University of Groningen
Subcutaneous and sublingual allergen specific immunotherapy in experimental models for
allergic asthma
Hesse, Laura
DOI:
10.33612/diss.158737284
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hesse, L. (2021). Subcutaneous and sublingual allergen specific immunotherapy in experimental models for allergic asthma. University of Groningen. https://doi.org/10.33612/diss.158737284
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Subcutaneous and sublingual
allergen specific immunotherapy in
experimental models for
allergic asthma
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Copyright © 2021
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Cover and chapters: Jannie Smit, Noa en Zoë Heijkens.
Layout: Peter van der Sijde, Groningen, proefschriftgroningen.nl. Druk: Ipskamp printing.
Printing of this thesis was financially supported by: University Medical Center Groningen (UMCG), the Graduate school of Medical Sciences Groningen (GSMS, GUIDE), Dhr. A.C. (Kees) van der Graaf, CEO Citeq Biologics Groningen.
The research in this thesis was financially supported by: het Longfonds (Netherlands Lung Foundation, NAF 10.060), Noordelijke CARA stichting (NCS), Biobased economy BioBrug Projects 91, 97, 103, and 108 in collaboration with Synvolux Therapeutics BV, Citeq Biologics BV, and DC4U Technologies BV.
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Subcutaneous and sublingual
allergen specific immunotherapy in
experimental models for
allergic asthma
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 1 maart 2021 om 11.00 uur
door
Laura Hesse
geboren op 4 september 1983 te Groningen
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Promotores
Prof. dr. ir. M.C. Nawijn
Prof. dr. A.J.M. van Oosterhout
Copromotor
Dr. J.N.G. Oude Elberink
Beoordelingscommissie
Prof. dr. R. Gosens
Prof. dr. J. Schwarze
Prof. dr. R. Gerth Van Wijk
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Paranimfen
Ronald Hesse MBA
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Tabel of Content
Chapter 1. Introduction 9
Review in preparation
Chapter 2. Low-dose SCIT using GP aggravates symptoms in a murine 55 model of allergic asthma
Manuscript in preparation
Chapter 3. SCIT suppresses Th2 inflammation and induces neutralizing 77 antibodies but SLIT suppresses AHR in GP mouse models for allergic asthma
Clin Exp Allergy. 2018 Aug;48(8):1035-1049.
Chapter 4. 1,25(OH)2VitD3 supplementation enhances suppression 105 of GP-induced allergic asthma by SCIT and SLIT in
a mouse model
Sci Rep. 2020 Jun 2;10(1):8960.
Chapter 5. Vitamin D3 enhances the effects of SCIT in a GP-driven 135 mouse model of asthma
Sci Rep. 2020 Nov 30;10(1):20876.
Chapter 6. SCIT using modified Phl p5a-derived peptides efficiently 155 alleviates allergic asthma in mice
Allergy. 2019 Dec;74(12):2495-2498.
Chapter 7. SCIT with purified Der p1 and 2 suppresses type-2 immunity 177 in a murine asthma model
Allergy. 2018 Apr;73(4):862-874.
Chapter 8. Methods for experimental AIT: s.c. and s.l. desensitization in 199 mouse models of allergic asthma
Methods Mol Biol. 2017;1559:137-168. Methods Mol Biol. 2021;2223:295-335.
Chapter 9. General discussion and future perspectives 237
Chapter 10. Summary 263
Chapter 11. Nederlandse Samenvatting 269
Chapter 12. Addenda 281
List of abbreviations 282
Dankwoord 285
Curriculum Vitae 293
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