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(1)Cover Page. The handle http://hdl.handle.net/1887/19776 holds various files of this Leiden University dissertation. Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis Date: 2012-09-12.

(2) 2 5373ĮDQG373İ6LJQDOLQJYLD)\Q<HVDQG5KR$ LV(VVHQWLDOIRU=HEUD¿VK&RQYHUJHQFHDQG([WHQVLRQ&HOO0RYHPHQWVGXULQJ*DVWUXODWLRQ Mark van Eekelen*, Vincent Runtuwene*, John Overvoorde, Jeroen den Hertog Dev Biol. 2010 Apr 15;340(2):626-39 *=equal contribution. 31.

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(5) ƒ†‡š–‡†ƒ”‘—†–Š‡›‘Žǡ‰‹˜‹‰”‹•‡–‘–Š‡ƒ–‡”‹‘”Ȁ’‘•–‡”‹‘”ƒš‹•ȋ ”‹ˆϐ‹‡– ƒŽǤǡͳͻͻͷǢ‡ŽŽ‡”‡–ƒŽǤǡͳͻͻʹǢ‘Ž‹ ƒǦ”‡œ‡Ž‡–ƒŽǤǡͳͻͻ͸ȌǤƬ ‡ŽŽ‘˜‡‡–•ƒ”‡ ”‡‰—Žƒ–‡† „› –Š‡ ‘Ǧ ƒ‘‹ ƒŽ – •‹‰ƒŽ‹‰ ’ƒ–Š™ƒ› ™Š‹ Š ‹• •‹‹Žƒ” –‘ –Š‡ ’Žƒƒ” ‡ŽŽ’‘Žƒ”‹–›ȋȌ’ƒ–Š™ƒ›‹†‡–‹ϐ‹‡†‹!"#$#%&'()ȋƒ–•—‹‡–ƒŽǤǡʹͲͲͷǢ ‡†‹ƒ‡–ƒŽǤǡʹͲͲͲǢ‘Ž‹ ƒǦ”‡œ‡Žƒ†ƒ–‘ǡʹͲͲ͵ȌǤ

(6) ˜‡”–‡„”ƒ–‡•ǡ–Š‡‘Ǧ ƒ‘‹ ƒŽ–’ƒ–Š™ƒ›„‡ ‘‡•ƒ –‹˜ƒ–‡†™Š‡ –ͳͳ‘”–ͷ„‹†•–‘ ”‹œœŽ‡†”‡ ‡’–‘”•”‡•—Ž–‹‰‹–Š‡†‘™•–”‡ƒƒ –‹˜ƒ! "#$%&$'&()$*&+%,&(+-.&()$*&+%,&(+-&/01/2302%"45&67$6+8+"2&")2&/#8%+4&"$&")2#7& ”‡•’‡ –‹˜‡ †‘™•–”‡ƒ ‡ˆˆ‡ –‘”•ǡ ‹ Ž—†‹‰ ‘ʹ ƒ†  ȋ ƒ„ƒ• ‡– ƒŽǤǡ ʹͲͲ͵ǡ ʹͲͲͳǢ‡‡ƒ‡–ƒŽǤǡʹͲͲ͵ȌǤ

(7) *+,-(-.)/$ǡ–Š‹• ƒ• ƒ†‡™‹ŽŽ”‡‘†‡Ž–Š‡ ‡ŽŽǡ‡•–ƒ„! Ž‹•Š‹‰’‘Žƒ”‹–›ƒ†ƒŽŽ‘™‹‰‹––‘‘—–ƒ’”‘’‡” Š‡‘–ƒ –‹ ”‡•’‘•‡–Š”‘—‰Š ”‡‘†‡Ž‹‰‘ˆ–Š‡ƒ –‹ ›–‘•‡Ž‡–‘ȋ ‘Ž†•–‡‹‡–ƒŽǤǡʹͲͲ͸ȌǤ

(8) –‹•ƒ••—‡†–Šƒ– %$%!-+%$%#-+4&9%"&/#8%+4#%8&#%,0-2,&-244&6$4+7#:+"#$%&#/&+"&")2&1+/#/&$'&;27"217+"2& Ƭ ‡ŽŽ ‘˜‡‡–• ƒ• ™‡ŽŽǤ  —„‡” ‘ˆ —–ƒ–• Šƒ˜‡ „‡‡ †‡• ”‹„‡† ‹ œ‡! „”ƒϐ‹•Š–Šƒ–Šƒ”„‘”—–ƒ–‹‘•‹‰‡‡•”‡‰—Žƒ–‹‰–Š‹•’”‘ ‡••ȋ ‡‹•‡„‡”‰‡–ƒŽǤǡ ʹͲͲͲǢ ‡••‡‡–ƒŽǤǡʹͲͲʹǢ‹Ž‹ƒ‡–ƒŽǤǡʹͲͲ͵Ǣ‘’ œ‡™•‹‡–ƒŽǤǡʹͲͲͳȌǤŠ‡’Š‡‘! "562&")+"&+44&$'&")2/2&<0"+%"/&)+;2&#%&-$<<$%&#/&")+"&")2&2<175$/&+72&/)$7"27&+%,& 17$+,27&+/&$%2&<#8)"&2=62-"&#'&>?@&+72&,#/706"2,. ‘”‡”‡ ‡–Ž›ƒ—„‡”‘ˆ•–—†‹‡•Šƒ˜‡ ‘‡–‘Ž‹‰Š––Šƒ–•Š‘™–Šƒ–Ƭ ‹•‘–•‘Ž‡Ž›‰‘˜‡”‡†„›–Š‡‘Ǧ ƒ‘‹ ƒŽ–’ƒ–Š™ƒ›ǤŠ‡Ž‹•–‘ˆ‘–Š‡”ˆƒ –‘”• ")+"&<$,04+"2&%$%!-+%$%#-+4&9%"&/#8%+4#%8&,#72-"45&A9+,+&2"&+4.B&CDDEF&$7&'0%-! –‹‘‹†‡’‡†‡–Ž›ȋ ƒ—•‡–ƒŽǤǡʹͲͲʹȌ‹•‡˜‡”‰”‘™‹‰Ǥ‡ ‡–Ž›ǡ™‡Šƒ˜‡•Š‘™ –Šƒ–•‹‰ƒŽ‹‰–Š”‘—‰Š–Š‡” ˆƒ‹Ž›‹ƒ•‡• ›ƒ†‡• ‘˜‡”‰‡•™‹–Š‘ ƒ! ‘‹ ƒŽ – •‹‰ƒŽ‹‰ ƒ† •‡”˜‡• –‘ ‘†—Žƒ–‡ –Š‡ ƒ –‹˜‹–› ‘ˆ –Š‡ •ƒŽŽ ƒ•‡ Š‘†—”‹‰Ƭ ‡ŽŽ‘˜‡‡–•ȋ ‘’Ž‹‰ƒ††‡ ‡”–‘‰ǡʹͲͲͷȌǤ•ǡƒ‡‰ƒ–‹˜‡ ”‡‰—Žƒ–‘”‘ˆ •ƒŽ•‘Šƒ•ƒ”‘Ž‡‹Ƭ ‡ŽŽ‘˜‡‡–•ȋ ‘’Ž‹‰ƒ††‡ ‡”–‘‰ǡ ʹͲͲ͹ȌǤ‘”‡‘˜‡”ǡ™‡Šƒ˜‡•Š‘™–Šƒ––Š‡’”‘–‡‹Ǧ–›”‘•‹‡’Š‘•’Šƒ–ƒ•‡Š’ʹǡƒ ‹†‹”‡ –ƒ –‹˜ƒ–‘”‘ˆ •ȋŠƒ‰‡–ƒŽǤǡʹͲͲͶȌǡ”‡‰—Žƒ–‡•Ƭ†—”‹‰‰ƒ•–”—Žƒ–‹‘ ˜‹ƒ ›Ȁ‡•ƒ†Š‘ȋ ‘’Ž‹‰‡–ƒŽǤǡʹͲͲ͹ȌǤ ‡”‡ ™‡ •Š‘™ –Šƒ– ‘ †‘™ ‘ˆ Ƚ ‘” ɂ ‹†— ‡† Ƭ †‡ˆ‡ –• 0/#%8&'/,$'01Š›„”‹†‹œƒ–‹‘‘ˆƬ•’‡ ‹ϐ‹ ƒ”‡”•Ǥ‘‹Œ‡ –‹‘‘ˆ’–’”ƒǦƒ† ’–’”‡Ǧ‹†— ‡†˜ƒ”‹‘—•†‡‰”‡‡•‘ˆ › Ž‘’‹ƒ‹ϐ‹•Šǡ‹†‹ ƒ–‹‰–Šƒ–Ƚƒ† ɂ ƒ”‡ ƒ– Ž‡ƒ•– ’ƒ”–‹ƒŽŽ›”‡†—†ƒ–Ǥ 20%")—–ƒ– œ‡„”ƒϐ‹•Š™‡”‡‹•‘Žƒ–‡†„› –ƒ”‰‡–•‡Ž‡ –‡†‰‡‡‹ƒ –‹˜ƒ–‹‘ƒ†™‡‡•–ƒ„Ž‹•Š‡†–Šƒ–’–’”ƒίȀί&2<175$/&,#/! ’Žƒ›‡†Ƭ†‡ˆ‡ –•ǡ•‹‹Žƒ”–‘–Š‡’–’”ƒǦ‹Œ‡ –‡†‡„”›‘•Ǥ‹‡ǦŽƒ’•‡ ‘ˆ‘! ƒŽ ‹ ”‘• ‘’› ™ƒ• —•‡† –‘ –”ƒ  ‡ŽŽ ‘˜‡‡–• †—”‹‰ ‰ƒ•–”—Žƒ–‹‘ ƒ† –Š‹• –‡ Š‘Ž‘‰›™ƒ•ƒ†ƒ’–‡†–‘ƒŽŽ‘™“—ƒ–‹ϐ‹ ƒ–‹‘‘ˆ ‡ŽŽ‘˜‡‡–•†—”‹‰‰ƒ•–”—! 4+"#$%.&–’”ƒίȀί&2<175$/&,#/64+52,&72,0-2,&>?@&-244&<$;2<2%"&/622,&+/&-$<! ’ƒ”‡†–‘™‹Ž†–›’‡•‹„Ž‹‰•Ǥ‘Ǧ‹Œ‡ –‹‘‘ˆŽ‘™ƒ‘—–•‘ˆ’–’”ƒǦ‘”’–’”‡Ǧ –‘‰‡–Š‡”™‹–ŠŽ‘™ƒ‘—–•‘ˆ–ͳͳǦ’Š‡‘ ‘’‹‡†–Š‡•‹Ž„‡”„Ž‹ ’Š‡‘–›’‡ǡ 33. !.

(9) •—‰‰‡•–‹‰–Šƒ–Ƚƒ†ɂŠƒ˜‡ƒ‰‡‡–‹ ‹–‡”ƒ –‹‘™‹–Š–ͳͳǤ

(10) •‡ƒ” Š ‘ˆ ƒ —†‡”Ž›‹‰ ‡ Šƒ‹•ǡ ™‡ ˆ‘—† ‡Šƒ ‡†   ’Š‘•’Š‘”›Žƒ–‹‘ ‘ –Š‡ ‹Š‹„‹–‘”›•‹–‡ƒ†”‡†— ‡† ƒ—–‘’Š‘•’Š‘”›Žƒ–‹‘ǡ‹†‹ ƒ–‹‰–Šƒ– ƒ –‹˜‹–› ™ƒ•”‡†— ‡†‹—–ƒ–‡„”›‘• ‘’ƒ”‡†–‘•‹„Ž‹‰•ǤƬ†‡ˆ‡ –•‹’–’”ƒίȀί! ‡„”›‘• ™‡”‡ ”‡• —‡† „› ƒ –‹˜‡ › ƒ† ‡•ǡ ™Š‹ Š ‹• ‘•‹•–‡– ™‹–Š Ƚ „‡‹‰—’•–”‡ƒ‘ˆ •Ǥ‘”‡‘˜‡”ǡƒ –‹˜‡Š‘”‡• —‡†–Š‡’–’”ƒίȀί!"#$%&'("$! ƒ•™‡ŽŽǤƒ•‡†‘‘—”†ƒ–ƒǡ™‡’”‘’‘•‡ƒ‘†‡Ž‹™Š‹ ŠȽƒ†ɂƒ –‹ ’ƒ”ƒŽŽ‡Ž–‘‘Ǧ ƒ‘‹ ƒŽ–•‹‰ƒŽ‹‰—’•–”‡ƒ‘ˆ–Š‡ •ǡ ›ƒ†‡•ƒ† )"*'+$,-!&.!/#&01 !"#$%&"'()"*+),$#-.+( ‡„”ƒϔ‹•Šƒ†‹•‹–—Š›„”‹†‹œƒ–‹‘ ‡„”ƒϐ‹•Š ™‡”‡ ‡’– ƒ† –Š‡ ‡„”›‘• ™‡”‡ •–ƒ‰‡† ƒ• †‡• ”‹„‡† „‡ˆ‘”‡ ȋ‡•–‡”ϐ‹‡Ž†ǡ ͳͻͻͷȌǤ !"# $%&' Š›„”‹†‹œƒ–‹‘• ™‡”‡ †‘‡ ‡••‡–‹ƒŽŽ› ƒ• †‡• ”‹„‡† ȋŠ‹••‡ ‡– ƒŽǤǡ ͳͻͻ͵Ȍ —•‹‰ ’”‘„‡• •’‡ ‹ϐ‹  ˆ‘” ()*+(,! Š†ǡ ‰• ǡ –Žƒǡ †Žš͹ǡ Š‰‰ͷ! ȋ —””‡–Ž›‘™ƒ• –•Žͷ„23!›‘†!,%4!”‘š͸Ͷƒ•†‡• ”‹„‡†ȋ ‘’Ž‹‰ƒ† ‡”–‘‰ǡ ʹͲͲ͹Ǣ ‘’Ž‹‰‡–ƒŽǤǡʹͲͲ͹ȌǤ!"#$%&'!"+&5$*!.&+!*&*-.3!*&*-/.!,%4!*&*-/(™‡”‡‰‡‡”6 ƒ–‡†„›’‡”ˆ‘”‹‰ƒ”‡ƒ –‹‘‘‹•‘Žƒ–‡†ˆ”‘œ‡„”ƒϐ‹•Š‡„”›‘•ȋͶͺ Š’ˆȌǤ‡†‡•‹‰‡†‘Ž‹‰‘•–‘’‡”ˆ‘”‘–Š‡  ‘•–”— –•‘ˆ*&*-.3!*&*-/.! ,%4!*&*-/(•’ƒ‹‰ƒ’’”‘š‹ƒ–‡Ž›ͺͲͲ„’ǡƒ†ƒ‡•–‡†‘Ž‹‰‘’ƒ‹”™‹–Šƒ͹•‡6 “—‡ ‡‹–Š‡”‡˜‡”•‡‘Ž‹‰‘Ǥ‡—•‡†–Š‡͹–ƒ‰–‘‰‡‡”ƒ–‡

