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(1)Cover Page. The handle http://hdl.handle.net/1887/19776 holds various files of this Leiden University dissertation. Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis Date: 2012-09-12.

(2) Addendum. 169.

(3) 170.

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(19)  ‘–”ƒ”›–‘–Š‡™‹Ž†–›’‡ ˆ‘”ǡ–Š‡—–ƒ–‹‘ ƒ—•‡•‰ƒ•–”—Žƒ–‹‘†‡ˆ‡ –•™Š‡‡š’”‡••‡†˜‹ƒ‹Œ‡ –‹‘‹œ‡„”ƒϐ‹•ŠǤ  ‘ŽŽ‡ –‹˜‡’‘Žƒ”‹œƒ–‹‘‘ˆ–Š‡ ‡ŽŽ•‹–Š‡‡†‹‘Žƒ–‡”ƒŽ†‹”‡ –‹‘‹•‡••‡5 –‹ƒŽ ˆ‘” –Š‡ ‘˜‡”‰‡ ‡ –‘™ƒ”†•–Š‡ ‹†Ž‹‡Ǥ Š‡’‘Žƒ”‹œ‡† ‡ŽŽ• ‹–‡” ƒŽƒ–‡ ƒ– –Š‡‹†Ž‹‡ǤŠ‹•‹–‡” ƒŽƒ–‹‘’”‘ ‡••ǡ™Š‹ ŠƒŽ•‘”‡“—‹”‡•’‘Žƒ”‹œƒ–‹‘ǡ”‡•—Ž–• ‹–Š‡‡š–‡•‹‘‘ˆ–Š‡ƒ–‡”‹‘Ǧ’‘•–‡”‹‘”„‘†›ƒš‹•ǤŠ‡ ‘‘”†‹ƒ–‹‘ƒ†”‡‰—Žƒ5 –‹‘‘ˆ–Š‡ ‡ŽŽ‘˜‡‡–•ƒ”‡‰‘˜‡”‡†„›‹–”‹ ƒ–‡•‹‰ƒŽ‹‰‡ Šƒ‹••Ǥ ›”‘•‹‡ ’Š‘•’Š‘”›Žƒ–‹‘ ‹• ‘‡ ‘ˆ •— Š ‡ Šƒ‹••Ǥ › ‡‹–Š‡” ’Š‘•’Š‘”›Žƒ5 –‹‘„›’”‘–‡‹Ǧ–›”‘•‹‡‹ƒ•‡•‘”†‡’Š‘•’Š‘”›Žƒ–‹‘„›’”‘–‡‹Ǧ–›”‘•‹‡’Š‘•5 ’Šƒ–ƒ•‡•ȋ•Ȍ‘ˆ–›”‘•‹‡”‡•‹†—‡•ǡƒŽƒ”‰‡—„‡”‘ˆ•‹‰ƒŽ‹‰’”‘–‡‹• ƒ„‡ •™‹– Š‡†ˆ”‘ƒ –‹˜‡–‘‹ƒ –‹˜‡•–ƒ–‡•ǤŠ‘•’Š‘”›Žƒ–‹‘‹•Š‹‰ŠŽ›†›ƒ‹ ƒ† ”‡‰—Žƒ–‡•ƒ› ‡ŽŽ—Žƒ”’”‘ ‡••‡•Ž‹‡ ‡ŽŽ‹‰”ƒ–‹‘ǡ’”‘Ž‹ˆ‡”ƒ–‹‘ƒ††‹ˆˆ‡”‡5 –‹ƒ–‹‘ǤŠ‡•—’‡”ˆƒ‹Ž›‹••—„†‹˜‹†‡†‹Ǯ Žƒ••‹ ƒŽǯȋ’Š‘•’Š‘Ǧ–›”‘•‹‡Ǧ•’‡5 ‹ϐ‹ Ȍ ’Š‘•’Šƒ–ƒ•‡• ƒ† †—ƒŽ •’‡ ‹ϐ‹ ‹–› ’Š‘•’Šƒ–ƒ•‡• ȋ™Š‹ Š †‡’Š‘•’Š‘Ž›”ƒ–‡ ’Š‘•’Š‘Ǧ–›”‘•‹‡ǡ ’Š‘•’Š‘Ǧ•‡”‹‡ ƒ† ’Š‘•’Š‘Ǧ–Š”‡‘‹‡ȌǤ 

