University of Groningen
Genomic medicine in inflammatory bowel disease
Voskuil, Michiel
DOI:
10.33612/diss.136307453
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
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Voskuil, M. (2020). Genomic medicine in inflammatory bowel disease. University of Groningen. https://doi.org/10.33612/diss.136307453
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GENOMIC MEDICINE IN
INFLAMMATORY BOWEL DISEASE
Printing of this thesis was financially supported by the University of Groningen, the Graduate School of Medical Sciences of the University Medical Center Groningen, Noord Negentig, Takeda, Pfizer, Mylan, Norgine, TEVA Nederland, Tramedico, Ferring, and Dr. Falk Pharma Benelux B.V.
Printed by Ipskamp Printing
Enschede, the Netherlands Design & layout Bianca Pijl, www.pijlldesign.nl Groningen, the Netherlands
© Copyright: 2020 M.D. Voskuil, Groningen, the Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of the publications included in this thesis.
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties
De openbare verdediging zal plaatsvinden op maandag 9 november 2020 om 14:30 uur
door
Michiel Dirk Voskuil geboren op 10 september 1991
te Nieuwegein
GENOMIC MEDICINE IN
Promotor Prof. dr. R.K. Weersma Copromotor Dr. E.A.M. Festen Beoordelingscommissie Prof. dr. H. Bootsma Prof. dr. G. Bouma Prof. dr. R.H. Sijmons
Paranimfen
Drs. F.J. Voskuil Dr. S.J. de Jongh
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Introduction
General introduction and outline of the thesis
Part I – Aetiology
The genetic background of inflammatory bowel disease: from correlation to causality
Journal of Pathology 2017
Single cell RNA sequencing of blood and ileal T cells from patients with Crohn’s disease reveals tissue-specific characteristics and drug targets
Gastroenterology 2019 (modified version)
Part II – Disease course
Genetic risk scores identify genetic aetiology of inflammatory bowel disease phenotypes
Submitted
Part III – Therapy
Predicting side effects for patients with inflammatory bowel disease: the promise of pharmacogenetics
World Journal of Gastroenterology 2019
Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease
JAMA 2019
Exome-wide association study identifies a frameshift mutation in
ZNF516 as genetic determinant of thiopurine-induced hepatoxicity
in patients with inflammatory bowel disease
In progress 11 21 47 75 93 109 135 Table of contents
Chapter 8
Chapter 9
Chapter 10 Chapter 11
Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease
Alimentary Pharmacology and Therapeutics 2020
COVID-19 and IBD
TNFα-antagonist use and mucosal inflammation are associated with increased intestinal expression of SARS-CoV-2 host protease TMPRSS2 in patients with inflammatory bowel disease
Gastroenterology 2020
Discussion
Summary
General discussion and future perspectives
Appendices Summary in Dutch List of publications Curriculum Vitae Dankwoord 157 179 189 195 219 225 233 237 Table of contents