(11) Žƒ„‡Ž‡†ƒ–‹•‡•‡ ˆ‘”%"#$%&'!#(5+7478,'7&%!,%4!'#$!%$*'$4!&97:&!",7+!'&!;$+7.(!'#$!*$<)$%=$*1!0! "+$-,')+$!*'&"!*&*-.—–ƒ–™ƒ•‹†‡–‹ϐ‹‡†—•‹‰–ƒ”‰‡–•‡Ž‡ –‡†‰‡‡‹ƒ –‹˜ƒ6 '7&%!,*!4$*=+75$4!7%!>7$%#&94*!$'!,91!?@AA@21!B#$!*&*-.Š—͹͹͹ͺ#ƒŽŽ‡Ž‡ Šƒ‰‡•ƒ  –‘ƒ  ‘†‘”‡•—Ž–‹‰‹ƒͳ͵͵ ‘†‹‰ Šƒ‰‡Ǥ 01"$&-'2&$ ‘—•‡*&*-. ‘•–”— –•™‡”‡—•‡†ƒ•†‡• ”‹„‡†‡ƒ”Ž‹‡”ȋ†‡ ‡”–‘‰ƒ† —–‡”ǡͳͻͻ͸ȌǤ ‘”œ‡„”ƒϐ‹•Š*&*-. ‘–”— –•ͳ†’ˆœ‡„”ƒϐ‹•Š™‡”‡Ž›•‡†ƒ† ™ƒ•‹•‘Žƒ–‡†Ǥ‡˜‡”•‡–”ƒ• ”‹’–‹‘™ƒ•†‘‡™‹–Š‘Ž‹‰‘†ƒ†*&*-. ™ƒ• ƒ’Ž‹ϐ‹‡†ƒ† Ž‘‡†‹–‘ƒ’ ͷǦͳ͵˜‡ –‘”ƒ†•‡“—‡ ‡†Ǥ •ǡƒ†‹Œ‡ –‹‘• –‹•‡•‡ •’Ž‹ ‡ •‹–‡ †‘‘” • ™‡”‡ †‡•‹‰‡† ‘‡ ‘” –™‘ ‡š‘• —’6 •–”‡ƒ ‘ˆ –Š‡ ƒ–ƒŽ›–‹  •‹–‡ ‘ˆ –Š‡ ”‡•’‡ –‹˜‡ • ƒ† ‘”†‡”‡† ˆ”‘ ‡‡6 ‘‘Ž• ȋŠ‹Ž‘ƒ–ŠǡȌǣ ’–’”ƒǡ ͷƍǦ .   Ǣ ’–’”‡ƒǡ ͷƍ6 .  Ǣ’–’”‡„ǡͷƍ!B0BCBB0BCBC0CCBCBBBBCBCBCD! ™–ͳͳƒ•†‡• ”‹„‡†‹ǣ‡Ž‡‡–ƒŽǤȋʹͲͲͳȌǤͷƍ ƒ’’‡†•‡•‡•™‡”‡•›–Š‡•‹œ‡† —•‹‰‡••ƒ‰‡ƒ Š‹‡‹–ȋ„‹‘ȌǤŠ‡ƒ‘—–‘ˆ–Šƒ–™ƒ•‹Œ‡ –‡† ƒ––Š‡‘‡ ‡ŽŽ•–ƒ‰‡™ƒ•‘’–‹‹œ‡†ˆ‘”‡ƒ Š•›–Š‡–‹ Ǥ ‘”–Š‡”‡• —‡‡š’‡”‹6 34.

(12) ‡–•ǡ™‡—•‡†—–ƒ–ǡ ‘•–‹–—–‹˜‡Ž›ƒ –‹˜‡ˆ‘”•‘ˆŠ—ƒ ›ǡ‡•ȋ ‘’Ž‹‰ ƒ††‡ ‡”–‘‰ǡʹͲͲ͹Ȍǡƒ†ƒ –‹˜‡Š—ƒŠ‘ƒ†ƒ ͳȋ ‘’Ž‹‰ƒ††‡ ‡”–‘‰ǡ ʹͲͲͷȌ ƒ• †‡• ”‹„‡† ’”‡˜‹‘—•Ž›Ǥ Š‡‘–›’‡• ™‡”‡ ƒ••‡••‡† ƒ– ‹†‹ ƒ–‡† •–ƒ‰‡•ǡ !"#$%&'(&)'*+,'-'./&'*&!"#$%&'(&†Žš͹0Š‰‰ͷƒ”‡”•ƒ–ͳͲŠ’ˆǤ !"#$"%&'()*$ „”›‘•™‡”‡‰”‘™—–‹ŽͷʹŠ’ˆƒ†™‡”‡†‡›‘Ž‡†™‹–Š†‡›‘Ž‹‰„—ˆ1 ˆ‡”ȋͳΤʹ ‹œ„—”‰ ‹•Š‹‰‡”Ȍ™‹–Š‘—– ƒŽ ‹—ȋ‹‡–ƒŽǤǡʹͲͲ͸Ǣ‡•–‡”ϐ‹‡Ž†ǡ ͳͻͻͷȌǤ—„•‡“—‡–Ž›‡„”›‘•™‡”‡‰”‹†‡†‹„—ˆˆ‡” ‘–ƒ‹‹‰ͷͲ”‹•ǡ’  ͹ǤͷǡͳͷͲƒŽǡͳǡͳ•‘†‹—‘”–Š‘˜ƒƒ†ƒ–‡ǡͳΨ‘‹†‡–ǦͶͲǡ ͲǤͳΨ•‘†‹—†‡‘š› Š‘Žƒ–‡ǡƒ†’”‘–‡ƒ•‡‹Š‹„‹–‘”‹š–—”‡ȋ‘’Ž‡–‡‹‹ǡ‘ Š‡ ‹ƒ‰‘•–‹ •Ȍƒ†Ž›•‡†—•‹‰ƒ•›”‹‰‡Ǥ›•ƒ–‡•™‡”‡ ‡–”‹ˆ—‰‡†ƒ–ͳͶǡͲͲͲ‰–‘ ’‡ŽŽ‡– ‡ŽŽ—Žƒ”†‡„”‹•Ǥ›•ƒ–‡•™‡”‡•—„Œ‡ –‡†–‘Ǧ ƒ†„Ž‘––‡†ȋƒ‘—– Ž‘ƒ†‡†’‡”Žƒ‡ ‘””‡•’‘†•–‘ͳͷ‡„”›‘•ȌǤˆ–‡”–”ƒ•ˆ‡”–Š‡‡„”ƒ‡™ƒ• •–ƒ‹‡†™‹–Š‘‘ƒ••‹‡Ž—‡•–ƒ‹–‘˜‡”‹ˆ›‡“—ƒŽŽ‘ƒ†‹‰‘ˆ–Š‡Ž›•ƒ–‡•Ǥ—„•‡1 “—‡–Ž›–Š‡ ‡„”ƒ‡™ƒ•„Ž‘ ‡†™‹–ŠͳΨ‘”ͷΨ‹Žƒ†–Š‡‹1 —„ƒ–‡†™‹–Š–Š‡ ‘””‡•’‘†‹‰ƒ–‹„‘†‹‡•ƒ‰ƒ‹•–’” ͶͳͺȋͳǣͳͲͲͲǡ‹‘‘—” ‡ ‡ Š‘Ž‘‰‹‡•Ȍǡƒ –‹ȋͳǣͷͲͲͲǡ‹†Ž›’”‘˜‹†‡†„›‡’’‡Ž‡„‘• Šǡ‹˜‡”•‹–› ‡†‹ ƒŽ‡–‡” ”‘‹‰‡ǡ–Š‡‡–Š‡”Žƒ†•Ȍƒ†ƒ–‹•‡”—ƒ‰ƒ‹•–Ƚ͓ͷͶ͹ͺ ȋͳǣͳͲͲͲǢ†‡ ‡”–‘‰‡–ƒŽǤǡͳͻͻͶȌˆ‘ŽŽ‘™‡†„›–Š‡Š‘”•‡”ƒ†‹•Š’‡”‘š‹†ƒ•‡ ‘Œ—1 ‰ƒ–‡† •‡ ‘†ƒ”› ƒ–‹„‘†›Ǥ Š‡ ‡„”ƒ‡• ™‡”‡ •—„Œ‡ –‡† –‘ †‡–‡ –‹‘ „› ‡1 ,"(2$%&2,$)3-4)3($#2$(2$5 ‘ˆ‘ ƒŽ‹ ”‘• ‘’› ‹•–‘‡ͷ‹Œ‡ –‹‘ ' Š‡‡„”›‘•™‡”‡‹Œ‡ –‡†ƒ––Š‡ͳǦ ‡ŽŽ•–ƒ‰‡™‹–Š ‹•–‘‡ͳ–ƒ‰‰‡†™‹–Š Ž‡šƒϐŽ—‘”Ͷͺͺˆ”‘‘Ž‡ —Žƒ””‘„‡•ȋ ͳȌǤ +,-."'-/012#2$2*& ‘”–‹‡ǦŽƒ’•‡‹ƒ‰‹‰–Š‡‡„”›‘•™‡”‡†‡ Š‘”‹‘ƒ–‡†ȋƒ–͵ͲΨ‡’‹„‘Ž›Ȍ ƒ†‘—–‡†ƒ–•Š‹‡Ž†•–ƒ‰‡‹ͳΨŽ‘™‡Ž–‹‰’‘‹–ƒ‰ƒ”‘•‡‹͵‡„”›‘”‡ƒ”1 ‹‰‡†‹—ƒ† ‘˜‡”‡†™‹–Š͵‹ƒ —Ž–—”‡†‹•Š™‹–Šƒ‰Žƒ•• ‘˜‡”•Ž‹’”‡’Žƒ ‹‰ –Š‡„‘––‘Ǥ‡‹ ƒʹ ‘ˆ‘ ƒŽ‹ ”‘• ‘’‡™‹–ŠƒͶͲš‘„Œ‡ –‹˜‡™ƒ•—•‡†ˆ‘” -36$&3)".3(.&'7&8,$&9-$:"&;<<&#3.("-&4#3(.&"&;<<&()&-"#$*&-3($&7'*&$:238"83'(5&=$)1 ’‡”ƒ–—”‡™ƒ•ƒ‹–ƒ‹‡†ƒ–ƒ’’”‘š‹ƒ–‡Ž›ʹͺǤͷ鑐ƒŠ‡ƒ–‡†•–ƒ‰‡Ǥ‹‡’‘‹–• ™‡”‡”‡ ‘”†‡†‡˜‡”›ʹ‹ˆ”‘•Š‹‡Ž†•–ƒ‰‡—–‹ŽͳǦ•‘‹–‡•–ƒ‰‡Ǥ 3*#2$2*&2&. Š‡ ͳǦ‹Œ‡ –‡†‡„”›‘•ƒ”‡’‘•‹–‹‘‡†™‹–Š–Š‡†‘”•ƒŽ•‹†‡ƒ‰ƒ‹•––Š‡ ‘˜‡”•Ž‹’ƒ’’”‘š‹ƒ–‡Ž›ͳͲͲɊƒ–‡”‹‘”–‘•Š‹‡Ž†’‘•‹–‹‘Ǥ––Š‹•’‘•‹–‹‘–Š‡ 35. !.

(13) !"#$%&''$()*&(&+,-$).$,/&$&012'3-,$%3+$2&$%'&34'5$*1-63'17&89 ƒŽ›•‹• ‹‡ǦŽƒ’•‡‹ƒ‰‡•™‡”‡ƒƒŽ›œ‡†—•‹‰

(14) ƒ‰‡ ȋŠ––’ǣȀȀ”•„™‡„Ǥ‹ŠǤ‰‘˜Ȁ ‹ŒȀȌǤŠ‡— Ž‡ƒ”Žƒ„‡Ž‹‰‹•—•‡†–‘†‡–‡”‹‡–Š‡’‘•‹–‹‘‘ˆ–Š‡‹†‹˜‹†—ƒŽ ‡ŽŽ• ‹ƒ•‹‰Ž‡‘’–‹ ƒŽ•Ž‹ ‡ˆ‘”‡ƒ Š–‹‡’‘‹–Ǥ

(15) –Š‡‹ƒ‰‡•–Š‡‡„”›‘‹•’‘•‹–‹‘‡† ™‹–Š–Š‡ƒ–‡”‹‘”•‹†‡–‘™ƒ”†•–Š‡–‘’‘ˆ–Š‡‹ƒ‰‡ǤŠ‡ƒ”–‡•‹ƒ ‘‘”†‹ƒ–‡•‘ˆ ‡ŽŽ–”ƒ •‰‡‡”ƒ–‡†‹–Š‹•™ƒ›™‹ŽŽ”‡’”‡•‡––Š‡ ‘–”‹„—–‹‘‘ˆ ‡ŽŽ‹‰”ƒ–‹‘ –‘ ‘˜‡”‰‡ ‡ȋǦƒš‹•Ȍƒ†‡š–‡•‹‘ȋǦƒš‹•ȌǤ ‡–‡ –‹‘ƒ†–”ƒ ‹‰‘ˆ ‡ŽŽ’‘•‹–‹‘• :6&$,)$,/&$1++3,&$%/3+;&-$1+$1+,&+-1,5<$-17&$3+8$-/30&$).$=>$-1;+3'$).$,/&$ — Ž‡‹ƒ††‹–‹‘ƒŽ‹ƒ‰‡’”‘ ‡••‹‰‹•‡‡†‡†ˆ‘”‡ˆϐ‹ ‹‡––”ƒ ‹‰‘ˆ–Š‡ ‡ŽŽ•Ǥƒ? ‹‰–Š‡‹ƒ‰‡•„‹ƒ”›•‘Ž˜‡•–Š‡’”‘„Ž‡‘ˆ˜ƒ”‹ƒ„Ž‡ϐŽ—‘”‡• ‡–‹–‡•‹–‹‡•ǤŠ‡ ‘ ƒ•‹‘ƒŽŽ› ‘ —””‹‰ ‘ˆ ˆ—•‡† ‘„Œ‡ –• ‹• Šƒ†Ž‡† „› ƒ ™ƒ–‡”•Š‡††‹‰ ’”‘ ‡•• ™Š‹ Š‹•ƒ„Ž‡–‘”‡•‡’ƒ”ƒ–‡‘•–ˆ—•‡†‘„Œ‡ –•ǤŠ‡•‡‘„Œ‡ –••–‹ŽŽ Šƒ‰‡†—”‹‰ –Š‡–‹‡ǦŽƒ’•‡”—‹•‹œ‡ƒ†•Šƒ’‡Ǥ”‘†‹‰‡˜‡”‘„Œ‡ ––‘ƒ•‹‰Ž‡’‹š‡Ž‰‡‡”? ƒ–‡•ƒ‹ƒ‰‡™‹–Š•‹‰Ž‡’‘‹–ƒ”‹‰•”‡’”‡•‡–‹‰–Š‡‹†‹˜‹†—ƒŽ’‘•‹–‹‘• ‘ˆ‡ƒ Š‘„Œ‡ –Ǥ ‘”–”ƒ ‹‰’—”’‘•‡•–Š‡•‡•‹‰Ž‡’‹š‡Ž•‡‡†–‘„‡†‹Žƒ–‡†ǤŠ‡ –Š‡”‡•—Ž–‹‰‹ƒ‰‡‹•”‡Ǧ’”‘Œ‡ –‡†‘–‘–Š‡‘”‹‰‹ƒŽ‹–•Š‘™•–Šƒ––Š‡‰‡‡”ƒ–‡† ‘„Œ‡ –•”‡’”‡•‡– ‡ŽŽ’‘•‹–‹‘•™‹–Šƒ˜‡”›Š‹‰Šƒ —”ƒ ›ǤŠ‡‘„Œ‡ –•‰‡‡”ƒ–‡† ƒ”‡”‡ƒ†‹Ž›–”ƒ ‡†™‹–ŠƒƒŽ‰‘”‹–Š’Ž—‰‹™Š‹ Š‹’Ž‡‡–•–Š‡ˆ‡ƒ–—”‡’‘‹– †‡–‡ –‹‘ƒ†–”ƒ ‹‰ƒŽ‰‘”‹–Šƒ•†‡• ”‹„‡†‹„ƒŽœƒ”‹‹ƒ†‘—‘—–•ƒ‘• ȋʹͲͲͷȌǤŠ‡ƒŽ‰‘”‹–Š‰‡‡”ƒ–‡•ƒ”‡’‘”–™‹–Š–Š‡ƒ”–‡•‹ƒ ‘‘”†‹ƒ–‡•ˆ‘”ƒŽŽ –”ƒ ‡†‘„Œ‡ –•ƒ–‡ƒ Š–‹‡’‘‹–Ǥ —ƒ–‹ϔ‹ ƒ–‹‘ —”‹‰‹†Ǧ‰ƒ•–”—Žƒ–‹‘–Š‡‰‡‡”ƒŽ ‡ŽŽ‘˜‡‡–•˜‹•—ƒŽ‹œ‡†™‹–Š–Š‹• ‡–Š‘† ƒ”‡ ‹ –Š‡ ‡š–‡•‹‘ †‹”‡ –‹‘Ǥ Š‡ Ǧ ‘‘”†‹ƒ–‡• ‘ˆ –Š‡ ‡ŽŽ –”ƒ • ƒ”‡ —•‡†ƒ•ƒ‡ƒ•—”‡‡–ˆ‘”–Š‡ ‘–”‹„—–‹‘‘ˆ–Š‡•‡ ‡ŽŽ–”ƒ •–‘‡š–‡•‹‘‘ˆ–Š‡ ‡„”›‘ǤŠ‡‹†‹˜‹†—ƒŽ‘˜‡‡–•„‡–™‡‡–‹‡ˆ”ƒ‡•‹–Š‡Ǧ†‹”‡ –‹‘‘ˆ–Š‡ –”ƒ ‡† ‡ŽŽ•ƒ”‡“—ƒ–‹ϐ‹‡†Ǥ—”‹‰Žƒ–‡‰ƒ•–”—Žƒ–‹‘–Š‡‰‡‡”ƒŽ ‡ŽŽ‘˜‡‡–• ˜‹•—ƒŽ‹œ‡†™‹–Š–Š‹•‡–Š‘†ƒ”‡‹–Š‡ ‘˜‡”‰‡ ‡†‹”‡ –‹‘ǤŠ‡Ǧ ‘‘”†‹ƒ–‡• ‘ˆ –Š‡ ‡ŽŽ –”ƒ • ƒ”‡ —•‡† ƒ• ƒ ‡ƒ•—”‡‡– ˆ‘” –Š‡ ‘–”‹„—–‹‘ ‘ˆ –Š‡•‡ ‡ŽŽ –”ƒ •–‘ ‘˜‡”‰‡ ‡‘ˆ–Š‡‡„”›‘ǤŠ‡‹†‹˜‹†—ƒŽ‘˜‡‡–•„‡–™‡‡–‹‡ ˆ”ƒ‡•‹–Š‡Ǧ†‹”‡ –‹‘‘ˆ–Š‡–”ƒ ‡† ‡ŽŽ•ƒ”‡“—ƒ–‹ϐ‹‡†ǤŠ‡•–ƒ–‹•–‹ ƒŽƒƒŽ›•‹• Šƒ•„‡‡’‡”ˆ‘”‡†„›–Š‡‹ ”‘•‘ˆ–š ‡Ž–—†‡––Ǧ–‡•–ƒ••—‹‰—‡“—ƒŽ˜ƒ”‹? ƒ ‡•™‹–ŠƒŽ’ŠƒαͲǤͲͷǤ ‡ŽŽ•Šƒ’‡ƒƒŽ›•‹• ‘ƒ Š‹‡˜‡—„‹“—‹–‘—•ϐŽ—‘”‡• ‡–‡„”ƒ‡Žƒ„‡Ž‹‰ǡ–Š‡‡„”›‘•™‡”‡ 36.

