–‡†‹–‘ƒ–Žƒ„ƒ†•—„•‡“—‡–Ž›’”‘& 2"11"#5+=/$1+,%>"'+!")/%#+%.+#()(+*"0*"1",)()$%,+,%)+%,'4+2%!7$,"1+)/"+(#>(,& )(-"1+%.+)/"+2%,>",)$%,('+1"0(*()"+*"0*"1",)()$%,+%.+2"''+"'%,-()$%,+(,#+!"#$%& 133. !.

(33) !"#$%"!&'%($)#"#(')*&(#&"!+'&",,+&",,(#(')"!&()-'%."#(')&%$/"%,()/&#0$(%&1'%%$!"#(')*& 2'#$)#("!!3&%$4$(!()/&4(#"!&()-'%."#(')5&. !"#$%&'()*(+($,-.  Š‡ ƒ—–Š‘”• ™‘—Ž† Ž‹‡ –‘ –Šƒ ‘‹ƒ ‹ƒŽ‡ ƒ ƒ† ƒ “—‡Ž‹‡ ‡•6 10".2+&-'%&7(),!3&2%'4(,()/&#0$&(."/$+&'-&.'8+$&$.9%3'+&+#"()$,&:(#0&#0$&,(-6 ˆ‡”‡–Ǧ ƒ†Š‡”‹ƒ–‹„‘†‹‡•ƒ† ‡”‘‡ƒ‡”•ƒ† ‡”‘‡—••ƒˆ‘”’Žƒ•6 .(,+& $)1',()/& -8'%$+1$)#& .$.9%")$& ."%7$%+5& ;0(+& :'%7& :"+& +822'%#$,& 93& "& ƒ”‹‡ —”‹‡ ‡•‡ƒ” Š ”ƒ‹‹‰ ‡–™‘” ȋ Ȁ ǦǦʹͲͲ͸ǦͲ͵ͷͺ͵ͲȌǤ ;0$&-8),$%+&0",&)'&%'!$&()&+#8,3&,$+(/)*&,"#"&1'!!$1#(')&"),&")"!3+(+*&,$1(+(')&#'& 289!(+0*&'%&2%$2"%"#(')&'-&#0$&.")8+1%(2#5. 134.

