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(2) 4 Noonan Syndrome Gain-of-Function Mutations LQ15$6FDXVH=HEUD¿VK*DVWUXODWLRQ'HIHFWV Vincent Runtuwene*, Mark van Eekelen*, John Overvoorde, Holger Rehmann, Helger G. Yntema, Willy M. Nillesen, Arie van Haeringen, Ineke van der Burgt, Boudewijn Burgering and Jeroen den Hertog Dis Model Mech. 2011 May; 4(3): 393–399. *=equal contribution. 99.
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(13) ȌǤ
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(22) ϐ +*5)'"&; @")12"-"7,0$-%(+:+0.&%,#%+*5)'"&%+O1)+&&,#7%*6.$#.%:")*&%":%!3<$&%8+)+% $11$)+#.%$.%PP%2"6)&%1"&.3:+).,-,4$.,"#%?21:D;%E2+%*")12"-"7'%":%.2+%289:3,#g+0.3 +(%+*5)'"&%8$&%*"#,.")+(%5'%.,*+3-$1&+%,*$7,#7;%!".$5-'9%!3<$&3HMN!%&++*+(% ǡϐ +O.+#&,"#%$.%PN%21:%?&611-+*+#.$)'%*$.+),$-%],7;%UPD%$#(%.2+%"/$-%&2$1+%":%.2+% +*5)'"&% $.% +1,5"-'% ?],7;% XAD;% U+/+)+% *")12"-"7,0$-% (+:+0.&% 8+)+% #".% "5&+)/+(% $.%PP%21:%")%MN%21:%,#%+*5)'"&%,#g+0.+(%8,.2%<!A%+#0"(,#7%8,-(3.'1+%!3<$&;%E2+% *")12"-"7,0$-%12+#".'1+&%,#(60+(%5'%!3<$&3HMN!%$.%MN%21:%)$#7+(%,#%&+/+),.'% :)"*%0"*1-+.+-'%(,&")7$#,4+(%+*5)'"&%."%*,-(-'%$::+0.+(%&2").+)%+*5)'"&%?],7;% XAD; ϐ $#(%*,#")%+*5)'"#,0%$O+&%?],7;%X`D;%!"#3,#g+0.+(%0"#.)"-%+*5)'"&%8+)+%$-*"&.% 1+):+0.%&12+)+&%$#(%.2+%)$.,"%":%.2+%*$g")%$#(%*,#")%+*5)'"#,0%$O+&%8$&%$11)"O3 ͳǤ
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(26) ǦͳͲͶͲȋͳɊȌͶǤͷͷǤͷǤ 3 Ǥ ǣͳǤȋȌ $&&+&&*+#.%":%.2+%&2$1+%":%.2+%+*5)'"&%$.%PP%21:;%E2+%)$.,"%":%.2+%-+#7.2%":%.2+%*$g")%$#(%*,#")% $O+&%8$&%(+.+)*,#+(9%$&%,#(,0$.+(%,#%+O$*1-+&%":%&+/+)+-'%$::+0.+(%?."1D9%*,-(-'%$::+0.+(%?*,((-+D% ȋȌǤ ǣͷͲͲɊǤȋȌϐ $#(%*,#")%$O+&%61"#%,#g+0.,"#%":%&'#.2+.,0%<!A&%+#0"(,#7%8,-(3.'1+%?TED%")%*6.$#.%!3<$&%$&%,#3 Ǥ ǡǣǦ +*5)'"&%?!H\D;%H#%$((,.,"#9%<!A%+#0"(,#7%8,-(3.'1+%`3<$:%")%$0.,/$.+(%*6.$#.%`3<$:3QJGGK%8$&% Ǥǣ ȋͲǤͳΨȌǢǣ
(27) ǦͳͲͶͲȋͳɊȌǤȋȌ ͷͶͲʹ ȋͷɊȌͶǤͷϐǤǣ Ǧ 105.