(16) ‹Œ‡ –‡†ƒ–ͳ ‡ŽŽ•–ƒ‰‡™‹–ŠʹͲ’‰‘ˆ‡ ‘†‹‰‡„”ƒ‡Ǧ ‹–”‹‡ȋƒ  ˜ƒ”‹ƒ– ™‹–Š ƒ Ǧ–‡”‹ƒŽ ˆ—•‹‘ ‘ˆ –Š‡ ƒ• ‡„”ƒ‡ Ž‘ ƒŽ‹œƒ–‹‘ •‡“—‡ ‡ !"##$%&'()*(+,-./0,12(342(5200(-4/62(,7(342(682-*9,3,5(92-*:289;(929<8/72=5,3= ”‹‡‡š’”‡••‹‰Ž‹˜‡‡„”›‘•™‡”‡‘—–‡†‹ͲǤ͹ͷΨ•‘ˆ–ƒ‰ƒ”‘•‡ƒ––Š‡†‘”•ƒŽ •‹†‡‹‰Žƒ••„‘––‘‡†‡–”‹†‹•Š‡•Ǥ•‹‰ƒʹ‡‹ ƒ ‘ˆ‘ ƒŽ‹ ”‘• ‘’‡–Š‡ ’”‡•‘‹–‹  ‡•‘†‡” ™ƒ• ‹ƒ‰‡† —•‹‰ ƒ ͶͲš ‘‹Ž ‘„Œ‡ –‹˜‡Ǥ

(17) ƒ‰‡• ™‡”‡ ’”‘= ‡••‡†‹

(18) ƒ‰‡ ƒ†ǡƒƒŽ›•‹•‘ˆ ‡ŽŽŽ‡‰–ŠǦ–‘Ǧ™‹†–Š”ƒ–‹‘ƒ†ƒ‰—Žƒ”†‡˜‹ƒ–‹‘ ™ƒ•’‡”ˆ‘”‡†„›–Š‡Šƒ’‡̴‡• ”‹’–‘”ͳ—’Ž—‰‹ȋ›˜‡”—†‡–ƒŽǤǡʹͲͲ͹ȌǤ !"#$%&#

(19) †‡–‹ϔ‹ ƒ–‹‘ƒ†‡š’”‡••‹‘‘ˆœ‡„”ƒϔ‹•Š’–’”ƒǡ’–’”‡ƒƒ†’–’”‡„ )*(/--2--(342(>.753,*7(*>(!"!#$(/7:(!"!#%(,7(2/80?(+2832<8/32(:2+20*69273( ™‡•‡–‘—––‘‹†‡–‹ˆ›–Š‡•‡‰‡‡•‹–Š‡œ‡„”ƒϐ‹•Š‰‡‘‡Ǥ‡„Žƒ•–‡†–Š‡ †‘ƒ‹ ‘ˆ Š—ƒ Ƚ ƒ† ɂ ”‡•’‡ –‹˜‡Ž› ƒ‰ƒ‹•– –Š‡ œ‡„”ƒϐ‹•Š ‰‡‘‡ ˜͹‹–Š‡•‡„Ž†ƒ–ƒ„ƒ•‡Ǥƒ†‹†ƒ–‡‰‡‡Š‹–•™‡”‡ˆ‘—†„ƒ•‡†‘Š‘‘Ž= ‘‰›‘ˆ–Š‡†‘ƒ‹ƒ†•‹‹Žƒ”‹–›‘ˆ–Š‡‘˜‡”ƒŽŽ’”‘–‡‹•–”— –—”‡ǤŠ‡›™‡”‡ „Žƒ•–‡† „ƒ  ƒ‰ƒ‹•– –Š‡ Š—ƒ ‰‡‘‡ ƒ† ƒŽ‹‰‡† ™‹–Š Ƚ ƒ† ɂ ‘ˆ •‡˜‡”ƒŽ•’‡ ‹‡•–‘˜ƒŽ‹†ƒ–‡–Š‡•‡Š‹–•ȋ ‹‰ǤͳȌǡ—•‹‰‡‰ƒͶ•‘ˆ–™ƒ”‡ȋƒ—”ƒ‡– ƒŽǤǡʹͲͲ͹ȌǤ’‘ƒŽ‹‰‹‰‹–„‡ ƒ‡ƒ’’ƒ”‡––Šƒ––Š‡œ‡„”ƒϐ‹•Š‰‡‘‡ ‘–ƒ‹• ‘‡ ‘”–Š‘Ž‘‰ ˆ‘” Ƚ ƒ† –™‘ ˆ‘” ɂǡ ƒ‡† ɂƒ ȋ!"!#%$Ȍ ƒ† ɂ„ "#$%&''(Ƚƒ†ɂƒ”‡ ‘( •‡”˜‡†‹–Š‡œ‡„”ƒϐ‹•Š‰‡‘‡Ǥ ”‘–‡‹ •‡“—‡ ‡• ™‡”‡ ‘„–ƒ‹‡† ˆ”‘•‡„Ž†ƒ–ƒ„ƒ•‡‘ˆȽ ƒ† ɂ ˆ”‘ ˆ—‰—ǡ ‡‘’—•ǡ Š‹ ‡ ƒ† Š—ƒǤ Š‡ Ǧ–‡”= ‹ƒŽ’Š‘•’Šƒ–ƒ•‡†‘ƒ‹•™‡”‡ —•‡† –‘ ƒŽ‹‰ ™‹–Š –Š‡ œ‡„”ƒϐ‹•Š Ƚƒ†–™‘ɂȋǦ–‡”‹ƒŽ 64*-64/3/-2&( 68*32,7( -2@.2752-( —•‹‰ –Š‡  Ͷ ’”‘‰”ƒǤ Š‡ ‡˜‘Ž—–‹‘ƒ”›Š‹•–‘”›™ƒ•‹ˆ‡””‡† —•‹‰–Š‡‡‹‰Š„‘”Ǧ ‘‹‹‰‡–Š= *:' Š‡ ‘’–‹ƒŽ –”‡‡ ™‹–Š –Š‡ •— ‘ˆ „”ƒ Š Ž‡‰–Š α ͲǤͻ͸Ͳ͸͸͹ͷ͹ ‹• •Š‘™Ǥ Š‡ ’‡” ‡–ƒ‰‡ ‘ˆ ”‡’Ž‹ ƒ–‡–”‡‡•‹™Š‹ Š–Š‡ƒ••‘ ‹ƒ–‡†–ƒšƒ Ž—•–‡”‡†–‘‰‡–Š‡”‹–Š‡„‘‘–•–”ƒ’–‡•–ȋͷͲͲ”‡’= Ž‹ ƒ–‡•Ȍ‹••Š‘™‡š––‘–Š‡„”ƒ Š‡•ǤŠ‡–”‡‡‹•†”ƒ™–‘• ƒŽ‡ǡ™‹–Š„”ƒ ŠŽ‡‰–Š•‹–Š‡ -/92(.7,3-(/-(34*-2(*>(342(2+*0.3,*7/8?(:,-3/752-(.-2:(3*(,7>28(342(64?0*A2723,5(3822'()42(2+*= Ž—–‹‘ƒ”›†‹•–ƒ ‡•™‡”‡ ‘’—–‡†—•‹‰–Š‡ƒ›Š‘ˆˆƒ–”‹š„ƒ•‡†‡–Š‘†ƒ†ƒ”‡‹–Š‡—‹–• *>(342(7.9<28(*>(/9,7*(/5,:(-.<-3,3.3,*7-(628(-,32'(#00(6*-,3,*7-(5*73/,7,7A(/0,A79273(A/6-(/7:( ‹••‹‰†ƒ–ƒ™‡”‡‡Ž‹‹ƒ–‡†‘Ž›‹’ƒ‹”™‹•‡•‡“—‡ ‡ ‘’ƒ”‹•‘•ȋ’ƒ‹”™‹•‡†‡Ž‡–‹‘‘’= –‹‘ȌǤŠ‡”‡™‡”‡ƒ–‘–ƒŽ‘ˆʹ͸Ͷ’‘•‹–‹‘•‹–Š‡ϐ‹ƒŽ†ƒ–ƒ•‡–Ǥ. 37. !.

(20) !!"!#$%Ȍ Š‡ ‡ˆ‘”–ŠǤ ‡„”ƒϐ‹•Š !"!#& ™ƒ• ˆ‘—† ‘ Š”‘‘•‘‡ ʹͳ ƒ† ƒ‘" –ƒ–‡†ƒ•’–’”ƒȋ ͲͲͲͲͲͲͲͳ͹͸ͻȌƒ†–Š‡ ‘†‹‰•‡“—‡ ‡‹• ‘•‹•–‡– ™‹–Š–Š‡ –Šƒ–™‡ Ž‘‡†’”‡˜‹‘—•Ž›ȋƒ ‡••‹‘—„‡”ͳͷͺ͹ͶȌȋ˜ƒ†‡” #$%&'(&$)*+&,--,.*&'"!#$&™ƒ•ˆ‘—†‘ Š”‘‘•‘‡͵ǡƒ‘–ƒ–‡†ƒ•ͷ͸͹ͶͶ͵ ȋ ͲͲͲͲͲͲͳͷͺͻͳȌǢ !"!#$% ™ƒ• ˆ‘—† ‘ Š”‘‘•‘‡ ͳ͹ǡ ƒ‘–ƒ–‡† ƒ• ̴ͲͲͳͲ͵ͺ͸ͶʹǤͳȋ ͲͲͲͲͲͲʹͳͳͷͳȌǤŠ‡œ‡„”ƒϐ‹•Š‘”–Š‘Ž‘‰•ƒ”‡Š‹‰ŠŽ› Š‘‘Ž‘‰‘—•–‘Š—ƒƒ†‘—•‡Ƚƒ†ɂǡ•Š‘™‹‰͹͹Ψǡ͸ͺΨƒ†͹ʹΨ ’”‘–‡‹•‡“—‡ ‡‹†‡–‹–›–‘Š—ƒƒ†͹ͷΨǡ͹ͳΨƒ†͹ʹΨ’”‘–‡‹•‡“—‡ ‡ /0'1(/(2&(3&4356'+&%'67'8(/9')2*

(21) ‘”†‡”–‘”‡˜‡ƒŽ–Š‡‡š’”‡••‹‘’ƒ––‡”•‘ˆ!"!#&+&!"!#$&&$10&!"!#$%&%'" •’‡ –‹˜‡Ž›ǡ™‡‰‡‡”ƒ–‡†()*+(",’”‘„‡•ƒ•†‡• ”‹„‡†‹–Š‡ƒ–‡”‹ƒŽ•ƒ†‡–Š" ‘†••‡ –‹‘Ǥ

(22) •Š‘”–ǣƒ‡•–‡†™ƒ•’‡”ˆ‘”‡†‘ƒ Ž‹„”ƒ”›–‘‰‡‡”ƒ–‡ :;<&7%3058(6&67$11/1=&$77%3>/4$(')2&?--&@7&3A&(B'&!"!#&+&!"!#$&&$10&!"!#$%& •ƒ†‹–”‘†— ‹‰ƒ͹–ƒ‰ˆ‘”ƒ–‹•‡•‡–”ƒ• ”‹’–‹‘‘–Š‡͵ƍ&'10*& Š‡’”‘„‡•™‡”‡˜‡”‹ϐ‹‡†„›•‡“—‡ ‹‰Ǥ-)*+(",Š›„”‹†‹œƒ–‹‘‡š’‡”‹‡–••Š‘™ (B$(&!"!#&+&!"!#$&&$10&!"!#$%&$%'&5@/C5/(356)2&'>7%'66'0&05%/1=&'$%)2&6($='6&3A& œ‡„”ƒϐ‹•Š†‡˜‡Ž‘’‡–ȋ ‹‰ǤͳȌǤ–Žƒ–‡”•–ƒ‰‡•ȋʹͶŠ’ˆǡ͵͸Š’ˆƒ†͹ʹŠ’ˆȌ!". !#&+&!"!#$&&$10&!"!#$%ƒ”‡„”‘ƒ†Ž›‡š’”‡••‡†™‹–Š‡Šƒ ‡†Ž‡˜‡Ž•‘ˆ‡š’”‡••‹‘ ‹–Š‡ƒ–‡”‹‘”’ƒ”–•‘ˆ–Š‡‡„”›‘ǤŠ‡’”‘†— –•™‡”‡˜‡”‹ϐ‹‡†„›•‡“—‡ " ‹‰ƒ†•‹ ‡™‡†‡–‡ –‡†‡š’”‡••‹‘‘ˆƒŽŽ–Š”‡‡‰‡‡•ǡ™‡ ‘ Ž—†‡–Šƒ– (B'2&$))&$%'&A518(/31$)&='1'6* Ƚƒ†ɂ‘ †‘™‹†— ‡†Ƭ†‡ˆ‡ –•†—”‹‰‰ƒ•–”—Žƒ–‹‘