(34) ‡ˆ‡”‡ ‡• ͳǤ‘•œ‘

(35) ǡƒ™ƒ†ƒǡ‘Ž‹ ƒǦ”‡œ‡ŽȋʹͲͲͻȌ‡‰—Žƒ–‹‘‘ˆ ‘˜‡”‰‡ ‡ !"#$%&'%"()*"$+*,%+%"'($#-.)"/$,%.'%0.!'%$/!('.-1!')*"$02$'3%$ –Ȁ’ƒ–Š™ƒ›Ǥ‡‹‡ŽŽ‡˜‹‘ŽʹͲǣͻͺ͸Ǧͻͻ͹Ǥ ʹǤ›‡”•ǡ‡’‹ Šǡ‘Ž‹ ƒǦ”‡œ‡ŽȋʹͲͲʹȌ’ƒ –‹˜‹–›‰”ƒ†‹‡– ”‡‰—Žƒ–‡• ‘˜‡”‰‡–‡š–‡•‹‘†—”‹‰œ‡„”ƒϐ‹•Š‰ƒ•–”—Žƒ–‹‘Ǥ‡˜ ‹‘ŽʹͶ͵ǣͺͳǦͻͺǤ ͵Ǥ›‡”•ǡ‡’‹ Šǡ‘Ž‹ ƒǦ”‡œ‡ŽȋʹͲͲʹȌ‘˜‡”‰‡ ‡ƒ†‡š–‡4 •‹‘‹˜‡”–‡„”ƒ–‡‰ƒ•–”—Žƒ‡ǣ ‡ŽŽ‘˜‡‡–•ƒ ‘”†‹‰–‘‘”‹ •‡ƒ” Š‘ˆ‹†‡–‹–›ǫ”‡†• ‡‡–ͳͺǣͶͶ͹ǦͶͷͷǤ ͶǤ‘’ œ‡™•‹ ǡ‡’‹ Šǡ›‡”•ǡƒŽ‡”ǡ‘”‡•ǡ‡–ƒŽǤȋʹͲͲͳȌŠ‡ œ‡„”ƒϐ‹•Š‰Ž›’‹ ƒ›’‡ ‘–”‘Ž• ‡ŽŽ’‘Žƒ”‹–›†—”‹‰‰ƒ•–”—Žƒ–‹‘ ‘˜‡‡–•‘ˆ ‘˜‡”‰‡–‡š–‡•‹‘Ǥ‡˜‡ŽŽͳǣʹͷͳǦʹ͸ͶǤ ͷǤ ‡••‡ ǡ‘’ œ‡™•‹ ǡ‹‰Šƒǡ‡’‹ Šǡƒ”Ž‘™ ǡ‡–ƒŽǤȋʹͲͲʹȌ‡4 „”ƒϐ‹•Š–”‹Ž‘„‹–‡‹†‡–‹ϐ‹‡•‡™”‘Ž‡•ˆ‘”–”ƒ„‹•—•‹‰ƒ•–”—Žƒ–‹‘ ƒ†‡—”‘ƒŽ‘˜‡‡–•Ǥƒ–‡ŽŽ‹‘ŽͶǣ͸ͳͲǦ͸ͳͷǤ ͸Ǥ‘ Šƒǡ†ƒ• ȋͳͻͻͺȌ”‹‡–‡† ‡ŽŽ†‹˜‹•‹‘•ƒ† ‡ŽŽ—Žƒ”‘”4 ’Š‘‰‡‡•‹•‹–Š‡œ‡„”ƒϐ‹•Š‰ƒ•–”—Žƒƒ†‡—”—Žƒǣƒ–‹‡ǦŽƒ’•‡ ƒƒŽ›•‹•Ǥ‡˜‡Ž‘’‡–ͳʹͷǣͻͺ͵ǦͻͻͶǤ ͹Ǥ‹ ǡ‡’‹ ŠǡŠ‡ǡ‘’ œ‡™•‹ ǡ‹ǡ‡–ƒŽǤȋʹͲͲͷȌ••‡–‹ƒŽ”‘Ž‡• ‘ˆ ȓƒŽ’ŠƒȔͳʹȀͳ͵•‹‰ƒŽ‹‰‹†‹•–‹ – ‡ŽŽ„‡Šƒ˜‹‘”•†”‹˜‹‰œ‡4 „”ƒϐ‹•Š ‘˜‡”‰‡ ‡ƒ†‡š–‡•‹‘‰ƒ•–”—Žƒ–‹‘‘˜‡‡–•Ǥ ‡ŽŽ ‹‘Žͳ͸ͻǣ͹͹͹Ǧ͹ͺ͹Ǥ ͺǤ‡ŽŽ‡” ǡ Š‹†–ǡ‹––„”‘†– ǡ–‡Žœ‡” ȋʹͲͲͺȌ‡ ‘•–”— –‹‘ ‘ˆœ‡„”ƒϐ‹•Š‡ƒ”Ž›‡„”›‘‹ †‡˜‡Ž‘’‡–„›• ƒ‡†Ž‹‰Š–•Š‡‡– ‹ ”‘• ‘’›Ǥ ‹‡ ‡͵ʹʹǣͳͲ͸ͷǦͳͲ͸ͻǤ ͻǤ‡‰ƒ•‘ ȋʹͲͲͻȌ

