Cover Page
The handle http://hdl.handle.net/1887/66124 holds various files of this Leiden University
dissertation.
Author: Meuleman, T.
Title: Paternal factors in recurrent miscarriage : a role beyond conception
Issue Date: 2018-10-09
Paternal factors in recurrent miscarriage;
A role beyond conception
Tess Meuleman
The studies described in this thesis were performed at the Department of Immunohe- matology and Blood Transfusion and the Department of Gynaecology and Obstetrics at the Leiden University Medical Center, the Netherlands.
Cover Wendy Schoneveld | Wenz id Layout Renate Siebes | Proefschrift.nu
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© 2018 Tess Meuleman
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage or retrieval system, without permission in writing from the author.
Financial support for printing this thesis was kindly provided by the department of Gynaecology and Obstetrics Leiden University Medical Center, Nationaal Referentie Centrum voor Histocompatibiliteit, Stichting Oranjekliniek, Stichting NVLE Fonds, Stichting
Paternal factors in recurrent miscarriage;
A role beyond conception
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 9 oktober 2018
klokke 15.00 uur
door
Tess Meuleman
geboren te Sittard in 1984
Promotoren Prof. dr. F.H.J. Claas Prof. dr. J.J.M. van Lith
Leden promotiecommissie Prof. dr. F. Koning Prof. dr. S. Robertson
Robinson Research Institute, Adelaide, Australia
Prof. dr. I. Joosten
RadboudUMC, Nijmegen
Dr. S. Heidt
Chapter 1 General introduction 7 Chapter 2 HLA associations and HLA sharing in recurrent miscarriage: a
systematic review and meta-analysis
29
Chapter 3 Lower frequency of the HLA-G UTR-4 haplotype in women with unexplained recurrent miscarriage
57
Chapter 4 Paternal HLA-C is a risk factor in unexplained recurrent miscarriage
75
Chapter 5 Beneficial or harmful effect of anti-paternal human leukocyte antibodies on pregnancy outcome? A systematic review and meta-analysis
95
Chapter 6 HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage
113
Chapter 7 Increased complement C4d deposition at the maternal-fetal interface in unexplained recurrent miscarriage
129
Chapter 8 The immunomodulating effect of seminal plasma on T cells 145 Chapter 9 Oral sex is associated with reduced incidence of recurrent
miscarriage
165
Chapter 10 Summary and general discussion 185
Chapter 11 Nederlandse samenvatting 203
Chapter 12 List of abbreviations 212
Authors’ affiliations 214
List of publications 216
Curriculum vitae 218
Dankwoord 219