(20)  –Š‹• –Š‡•‹•ǡ ™‡ ˆ‘ —•‘–Š‡”‘Ž‡‘ˆǮ Žƒ••‹ ƒŽǯ•‹œ‡„”ƒϐ‹•Š‰ƒ•–”—Žƒ–‹‘Ǥ

(21) "#$%&'()+6)7,)‹†‡–‹ϐ‹‡†Ǧƒ†–’ʹͲƒ••–”— –—”ƒŽ’ƒ”ƒŽ‘‰—‡• ƒ† †‡–‡”‹‡† „‘–Š –‘ „‡ ”‹–‹ ƒŽ –‘  ‡ŽŽ ‘˜‡‡–• ƒ• ‘’‘‡–• ‘ˆ ƒ •›•–‡ ”‡‰—Žƒ–‹‰ ‡ŽŽ ’‘Žƒ”‹–› ‹ ‘ ‡”– ™‹–Š _ ƒ† ¡ ™Š‹ Š ƒ”‡ ƒŽ•‘†‡• ”‹„‡†‹"#$%&'(),ȌǤ‡•Š‘™–Šƒ––Š‡•‡Ͷ•”‡‰—Žƒ–‡–Š‡ƒ –‹˜ƒ–‹‘ •–ƒ–‡‘ˆŠ‘Ǥ –‹˜ƒ–‹‘‘ˆŠ‘‹•”‡“—‹”‡†ˆ‘”–Š‡’‘Žƒ”‹œƒ–‹‘‘ˆ ‡ŽŽ•ƒ†ƒ•ƒ 173. !.

(22) ‘•‡“—‡ ‡ ”— ‹ƒŽˆ‘” ‡ŽŽ‘˜‡‡–•Ǥ

(23) !"#$%&'()ǡ™‡’‡”ˆ‘”‡†ƒ• ”‡‡‘ˆ–Š‡ˆƒ‹Ž›‘ˆǮ Žƒ••‹ ƒŽǯ•–‘ ‹†‡–‹ˆ›‰‡‡•™‹–Šƒ”‘Ž‡‹‰ƒ•–”—Žƒ–‹‘ ‡ŽŽ‘˜‡‡–•‹œ‡„”ƒϐ‹•ŠǤ‡†‡•‹‰‡† ʹ‹†‡’‡†‡–•’Ž‹ ‡•‹–‡‘”’Š‘Ž‹‘•ˆ‘”‡ƒ Š‘ˆ–Š‡Ͷͺ‰‡‡•ǡ‡ ‘†‹‰•Ǥ

(24) –Š‡ϐ‹”•–”‘—†ƒŽŽ‡„”›‘•™‡”‡ƒƒŽ›œ‡†‘”’Š‘Ž‘‰‹ ƒŽŽ›Ǥ‘•‹–‹˜‡Š‹–•™‡”‡ ƒƒŽ›œ‡†‹†‡–ƒ‹Žˆ‘”†‡ˆ‡ –•‹–Š‡•‡ ‘†”‘—†„›!"#$!%&Š›„”‹†‹œƒ–‹‘—•‹‰ ™‡ŽŽǦ‡•–ƒ„Ž‹•Š‡†ƒ”‡”•ˆ‘” ‡ŽŽ‘˜‡‡–•ǤŠ‡–‘‘Ž•†‡• ”‹„‡†‹!"#$%&'( *™‡”‡—•‡†–‘ƒ••‡••†‡ˆ‡ –•‹ ‡ŽŽ’‘Žƒ”‹œƒ–‹‘‘ˆ–Š‡’”‡•‘‹–‹ ‡•‘†‡”Ǥ ƒ•‡†‘–Š‡ ‘’ƒ”ƒ–‹˜‡ƒƒŽ›•‹•‘ˆ–Š‡”‡•—Ž–•™‹–Šˆ‘—”’‘•‹–‹˜‡ ‘–”‘Ž•ǡ‘‡ ƒ††‹–‹‘ƒŽ ǡ '%'()*ǡ ™ƒ• ‹†‡–‹ϐ‹‡† ƒ• ‡••‡–‹ƒŽ ˆ‘” ‘”ƒŽ ‰ƒ•–”—Žƒ–‹‘ ‡ŽŽ !"#$!$%&'( —ƒ–‹–ƒ–‹˜‡ƒƒŽ›•‹•ƒ† Ž‡ƒ””‡’”‡•‡–ƒ–‹‘‘ˆ–Š‡†ƒ–ƒ‹•‡••‡–‹ƒŽ–‘ ‘†‡”†ƒ›„‹‘Ž‘‰›Ǥ–—†›‹‰ ‘ŽŽ‡ –‹˜‡ ‡ŽŽ‹‰”ƒ–‹‘•”‡“—‹”‡•–Š‡ƒƒŽ›•‹•‘ˆ –Š‡‡–‡ˆˆ‡ –‘ˆ ‡ŽŽ’‘Žƒ”‹œƒ–‹‘ƒ†Ȁ‘”†‹•’Žƒ ‡‡–•‘ˆƒŽƒ”‰‡—„‡”‘ˆ ‡ŽŽ• ™‹–Š‹ƒ–‹••—‡”ƒ–Š‡”–Šƒ‡ƒ•—”‡‡–•‘ˆƒˆ‡™‹†‹˜‹†—ƒŽ•Ǥ