(36) –‘–‘‹ƒ‰‹‰‘ˆ‡„”›‘‰‡‡•‹•™‹–Š ‘ˆ‘ ƒŽ –‹‡ǦŽƒ’•‡‹ ”‘• ‘’›Ǥ‡–Š‘†•‘Ž‹‘ŽͷͶ͸ǣ͵ͳ͹Ǧ͵͵ʹǤ ͳͲǤ‘•ƒŽ‹‰ƒ–‹ǡ ƒ‘‘• ǡ ‡Žƒ•ǡ‘ Š‡ǡ„Š‘Žœ‡”ǡ‡–ƒŽǤȋʹͲͳͲȌ ‹•‘–”‘’‹ Žƒ–‡‹ˆˆ—•‹‘ ‹Ž–‡”‹‰ˆ‘”‡–‡ –‹‘‘ˆ‡ŽŽ‡4 „”ƒ‡•‹͵†‹ ”‘• ‘’›

(37) ƒ‰‡•Ǥ”‘ 

(38) 

(39) –›’‹‘‡†

(40) ƒ‰4 ‹‰ǣͷͺͺǦͷͻͳǤ ͳͳǤ‡‰ƒ•‘ ǡ ”ƒ•‡”ȋʹͲͲ͹Ȍ

(41) ƒ‰‹‰‹•›•–‡•„‹‘Ž‘‰›Ǥ‡ŽŽͳ͵Ͳǣ ͹ͺͶǦ͹ͻͷǤ 135. !.

(42) ͳʹǤ —””—•ǡƒ‹˜ƒǡƒ–ƒƒ„‡ǡ†‡”•‘ ǡ ‘‡•ǡ‡–ƒŽǤȋʹͲͳͲȌ‡–‡ ! "#$%&$'&%()*$%&+(+,*-%(.&#%&(/(0"*$%&+#0*$.0$12&#+-3(.&).#%3&-&.(*#-/& ‡—”ƒŽ‡–™‘”ƒ” Š‹–‡ –—”‡Ǥ‡†

(43) ƒ‰‡ƒŽͳͶǣ͹͹ͲǦ͹ͺ͵Ǥ ͳ͵ǤǤǤ—‡‰‘Ǧ”‘œǡǤƒ•–” ϐ‹ǡǤƒ˜›Ǥ ƒ—”‡ǡǤ‘„ƒ”†‘ǡǡǤ‘—”‰‹‡ ƒȋʹͲͲͺȌƒ˜‘”‘‘‹†‹ƒ‰”ƒ‘†‡Ž ‡ŽŽ‰‡‘‡–”‹‡•‹‡ƒ”Ž›•‡ƒ —” Š‹‡„”›‘‰‡‡•‹•ǫ

(44) 

(45) ǣͷͲͶǦͷͲ͹Ǥ ͳͶǤ‡•–‡”ϐ‹‡Ž†ȋͳͻͻͷȌŠ‡œ‡„”ƒϐ‹•Š„‘‘ǣ‹˜‡”•‹–›‘ˆ”‡‰‘’”‡••ǡ—‰‡‡ǡ 4*(3$%5 ͳͷǤƒ™•‘ȋͳͻͻͻȌ ƒ–‡ƒ’’‹‰–Š‡‘—•‡‡„”›‘Ǥ

(46) – ‡˜‹‘ŽͶ͵ǣ͹͹͵Ǧ ͹͹ͷǤ ͳ͸Ǥƒ™Ž‡› ȋʹͲͲ͸Ȍ ƒ†„‘‘‘ˆ„‹‘Ž‘‰‹ ƒŽ ‘ˆ‘ ƒŽ‹ ”‘• ‘’›Ǥ ͳ͹Ǥƒ˜‹‡•ȋͳͻͻͲȌƒ Š‹‡˜‹•‹‘ǣ–Š‡‘”›ǡƒŽ‰‘”‹–Š•ƒ†’”ƒ –‹ ƒŽ‹–‹‡•ǣ ƒ! 6(+#0&1*(..5 ͳͺǤ‡”•‡ Ǥ›ƒ‹ Š”‡•Š‘Ž†‹‰‘ˆ ”‡›Ǧ‡˜‡Ž

