University of Groningen
Risk variables for the development of obesity and type 2 diabetes
van der Meer, Tom
DOI:
10.33612/diss.170143787
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Publication date: 2021
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van der Meer, T. (2021). Risk variables for the development of obesity and type 2 diabetes. University of Groningen. https://doi.org/10.33612/diss.170143787
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Risk variables for the development of
obesity and type 2 diabetes
Risk variables for the development
of obesity and type 2 diabetes
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Wednesday 12 May 2021 at 14.30 hours
by
Thomas Peter van der Meer
born on 8 May 1992 in Leiden
Risk variables for the development of obesity and type 2 diabetes PhD thesis, University of Groningen, the Netherlands
The studies in this thesis have been made possible by the Dutch Diabetes Research Foundation (junior Fellowship mw. J.V. van Vliet-Ostaptchouk, project grant 2013.81.1673) and the Endocrinology Fund (as part of the Ubbo Emmius Fund).
Financial support for the printing of this thesis was kindly provided by the University of Groningen Medical Center, the University of Groningen, the Graduate School of Medical Sciences of the University of Groningen, and the Endocrinology Fund (as part of the Ubbo Emmius Fund).
Cover design: Noortje Smit and Off Page, Amsterdam Layout and printing: Off Page, Amsterdam
Copyright Thomas Peter van der Meer, 2021
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior written permission of the authors.
Risk variables for the development
of obesity and type 2 diabetes
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 12 May 2021 at 14.30 hours
by
Thomas Peter van der Meer
born on 8 May 1992 in Leiden
Paranimfen
Charlotte Vollenbrock Hanneke WoutersSupervisor
Prof. B.H.R. WolffenbuttelCo-supervisor
Dr. J.V. van Vliet-OstaptchoukAssessment Committee
Prof. A.F. Bos Prof. J.A. Romijn Prof. O.H. Franco
Paranimfen
Charlotte Vollenbrock Hanneke WoutersSupervisor
Prof. B.H.R. WolffenbuttelCo-supervisor
Dr. J.V. van Vliet-OstaptchoukAssessment Committee
Prof. A.F. Bos Prof. J.A. Romijn Prof. O.H. Franco
Table of Contents
Chapter 1 General introduction and thesis outline 9
Part I Exposure to endocrine disrupting chemicals in the Dutch 21
population and its role in the development of obesity and type 2 diabetes
Chapter 2 Distribution of non-persistent endocrine disruptors in 23
two different regions of the human brain
Chapter 3 Development and interlaboratory validation of 41
two fast UPLC-MS/MS methods determining urinary bisphenols, parabens and phthalates
Chapter 4 Exposure to endocrine disrupting chemicals in 69
the Dutch general population is associated with adiposity-related traits
Chapter 5 Endocrine disrupting chemicals during diet-induced 103
weight loss – a post-hoc analysis of the LOWER study
Chapter 6 Associations between endocrine disrupting chemicals 129
and type 2 diabetes in a pre-diabetic population
Chapter 7 Temporal exposure and consistency of endocrine 157
disrupting chemicals in a longitudinal study of individuals with impaired fasting glucose
Part II Assessment, contextualization, and implementation of 191
risk variables for the development of type 2 diabetes
Chapter 8 Data-driven assessment, contextualization and 193
implementation of 134 variables in their risk for type 2 diabetes: An analysis of Lifelines, a prospective cohort study in the Netherlands
Chapter 9 Summary, general discussion and future perspectives 249
Chapter 10 Appendices 271
Nederlandse samenvatting 273
Acknowledgements (Dankwoord) 281
About the author 285