(25) !"#$%&'(+)*+%* ƒ—–‘ƒ–‡† ‡ŽŽ–”ƒ ‹‰ƒŽ‰‘”‹–Š™ƒ•†‡˜‡Ž‘’‡†–‘†‡–‡”‹‡–Š‡‹‰”ƒ–‹‘•’‡‡†• ‘ˆ‹†‹˜‹†—ƒŽ ‡ŽŽ•ƒ†™ƒ•—•‡†–‘†‡‘•–”ƒ–‡ƒ•‹‰‹ϐ‹ ƒ–†‹ˆˆ‡”‡ ‡„‡–™‡‡ –Š‡ƒ˜‡”ƒ‰‡ ‘˜‡”‰‡ ‡ƒ†‡š–‡•‹‘”ƒ–‡‘ˆ–Š‡‰ƒ•–”—Žƒ–‹‘ ‡ŽŽ‘˜‡‡–•‘ˆ '%'(*ǦȀǦŠ‘‘œ›‰‘—•—–ƒ–‡„”›‘•ƒ†™–•‹„Ž‹‰•Ǥ

(26) !"#$%&'(*™‡†‡• ”‹„‡ –Š‡†‡˜‡Ž‘’‡–‘ˆƒƒ—–‘ƒ–‡†ƒŽ‰‘”‹–Š‡ŽŽ—–Ž‹‡”ˆ‘”–Š‡†‡–‡ –‹‘‘ˆ ‡ŽŽ ‡„”ƒ‡•ǡ–‘ˆƒ ‹Ž‹–ƒ–‡†ƒ–ƒ ‘ŽŽ‡ –‹‘ˆ‘”’‘Žƒ”‹œƒ–‹‘ƒƒŽ›•‹•Ǥ††‹–‹‘ƒŽŽ›ǡƒ ‘˜‡Ž ‡–Š‘† ‘ˆ ‰”ƒ’Š‹ ƒŽ †ƒ–ƒ ”‡’”‡•‡–ƒ–‹‘ ‹• ‹–”‘†— ‡† ƒŽŽ‡† ‡ŽŽ ‘•‡•ǡ ™Š‹ Š ƒ††• –Š‡ ƒ†˜ƒ–ƒ‰‡ ‘ˆ •Š‘™‹‰ –Š‡ ‘””‡Žƒ–‹‘ „‡–™‡‡ „‘–Š †‡ϐ‹‹‰ “—ƒ–‹–ƒ–‹˜‡ ’ƒ”ƒ‡–‡”• ‘ˆ ‡ŽŽ ’‘Žƒ”‹œƒ–‹‘ǡ ‡ŽŽ ‡Ž‘‰ƒ–‹‘ ƒ† ‡†‹‘ǦŽƒ–‡”ƒŽ ‘”‹‡–ƒ–‹‘ǡ„›’Ž‘––‹‰–Š‡‘‘‡ ‘’”‡Š‡•‹˜‡‰”ƒ’Š”ƒ–Š‡”–Šƒ•‡’ƒ”ƒ–‡ ‘‡•Ǥ • ƒ ’”‘‘ˆǦ‘ˆǦ’”‹ ‹’Ž‡ –Š‹• ‡–Š‘† ™ƒ• —•‡† –‘ ƒƒŽ›œ‡ –Š‡ ’”‡•‘‹–‹  ‡•‘†‡” ‘ˆ '%'(*ǦȀǦ —–ƒ– œ‡„”ƒϐ‹•Šǡ ƒ ™‡ŽŽǦ†‡• ”‹„‡†  ’Š‡‘–›’‡Ǥ Š‡ ‡ŽŽ‘•‡• Ž‡ƒ”Ž›•Š‘™‡†–Š‡ ‘ ‘‹–ƒ–Ž‘••‘ˆ‡Ž‘‰ƒ–‹‘ƒ†‡†‹‘Žƒ–‡”ƒŽ ‘”‹‡–ƒ–‹‘‘ˆ–Š‡ ‡ŽŽ•‹–Š‡—–ƒ––‹••—‡•‹ ‘’ƒ”‹•‘–‘™‹Ž†–›’‡•‹„Ž‹‰•Ǥ. 174.