(23) ‘”†‡”–‘‘ †‘™‡š’”‡••‹‘‘ˆȽƒ†ɂǡ™‡†‡•‹‰‡†•’Ž‹ ‡ †‘‘”•–ƒ”‰‡–‹‰–Š‡‡š‘‹‡†‹ƒ–‡Ž›—’•–”‡ƒ‘ˆ–Š‡ ƒ–ƒŽ›–‹ •‹–‡‘ˆ–Š‡•‡ ‰‡‡• ƒ† ‹Œ‡ –‡† –Š‡ ƒ– –Š‡ ‘‡ ‡ŽŽ •–ƒ‰‡Ǥ ‡ ˆ‘—† –Šƒ– ͲǤ͵ ‰ ’–’”ƒǦ ‘•‹•–‡–Ž›’”‘†— ‡†•’‡ ‹ϐ‹ †‡ˆ‡ –•‹‡„”›‘‹ †‡˜‡Ž‘’‡–Ǥ’–’”‡ƒǦ‘” ’–’”‡„Ǧ „› –Š‡•‡Ž˜‡• †‹† ‘– ‹†— ‡ ’Š‡‘–›’‡•ǡ ‡˜‡ ƒ– Š‹‰Š ‘ ‡–”ƒ" –‹‘•Ǥ ‘™‡˜‡”ǡʹǤͷ‰’–’”‡ƒǦ–‘‰‡–Š‡”™‹–ŠʹǤͷ‰’–’”‡„Ǧ‹†— ‡†•’‡" ‹ϐ‹  †‡ˆ‡ –•ǡ •—‰‰‡•–‹‰ ”‡†—†ƒ › „‡–™‡‡ –Š‡ –™‘ !"!#$& ='1'6*& D'18'A3%(B+& ’–’”‡ƒǦƒ†’–’”‡„Ǧ™‡”‡ ‘Ǧ‹Œ‡ –‡†ƒ†”‡ˆ‡””‡†–‘ƒ•Dz’–’”‡Ǧ•dzǤŠ‡ ‡ƒ”Ž‹‡•–˜‹•‹„Ž‡†‡ˆ‡ –ˆ‘”„‘–Š’–’”ƒǦƒ†’–’”‡Ǧ•™ƒ•ƒ–ͳͲŠ’ˆ™Š‡–Š‡ ‡„”›‘ˆƒ‹Ž•–‘‡š–‡†’”‘’‡”Ž›ƒ”‘—†–Š‡›‘ŽǤ–Žƒ–‡”•–ƒ‰‡•ȋʹ†’ˆȌ–Š‡Ƚ ‘ †‘™ƒ†ɂ‘ †‘™‡„”›‘•™‡”‡•Š‘”–‡”ƒ†’–’”ƒǦ‹Œ‡ –‡† ‡„”›‘• †‡˜‡Ž‘’‡† ‡†‡ƒ• ƒ”‘—† –Š‡ Š‡ƒ”– ƒ† ›‘Ž ȋ ‹‰•Ǥ ʹǡ ȌǤ Š‡ ‘Ǧ ‹Œ‡ –‡†ǡ ’–’”ƒǦ ƒ† ’–’”‡Ǧ• ‹†— ‡† ƒ ‹ ”‡ƒ•‹‰Ž› •‡˜‡”‡ ’Š‡‘–›’‡ ‡˜‡™Š‡Ž‘™‡”ƒ‘—–•‘ˆ‘”’Š‘Ž‹‘™‡”‡—•‡†Ǥ ƒ•‹‘ƒŽŽ›ǡ™‡‘„•‡”˜‡†ƒ 7B'13(27'&%'6'4@)/1=&(B'&+(/%$#%/(01&45($1(&7B'13(27'&!D'/6'1@'%=&'(&$)*+&,---.& ƒ†–Š‡ ›Ȁ‡•‘ †‘™’Š‡‘–›’‡ȋ ‘’Ž‹‰ƒ††‡ ‡”–‘‰ǡʹͲͲͷȌǡ™‹–Šƒ •—„•‡–‘ˆϐ‹•Š•Š‘™‹‰•‡˜‡”‡ › Ž‘’‹ƒȋ ‹‰•ǤʹȂ ȌǤŠ‡’Š‡‘–›’‡™ƒ•”‡‹‹•" ‡–‘ˆƬ†‡ˆ‡ –•ƒ†–‘˜‡”‹ˆ›–Šƒ–‘ †‘™‘ˆȽƒ†ɂƒˆˆ‡ –‡† 38.

(24) ‹‰Ǥ ʹǤ Ƚ ƒ† ɂ ‘ " †‘™ ϐ‹•Š •Š‘™ ‘˜‡”‰‡ ‡ ƒ† ‡š–‡•‹‘†‡ˆ‡ –•Ǥ ‹Ž†–›’‡ œ‡„”ƒϐ‹•Š ‡„”›‘• ™‡”‡ ‹ ”‘Ǧ‹Œ‡ –‡† ™‹–Š ͲǤ͵ ‰ ’–’”ƒǦ  ȋȌǡ ʹǤͷ ‰ ’–’”‡ƒǦΪ ʹǤͷ ‰ ’–’”‡„ǦȋȌ‘”–”‹’Ž‡‹Œ‡ –‡†™‹–Š ’–’”ƒǦȋͲǤͳͷ‰Ȍƒ†’–’”‡Ǧȋͳ ‰‡ƒ ŠǡȂ Ȍ‡ƒ Šƒ––Š‡ͳ ‡ŽŽ•–ƒ‰‡ ƒ†‰”‘™–‘ͶͺŠ’ˆǤ‹ –—”‡••Š‘™ #&0#&)&,*.*2>&$ &56#7"):$ ?$ ,",92,9 Œ‡ –‡†‡„”›‘‹•‹ Ž—†‡†ˆ‘””‡ˆ‡”9 ‡ ‡ ȋȌǤ ””‘™• ‹†‹ ƒ–‡ •Š‘”–‡” ›‘Ž‡š–‡•‹‘ȋǡȌǡ ƒ”†‹ƒ ‡†‡ƒ ȋȌ‘”ˆ—•‡†‡›‡•ȋ ȌǤȋ Ȍ‡„”ƒϐ‹•Š ‡„”›‘•‹ ”‘Ǧ‹Œ‡ –‡†™‹–Š’–’”ƒǦ  ȋͲǤ͵ ‰Ȁ‡„”›‘Ȍ ‘” ’–’”‡Ǧ ȋʹǤͷ ‰ ’–’”‡ƒǦΪʹǤͷ ‰ ’–’”‡„Ǧ Ȁ‡„”›‘Ȍ ƒ– –Š‡ ‘‡ ‡ŽŽ •–ƒ‰‡ ƒ† ‘Ǧ‹Œ‡ –‡† ‘–”‘Ž ‡„”›‘• ™‡”‡ ‰”‘™ –‘ ͳ •‘‹–‡ •–ƒ‰‡ ƒ† ϐ‹š‡†Ǥ Š‘Ž‡ ‘—– !"# $!%&$ )*.2,2,($ ™ƒ•’‡”ˆ‘”‡†—•‹‰’”‘„‡•ˆ‘”†Žš͹$ .,'$Š‰‰ͷ:$@+&$#&)-/*2,($)*.2,2,($0.*9 –‡”•™‡”‡ƒƒŽ›œ‡†—•‹‰

(25) ƒ‰‡ •‘ˆ–™ƒ”‡ǡ‡ƒ•—”‹‰–Š‡’‘•–‡”‹‘”•Š‹ˆ–‘ˆ–Š‡Š‰‰ͷ$)*.2,2,($.)$ ‹†‹ ƒ–‡†‹–Š‡’ƒ‡Ž‘–Š‡”‹‰Š–ǡƒ†‡ƒ•—”‹‰–Š‡™‹†–Š‘ˆ–Š‡†Žš͹•–ƒ‹‹‰ŠƒŽˆǦ™ƒ›„‡–™‡‡ –Š‡Šƒ– Š‹‰‰Žƒ†ƒ†–Š‡‡†‰‡‘ˆ–Š‡‡„”›‘™Š‡•‡‡ˆ”‘–‘’˜‹‡™™‹–Š–Š‡Šƒ– Š‹‰‰Žƒ† ’‘•‹–‹‘‡†‹–Š‡‹††Ž‡ǤŠ‡‡ƒ•—”‡††‹•–ƒ ‡•™‡”‡’Ž‘––‡†ƒ•–Š‡ƒ˜‡”ƒ‰‡’‘•–‡”‹‘”•Š‹ˆ–‘” ™‹†–Šƒ•ƒ’‡” ‡–ƒ‰‡‘ˆ–Š‡–‘–ƒŽ™‹†–Š‘ˆ–Š‡‡„”›‘ȋ›‘ŽȌǤ””‘”„ƒ”•‹†‹ ƒ–‡•–ƒ†ƒ”††‡˜‹ƒ9 –‹‘•ǡ–—†‡––Ǧ–‡•–•ȋʹ–ƒ‹Ž‡†ǡƒ••—‹‰—‡“—ƒŽ˜ƒ”‹ƒ ‡Ȍ™‡”‡’‡”ˆ‘”‡†„‡–™‡‡‰”‘—’•‹9 †‹ ƒ–‡†ǡȗȗ‹†‹ ƒ–‡•ƒǦ˜ƒŽ—‡δͲǤͲͲͳǤ ƒŽ‡„ƒ”•αʹͷͲɊǤŽš͹AŠ‰‰ͷ$!"#$!%&$'.*.$3.,$6&$3"50.#&'$ ™‹–Š‹‡š’‡”‹‡–•ǡ„—–‘–„‡–™‡‡‡š’‡”‹‡–•„‡ ƒ—•‡‘ˆ•—„–Ž‡†‹ˆˆ‡”‡ ‡•‹‡š’‡”‹‡–ƒŽ 3",'2*2",):$@+2)$&B0&#25&,*$+.)$6&&,$'",&$.*$/&.)*$*+#&&$*25&):$?$#&0#&)&,*.*2>&$&B0&#25&,*$2)$ '&023*&'$+&#&:. Ƭǡ‘”’Š‘Ž‹‘‹Œ‡ –‡†‡„”›‘•™‡”‡ϐ‹š‡†ƒ––Š‡ͳ•‘‹–‡•–ƒ‰‡ƒ†•–ƒ‹‡† !"#$†Žš͹$%&'(&)$"!$*+&$,&-#./$0/.*&1$.,'$ –•Žͷ„$%#&!&##&'$*"$2,$*+2)$.#*23/&$.)$Š‰‰ͷ4$ ’”‡ —”•‘”‘ˆ–Š‡Šƒ– Š‹‰‰Žƒ†Ȍ„›™Š‘Ž‡‘—–!"#$!%&Š›„”‹†‹œƒ–‹‘ȋ ‹‰Ǥʹ ȌǤ Ƭ’Š‡‘–›’‡•™‡”‡ƒ••‡••‡†„›‡ƒ•—”‹‰–Š‡’‘•–‡”‹‘”•Š‹ˆ–‘ˆ–Š‡Šƒ– Š‹‰ ‰Žƒ†ƒ†–Š‡™‹†‡‹‰‘ˆ–Š‡†Žš͹•–ƒ‹‹‰‹‹Œ‡ –‡†ƒ† ‘–”‘Ž‡„”›‘•ƒ• ‹†‹ ƒ–‡†‹–Š‡‹•‡–‘ˆ ‹‰Ǥʹ ǤŠ‡ƒ˜‡”ƒ‰‡Ž‡‰–Š•™‡”‡’Ž‘––‡†ƒ•ƒ’‡” ‡–ƒ‰‡ "!$*+&$&56#7"$'2.5&*&#$.,'$3"50.#&'$*"$3",*#"/$&56#7")$67$8*-'&,*$*9*&)*:$;&$ ˆ‘—†–Šƒ–‘ †‘™‘ˆȽ‘”ɂ•‡˜‡”‡Ž›ƒˆˆ‡ –‡†Ƭ‘˜‡‡–•ȋ ‹‰Ǥ <=1:

(26) ‘”†‡”–‘‡•–ƒ„Ž‹•Š–Š‡‡ˆˆ‡ –‹˜‡‡••‘ˆ–Š‡Ƚ‘ †‘™ǡ™‡ƒƒ9 Ž›œ‡†Ƚ’”‘–‡‹Ž‡˜‡Ž•‹œ‡„”ƒϐ‹•ŠŽ›•ƒ–‡•„›‹—‘„Ž‘––‹‰™‹–Šƒ‹9 —‘•‡”—ƒ‰ƒ‹•–‘—•‡ȽǤ‡ˆ‘—†–Šƒ–’–’”ƒǦ”‡†— ‡†Ƚ’”‘9 –‡‹‡š’”‡••‹‘‹ƒ†‘•‡Ǧ†‡’‡†‡–ƒ‡”ȋ ‹‰Ǥ͵ȌǤ‡’”‘ ‡‡†‡†–‘ ‘Ǧ‹Œ‡ – 39. !.

(27) ‘”’Š‘Ž‹‘• ™‹–Š ˜ƒ”›‹‰ ƒ‘—–• ‘ˆ  ‡ ‘†‹‰ ‘—•‡ Ƚ ‘” ɂǡ ™Š‹ Šƒ”‡‘–”‡ ‘‰‹œ‡†„›–Š‡‹””‡•’‡ –‹˜‡‘”’Š‘Ž‹‘•ǤȽ‘”ɂ ”‡• —‡†–Š‡‘„•‡”˜‡†’Š‡‘–›’‡•™Š‡ ‘Ǧ‹Œ‡ –‡†™‹–Š’–’”ƒǦ‘”’–’”‡Ǧǡ ”‡•’‡ –‹˜‡Ž› ȋ ‹‰•Ǥ ͵ȂȌǤ

(28) Œ‡ –‹‘ ‘ˆ Ƚ ‘” ɂ  ƒ– –Š‡•‡ ‘ ‡–”ƒ! –‹‘•„›‹–•‡Žˆ†‹†‘–ƒˆˆ‡ –‡ƒ”Ž›œ‡„”ƒϐ‹•Š†‡˜‡Ž‘’‡–‘”’Š‘Ž‘‰‹ ƒŽŽ›ȋ†ƒ–ƒ ‘–•Š‘™ȌǤ•ƒ ‘–”‘Žǡ™‡ ‘Ǧ‹Œ‡ –‡†•‹‹Žƒ”ƒ‘—–•‘ˆ ǡ™Š‹ Š†‹† ‘– ”‡• —‡ –Š‡•‡ ’Š‡‘–›’‡• ȋ ‹‰Ǥ ʹȌǤ ‡ ‘ Ž—†‡ –Šƒ– –Š‡ Ƚ ƒ† ɂ ‘ †‘™•™‡”‡•’‡ ‹ϐ‹ ƒ†‹†— ‡†’Š‡‘–›’‡•–Šƒ–™‡”‡ ‘•‹•–‡–™‹–Š†‡! "#$%&'()'*+,'$#--'./0#.#)%&1 Ƭ†‡ˆ‡ –•‹’–’”ƒίȀίœ‡„”ƒϔ‹•Š‡„”›‘•

(29) •‡ƒ” Š‘ˆ‰‡‡–‹ —–ƒ–•–Šƒ–Žƒ ˆ— –‹‘ƒŽȽǡ™‡—•‡†–ƒ”‰‡– •‡Ž‡ –‡†‰‡‡‹ƒ –‹˜ƒ–‹‘ȋ‹‡Š‘Ž†•‡–ƒŽǤǡʹͲͲʹȌƒ†‹†‡–‹ϐ‹‡†ƒ‘•‡•‡—! –ƒ–‹‘ ‹‡š‘͵‘ˆ’–’”ƒǤŠ‡‹†‡–‹ϐ‹‡†!"!#$Š—͹͹͹ͺƒŽŽ‡Ž‡Šƒ•ƒ Ȃ  ‘†‘ Šƒ‰‡”‡•—Ž–‹‰‹ƒͳ͵͵’”‡ƒ–—”‡•–‘’‹–Š‡‡š–”ƒ ‡ŽŽ—Žƒ””‡‰‹‘‘ˆȽǡ Ž‹‡Ž›”‡†‡”‹‰–Š‡’”‘–‡‹‘Ǧˆ— –‹‘ƒŽƒ†Š‡ ‡ˆ‘”™ƒ”†”‡ˆ‡””‡†–‘ƒ•!"% ’”ƒήȀί'"/2'3#%#2/456/7&'8)9'’–’”ƒίȀίˆ‘”Š‘‘œ›‰‘—•—–ƒ–ƒŽŽ‡Ž‡•ȋ ‹‰ǤͶȌǤ

