Citation
Krens, S. F. G. (2007, September 19). The function of mitogen activated protein kinases in
zebrafish development. Molecular Cell Biology, (IBL) and biophysics, (LION), Faculty of
Science, Leiden University. Retrieved from https://hdl.handle.net/1887/12348
Version: Corrected Publisher’s Version
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The function of
Mitogen Activated Protein Kinases
in zebrafish development
Gabby Krens
The function of
Mitogen Activated Protein Kinases
in zebrafish development
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P. F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 19 september 2007
klokke 15.00 uur door
Simon Frederik Gabriel Krens Geboren te Roosendaal en Nispen,
in 1977
Dr. C.P. Heisenberg • referent
Prof. dr. P.J.J. Hooykaas Prof. dr. B. van de Water Prof. dr. P.C.W. Hogendoorn
Contents
I Functions of the MAPK family in vertebrate development 7
II Specific activation of ERK pathway by chitin oligosaccharides 27 in embryonic zebrafish cell lines
III Characterization and expression patterns of the MAPK family 45
in zebrafish
IV Distinct functions for ERK1 and ERK2 in cell migration 63 processes during zebrafish gastrulation
V ERK1 and ERK2 MAPK are key regulators of distinct target 91 gene signature sets in zebrafish embryogenesis
VI Summary and general discussion 125
• Nederlandse samenvatting 133
• Curriculum vitae 139
• Publications 141