(27) !"#$%&'%()*+",-$"&.# !!!!"#$#%&'(%)%*+)#$#,'-.&/*)0.1*%&.*1)2.%)34*56,-)%*+)"(/!).-)7--,*8.%&) ˆ‘”‡„”ƒϐ‹•Š‘˜‡”‰‡ ‡ƒ†š–‡•‹‘‡ŽŽ‘˜‡‡–•†—”‹‰ ƒ•–”—Ǧ ))))&%8./*9 !!!!"#$!%&'&(&$!)*+!,-$.-/&$&!0*+!1"&2"3324&!5+!4&$!6&2.37!58 !!!!9&"!:;3(8!<=>=!?@2!>ABCD=E<FGH<HICJ8!%@-K!<=>=!L&K!<D8 !!!!!!!!!!!!! !!!!‘‘ƒ›†”‘‡ ƒ‹Ǧ‘ˆǦ — –‹‘—–ƒ–‹‘•‹ƒ—•‡‡„”ƒϐ‹•Š  ƒ•–”—Žƒ–‹‘‡ˆ‡ –•Ǥ !!!!0;$M&$.!,-$.-/&$&*+!)#2'!"#$!%&'&(&$*+!53N$!1"&2"3324&+!63(7&2!,&NO#$$+!! !!!!6&(7&2!P8!Q$.&O#+!R;((S!)8!T;((&U&$+!?2;&!"#$!6#&2;$7&$+!V$&'&!"#$!4&2!:-27.+!!! !!!!:3-4&/;W$!:-27&2;$7!#$4!5&23&$!4&$!6&2.37 !!!!9;U8!)34&(8!)&MN8!4OO8==X>><B!Y-K(;UN&4!3$(;$&!#N&#4!3Z!@2;$.!5#$-#2S!<D+! !!!!<=>>+!!! !!!!43;G>=8><D<[4OO8==X>>< !!!!••‡–‹ƒŽ”‘Ž‡ˆ‘”–Š‡†Ǧ•„ͳͳ —Žͷ‘š‘ƒ‹ˆ‘””‘’‡”‘– Š•‹‰ƒŽǦ ‹‰ƒ†‡—”ƒŽ‡ŽŽ ƒ–‡‡ ‹•‹‘•‹‹˜‘!!!!! !!!!)#2;#!?8!\#2.32;!4#!\;("#+!5;$I);$7!]&&+!5-4;.N!Y#2;4#&$+!?$'&!:23-/&2U+! !!!!\#$4&2!68!9;'U+!0;$M&$.!,-$.-/&$&+!9#$;M#!^;"'3";M+!9#$;&(&! !!!!P-#24#"#MM#23+!)#;'&(!Y8!Y&@@&(&$K3UMN !!!!Y_3\!1$&8!<=>=!T3"!>JBAE>>FG&>D=<C8 !!!!ƒ‹”Ǧ‹•‡‡‰—Žƒ–‹‘‘ˆ‘˜‡”‰‡ ‡ƒ†š–‡•‹‘‡ŽŽ‘˜‡‡–•„›  ‘—”Š‘•’Šƒ–ƒ•‡•˜‹ƒŠ‘ !!!!)#2'!"#$!%&'&(&$+!0;$M&$.!,-$.-/&$&+!R3-.&2!)#UU&(;$'!#$4!5&23&$!4&$!!!! !!!!6&2.37! !!!!PLoS One. 2012; 7(4): e35913 !!!!*`&a-#(!M3$.2;K-.;3$. 175. !.