(30)  ”‘••‡•‘ˆŠ‡–‡”‘œ›‰‘—•’–’”ƒήȀίϐ‹•ŠŽ‡†–‘‘”’Š‘Ž‘‰‹ ƒŽ†‡ˆ‡ –•‹ƒ‡†‡! Ž‹ƒ”ƒ–‹‘ǤŠ‡•‡†‡ˆ‡ –•™‡”‡†‡–‡ –ƒ„Ž‡ˆ”‘ʹͶŠ’ˆ‘™ƒ”†•Ǥ

(31) ‘”†‡”–‘˜‡”‹ˆ› –Šƒ–Ƚ’”‘–‡‹‡š’”‡••‹‘™ƒ•ƒˆˆ‡ –‡†ǡŠ‡–‡”‘œ›‰‘—•’–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡† ƒ† –Š‡ ‘ˆˆ•’”‹‰ ™ƒ• •‘”–‡† „ƒ•‡† ‘ ’Š‡‘–›’‡Ǥ – ͷʹ Š’ˆ ‡„”›‘• ™‡”‡Ž›•‡†ƒ†ƒƒŽ›œ‡†„›‹—‘„Ž‘––‹‰™‹–Šƒƒ–‹ǦȽƒ–‹„‘†›ȋ ‹‰Ǥ ͶȌǤȽ‡š’”‡••‹‘™ƒ•”‡ƒ†‹Ž›†‡–‡ –ƒ„Ž‡‹‘”’Š‘Ž‘‰‹ ƒŽŽ›™‹Ž†–›’‡‡! „”›‘• ȋ•‹„Ž‹‰•Ȍǡ ™Š‡”‡ƒ• Ƚ ’”‘–‡‹ ™ƒ• Šƒ”†Ž› †‡–‡ –ƒ„Ž‡ ‹ —–ƒ– ‡! „”›‘•Ǥ š’”‡••‹‘ ‘ˆ ƒ –‹ ™ƒ• ‘‹–‘”‡† –‘ ‘–”‘Ž ˆ‘” ‡“—ƒŽ ’”‘–‡‹ Ž‘ƒ†‹‰Ǥ Š‡‰‡‘–›’‡‘ˆ–Š‡‡„”›‘•–Šƒ–™‡”‡—•‡†ˆ‘”‹—‘„Ž‘––‹‰ ‘—Ž†‘–„‡ †‡–‡”‹‡†„‡ ƒ—•‡Ž›•‹•ˆ‘”‹—‘„Ž‘––‹‰‹•‘– ‘’ƒ–‹„Ž‡™‹–Š‰‡‘–›’‹‰ ’”‘ ‡†—”‡•Ǥ‡˜‡”–Š‡Ž‡••ǡ–Š‡•‡”‡•—Ž–•†‡‘•–”ƒ–‡–Šƒ–Ƚ’”‘–‡‹‡š’”‡•! &(/)'(&'8:/-(&3#9'()'2/763-5'8';782%#2'/"'%3#'/""&<2()6'/"'8)'()$2/&&'/"'3#%#2/45! 6/7&'’–’”ƒήȀίϐ‹•Šǡ™Š‹ Šƒ”‡Ž‹‡Ž›Š‘‘œ›‰‘—•—–ƒ–‡„”›‘•Ǥ

(32)  ”‘••‡•‘ˆ’–’”ƒήȀίϐ‹•Š™‡”‡•‡’ƒ”ƒ–‡†„ƒ•‡†‘‘”’Š‘Ž‘‰›ƒ††‡! ˜‡Ž‘’‡–™ƒ•ˆ‘ŽŽ‘™‡†‘˜‡”–‹‡Ǥ ‹ƒŽŽ›ǡ–Š‡‰‡‘–›’‡‘ˆ–Š‡•‡‡„”›‘•™ƒ• 9#%#2.()#9':5'&#;7#)$()6'/"'<%<28'#=/)'>1'?/./456/7&'.7%8)%'#.:25/&'$8)':#' ‹†‡–‹ϐ‹‡†ƒ•‡ƒ”Ž›ƒ•ʹͶŠ’ˆǡŠƒ˜‹‰•Š‘”–‡”›‘Ž‡š–‡•‹‘•ƒ†ƒ•Š‘”–‡”„‘†› ƒš‹•ȋ ‹‰•ǤͶǡ ǡƒ””‘™ȌǤ–ƒ”–‹‰ˆ”‘ƒ”‘—†ͶͺŠ’ˆ–Š‡•‡‡„”›‘•†‡˜‡Ž‘’‡† ƒ”†‹ƒ ‡†‡ƒ•ȋ ‹‰•ǤͶǡ ȌǤŠ‡’Š‡‘–›’‡‘ˆ’–’”ƒίȀί‡„”›‘•™ƒ•˜‡”›•‹‹! Žƒ”–‘’–’”ƒǦ‹Œ‡ –‡†‡„”›‘•ǡƒ•’–’”ƒǦ‹Œ‡ –‡†‡„”›‘•‰‡‡”ƒŽŽ›Šƒ† •Š‘”–‡”›‘Ž‡š–‡•‹‘•ƒ†ƒŽ•‘†‡˜‡Ž‘’‡† ƒ”†‹ƒ ‡†‡ƒ•ȋ&'( ‹‰•ǤͶƒ†ʹȌǤ –Žƒ–‡”•–ƒ‰‡•–Š‡•‡‡†‡ƒ•‰”‡™„‹‰‰‡”ƒ† ƒ—•‡†„Ž‘‘† ‹” —Žƒ–‹‘–‘•–‘’Ǥ ‘‘œ›‰‘—• —–ƒ– ‡„”›‘• †‹‡† ƒ”‘—† ͷȂ͸ †’ˆ ™‹–Š ƒ••‹˜‡ ƒ”†‹ƒ  ‡†‡! .8&1 40.

(33) ‹‰Ǥ ͵Ǥ Ƚ ‘ †‘™ ƒ„‘Ž" ‹•Š‡† ’”‘–‡‹ ‡š’”‡••‹‘ ƒ† ptpra-MO (ng): 0 0.1 0.4 „‘–Š Ƚ ƒ† ɂ ‘ " intermediate 114 kD Ptpra †‘™•™‡”‡”‡• —‡†„› ‘Ǧ‹Œ‡ " –‹‘‘ˆǤ ȋȌ‡„”ƒϐ‹•Š‡„”›‘•™‡”‡‹ ”‘Ǧ 45 kD actin severe ‹Œ‡ –‡† ƒ– –Š‡ ͳ ‡ŽŽ •–ƒ‰‡ ™‹–Š ’–’”ƒǦ ȋͲǤͳ ‰Ȁ‡„”›‘ ‘” ͲǤͶ ‰Ȁ‡„”›‘Ȍ ƒ† ‰”‘™ –‘ ͷʹ Š’ˆǤ C 100% D 100% „”›‘• ™‡”‡ †‡ Š‘”‹‘ƒ–‡†ǡ 80% 80% †‡›‘Ž‡† ƒ† Ž›•‡† —•‹‰ •‘†‹— 60% 60% +)16+4.,.".1%& .,"& @)+1%.0%& -,! 40% 40% Š‹„‹–‘”•Ǥ ƒ’Ž‡• ‘ˆ ‘Ǧ‹Œ‡ –‡† 20% 20% 0% 0% ‘–”‘Ž ƒ†  ‹Œ‡ –‡† ‡„”›‘• n= 43 26 19 43 38 31 27 34 32 32 n= MO: ptpra ptpra ptpra ptpre ptpre ptpre ptpre ptpre ™‡”‡Ž‘ƒ†‡†‘Ǧ ‹•— Šƒ MO: RNA: 1pg 5pg 1 pg 5 pg 10 pg 25 pg RNA: ™ƒ›–Šƒ–ƒŽŽ •ƒ’Ž‡• ‘–ƒ‹‡“—ƒŽ (mPTPα) (mPTPε) ƒ‘—–• ‘ˆ ’”‘–‡‹Ǥ

(34) —‘„Ž‘–• ™‡”‡ ƒƒŽ›œ‡† ˆ‘” ‡š’”‡••‹‘ ‘ˆ Ƚƒ†ƒ –‹ƒ•ƒŽ‘ƒ†‹‰ ‘–”‘ŽǤȋȂȌ‡„”ƒϐ‹•Š‡„”›‘•™‡”‡‹ ”‘Ǧ‹Œ‡ –‡†™‹–Š’–’”ƒǦ  ȋȌ ‘” ’–’”‡Ǧ ȋȌ ™‹–Š ‘” ™‹–Š‘—–  ‡ ‘†‹‰ ‘—•‡ Ƚ ȋȌ ‘” ɂ ȋȌǤ ! „”›‘•™‡”‡‰”‘™–‘ʹ†’ˆƒ†’Š‡‘–›’‡•™‡”‡ƒ••‹‰‡†ƒ•‹†‹ ƒ–‡†‹’ƒ‡Žǡ™Š‡”‡‡„”›‘• • ‘”‡†ƒ•‘”ƒŽ”‡•‡„Ž‡‘Ǧ‹Œ‡ –‡† ‘–”‘Žǡ‡„”›‘•™‹–Š‘˜‡”ƒŽŽ‘”ƒŽŽ‘‘‹‰’Š‡‘–›’‡ ƒ†„‘†›’Žƒ„—–•Š‘”–‡‡†„‘†›ƒš‹•™‡”‡Žƒ„‡Ž‡†ƒ•‹–‡”‡†‹ƒ–‡ǡƒ†‡„”›‘•™‹–Š•‡˜‡”‡Ž› †‹•”—’–‡†‘”’Š‘Ž‘‰›™‡”‡Žƒ„‡Ž‡†•‡˜‡”‡Ǥ B. normal. Percentage:. Percentage:. A. Š‡‘”’Š‘Ž‘‰‹ ƒŽ†‡ˆ‡ –•ˆ”‘ʹͶŠ’ˆ‘™ƒ”†•™‡”‡ ‘•‹•–‡–™‹–Š†‡! ˆ‡ –•‹Ƭ ‡ŽŽ‘˜‡‡–•†—”‹‰‰ƒ•–”—Žƒ–‹‘–Šƒ–ƒ”‡‘™–‘”‡•—Ž–‹”‡! "#$%"&%'()*+,-$&./-0&%/1%,0-+,2&3+&4%)-5*&16.1&’–’”ƒίȀί&'#1.,10&6.4%&"%5%$1-4%& 789& '+4%'%,10:& %'()*+0& 5)+'& ’–’”ƒήȀί ‹ ”‘••‡• ™‡”‡ ϐ‹š‡† ƒ– –Š‡ ͳ •‘‹–‡ 01.;%&.,"&01.-,%"&5+)&†Žš͹&.,"&Š‰‰ͷ—•‹‰™Š‘Ž‡‘—–!"#$!%&Š›„”‹†‹œƒ–‹‘ȋ ‹‰Ǥ Ͷ

(35) ȌǤŠ‡‡„”›‘•™‡”‡• ‘”‡†‹ƒ•‹‹Žƒ”ˆƒ•Š‹‘ƒ•†‡• ”‹„‡†ƒ„‘˜‡Ǥˆ–‡”‹! †‹˜‹†—ƒŽ•–ƒ‹‹‰ƒ†• ‘”‹‰ǡ–Š‡‡„”›‘•™‡”‡‰‡‘–›’‡†ǤŠ‡”‡ƒ•–Š‡’Š‡‘! –›’‡™ƒ•‘–ˆ—ŽŽ›’‡‡–”ƒ–ǡŠ‘‘œ›‰‘—•'%'()—–ƒ–•†‹•’Žƒ›‡†ƒ•‹‰‹ϐ‹ ƒ– ‹ ”‡ƒ•‡‹’‘•–‡”‹‘”•Š‹ˆ–‘ˆ–Š‡Šƒ– Š‹‰‰Žƒ†ƒ†™‹†‡‹‰‘ˆ–Š‡‡—”ƒŽ’Žƒ–‡ǡ ™Š‹ Š™ƒ• ‘•‹•–‡–™‹–Š–Š‡Ƚ‘ †‘™’Š‡‘–›’‡ǤŽ–Š‘—‰Š‘†‹ˆ! ˆ‡”‡ ‡•„‡–™‡‡™‹Ž†–›’‡•‹„Ž‹‰•ƒ†Š‡–‡”‘œ›‰‘—•&%'()*+0&™‡”‡‘„•‡”˜‡†ƒ– <.1%)&01.;%0:&6%1%)+=*;+#0&%'()*+0&0+'%1-'%0&ƒ’’‡ƒ”‡†–‘•Š‘™ƒ‹–‡”‡†‹ƒ–‡ ’Š‡‘–›’‡™Š‡Ž‘‘‹‰ƒ–†Žš͹>Š‰‰ͷ&01.-,-,;&.1&16%&?&0+'-1%&01.;%2&36-0&'-;61& (%&"#%&1+&.&"+0.;%&‡ˆˆ‡ –„—–„‡ ƒ—•‡–Š‡‡ˆˆ‡ –™ƒ•‘– ‘•‹•–‡–Ž›‘„•‡”˜‡†ǡ™‡ "-"&,+1&-,4%01-;.1%&16-0&.,*&5#)16%)2&3+&4%)-5*&16.1&16%&+(0%)4%"&@6%,+1*@%&™ƒ•‹! †‡‡† ƒ—•‡†„›Žƒ ‘ˆȽ™‡‹Œ‡ –‡†‡„”›‘•ˆ”‘ƒ&’–’”ƒήȀί&-,$)+00&.1&16%& ͳ ‡ŽŽ•–ƒ‰‡™‹–ŠͳͲ’‰œˆǦ’–’”ƒǤ&

(36) Œ‡ –‹‘‘ˆ”‡†— ‡†–Š‡—„‡”‘ˆ —–ƒ–‡„”›‘••Š‘™‹‰&"%5%$1-4%&789&.0&.00%00%"&(*&.,.<*=-,;&†Žš͹&.,"&Š‰‰ͷ& %/@)%00-+,&1+&Ž‡˜‡Ž•‘„•‡”˜‡†‹•‹„Ž‹‰•ȋ ‹‰ǤͶ

(37) ȌǤ‡ ‘ Ž—†‡–Šƒ–Š‘‘œ›‰‘—•& ’–’”ƒίȀί ‡„”›‘• †‹•’Žƒ› Ƭ †‡ˆ‡ –• –Šƒ– ™‡”‡ ”‡• —‡† „› ‹ ”‘‹Œ‡ –‹‘& +5& '%'()Ǥ 41. !.

(38) 42.

