ANCA-associated vasculitis : towards patient-tailored therapy Berden, A.E.

ANCA-associated vasculitis : towards patient-tailored therapy

Berden, A.E.

Citation

Berden, A. E. (2011, October 13). ANCA-associated vasculitis : towards patient-tailored therapy. Retrieved from https://hdl.handle.net/1887/17938

Version: Corrected Publisher’s Version License:

Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/17938

Note: To cite this publication please use the final published version (if applicable).

ANCA-associated vasculitis:

towards patient-tailored therapy

Annelies Evaline Berden

ANCA-associated vasculitis: towards patient-tailored therapy

Thesis, Leiden University, Leiden, the Netherlands

© A.E. Berden, 2011, Leiden, the Netherlands

Used with permission:

Chapter 2 © BMJ Publishing Group Ltd., Annals of the Rheumatic Diseases Chapter 5 © John Wiley and Sons, Arthritis & Rheumatism

Chapter 6 © ASN, Journal of the American Society of Nephrology Chapter 7 © ASN, Journal of the American Society of Nephrology

No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without prior written permission of the author.

Printing: Gildeprint Drukkerijen - Enschede, the Netherlands Cover design and illustrations: Willemijn Huijgen

ISBN: 978-90-9026342-7

ANCA-associated vasculitis:

towards patient-tailored therapy

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op donderdag 13 oktober 2011 klokke 15.00 uur

door

Annelies Evaline Berden

geboren te Rotterdam in 1985

PROMOTIECOMMISSIE

Promotor: Prof. dr. J.A. Bruijn Co-promotores: Dr. I.M. Bajema

Dr. E.C. Hagen

Overige leden: Prof. dr. A.J. Rabelink Prof. dr. R.M. Bertina Prof. dr. C.G.M. Kallenberg

The studies described in this thesis were performed at the Department of Pathology (head: Prof. Dr. G.J. Fleuren) of the Leiden University Medical Center, Leiden, the Netherlands.

The printing of this thesis was financially supported by: Astellas Pharma B.V., Friedrich Wegener Stichting, Genzyme Nederland, J.E. Jurriaanse Stichting, Novartis Pharma B.V., Reumafonds, Roche Nederland B.V.

We zijn allang begonnen, maar nu begint het echt.

Joke van Leeuwen

Aan mijn ouders en Barry

CONTENTS

C

1 G

C

2 l

-

anca-

vasculitis

C

3 p

-

(≥ 5

)

535

anca-

C

4 t

outcomein

anca-

C

5 c

w

’

G

:

characterizinG

t

C

6 a

-

andassociatewithrenalhistoloGyin

anca-

C

7 h

anca-

Glomerulonephritis

C

8 s

C

9 n

a

a a

a

B c

a

C l

a

d d

(a

)

9 59

79

101

121

145

177

199 211

229 225

233 235 –

–

–

–

–

–

–

–

–

–

–

–

–