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(29) Ǧ PGNG%."%&611)+&&%("8#&.)+$*%@ABC%$0.,/$.,"#9%8+%:"6#(%.2$.%.2+%(+-+.+),"6&% +::+0.&%":%!3<$&3HMN!%"#%+1,5"-'%$#(%-$.+)%(+/+-"1*+#.%8+)+%0"*1-+.+-'%)+&06+(% ȋ Ǥ ͵ȌǤ ϐ ϐ .2+%0"*1-+.+%)+&06+%":%.2+%!3<$&3HMN!9%!3<$&3IPMQ9%!3<$&3IJGK%$#(%!3<$&3EFGH% *6.$#.&9%$&%8+--%$&%`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`D;%],3 5)"5-$&.%7)"8.2%:$0.")%)+0+1.")%?]I]<D%&,7#$-,#7%,&%$#%61&.)+$*%:$0.")%,#%0"#/+)3 7+#0+%$#(%+O.+#&,"#%0+--%*"/+*+#.&%(6),#7%7$&.)6-$.,"#;%T+%$&&+&&+(%.2+%+::+0.% ͷͶͲʹǦǦ
(30) ʹͶǦ Ǥ
(31) 3 ǡͷͶͲʹ ǦǦ
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(33) ͶǤ Ǧ Ǧ ǦǦ Ǧ Ǥ ?AD% H#% &,.6% 2'5),(,4$.,"#% 8$&% 1+)3 :")*+(% 6&,#7% +*5)'"&% $.% .2+% +,72.3 ȋ̱ͳʹ Ȍ =85>*?% $#(%@A56Ǧ ϐ ǣǦ 3 +(%0"#.)"-%?!H\D%+*5)'"&%")%+*5)'"&% ,#g+0.+(%8,.2%&'#.2+.,0%<!A%+#0"(,#7% 8,-(3.'1+% ?TED% !3<$&% ")% *6.$#.&9% $&% ,#(,0$.+(9% 8+)+% 6&+(;% [")&$-% /,+8&% ":% ϐǦ ǡ Ǥ ǣ ʹͷͲ ɊǤ ȋȌ >)"OMG% &.$,#,#7% $#(% .2+% -+#7.2% :)"*% ϐ3 .+)*,#+(% 6&,#7% H*$7+b% &":.8$)+% $#(% ,&% (+1,0.+(% 2+)+;% K))")% 5$)&% ,#(,0$.+% &;+;*;S% U.6(+#.a&% .3.+&.&% ?.8"3.$,-+(9% $&&6*,#7% 6#+_6$-% /$),$#0+D% 8+)+% 1+):")*+(%5+.8++#%*6.$#.%$#(%8,-(3 .'1+%!3<$&3,#g+0.+(%7)"61&S%hBiG;GGF;% E".$-% #6*5+)&% ":% +*5)'"&% .2$.% 8+)+% 6&+(% :")% .2+% $#$-'&+&% $)+% ,#(,0$.+(% ?#D;% ?\D% K*5)'"&% :)"*% .2+% .)$#&7+#,0% &EFGHIJ:5>'?KLM/%NO9% -,#+9% ,#% 82,02% #+6)$-%0)+&.%0+--&%$)+%*$)>+(9%8+)+%,#3 g+0.+(% $.% .2+% "#+30+--% &.$7+% 8,.2% <!A% +#0"(,#7%!3<AU3HMN!;%E2+%0+)$."2'$-% ,&% *$)>+(% 5'% I]B% ,#% .2+% .)$#&7+#,0% +*5)'"&%$.%N%(1:%$#(%-,#+&%?)+(D%8+)+% ()$8#%(+*$)0$.,#7%.2+%0+)$."2'$-9%:$3 0,-,.$.,#7% $#$-'&,&% ":% .2+% $#7-+% ,#% .2+% 0+)$."2'$-9% 82,02% ,&% $% (,)+0.% *$)>+)% :")% .2+% 8,(.2% $#(% 5-6#.#+&&% ":% .2+% 2+$(&% ":% .2+&+% +*5)'"&;% <+1)+&+#.$3 .,/+% ,*$7+&% ":% $% #"#3,#g+0.+(% 0"#.)"-% ?!H\D%$#(%$%!3<AU3HMN!3,#g+0.+(%+*3 Ǥ ǣͳͲͲɊǤ ȋȌ ϐ 0+)$."2'$-;% E2+%#6*5+)%":%,#(,/,(6$-&%6&+(%?#D%,&%,#(,0$.+(;%A%U.6(+#.a&% .3.+&.%8$&%1+):")*+(S% ϐ ǡδͲǤͲͲͷǤ. ϐ 3 ,#7%*6.$#.%!3<$&3IPMQ9%!3<$&3HMN!%$#(%!3<$&3IJGK9%0"*1$)+(%8,.2%8,-(3.'1+% 289:3,#g+0.+(%$#(%#"#3,#g+0.+(%0"#.)"-&%?],7;%N`D;%!3<$&3EFGH%$-&"%,#(60+(%$%&,73 ϐ ǡ Ǧ ǦǤ *$)>+)%:")%0"#/+)7+#0+%$#(%+O.+#&,"#%0+--%*"/+*+#.&%,&%6C>D%$#(%(EE'%&.$,#,#7% 107. !.
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(35) ʹͶϐ 0+)$."2'$-%?%iG;GFS%U.6(+#.a&%;3.+&.D%?],7;%N\9[D%$#(%2+#0+%8+%0"#0-6(+%.2$.%!3 Ǧ
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(55)
GERELATEERDE DOCUMENTEN
Author: Runtuwene, Vincent Jimmy Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis Date: 2012-09-12...
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To give one example, I approached this by compressing dirt, plant fragments and building debris, collect- ed on the ruins of an early 20th century socialist commune in the
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Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.
Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.
Title: Functional characterization of protein-tyrosine phosphatases in zebrafish development using image analysis.