(39) ‹‰ǤͶǤ!"!#$•–‘’—–ƒ–‹‘’Š‡‘ ‘’‹‡†–Š‡’–’”ƒ‘ †‘™ƒ† ƒ„‡”‡• —‡†„› œˆǦ’–’”ƒǤ :;<";"'%'()—–ƒ–ȋŠ—͵͵͵ͶȌ™ƒ•‹†‡–‹ϐ‹‡†„›–ƒ”‰‡–•‡Ž‡ –‡†‰‡‡‹ƒ –‹˜ƒ–‹‘Ǥ ‘‘œ›‰‘—• —–ƒ–ȋ–‘’ȌǡŠ‡–‡”‘œ›‰‘—•ȋ‹††Ž‡Ȍƒ†™‹Ž†–›’‡ȋ„‘––‘Ȍ•‡“—‡ ‡•ƒ”‡†‡’‹ –‡†Š‡”‡ƒ†–Š‡  –‘  ‘†‘ Šƒ‰‡”‡•—Ž–‹‰‹ƒͳ͵͵•–‘’‹–Š‡‡š–”ƒ ‡ŽŽ—Žƒ”†‘ƒ‹‹•‹†‹ ƒ–‡†ǤȋȌ ='('4)>?8)6/’–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡†ƒ†–Š‡‹”‘ˆˆ•’”‹‰™ƒ•‰”‘™–‘ͷʹŠ’ˆǤ„”›‘• ™‡”‡ Šƒ”ƒ –‡”‹œ‡†ƒ•—–ƒ–‘”•‹„Ž‹‰„ƒ•‡†‘‘„•‡”˜‡†’Š‡‘–›’‡ǡ†‡ Š‘”‹‘ƒ–‡†ǡ†‡›‘Ž‡† ƒ†Ž›•‡†—•‹‰•‘†‹—‘”–Š‘˜ƒƒ†ƒ–‡ƒ†’”‘–‡ƒ•‡‹Š‹„‹–‘”•ǤŠ‡”‡•—Ž–‹‰Ž›•ƒ–‡•™‡”‡ƒƒ! Ž›œ‡†ˆ‘”Ƚ‡š’”‡••‹‘Ǥ –‹‡š’”‡••‹‘™ƒ•‘‹–‘”‡†ƒ•ƒŽ‘ƒ†‹‰ ‘–”‘ŽǤ ‡–‡”‘œ›‰‘—• ’–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡†ƒ†‘ˆˆ•’”‹‰‡„”›‘•™‡”‡’Š‘–‘‰”ƒ’Š‡†ƒ†‰‡‘–›’‡†ƒ–ʹͶŠ’ˆ ȋǡ ȌǡͶͺŠ’ˆȋǡ Ȍƒ†͹ʹŠ’ˆȋǡ ȌǤ—–ƒ–•ȋȂȌƒ†•‹„Ž‹‰•ȋȂ Ȍƒ”‡•Š‘™Ǥȋ

(40) Ȍ ‡–‡”‘œ›! 8)6/"’–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡†ƒ†‡„”›‘•™‡”‡‡‹–Š‡”‰”‘™–‘ͳ•‘‹–‡•–ƒ‰‡ƒ†ϐ‹š‡† ™‹–Š‘—–‹Œ‡ –‹‘ǡ‘”‹ ”‘Ǧ‹Œ‡ –‡†ƒ––Š‡‘‡ ‡ŽŽ•–ƒ‰‡™‹–ŠͳͲ’‰Ȁ‡„”›‘œˆǦ’–’”ƒƒ† –Š‡‰”‘™–‘ͳ•‘‹–‡•–ƒ‰‡ƒ†ϐ‹š‡†ǤŠ‘Ž‡‘—–#!"#$!%&•–ƒ‹‹‰™ƒ•’‡”ˆ‘”‡†—•‹‰’”‘„‡• -)4"†Žš͹"#$%"Š‰‰ͷǤŠ‡”‡•—Ž–‹‰•–ƒ‹‹‰’ƒ––‡”•™‡”‡ƒƒŽ›œ‡†„›‡ƒ•—”‹‰–Š‡’‘•–‡”‹‘”•Š‹ˆ– ‘ˆ–Š‡Šƒ– Š‹‰‰Žƒ†ƒ†–Š‡™‹†–Š‘ˆ–Š‡†Žš͹•–ƒ‹‹‰ƒ•†‡• ”‹„‡†‹ ‹‰Ǥʹ Ǥˆ–‡”’‹ –—”‡• ™‡”‡–ƒ‡‡„”›‘•™‡”‡Ž›•‡†ƒ†‰‡‘–›’‡†ǤŠ‡ƒ˜‡”ƒ‰‡’‘•–‡”‹‘”•Š‹ˆ–‘ˆ–Š‡Šƒ– Š‹‰‰Žƒ† :Š‰‰ͷȌ ‘” ™‹†–Š ‘ˆ –Š‡ †Žš͹ •–ƒ‹‹‰ ‹• ’Ž‘––‡† ƒ• ƒ ’‡” ‡–ƒ‰‡ ‘ˆ –Š‡ ‡„”›‘ ȋ›‘ŽȌ †‹ƒ‡–‡”Ǥ ȋ Ȍ ‡–‡”‘œ›‰‘—•’–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡†ƒ†‡„”›‘•™‡”‡‰”‘™–‘ͺ•‘‹–‡•–ƒ‰‡ƒ† ϐ‹š‡†ǡ‘”™‹Ž†–›’‡‡„”›‘•™‡”‡‹ ”‘Ǧ‹Œ‡ –‡†ƒ––Š‡‘‡ ‡ŽŽ•–ƒ‰‡™‹–ŠͲǤ͵‰Ȁ‡„”›‘’–’”ƒǦ ‘”’–’”‡Ǧƒ†–Š‡‰”‘™–‘ͺ•‘‹–‡•–ƒ‰‡ƒ†ϐ‹š‡†ǤŠ‘Ž‡‘—–‹•‹–—•–ƒ‹‹‰™ƒ• 3'4-)42'%"6/5$8"34)@'/"-)4"”‘š͸Ͷ"#$%"›‘†ǤŠ‡”‡•—Ž–‹‰•–ƒ‹‹‰’ƒ––‡”•™‡”‡ƒƒŽ›œ‡†„› ‡ƒ•—”‹‰–Š‡”Š‘„‘‡”‡™‹†–Šƒ†–Š‡†‹•–ƒ ‡ˆ”‘–Š‡ͳ•––‘–Š‡ͺ–Š•‘‹–‡Ǥ*%'()"5$.4)//" ‡„”›‘•™‡”‡•—„•‡“—‡–Ž›‰‡‘–›’‡†Ǥ ‘”‡ƒ Š‰”‘—’ƒ”‡’”‡•‡–ƒ–‹˜‡‡„”›‘‹••Š‘™ǤŠ‡ ”Š‘„‘‡”‡™‹†–Šƒ†–Š‡†‹•–ƒ ‡ˆ”‘–Š‡ͳ•––‘–Š‡ͺ–Š•‘‹–‡™‡”‡‡ƒ•—”‡†ǤŠ‡”‡•—Ž–! ‹‰”ƒ–‹‘™ƒ•’Ž‘––‡†ȋȌǤ—–ƒ–ƒ†‘ †‘™‡„”›‘•™‡”‡ ‘’ƒ”‡†–‘™‹Ž†–›’‡‡„”›‘•Ǥ ””‘”„ƒ”•‹ƒŽŽ‰”ƒ’Š•‹†‹ ƒ–‡•–ƒ†ƒ”††‡˜‹ƒ–‹‘•ǡ–—†‡––Ǧ–‡•–•™‡”‡’‡”ˆ‘”‡†ȋʹ–ƒ‹Ž‡†ǡ ƒ••—‹‰—‡“—ƒŽ˜ƒ”‹ƒ ‡Ȍ„‡–™‡‡‹†‹ ƒ–‡†‰”‘—’•™Š‡”‡ȗȗ‹†‹ ƒ–‡•ƒǦ˜ƒŽ—‡δͲǤͲͲͳǡȗƒǦ ˜ƒŽ—‡δͲǤͲͷƒ†‘ƒ•–‡”‹•‹†‹ ƒ–‡•‘•‹‰‹ϐ‹ ƒ–†‹ˆˆ‡”‡ ‡ǡǦ˜ƒŽ—‡δͲǤͲͷǤ ƒŽ‡„ƒ”•αʹͷͲɊǤ. ‘ˆ—”–Š‡” Šƒ”ƒ –‡”‹œ‡–Š‡Ƭ†‡ˆ‡ –’Š‡‘–›’‡‹—–ƒ–ƒ†‘ ! †‘™‡„”›‘•™‡’‡”ˆ‘”‡†!"#$!%&Š›„”‹†‹œƒ–‹‘‡š’‡”‹‡–•™‹–Š”‘š͸Ͷ"#$%" ›‘†’”‘„‡•ƒ––Š‡ͺ•‘‹–‡•–ƒ‰‡ȋ‹‡–ƒŽǤǡʹͲͲͺȌȋ ‹‰ǤͶ ȌǤ‡ƒƒŽ›œ‡†—–ƒ– ƒ†‘ †‘™‡„”›‘•ƒ† ‘’ƒ”‡†–Š‡–‘™‹Ž†–›’‡•‹„Ž‹‰•„›†‡–‡”‹! ‹‰–Š‡”ƒ–‹‘‘ˆ”Š‘„‘‡”‡™‹†–Šƒ††‹•–ƒ ‡ˆ”‘–Š‡ͳ•––‘–Š‡ͺ–Š•‘‹–‡ ȋ ‹‰Ǥ ͶȌǤ ‡ ˆ‘—† ƒ •‹‰‹ϐ‹ ƒ– ‹ ”‡ƒ•‡ ‹ ”Š‘„‘‡”‡ ™‹†–Š –‘ •‘‹–‡ †‹•! –ƒ ‡”ƒ–‹‘ǡ‹†‹ ƒ–‹‰•Š‘”–‡”ƒ†™‹†‡”‡„”›‘•ǤŠ‡•‡”‡•—Ž–•ƒ”‡ ‘•‹•–‡– ™‹–Š–Š‡ ‘ Ž—•‹‘–Šƒ––Š‡Ž‘••‘ˆȽ‘”ɂ„›‘ †‘™‘”—–ƒ–‹‘ &'%"()"*+,"%'-'.(/0 Ƚƒ†ɂ†‘‘–ƒˆˆ‡ – ‡ŽŽ•’‡ ‹ϔ‹ ƒ–‹‘ Ƚ ƒ† ɂ Šƒ˜‡ „‡‡ ”‡’‘”–‡† –‘ ƒˆˆ‡ – •‡˜‡”ƒŽ †‹•–‹ – •‹‰ƒŽ‹‰ ’ƒ–Š™ƒ›•ȋ ‹ŽǦ ‡ƒ†Ž•‘ǡʹͲͲ͵Ǣƒ ƒ•ƒ‡–ƒŽǤǡʹͲͲͷǢƒ•—‘˜ƒ‡–ƒŽǤǡʹͲͲͷǢ ˜‘‹ Š‡”–‡–ƒŽǤǡʹͲͲ͵ȌǤŠ‡•‡’ƒ–Š™ƒ›•ƒ›ƒˆˆ‡ – ‡ŽŽ•’‡ ‹ϐ‹ ƒ–‹‘ǡ™Š‹ Šƒ› 1#23'4"5$('434'(#(5)$")-"(1'"4'/6&(/"-4)2"(1'"†Žš͹7Š‰‰ͷ"/(#5$5$89"5$"(1#("%'-'.(/" 43. !.

(41) ‹ ‡ŽŽ•’‡ ‹ϐ‹ ƒ–‹‘ƒ›„‡‹•–ƒ‡ˆ‘”Ƭ†‡ˆ‡ –•Ǥ‘‡•—”‡–Šƒ– ‡ŽŽ•’‡ ‹ϐ‹! ƒ–‹‘‹•‘–ƒˆˆ‡ –‡†ƒ†–Š‡†‡ˆ‡ –•™‡‘„•‡”˜‡†‹–Š‡‡š’‡”‹‡–•†‡• ”‹„‡† ƒ„‘˜‡ƒ”‡†—‡–‘Ƭ ‡ŽŽ‘˜‡‡–•ǡ™‡’‡”ˆ‘”‡†!"#$!%&Š›„”‹†‹œƒ–‹‘™‹–Š ͸ Š’ˆ ‘Ž†  ‹Œ‡ –‡† ‡„”›‘•ǡ —–ƒ– ‡„”›‘• ƒ† •‹„Ž‹‰• —•‹‰ ƒ ’ƒ‡Ž ‘ˆ ƒ”‡”•–Šƒ–ƒ”‡ƒŽŽ‘™–‘„‡‹˜‘Ž˜‡†‹ ‡ŽŽ•’‡ ‹ϐ‹ ƒ–‹‘ȋ ‹‰ǤͷȌǣ'(")#*(+, -.(/)")%!0#-+(%)!"#1'"#'*-1'Ȍ•’‡ ‹ϐ‹‡• ‡ŽŽ•™‹–Š˜‡–”ƒŽˆƒ–‡•ǡ Š‘”†‹"# Š†$"%&'" ‰‘‘•‡ ‘‹†"#/$0Ȍƒ”‡†‘”•ƒŽ‹œ‹‰ˆƒ –‘”•‹–Š‡œ‡„”ƒϐ‹•Š‘”‰ƒ‹œ‡”ƒ†"(%2!3"#"%32$" ‹•ƒ‡•‘†‡”ƒŽƒ”‡”Ǥ‘‡‘ˆ–Š‡•‡ƒ”‡”•†‹•’Žƒ›‡†ƒ›ƒŒ‘”†‹ˆˆ‡”‡ ‡• ™Š‡Ƚ‘”ɂ‘ †‘™‘”—–ƒ–‡„”›‘•™‡”‡ ‘’ƒ”‡†–‘•‹„Ž‹‰ ()*+,-./" ‘‘•‡ ‘‹†"(01+(..2-&"2&"’–’”ƒίȀί"()*+,-."%11(%+('"3-"*("4-5%3('")-+(" –‘™ƒ”†•–Š‡Ž‡ƒ†‹‰‡†‰‡ƒ†™ƒ•‘–’”‘’‡”Ž›Ž‘ ƒŽ‹œ‡†–‘™ƒ”†•–Š‡ƒ‹ƒŽ’‘Ž‡ǡ ™Š‹ Š‹‰Š–”‡ϐŽ‡ –Ƭ ‡ŽŽ‹‰”ƒ–‹‘†‡ˆ‡ –Ǥƒ‡–‘‰‡–Š‡”ǡ–Š‡•‡”‡•—Ž–••Š‘™ –Šƒ–†‘”•ƒŽȂ˜‡–”ƒŽ•’‡ ‹ϐ‹ ƒ–‹‘™ƒ•‘–ƒˆˆ‡ –‡†‹Š‘‘œ›‰‘—•-%-+2")63%&37" Ƚ‘”ɂ‘ †‘™‡„”›‘•ǡ•—‰‰‡•–‹‰–Šƒ––Š‡‘„•‡”˜‡††‡ˆ‡ –•™‡”‡ †—‡–‘†‡ˆ‡ –‹˜‡‘”’Š‘‰‡‡–‹  ‡ŽŽ‘˜‡‡–•ǡ‘––‘†‡ˆ‡ –•‹ ‡ŽŽ•’‡ ‹ϐ‹ ƒ! 32-&"'6+2&8"8%.3+64%32-&/ ‹•—ƒŽ‹œ‹‰Ƭ ‡ŽŽ‹‰”ƒ–‹‘’ƒ––‡”•ƒ†‹–‡” ƒŽƒ–‹‘

(42) ‘”†‡”–‘˜‹•—ƒŽ‹œ‡Ƭ ‡ŽŽ‘˜‡‡–•ǡ™‡’”‘ ‡‡†‡†–‘–”ƒ ‡’‹„Žƒ•– ‡ŽŽ• †—”‹‰ œ‡„”ƒϐ‹•Š ‰ƒ•–”—Žƒ–‹‘ —•‹‰ ‘ˆ‘ ƒŽ ϐŽ—‘”‡• ‡– ‹ ”‘• ‘’›Ǥ ‡! „”ƒϐ‹•Š‡„”›‘•™‡”‡‹Œ‡ –‡†ƒ––Š‡ͳ ‡ŽŽ•–ƒ‰‡™‹–ŠϐŽ—‘”‡• ‡–Ž›Žƒ„‡Ž‡† ‹•! –‘‡ͳȋ ͳȌ’”‘–‡‹ǡŽƒ„‡Ž‹‰ƒŽŽ— Ž‡‹Ǥ ‘”–‹‡ǦŽƒ’•‡‹ƒ‰‹‰–Š‡‡„”›‘•™‡”‡ †‡ Š‘”‹‘ƒ–‡†ƒ–͵ͲΨ‡’‹„‘Ž›ƒ†‘—–‡†ƒ–•Š‹‡Ž†•–ƒ‰‡‹ͳΨŽ‘™‡Ž–‹‰ ’‘‹– ƒ‰ƒ”‘•‡Ǥ Š‡ ͳǦ‹Œ‡ –‡† ‡„”›‘• ™‡”‡ ’‘•‹–‹‘‡† ™‹–Š –Š‡ †‘”•ƒŽ •‹†‡ ƒ‰ƒ‹•––Š‡ ‘˜‡”•Ž‹’ƒ’’”‘š‹ƒ–‡Ž›ͳͲͲɊƒ–‡”‹‘”–‘•Š‹‡Ž†’‘•‹–‹‘ƒ†‹! ‹‰Ǥ ͷǤ ‘ ‡ŽŽ •’‡ ‹ϐ‹ ƒ–‹‘ †‡! ˆ‡ –• ‹ !"!#$ —–ƒ– ‘” Ƚ ƒ† ɂ ‘ †‘™ ‡„”›‘•Ǥ „”›‘• ™‡”‡ ϐ‹š‡† ƒ– ͸ Š’ˆ ƒ† ™Š‘Ž‡ ‘—– ‹ •‹–— Š›„”‹†‹œƒ! –‹‘ ™ƒ• ’‡”ˆ‘”‡† —•‹‰ ’”‘„‡• 9-+" '*-1'7" Š‘”†‹" # Š†$7" ‰‘‘• ‘‹†" #/$0$" -+" "(# %2!3" #"%32$/" :)*+,-." 9+-)"’–’”ƒήȀί‹ ”‘••‡•™‡”‡’”‘! 5(..('" %&'" 8(&-3,1('" %93(+" !"# $!%&" ;,*+2'2<%32-&/" =43(+&%32>(4,7" ()! „”›‘• ‹Œ‡ –‡† ƒ– –Š‡ ͳǦ ‡ŽŽ •–ƒ‰‡ ™‹–Š’–’”ƒǦȋͲǤ͵‰Ȁ‡„”›‘Ȍ‘” ’–’”‡ǦȋʹǤͷ‰’–’”‡ƒǦΪʹǤͷ‰’–’”‡„ǦȀ‡„”›‘Ȍ™‡”‡—•‡†Ǥƒ Š’ƒ‡Ž†‡’‹ –•‘–Š‡ Ž‡ˆ–ǣƒ‹ƒŽ’‘Ž‡˜‹‡™™‹–Š†‘”•ƒŽ–‘–Š‡”‹‰Š–Ǣ‘–Š‡”‹‰Š–ǣŽƒ–‡”ƒŽ˜‹‡™™‹–Š†‘”•ƒŽ–‘–Š‡”‹‰Š–Ǥ  ƒŽ‡„ƒ”αʹͷͲɊǤ. 44.

