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University of Groningen Methodological aspects and standardization of PET radiomics studies Pfaehler, Elisabeth

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University of Groningen

Methodological aspects and standardization of PET radiomics studies

Pfaehler, Elisabeth

DOI:

10.33612/diss.149306583

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Pfaehler, E. (2021). Methodological aspects and standardization of PET radiomics studies. University of

Groningen. https://doi.org/10.33612/diss.149306583

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Methodological aspects

and standardization

of

PET radiomics studies

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4

Methodological aspects and standardization of PET radiomics studies Elisabeth Pfaehler

Copyright © 2020 Elisabeth Pfaehler

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers. The research reported in this thesis was carried out in the Department of Nuclear medicine and Molecular Imaging of the University Medical Center Groningen.

The research reported in this thesis was (partially) financially supported by the research program Strategy (grant nr. 14929).

Printing of this thesis was financially supported by the Graduate School of Medical Sciences and the University Medical Center Groningen.

Cover image: Maya Portolés Pfaehler Layout and design by Elisabeth Pfaehler Printing: Ridderprint | www.ridderprint.nl

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Methodological aspects and

standardization of PET radiomics

studies

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 11 January 2021 at 12.45 hours

by

Elisabeth Anna Gabriele Pfaehler

born on 26 July 1985 in Würzburg, Germany

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Supervisor

Prof. R. Boellaard

Co-supervisor

Dr. J.R. de Jong

Assessment Committee

Prof. A.W.J.M. Glaudemans Prof. L.F. De Geus-Oei Prof. H.W.A.M. De Jong

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Paranymphs

Joyce van Sluis

Saskia Peels-Matthey

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Table of contents

Chapter 1 : Introduction p. 11

Chapter 2: Repeatability and Reproducibility of Radiomic

Features: systematic review and quality of reporting checklist

p. 23

Chapter 3: RaCaT: An open source and easy to use Radiomics

Calculator Tool

p. 49

Chapter 4: Repeatability of

18

F-FDG PET Radiomic Features: a

Phantom Study to Explore Sensitivity to Image Reconstruction

Settings, Noise, and Delineation Method

p. 79

Chapter 5: Experimental multicenter and multivendor

evaluation of PET radiomic features performance using 3D

printed phantom inserts

p.103

Chapter 6:

Procedure and methods to select reproducible and

meaningful PET radiomic features

p.121

Chapter 7: PET segmentation of bulky tumours: strategies to

improve inter-observer variability.

p.141

Chapter 8: Repeatability of two artificial intelligence

approaches for tumour segmentation in PET

p.161

Chapter 9: Textural Feature Based Segmentation: A Repeatable

and Accurate Segmentation Approach for Tumours in PET

Images

p.181

Chapter 10: Summary and future perspectives

p.195

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