(28) !"##$%"&"'()$*+, !"#$%#&'("))*'+,#&,-%#%'-./'012#'1#'&3%'45&3'(,6"'7894'"#':%,;%#<'=%'$1)> ?6%&%@'3"/'/%$1#@.2*'%@,$.&"1#'"#'4AAA'"#':.&"#'.#@'B$"%#$%/<'C#'&3.&'/.)%'*%.2' 3%' /&.2&%@' 3"/' D"1>%#E"#%%2"#E' /&,@"%/' "#' :%,;%#<' !"#$%#&' @"@' .#' "#&%2#/3"?' "#' &3%' F%#&2%' 1G' H"$210".6' .#@' I6.#&' J%#%&"$/' ,#@%2' I21G<' K2<' (.#' H"$3"%6/L' -3%2%' 3%'-12M%@'1#'&3%'"#&%2.$&"1#'0%&-%%#'/*)0"1#&/!"#$%&'$()!*+,$'FNIOP574'.#@' -#./*&,(/!0(,1.2$/3'=%'E2.@,.&%@'"#'4AAQ'-"&3'@"/&"#$&"1#'G21)'&3%'F.&316"$'R#"> ;%2/"&*'1G':%,;%#'./'.'D"1>%#E"#%%2'"#'$%66'.#@'E%#%'0"1&%$3#161E*'SHB$T<'C#'4AAUL' 3%'0%E.#'./'.'I3K'/&,@%#&'.&'&3%'=,02%$3&'C#/&"&,&%'"#'R&2%$3&'./'.')%)0%2'1G' &3%'E21,?'1G'I21G<'K2<'(%21%#'@%#'=%2&1E<'V3%'-12M'@%/$2"0%@'"#'&3"/'&3%/"/'-./' $.22"%@'1,&',#@%2'&3%'/,?%2;"/"1#'1G'I21G<'K2<'(%21%#'@%#'=%2&1E<'!"#$%#&'"/'#1-'.' $6"#"$.6'@.&.').#.E%2'.&'BJB'"#'H%$3%6%#<'. 176.

(29) Stellingen

(30)   behorende

(31)   bij

(32)   het

(33)   proefschrift:. Functional

(34)   characterization

(35)   of

(36)   Protein

(37)   -­Tyrosine

(38)   Phosphatases

(39)   ‹‡„”ƒϐ‹•Š‡˜‡Ž‘’‡–—•‹‰

(40) ƒ‰‡ƒŽ›•‹• 1.

(41)   NRAS

(42)   I24N

(43)   is

(44)   a

(45)   novel

(46)   Noonan-­‐associated

(47)   mutation

(48)   which

(49)   hyper-­‐activates

(50)   –Š‡ ǦǦ’ƒ–Š™ƒ›ƒ†‹••—ˆϐ‹ ‹‡––‘ ƒ—•‡‘‘ƒ›†”‘‡Ǧ Ž‹‡•›’–‘•‹œ‡„”ƒϐ‹•ŠȋŠƒ’–‡”ͶȌ 2.

(51)   RPTP_

(52)   and

(53)   RPTP¡

(54)   have

(55)   an

(56)   essential

(57)   role

(58)   in

(59)   convergence

(60)   and

(61)   extension

(62)   ‘˜‡‡–•†—”‹‰œ‡„”ƒϐ‹•Š‰ƒ•–”—Žƒ–‹‘‹ƒ’ƒ–Š™ƒ›’ƒ”ƒŽŽ‡Ž–‘–Š‡‘Ǧ ƒ‘‹ ƒŽ–ƒ–Š™ƒ›ȋŠƒ’–‡”ʹȌ 3.

(63)   RPTP_

(64)   and

(65)   RPTP¡

(66)   have

(67)   opposing

(68)   effects

(69)   on

(70)   RhoA

(71)   activation

(72)   to

(73)   PTP-­‐BL

(74)   and

(75)   Ptpn20,

(76)   however

(77)   the

(78)   knockdown

(79)   of

(80)   all

(81)   these

(82)   genes

(83)   reveals

(84)   a

(85)   similar

(86)   ’Š‡‘–›’‡ǣŽ‘••‘ˆ ‡ŽŽ’‘Žƒ”‹œƒ–‹‘ȋŠƒ’–‡”͵Ȍ 4.

(87)   Defective

(88)   gastrulation

(89)   cell

(90)   movements

(91)   underlie

(92)   Noonan

(93)   syndrome

(94)   pheno-­‐ –›’‡•ȋŠƒ’–‡”ͶȌ 5.

