Cover Page
The handle http://hdl.handle.net/1887/19077 holds various files of this Leiden University dissertation.
Author: Cohen, Danielle
Title: Clinical significance of C4d in SLE and antiphospholipid syndrome Date: 2012-06-13
clinical significance of c4d in sle and antiphospholipid syndrome
clinical
significance of c4d in sle and antiphospholipid
syndrome
proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden op gezag van Rector Magnificus prof. mr. P.F. van der Heijden
volgens besluit van het College voor Promoties te verdedigen op 13 juni 2012
klokke 11.15 door Danielle Cohen
Geboren te Lambeth, Londen in 1983 Dedicated to my parents and grandfather
dr. E.H.Cohen (1916-2011) who encouraged me to be curious
general introduction 1 Prologue: A case history – 9
2 General introduction: Complement in auto- and alloimmunity and the introduction of c4d –13
3 Diagnosis and management of the antiphospholipid syndrome – 37
part one: c4d and thrombotic complications 4 Potential for glomerular c4d as an indicator of thrombotic
microangiopathy in lupus nephritis – 65
5 Nationwide autopsy study links complement to thrombo-ischemia in neurolupus – 87
part two: c4d and adverse pregnancy outcome 6 Classical complement activation as a footprint for murine and
human antiphospholipid antibody-induced fetal loss – 115 7 C4d as a footprint of maternal anti-fetal immunity in recurrent
miscarriage. A novel pathogenic mechanism – 141
conclusion and discussion
8 General discussion: Pros and cons for c4d as a biomarker – 159 9 Nederlandse samenvatting – 193
appendices
Curriculum Vitae – 201 Bibliography – 203 Acknowledgements – 204 promotiecommissie
Promotor: Prof. Dr. J.A. Bruijn Co-promotores: Dr. I.M. Bajema
Dr. K.W.M. Bloemenkamp Overige Leden: Prof. Dr. T.W.J. Huizinga
Prof. Dr. F.M. Helmerhorst
Prof. Dr. M. Levi (Academisch Medisch Centrum, Amsterdam)
isbn 9789090268002
The studies described in this thesis were performed at the Department of Pathology (head: Prof. Dr. G.J. Fleuren) of the Leiden University Medical Center, the Netherlands
This thesis was supported by:
* The departments of pathology, obstetrics, rheumatology and radiology of the Leiden University Medical Center
* The MD/PhD fund of the Leiden University Medical Center
* Stichting hellp-syndroom Nederland
* Nederlandse Vereniging voor Lupus Erythematodes (nvle)
* Reumafonds Nederland
* bma bv ‘Mosos’
Design: Caroline de Lint, Voorburg (caro@delint.nl)