(47) ƒ‰‡•Ǣͳͻͺ͸Ǥ ͳͻǤ‹„Žƒ ȋͳͻͺ͸Ȍ‹–”‘†— –‹‘–‘‹‰‹–ƒŽ

(48) ƒ‰‡”‘ ‡••‹‰ǣ”‡–‹ ‡Ǧ ƒŽŽǤ ʹͲǤƒ—˜‘Žƒ ǡ‹‡–ƒ•‹‡ȋʹͲͲͲȌ†ƒ’–‹˜‡‘ —‡–

(49) ƒ‰‡‹ƒ”‹œƒ–‹‘Ǥƒ–! –‡”‡ ‘‰‹–‹‘͵͵ǣʹʹͷǦʹ͵͸Ǥ ʹͳǤŠ‘›ǡŠ‹—ǡ‹ŽŽ‡––‹ ǡ ‡‘–‹•–‘˜ǡ‘”‹‘–‘ǡ‡–ƒŽǤȋͳͻͻͻȌ†‘‡! „”ƒ‡–”ƒˆϐ‹ ‹‰‘ˆ”ƒ•ǣ–Š‡‘–‹ˆ–ƒ”‰‡–•’”‘–‡‹•–‘–Š‡ƒ†. ‘Ž‰‹Ǥ‡ŽŽͻͺǣ͸ͻǦͺͲǤ ʹʹǤ—”‡Šƒ‡” ȋͳͻͻͳȌ‘”‘‘‹‹ƒ‰”ƒ•Ǧ—”˜‡›‘ˆƒ —†ƒ‡–ƒŽ ‡‘! ‡–”‹ ƒ–ƒ–”— –—”‡Ǥ‘’—–‹‰—”˜‡›•ʹ͵ǣ͵ͶͷǦͶͲͷǤ ʹ͵Ǥ˜ƒ‡‡Ž‡ǡ—–—™‡‡ǡ˜‡”˜‘‘”†‡ ǡ†‡ ‡”–‘‰ ȋʹͲͳͲȌƒŽ’Šƒ ƒ†‡’•‹Ž‘•‹‰ƒŽ‹‰˜‹ƒ ›Ȁ‡•ƒ†Š‘‹•‡••‡–‹ƒŽˆ‘”œ‡„”ƒϐ‹•Š ‘˜‡”‰‡ ‡ƒ†‡š–‡•‹‘ ‡ŽŽ‘˜‡‡–•†—”‹‰‰ƒ•–”—Žƒ–‹‘Ǥ‡˜‹‘Ž ͵ͶͲǣ͸ʹ͸Ǧ͸͵ͻǤ ʹͶǤŽƒ†‡ ȋͳͻ͸ͺȌ‡–‡‘”‘Ž‘‰›ƒ†ƒ–‘‹ ‡‡”‰›ǣ–‘‹ ‡”‰›‘! ‹••‹‘ǤʹͺǦ͵Ͳ’Ǥ ʹͷǤ ”‡ƒ˜‡• ǡ”‡• ‘–– ǡ —ƒ–ƒǡ —ƒ–ƒǡƒŽƒ—ǡ‡–ƒŽǤȋʹͲͲͻȌŠ‡Š›! †”‘’Š‘„‹  ›•–‡‹‡Ǧ”‹ Š†‘ƒ‹‘ˆʹͷ ‘—’Ž‡•™‹–Š†‘™•–”‡ƒ *(.#6)(.&"$&+(6#-"(&+(+,*-%(&#%"(*-0"#$%.&-%6&*(0$3%#"#$%&,2&7889& ’ƒŽ‹–‘›Ž–”ƒ•ˆ‡”ƒ•‡•Ǥ‘Ž‹‘Ž‡ŽŽʹͲǣͳͺͶͷǦͳͺͷͶǤ 136.