(43) ‹‰Ǥ ͸Ǥ ‡ ”‡ƒ•‡† ‘˜‡”‰‡ ‡ ƒ† ‡š–‡•‹‘ ‡ŽŽ ‹‰”ƒ–‹‘ •’‡‡† ƒ† ‡ŽŽ ‹–‡” ƒŽƒ–‹‘ ‹ ’–’”ƒΫȀۏ—–ƒ–Ǥ

(44) ƒ‰‡ ’”‘ ‡••‹‰ —•‡† ˆ‘” ‡ŽŽ –”ƒ ‹‰ ‹ ‘”†‡” –‘ “—ƒ–‹ˆ› ‹! ‰”ƒ–‹‘•’‡‡†•ǣȋȌ‘”‹‰‹ƒŽ•‹‰Ž‡ "!#$%&'(%)*+'(*&,-%.'/(01(&2342&*$( ‹ƒ‰‹‰‘ˆƒ™‹Ž†–›’‡‡„”›‘‹! ”‘Ǧ‹Œ‡ –‡† ™‹–Š ϐŽ—‘”‡• ‡–Ž› Žƒ! 0'$'/(5%#623'(7(8.26'%39(:;<(0%3*.1( %)*+'9(:=<(0%3*.1(%)*+'(8.2&'##'/( „› ™ƒ–‡”•Š‡††‹‰ǡ ȋȌ ƒŽŽ ‘„Œ‡ –• *.'( '.2/'/( 62( *( #%3+$'( 8%>'$( :%3#'6( •Š‘™• Ͷέ ƒ‰‹ϐ‹ ƒ–‹‘ ˆ‘” Žƒ”! ‹–›Ȍǡ ȋȌ ‡˜‡”› ’‹š‡Ž ‹• †‹Žƒ–‡†ǡ ȋ Ȍ ’”‘Œ‡ –‹‘ ‘ˆ –Š‡ ”‡•—Ž–‹‰ ‘„Œ‡ –• -#'/( 42.( 6.*&%3+( 2362( 6?'( 2.%+%! ƒŽ ‹ƒ‰‡ǡ ȋ Ȍ –”ƒ • ‰‡‡”ƒ–‡† „› –”ƒ ‹‰ ƒŽ‰‘”‹–Š ’”‘Œ‡ –‡† ‘–‘–Š‡‘”‹‰‹ƒŽ‹ƒ‰‡ǡȋ Ȍ–”ƒ • ‰‡‡”ƒ–‡† „› –”ƒ ‹‰ ƒŽ‰‘”‹–Š ’”‘Œ‡ –‡†‘–‘–Š‡‘”‹‰‹ƒŽ‹ƒ‰‡Ǣ –Š‡ ›‡ŽŽ‘™ ”‡ –ƒ‰Ž‡ ‹†‹ ƒ–‡• –Š‡ ƒ”‡ƒ ™Š‡”‡ –”ƒ • ˆ‘” ‡š–‡•‹‘ #8''/#(*.'(&2$$'&6'/9(6?'(0$-'(.'&6! ƒ‰Ž‡ ”‡’”‡•‡–• –Š‡ ƒ”‡ƒ ™Š‡”‡ –”ƒ •ˆ‘” ‘˜‡”‰‡ ‡•’‡‡†•ƒ”‡ ‘ŽŽ‡ –‡†Ǥ ȋ

(45) Ȍ –’”ƒήȀί ϐ‹•Š ™‡”‡ ‹Ǧ ”‘••‡† ƒ† ‡„”›‘• ™‡”‡ ‹! Œ‡ –‡†™‹–ŠŽ‡šƒ ‹•–‘‡ͳǤ—„•‡“—‡–Ž›ǡͶȂ͸‡„”›‘•™‡”‡‹ƒ‰‡†‹’ƒ”ƒŽŽ‡Ž—•‹‰ ‘ˆ‘ ƒŽ ‹ ”‘• ‘’›•–ƒ”–‹‰ˆ”‘•Š‹‡Ž†•–ƒ‰‡Ǥ

(46) ƒ‰‡•™‡”‡’”‘ ‡••‡†ƒ•†‡• ”‹„‡†ƒ„‘˜‡ƒ†ƒ˜‡”ƒ‰‡ ‡ŽŽ ‹‰”ƒ–‹‘•’‡‡†™ƒ• ƒŽ —Žƒ–‡†„›†‹˜‹†‹‰–Š‡–”ƒ Ž‡‰–Š„›–Š‡—„‡”‘ˆˆ”ƒ‡•Ǥ ‘”‡˜‡”› ‡š’‡”‹‡––Š‡ƒ˜‡”ƒ‰‡•’‡‡†™ƒ• ƒŽ —Žƒ–‡†‹‡‹–Š‡”–Š‡ ‘˜‡”‰‡ ‡‘”–Š‡‡š–‡•‹‘†‹”‡ ! –‹‘ˆ‘”–›’‹ ƒŽŽ›‘”‡–ŠƒͳͲͲͲ ‡ŽŽ•’‡”‡„”›‘ǤŠ‡‡„”›‘•™‡”‡•—„•‡“—‡–Ž›‰‡‘–›’‡† *3/(6?'(*@'.*+'(&23@'.+'3&'(*3/('>6'3#%23(#8''/#(%3(’–’”ƒίȀߏ—–ƒ–‡„”›‘•™‡”‡’Ž‘––‡†ƒ• ƒ’‡” ‡–ƒ‰‡‘ˆ–Š‡ƒ˜‡”ƒ‰‡•’‡‡†•‹™‹Ž†–›’‡•‹„Ž‹‰•ˆ‘”‡˜‡”›‡š’‡”‹‡–‹†‹˜‹†—ƒŽŽ›ǤŠ‡ ƒ˜‡”ƒ‰‡‘ˆ–Š‡͵‡š’‡”‹‡–•‹•‹†‹ ƒ–‡†ƒ•™‡ŽŽǤ•ƒ’‘•‹–‹˜‡ ‘–”‘Žǡ ‘˜‡”‰‡ ‡ƒ†‡š–‡•‹‘ •’‡‡†™ƒ•†‡–‡”‹‡†‹™–ͷͷ‘ †‘™‡„”›‘•ǡ–Šƒ–ƒ”‡™‡ŽŽ‘™–‘Šƒ˜‡ ‘˜‡”‰‡ ‡ *3/('>6'3#%23(&'$$()2@')'36(/'4'&6#A(B?'(*@'.*+'(.'/-&6%23(/'6'.)%3'/(%3(C(%3/'8'3/'36('>8'.%! ‡–•‹••Š‘™Ǥȋ Ȍ–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡†ƒ†‡„”›‘•™‡”‡‹Œ‡ –‡†™‹–Š Ǧƒ† ʹǦŠ‡””›Ǥ„”›‘•™‡”‡‘—–‡†ƒ†‹ƒ‰‡†ƒ–Žƒ–‡‰ƒ•–”—Žƒ–‹‘•–ƒ‰‡’‘•–‡”‹‘”‘ˆ –Š‡ˆ—–—”‡•‹–‡‘ˆ–Š‡ϐ‹”•–•‘‹–‡‹–Š‡”‡‰‹‘‡š––‘–Š‡‘–‘ Š‘”†Ǥˆ–‡”‹ƒ‰‹‰‡„”›‘•™‡”‡ ‰‡‘–›’‡†ǤŠ‘™ƒ”‡—–ƒ–ƒ†™‹Ž†–›’‡‡„”›‘•Ǥ„–ƒ‹‡†‹ƒ‰‡•™‡”‡’”‘ ‡••‡†ƒ†–Š‡ ƒ‰Ž‡•‘ˆ ‡ŽŽ•™‡”‡†‡–‡”‹‡†—•‹‰

(47) ƒ‰‡ •‘ˆ–™ƒ”‡ƒ†Šƒ’‡̴‡• ”‹’–‘”ͳ—’Ž—‰‹ȋ›˜‡”—† ‡–ƒŽǤǡʹͲͲ͹ȌǤ‡•—Ž–‹‰ƒ‰Ž‡•ƒ”‡ˆ”‘ʹ—–ƒ–‡„”›‘•ƒ†ʹ™‹Ž†–›’‡‡„”›‘•ƒ†ƒ”‡’Ž‘––‡† ‹ƒ”‘•‡†‹ƒ‰”ƒȋȌǤ‡‰–Šƒ†™‹†–Š‘ˆ–Š‡ ‡ŽŽ•™‡”‡†‡–‡”‹‡†‹ƒ•‹‹Žƒ”ˆƒ•Š‹‘ƒ†–Š‡ ”ƒ–‹‘•™‡”‡’Ž‘––‡†ȋȌǤ—–ƒ–•™‡”‡ ‘’ƒ”‡†–‘™‹Ž†–›’‡†ƒ–ƒ—•‹‰–—†‡––Ǧ–‡•–ǡ‡””‘”„ƒ”• ”‡’”‡•‡–•–ƒ†ƒ”††‡˜‹ƒ–‹‘ǡƒ•–‡”‹•‹†‹ ƒ–‡•ƒǦ˜ƒŽ—‡δͲǤͲͲͳǤ 45. !.

(48) ƒ‰‡†ƒ–ͶͲšƒ‰‹ϐ‹ ƒ–‹‘Ǥ––Š‹•’‘•‹–‹‘–Š‡Ƭ‘˜‡‡–•‘ˆ–Š‡‡’‹„Žƒ•– ƒ„‡ Ž‡ƒ”Ž›˜‹•—ƒŽ‹œ‡†Ǥ‡”‡ ‘”†‡†ˆ”‘•Š‹‡Ž†•–ƒ‰‡—–‹ŽͳǦ•‘‹–‡•–ƒ‰‡™‹–Š ʹ‹—–‡‹–‡”˜ƒŽ•Ǥ‹‡ǦŽƒ’•‡‹ƒ‰‡•™‡”‡ƒƒŽ›œ‡†—•‹‰

(49) ƒ‰‡ ǤŠ‡— Ž‡ƒ” Žƒ„‡Ž‹‰™ƒ•—•‡†–‘†‡–‡”‹‡–Š‡’‘•‹–‹‘‘ˆ‹†‹˜‹†—ƒŽ ‡ŽŽ•‹ƒ•‹‰Ž‡‘’–‹ ƒŽ •Ž‹ ‡ˆ‘”‡ƒ Š–‹‡’‘‹–ȋ ‹‰Ǥ͸ȌǤ‘ƒ ‘—–ˆ‘”œǦ†”‹ˆ––Š‡‹ƒ‰‡†˜‘Ž—‡”‡! ‰‹‘‹ Ž—†‡†–Š‡‡˜‡Ž‘’‹‰Žƒ›‡”ȋȌǡ‡’‹„Žƒ•–ǡŠ›’‘„Žƒ•–ǡƒ†–Š‡›‘Ž•› ›! –‹ƒŽŽƒ›‡”™‹–ŠͶɊ•’ƒ ‹‰„‡–™‡‡–Š‡œǦ’‘•‹–‹‘•ǤŠ‡†‹ˆˆ‡”‡ ‡„‡–™‡‡–Š‡ ‡’‹„Žƒ•–ƒ†™ƒ••–”ƒ‹‰Š–ˆ‘”™ƒ”†•‹ ‡–Š‡— Ž‡‹™‡”‡Žƒ”‰‡”ƒ† Ž‡ƒ”! Ž› †‹•–‹‰—‹•Šƒ„Ž‡ ˆ”‘ ‡’‹„Žƒ•– — Ž‡‹Ǥ Š‡ †‹ˆˆ‡”‡ ‡ „‡–™‡‡ Š›’‘„Žƒ•– ƒ† ‡’‹„Žƒ•–™ƒ•‡˜‹†‡–„‡ ƒ—•‡‘ˆ–Š‡†‹ˆˆ‡”‡ ‡‹†›ƒ‹ •‘ˆ–Š‡ƒš‹ƒŽ‡•‡†‘! †‡” ‡ŽŽ•–‘–Š‡‘˜‡”Žƒ›‹‰‡’‹„Žƒ•–Ǥ ”‘•Š‹‡Ž†•–ƒ‰‡–‘͸ͷΨȂ͹ͲΨ‡’‹„‘Ž›–Š‡ ƒš‹ƒŽ ‡•‡†‘†‡” ‡ŽŽ• ‹‰”ƒ–‡† ƒ–‡”‹‘”Ž› ™Š‹Ž‡ –Š‡ ‘˜‡”Ž›‹‰ ‡’‹„Žƒ•– ‡ŽŽ• ™‡”‡•Ž‹‰Š–Ž›‘˜‹‰–‘™ƒ”†•–Š‡˜‡‰‡–ƒŽ’‘Ž‡—†‡”‰‘‹‰–Š‡‡ƒ”Ž›‰ƒ•–”—Žƒ–‹‘ ‡’‹„‘Ž›‘˜‡‡–ǤŠ‡Žƒ›‡”•™‡”‡ƒŽ•‘ Ž‡ƒ”Ž›•‡’ƒ”ƒ–‡†„›”ƒ Š‡–ǯ• Ž‡ˆ–Ǥ•! ‹‰–Š‡•‡’ƒ”ƒ‡–‡”•–Š‡œǦ’‘•‹–‹‘‘ˆ–Š‡‡’‹„Žƒ•– ‡ŽŽ•™ƒ•”‡ƒ†‹Ž›†‡–‡”‹‡† ‹–Š‡†ƒ–ƒǤʹ ‡ŽŽ–”ƒ ‹‰ˆ‘”–Š‡‡’‹„Žƒ•–™ƒ•’‡”ˆ‘”‡†ƒ––Š‹•œǦ’‘•‹–‹‘Ǥ

