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University of Groningen

The roles of noncoding RNAs in B-cel lymphomas

Niu, Fubiao

DOI:

10.33612/diss.134190556

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Niu, F. (2020). The roles of noncoding RNAs in B-cel lymphomas. University of Groningen. https://doi.org/10.33612/diss.134190556

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The Roles of Noncoding RNAs in

B-cell Lymphomas

Fubiao Niu

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The studies presented in this thesis were financially supported by:

University of Groningen, Netherlands

University Medical Center of Groningen, Netherlands

China Scholarship Council (CSC), China

National Science Centre, Poland

The Cock-Hadders foundation, Netherlands

Printing of this thesis was financially supported by the university of Groningen, the Graduate

School of Medical Sciences, University of Groningen.

Cover design: Fubiao Niu

Layout design: Fubiao Niu

Copyright © 2020, F. Niu, The Netherlands

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise without prior written permission of the author.

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The Roles of Noncoding RNAs in

B-cell Lymphomas

PhD thesis

To obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus

and in accordance with

the decision by the College of Deans.

This thesis will be defended in public on

Wednesday 14 October 2020 at 11.00 hours

by

Fubiao Niu

born on 28 December 1986

in Baoding, China

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Supervisor

Prof. J.H.M. van den Berg

Co-supervisors

Dr. A. Dzikiewicz-Krawczyk

Dr. J. L. Kluiver

Assessment committee

Prof. R. F. Jarrett

Prof. P. Heeringa

Prof. G. de Haan

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Paranymphs

Peijia Jiang

Dr. Wangzhao Song (Larissa)

To my family

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Contents

Chapter 1 Introduction and scope of the thesis

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Chapter 2

MicroRNA high throughput loss-of-function screening

reveals an oncogenic role for miR-21-5p in Hodgkin

Lymphoma

Cellular Physiology and Biochemistry, 5 September,

2018

35

Chapter 3

MiR-378a-3p is critical for Burkitt lymphoma cell

growth

Cancers, in revision

65

Chapter 4

The miR-26b-5p/KPNA2 axis is an important regulator

of Burkitt lymphoma cell growth

Cancers, 4 June, 2020

93

Chapter 5

A lncRNA loss-of-function screen revealed a crucial

role of MAFG-AS1 in Burkitt lymphoma cell growth

Manuscript in preparation

133

Chapter 6

Summary, discussion and future perspective

163

Appendix

Nederlandse samenvatting

中文概述

Publications

Acknowledgements

中文致谢

About the author 作者简介

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