Pharmacogenetics of antiemetics in Indonesian cancer patients
Perwitasari, D.A.
Citation
Perwitasari, D. A. (2012, January 11). Pharmacogenetics of antiemetics in Indonesian cancer patients. Retrieved from
https://hdl.handle.net/1887/18326
Version: Corrected Publisher’s Version License:
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the
University of Leiden
Downloaded from: https://hdl.handle.net/1887/18326
Note: To cite this publication please use the final published version (if applicable).
Pharmacogenetics of
Antiemetics in Indonesian Cancer Patients
Dyah Aryani Perwitasari
The research presented in this thesis was performed at the Department of Clinical Pharmacy and Toxicology of Leiden University Medical Center, Leiden, The Netherlands, and the Dr Sardjito Hospital, Yogyakarta, Indonesia.
Financial support for the publication of this thesis was provided by AZL Onderzoeks- en Ontwikkelingskrediet Apotheek, and the Netherlands organisation for international cooperation in higher education (Nuffic).
Cover design Esther Ris, Proefschriftomslag.nl Layout Renate Siebes, Proefschrift.nu Printed by Ipskamp Drukkers B.V.
ISBN 978-94-90791-08-7
© 2012 D.A. Perwitasari
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage or retrieval system, without permission in writing from the author.
Pharmacogenetics of
Antiemetics in Indonesian Cancer Patients
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 11 januari 2012
klokke 15.00 uur door
Dyah Aryani Perwitasari
geboren te Semarang, Indonesië in 1976
PROMOTIECOMMISSIE
Promotores Prof.dr. H.-J. Guchelaar Prof.dr. J.W.R. Nortier Copromotor Dr. J. At Thobari
Gadjah Mada Universiteit, Yogyakarta, Indonesië Overige leden Prof.dr. J.G.W. Kosterink
Universitair Medisch Centrum Groningen
Prof.dr. N.K. Aaronson
Academisch Medisch Centrum Universiteit van Amsterdam
Dr. K.J.M. Schimmel
Dr. J.R. Kroep
Leids Universitair Medisch Centrum
Contents
Chapter 1 General introduction 7
Chapter 2 Antiemetic drugs in oncology: pharmacology and individualization by pharmacogenetics
17
Chapter 3 Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy
39
Chapter 4 Differences in 5-Hydroxytryptamine-3B haplotype frequencies between Asians and Caucasians
57
Chapter 5 Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia
67
Chapter 6 Impact of chemotherapy induced nausea and vomiting on quality of life in Indonesian patients with gynecological cancer
89
Chapter 7 General discussion and future perspectives 105
Chapter 8 Summary 115
Chapter 9 Rangkuman (Summary in Indonesian) 119
Chapter 10 Samenvatting (Summary in Dutch) 123
About the author 129
Acknowledgements 133