(50)  ƒ•‡‘ˆœǦ†”‹ˆ––Š‡’‘•‹–‹‘‘ˆ–”ƒ ‹‰™ƒ•ƒ†Œ—•–‡†ƒ ‘”†‹‰Ž›–‘ƒŽ‘™‡”‘”Š‹‰Š! "#$%&'()(&*$+)$),"$)(-"$%&(*)$&.$),"$/#(.)0 ‡ŽŽ–”ƒ ‹‰ǡƬƒƒŽ›•‹•ƒ†‹ƒ‰‡’”‘ ‡••‹‰ ‹‡ǦŽƒ’•‡ ‹ƒ‰‡• ™‡”‡ ƒƒŽ›œ‡† —•‹‰

(51) ƒ‰‡ Ǥ Š‹• ʹ ‹ƒ‰‡ ƒƒŽ›•‹• ’”‘‰”ƒ™ƒ•ƒ‡ƒ„Ž‡ƒ––Š‹•ƒ‰‹ϐ‹ ƒ–‹‘‹–Š‹•”‡‰‹‘„‡ ƒ—•‡–Š‡‹ƒ‰‡† ”‡‰‹‘—•‡†ˆ‘”ƒƒŽ›•‹•™ƒ•ƒ’’”‘š‹ƒ–‡Ž›ϐŽƒ–ƒ†–Š‡”‡‰‹‘‰‘–‡˜‡‘”‡ϐŽƒ–! )"*"/$1"2+3'"$&.$),"$%&'()(&*(*4$+4+(*')$),"$2&5"#'6(%0$7,"$'6(4,)$)(''3"$23#5+)3#"$ ™Š‹ Š™ƒ••–‹ŽŽƒ’’ƒ”‡–™ƒ•„‘–Š’”‡•‡–‹–Š‡—–ƒ–ƒ†™– ‘–”‘Ž‡„”›‘• ƒ†ƒ••— Šƒ ‘—–‡†ˆ‘”™Š‡ ƒŽ —Žƒ–‹‰–Š‡”‡Žƒ–‹˜‡†‹ˆˆ‡”‡ ‡•‘ˆ–Š‡ ‡ŽŽ‹! ‰”ƒ–‹‘•ȋ†ƒ–ƒ‘–•Š‘™ȌǤ

(52) –Š‡‹ƒ‰‡•–Š‡‡„”›‘™ƒ•’‘•‹–‹‘‡†™‹–Š–Š‡ƒ! –‡”‹‘”•‹†‡–‘™ƒ”†•–Š‡–‘’‘ˆ–Š‡‹ƒ‰‡ǤŠ‡ƒ”–‡•‹ƒ ‘‘”†‹ƒ–‡•‘ˆ ‡ŽŽ–”ƒ • ‰‡‡”ƒ–‡†‹–Š‹•™ƒ›”‡’”‡•‡–‡†–Š‡ ‘–”‹„—–‹‘‘ˆ ‡ŽŽ‹‰”ƒ–‹‘–‘ ‘˜‡”! ‰‡ ‡ ȋǦƒš‹•Ȍ ƒ† ‡š–‡•‹‘ ȋǦƒš‹•ȌǤ Š‡ ‡ŽŽ• ™‡”‡ ”‡ƒ†‹Ž› –”ƒ ‡† ƒˆ–‡” •‘‡ ‹ƒ‰‡’”‘ ‡••‹‰ȋ•‡‡„‡Ž‘™Ȍ™‹–ŠƒƒŽ‰‘”‹–Š–Šƒ–‹’Ž‡‡–‡†ˆ‡ƒ–—”‡’‘‹– †‡–‡ –‹‘ƒ†–”ƒ ‹‰ȋ„ƒŽœƒ”‹‹ƒ†‘—‘—–•ƒ‘•ǡʹͲͲͷȌǤŠ‡ƒŽ‰‘”‹–Š‰‡! ‡”ƒ–‡†ƒ”‡’‘”–™‹–Š–Š‡ƒ”–‡•‹ƒ ‘‘”†‹ƒ–‡•ˆ‘”ƒŽŽ–”ƒ ‡†‘„Œ‡ –•ƒ–‡ƒ Š–‹‡ ’‘‹–Ǥ•‹‰–Š‡ ‘‘”†‹ƒ–‡•™‡™‡”‡ƒ„Ž‡–‘ ƒŽ —Žƒ–‡εͳͲͲͲ ‡ŽŽ‘˜‡‡–•’‡” ƒƒŽ›œ‡†‡„”›‘ǡ™Š‹ Š™‡”‡—•‡†–‘†‡–‡”‹‡–Š‡ƒ˜‡”ƒ‰‡ ‘–”‹„—–‹‘‘ˆ–Š‡ ‹†‹˜‹†—ƒŽ ‡ŽŽ–”ƒ •–‘ ‘˜‡”‰‡ ‡ȋǦ†‹”‡ –‹‘Ȍ‘”‡š–‡•‹‘ȋǦ†‹”‡ –‹‘ǡ ‹‰Ǥ ͸ ȌǤ”ƒ •—•‡†ˆ‘”–Š‡ƒƒŽ›•‹•‘ˆ‡š–‡•‹‘™‡”‡ ƒŽ —Žƒ–‡†ˆ”‘ ‡ŽŽ•ƒ––Š‡ ƒš‹ƒŽ‡’‹„Žƒ•–”‡‰‹‘ƒ––‹‡’‘‹–•„‡–™‡‡͹ͲΨƒ†ͻͲΨ‡’‹„‘Ž›Ǥ”ƒ •—•‡† ˆ‘”–Š‡ƒƒŽ›•‹•‘ˆ ‘˜‡”‰‡ ‡™‡”‡ ƒŽ —Žƒ–‡†ˆ”‘ ‡ŽŽ•ƒ––Š‡’ƒ”ƒš‹ƒŽ”‡‰‹‘ ƒ––‹‡’‘‹–•„‡–™‡‡ͻͲΨ‡’‹„‘Ž›ƒ†ͳǦ•‘‹–‡•–ƒ‰‡ˆ”‘–Š‡•ƒ‡†ƒ–ƒ•‡–Ǥ 83"$)&$),"$(**+)"$2,+*4"'$(*$(*)"*'()9:$'(;"$+*/$',+%"$&.$<=$'(4*+6$&.$),"$ 46.

(53) — Ž‡‹ǡ™‡†‡˜‡Ž‘’‡†ƒ††‹–‹‘ƒŽ‹ƒ‰‡’”‘ ‡••‹‰ˆ‘”‡ˆϐ‹ ‹‡––”ƒ ‹‰‘ˆ–Š‡ ‡ŽŽ•Ǥ ƒ‹‰–Š‡‹ƒ‰‡•„‹ƒ”›•‘Ž˜‡•–Š‡’”‘„Ž‡‘ˆ˜ƒ”‹ƒ„Ž‡ϐŽ—‘”‡• ‡–‹–‡•‹–‹‡• ȋ ‹‰Ǥ ͸ȌǤ Š‡ ‘ ƒ•‹‘ƒŽ ‘ —””‡ ‡ ‘ˆ ˆ—•‡† ‘„Œ‡ –• ™ƒ• Šƒ†Ž‡† „› ƒ ™ƒ–‡”! •Š‡††‹‰’”‘ ‡••™Š‹ Š”‡•‡’ƒ”ƒ–‡†‘•–ˆ—•‡†‘„Œ‡ –•ȋ ‹‰Ǥ͸ȌǤŠ‡•‡‘„Œ‡ –• •–‹ŽŽ Šƒ‰‡††—”‹‰–Š‡–‹‡ǦŽƒ’•‡”—‹•‹œ‡ƒ†•Šƒ’‡Ǥ”‘†‹‰‡˜‡”›‘„Œ‡ – –‘ƒ•‹‰Ž‡’‹š‡Ž‰‡‡”ƒ–‡†ƒ‹ƒ‰‡™‹–Š•‹‰Ž‡’‘‹–ƒ”‹‰•”‡’”‡•‡–‹‰–Š‡ ‹†‹˜‹†—ƒŽ ’‘•‹–‹‘• ‘ˆ ‡ƒ Š ‘„Œ‡ – ȋ ‹‰Ǥ ͸ȌǤ ‘” –”ƒ ‹‰ ’—”’‘•‡• –Š‡•‡ •‹‰Ž‡ ’‹š‡Ž•™‡”‡†‹Žƒ–‡†ȋ ‹‰Ǥ͸ȌǤŠ‡–Š‡”‡•—Ž–‹‰‹ƒ‰‡™ƒ•”‡Ǧ’”‘Œ‡ –‡†‘–‘–Š‡ ‘”‹‰‹ƒŽ‹–™ƒ•‡˜‹†‡––Šƒ––Š‡‰‡‡”ƒ–‡†‘„Œ‡ –•”‡’”‡•‡–‡† ‡ŽŽ’‘•‹–‹‘•™‹–Š ƒ˜‡”›Š‹‰Šƒ —”ƒ ›ȋεͻͻΨǡ ‹‰Ǥ͸ ȌǤ ‡†— ‡†Ƭ‘˜‡‡–•‹’–’”ƒίȀί‡„”›‘• ‡—•‡†–Š‡–”ƒ ‹‰‡–Š‘††‡• ”‹„‡†ƒ„‘˜‡–‘“—ƒ–‹ˆ›Ƭ ‡ŽŽ‘˜‡! "#$%&'($'’–’”ƒίȀί‡„”›‘•ƒ†–‘ ‘’ƒ”‡™‹–Š™‹Ž†–›’‡•‹„Ž‹‰•Ǥ‘–Š‹•‡†ǡ )#%#*+,-.+/&'’–’”ƒήȀίϐ‹•Š™‡”‡‹Ǧ ”‘••‡†ƒ†ˆ‘—”–‘•‹š‡„”›‘•™‡”‡‘—–! #0'1$0'("1.#0'1&'0#&2*(3#0'13+4#5'6)#$'2+"71*($.'’–’”ƒίȀߏ—–ƒ–•™‹–Š™‹Ž†! –›’‡ ‡„”›‘• ‰”‡ƒ– ’”‡ ƒ—–‹‘ ™ƒ• –ƒ‡ –‘ ’‘•‹–‹‘ –Š‡ ‡„”›‘• ‹ ƒ •‹‹Žƒ” ™ƒ›Ǥ Š‡ ‡šƒ – ‹ƒ‰‹‰ ’‘•‹–‹‘ ™ƒ• †‡–‡”‹‡† ”‡–”‘•’‡ –‹˜‡Ž› —•‹‰ ‡„”›! +$(2'8#1%/*#&9'($2:/0($.'+%+:(%)&'1$0'&+"(%#&'%)1%')10'0#4#:+7#0'1%'%)#'#$0'+8'%)#' ”—ƒ• ‘‘”†‹ƒ–‡•Ǥƒ–ƒˆ”‘‡„”›‘•–Šƒ–™‡”‡‘–’‘•‹–‹‘‡† ‘””‡ –Ž›‘”–Šƒ– ‘˜‡†•Ž‹‰Š–Ž›†—”‹‰‹ƒ‰‹‰™‡”‡†‹• ƒ”†‡†Ǥ ‘ŽŽ‘™‹‰‹ƒ‰‹‰ǡ–Š‡‡„”›‘• ™‡”‡ ‰‡‘–›’‡† „› •‡“—‡ ‹‰Ǥ Š‡ ”‡Žƒ–‹˜‡ •’‡‡† ‘ˆ ‡ŽŽ• ‹ ’–’”ƒίȀί' #"3*-! ‘• ‘’ƒ”‡†–‘™‹Ž†–›’‡•‹„Ž‹‰•ˆ”‘͵‹†‡’‡†‡–‡š’‡”‹‡–•‹•’Ž‘––‡†‹ ‹‰Ǥ͸

(54) Ǥ‡ ‘•‹•–‡–Ž›ˆ‘—†ƒ”‡†— –‹‘‹‹‰”ƒ–‹‘•’‡‡†‹„‘–ŠǦ†‹”‡ –‹‘ ȋ ‘˜‡”‰‡ ‡Ȍ ƒ† Ǧ†‹”‡ –‹‘ ȋ‡š–‡•‹‘Ȍ ˆ‘” —–ƒ– ‡„”›‘•Ǥ Š‡ •–ƒ–‹•–‹ ƒŽ ƒƒŽ›•‹•Šƒ•„‡‡’‡”ˆ‘”‡†„›–—†‡––Ǧ–‡•–ƒ••—‹‰—‡“—ƒŽ˜ƒ”‹ƒ ‡•™‹–Š ƒŽ’ŠƒαͲǤͲͷǤ ‹ ‡ –Š‡ †ƒ–ƒ ˆ‘” ‡˜‡”› ‡š’‡”‹‡– ‘•‹•–‡† ‘ˆ ‘˜‡” ͳͲͲͲ †ƒ–ƒ! 7+($%&'8+*'#4#*-'#;7#*("#$%9'!Ǧ˜ƒŽ—‡•™‡”‡— ŠŽ‘™‡”–ŠƒͲǤͲͲͲͳǤ‡•–‹ŽŽ†‡! –‡ –‡† ƒ ϐŽ— –—ƒ–‹‘ „‡–™‡‡ ˜ƒŽ—‡• ‘ˆ –Š‡ ”‡Žƒ–‹˜‡ •’‡‡† ˆ‘” —–ƒ–• „‡–™‡‡ ‡š’‡”‹‡–•ǡ™Š‹ Š ‘—Ž†„‡ƒ ‘—–‡†ˆ‘”„›•ƒŽŽ†‹ˆˆ‡”‡ ‡•ˆ”‘‡š’‡”‹‡– %+'#;7#*("#$%'($'%#"7#*1%/*#'($&(0#'%)#'("1.($.'2)1"3#*'+*'&:(.)%'0(88#*#$2#&'($' ’‘•‹–‹‘‹‰‘ˆ–Š‡‡„”›‘Ǥ

(55) ‘”†‡”–‘˜ƒŽ‹†ƒ–‡‘—”‡–Š‘†™‡—•‡†ƒ™‡ŽŽ‘™ *#./:1%+*'+8'<=>'%+'1&&#&&'(%&'#88#2%'+$'2#::'"(.*1%(+$'&7##0'($'+/*'&#%/75'6#'/&#0' ™–ͳͳǦ‹Œ‡ –‡†‡„”›‘•ƒ†ˆ‘—†ƒ”‡†— –‹‘‹‹‰”ƒ–‹‘•’‡‡† ‘’ƒ”‡† –‘‘Ǧ‹Œ‡ –‡†•‹„Ž‹‰•‹ ‘˜‡”‰‡ ‡ȋͳʹΨȌƒ†‡š–‡•‹‘ȋͳͷΨȌǡ™Š‹ Š™ƒ• 2+"71*13:#'%+'%)#'"#1&/*#0'*#0/2%(+$'+8'"(.*1%(+$'&7##0'($'’–’”ƒίȀί'#"3*-+&' ‘’ƒ”‡†–‘•‹„Ž‹‰•ȋ ‹‰Ǥ͸

(56) ȌǤ

(57)  ‘ Ž—•‹‘ǡ™‡Šƒ˜‡†‡˜‡Ž‘’‡†ƒ‡–Š‘†–‘”‡Ž‹! ƒ„Ž›“—ƒ–‹ˆ›Ƭ ‡ŽŽ‘˜‡‡–•—•‹‰–‹‡ǦŽƒ’•‡ ‘ˆ‘ ƒŽ‹ ”‘• ‘’›Ǥ•‹‰ –Š‹• ‡–Š‘†ǡ ™‡ ˆ‘—† –Šƒ– –Š‡ ƒ˜‡”ƒ‰‡ ”‡Žƒ–‹˜‡ •’‡‡† ‘ˆ Ƭ ‡ŽŽ ‘˜‡‡–• †—”‹‰‰ƒ•–”—Žƒ–‹‘™ƒ••‹‰‹ϐ‹ ƒ–Ž›”‡†— ‡†‹’–’”ƒίȀί'"/%1$%'#"3*-+&'2+"! ’ƒ”‡†–‘™‹Ž†–›’‡•‹„Ž‹‰•Ǥ 47. !.

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