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The handle http://hdl.handle.net/1887/20635 holds various files of this Leiden University dissertation.

Author: Paus, Roelof Anne de

Title: Impaired type I immunity to mycobacterial infections

Issue Date: 2013-03-20

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Impaired type I immunity to mycobacterial infections

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Greiner Bio-One, BD Biosciences and Life Technologies.

Copyright © 2013 by R. A. de Paus

All rights reserved No part of this publication may be reproduced in any form or by any

means, by print, photocopy, electronically or any other means without permission of the

author.

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Impaired type I immunity to mycobacterial infections

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 20 maart 2013

klokke 16.15 uur

door Roelof Anne de Paus geboren te Dordrecht

in 1965

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Prof. dr. T.H.M. Ottenhoff Prof. dr. M. Yazdanbakhsh

The research presented in this thesis was performed at the Department of Infectious Diseases,

Leiden University Medical Center, Leiden, The Netherlands.

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It is better to travel a mile than to read 1609344 articles.

(naar een uitspraak van Confucius)

Voor mijn ouders

Aan Jenny en Monica

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Contents

Chapter 1 General introduction 9

Outline of the thesis 32

Chapter 2 Disseminated Mycobacterium genavense infection in a patient 43 with a novel partial interleukin-12 receptor β1 deficiency

Extended version of manuscript in Clinical Immunology 2012;144(2):83-86

Addendum IL-12Rβ1 variants and Mendelian susceptibility to mycobacterial 55 to chapter 2 disease: an overview of polymorphisms and mutations

Chapter 3 IL-23 and IL-12 responses in activated human T cells retrovirally 67 transduced with IL-23 receptor variants

Molecular Immunology 2008;45(15):3889-95

Chapter 4 IL-23 modulates CD56

+

/CD3

-

NK Cell and CD56

+

/CD3

+

NK-like 85 T Cell function differentially from IL-12

International Immunology 2009;21(2):145-53

Chapter 5 Functional analysis of naturally occurring amino acid substitutions 103 in human IFN-γR1

Molecular Immunology 2009;47(5) :1023–1030

Chapter 6 Effect of amino acid substitutions in the human IFN-γR2 on 123 IFN-γ responsiveness

Genes and Immunity 2011;12(2):136-44

Chapter 7 Inhibition of the type I immune responses of human monocytes 141 by IFN-α and IFN-β

Cytokine 2013; 61(2):645-55

Chapter 8 The influence of influenza virus infections on the development 163 of tuberculosis

Accepted for publication in Tuberculosis

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Publications 206

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