(95)   A

(96)   functional

(97)   characterization

(98)   of

(99)   the

(100)   entire

(101)   family

(102)   of

(103)   classical

(104)   PTPs

(105)   using

(106)   morpholino

(107)   knockdown

(108)   provides

(109)   an

(110)   important

(111)   step

(112)   in

(113)   elucidating

(114)   the

(115)   ”‘Ž‡•‘ˆ–Š‹•†‹˜‡”•‡ˆƒ‹Ž›‘ˆ’”‘–‡‹•‹œ‡„”ƒϐ‹•ŠȋŠƒ’–‡”͸Ȍ ͸Ǥ Š‡‘†‡Ž‹‰Š—ƒ‘’ƒ–Š‹‡•‹œ‡„”ƒϐ‹•Š‘ˆˆ‡”•ƒ’Žƒ–ˆ‘”ˆ‘”‹†‡-­‐ –‹ϐ‹ ƒ–‹‘‘ˆ’‘••‹„Ž‡–Š‡”ƒ’‡—–‹  ‘’‘—†• 7.

(116)   Image

(117)   processing

(118)   algorithms

(119)   for

(120)   detecting

(121)   cell

(122)   structures

(123)   are

(124)   highly

(125)   valu-­‐ able

(126)   tools

(127)   for

(128)   morphological

(129)   analysis

(130)   because

(131)   they

(132)   are

(133)   extremely

(134)   fast,

(135)   ob-­‐ jective,

(136)   and

(137)   reliable

(138)   and

(139)   they

(140)   eliminate

(141)   the

(142)   need

(143)   for

(144)   conventional,

(145)   labor-­‐ intensive

(146)   manual

(147)   annotation. 8.

(148)   Š‡œ‡„”ƒϐ‹•Š•›•–‡‘ˆˆ‡”•‹ƒ‰‹‰’‘••‹„‹Ž‹–‹‡•™Š‹ Šƒ”‡—’ƒ”ƒŽŽ‡Ž‡† by

(149)   any

(150)   other

(151)   vertebrate

(152)   system. 9.

(153)   Š‡œ‡„”ƒϐ‹•Š•›•–‡ ƒ‘–”‡’Žƒ ‡‘–Š‡”˜‡”–‡„”ƒ–‡‘†‡Ž•›•–‡•‹ research,

(154)   however

(155)   it

(156)   offers

(157)   a

(158)   complementary

(159)   system

(160)   in

(161)   which

(162)   processes

(163)   related

(164)   to

(165)   early

(166)   morphogenesis

(167)   and

(168)   in

(169)   vivo

(170)   studies

(171)   of

(172)   disease

(173)   progression

(174)   can

(175)   be

(176)   readily

(177)   visualized. 10.

(178)   Every

(179)   honest

(180)   researcher

(181)   I

(182)   know

(183)   admits

(184)   he’s

(185)   just

(186)   a

(187)   professional

(188)   amateur.

(189)   ‡ǯ•†‘‹‰™Šƒ–‡˜‡”Š‡ǯ•†‘‹‰ˆ‘”–Š‡ϐ‹”•––‹‡ǤŠƒ–ƒ‡•Š‹ƒƒƒ-­‐ teur.

(190)   He

(191)   has

(192)   sense

(193)   enough

(194)   to

(195)   know

(196)   that

(197)   he’s

(198)   going

(199)   to

(200)   have

(201)   a

(202)   lot

(203)   of

(204)   trouble,

(205)   so

(206)   that

(207)   makes

(208)   him

(209)   a

(210)   professional.

(211)   .

(212) ǦŠƒ”Ž‡• ”ƒŽ‹‡––‡”‹‰ȋͳͺ͹͸ǦͳͻͷͺȌǤǤ‰‹‡‡”ƒ†

(213) ˜‡-­‐ tor. 11.

(214)   Strange

(215)   as

(216)   it

(217)   may

(218)   sound,

(219)   the

(220)   power

(221)   of

(222)   mathematics

(223)   rests

(224)   on

(225)   its

(226)   evasion

(227)   of

(228)   all

(229)   unnecessary

(230)   thought

(231)   and

(232)   on

(233)   its

(234)   wonderful

(235)   saving

(236)   of

(237)   mental

(238)   opera-­‐ tions.

(239)  

(240)   Ǧ”•–ƒ Šȋͳͺ͵ͺǦͳͻͳ͸Ȍ—•–”‹ƒ’Š›•‹ ‹•–ǡ’Š‹Ž‘•‘’Š‡”Ǥ.

(241)

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