(50) ʹ͸Ǥ ”‡ƒ˜‡• ǡƒŽƒ—ǡ —ƒ–ƒǡ —ƒ–ƒǡŠƒ„‡”Žƒ‹ ȋʹͲͲͺȌƒŽ‹–‘›! "#$%&'(#')(*+*,-#'+(%'$+-#.$%&'/(&0($1+('+2-&3-&$+.$%4+(.1#3+-&'+( ›•–‡‹‡Ǧ•–”‹‰’”‘–‡‹Ǥ ‹‘ŽŠ‡ʹͺ͵ǣʹͷͲͳͶǦʹͷͲʹ͸Ǥ ʹ͹Ǥ‹”‘‡ǡ‹ǡ ”‹‡•„ƒ Š ǡŠƒ‰ǡŽ—•ƒ”•‹ǡ‡–ƒŽǤȋʹͲͲͺȌ”‘Ž‡ˆ‘” ’Žƒƒ” ‡ŽŽ’‘Žƒ”‹–›•‹‰ƒŽ‹‰‹ƒ‰‹‘‰‡‡•‹•Ǥ‰‹‘‰‡‡•‹•ͳͳǣ͵Ͷ͹Ǧ͵͸ͲǤ ʹͺǤ‡ŽŽ›ǡŠ‡ȋʹͲͲ͹ȌŠƒ’‹‰–Š‡ƒƒŽ‹ƒƒ—†‹–‘”›•‡•‘”›‘”‰ƒ„› –Š‡’Žƒƒ” ‡ŽŽ’‘Žƒ”‹–›’ƒ–Š™ƒ›Ǥ

(51) – ‡˜‹‘Žͷͳǣͷ͵ͷǦͷͶ͹Ǥ ʹͻǤ‹–‘”‹‘ǡ‡›‡”ȋʹͲͲͺȌ‘†—Žƒ” ‘–”‘Ž‘ˆ‡†‘–Š‡Ž‹ƒŽ•Š‡‡–‹‰”ƒ–‹‘Ǥ. ‡‡•‡˜ʹʹǣ͵ʹ͸ͺǦ͵ʹͺͳǤ ͵ͲǤ› ‘ˆˆ ǡƒ‰ǡ‹ǡ‹ ǡ ‘•™ƒ‹ǡ‡–ƒŽǤȋʹͲͲ͹Ȍ‹”‡ –˜‹•—ƒŽ‹œƒ–‹‘ &0(*#.-&31#5+!#//%/$+)($2*&-(.+""(%'$-#4#/#$%&'(%'(*#**#-6($2*&-/7( ƒ ‡”‡•͸͹ǣʹ͸ͶͻǦʹ͸ͷ͸Ǥ. 137. !.

(52) 138.

(53)

Referenties

Download het nu ( PDF - 21 pagina - 1.33 MB )

GERELATEERDE DOCUMENTEN

(3) !&quot;#$%&amp amp;/(%&amp amp;#234-'5&amp

Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis Date: 2012-09-12...

Cover Page The handle

Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis

Cover Page The handle http://hdl.handle.net/1887/36549 holds various files of this Leiden University dissertation Author: Noorda, Ruchama Title: ℞eForm Issue Date: 2015-12-09

36 Chapter 1 ŔeForm SUBCONSCIOUS (Muddled Thinking) Internal Colonization Unrealistic Dreamer American Walden (Sub-)Consciousness Enclosed Garden. Asocialen –

Cover Page The handle http://hdl.handle.net/1887/36549 holds various files of this Leiden University dissertation Author: Noorda, Ruchama Title: ℞eForm Issue Date: 2015-12-09

To give one example, I approached this by compressing dirt, plant fragments and building debris, collect- ed on the ruins of an early 20th century socialist commune in the

Cover Page The handle http://hdl.handle.net/1887/36549 holds various files of this Leiden University dissertation Author: Noorda, Ruchama Title: ℞eForm Issue Date: 2015-12-09

Asocialen-Private Prophesy-Detox, performance and installation, Ruchama Noorda, Diepenheim, 2012..

Cover Page The handle

Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.

Cover Page The handle

Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.

Cover Page The handle

Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.