University of Groningen
Lipotoxicity in Non-alcoholic Fatty Liver Disease: Mechanisms and Prevention in Experimental
Models
Geng, Yana
DOI:10.33612/diss.130260314
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Geng, Y. (2020). Lipotoxicity in Non-alcoholic Fatty Liver Disease: Mechanisms and Prevention in Experimental Models. University of Groningen. https://doi.org/10.33612/diss.130260314
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Lipotoxicity in
Non-alcoholic Fatty Liver Disease:
Mechanisms and Prevention in
Experimental Models
The research presented in this thesis was performed in the Department of Gastroenterology and Hepatology, Faculty of Medical Sciences, University Medical Center Groningen (UMCG), University of Groningen, the Netherlands.
The research described In this thesis was financially supported by the China Scholarship Council (CSC), Graduate School of Medical Science, University of Groningen and De Stichting De Cock-Hadders.
The author gratefully acknowledges the financial support of the University Medical Center Groningen (UMCG), Graduate School of Medical Sciences (GUIDE) and University of Groningen (RUG) for printing the thesis.
Cover design: Yana Geng
Printing: Ridderprint BV | www.ridderprint.nl
Copyright © Yana Geng. 2020. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without written permission of the author.
Lipotoxicity in
Non-alcoholic Fatty Liver Disease:
Mechanisms and Prevention in
Experimental Models
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Tuesday 25 August 2020 at 11.00 hours
by
Yana Geng
born on 27 February 1990
Supervisors
Prof. A.J. Moshage Prof. K.N. Faber
Co-supervisor
Dr. J. Blokzijl
Assessment Committee
Prof. J. Fernandez-Checa Prof. A.J.A. van de Sluis Prof. M. Schmidt
To the lives sacrificed due to these studies, may we deserve it.
Paranymphs
Fabio.A. Aguilar Mora Shanshan Song
TABLE OF CONTENT
CHAPTER 1 ... - 9 -
Introduction to the thesis CHAPTER 2 ... - 17 -
Lipotoxicity in non-alcoholic fatty liver diseases: Mechanisms and clinical implications CHAPTER 3 ... - 45 -
Protective effect of metformin against palmitate-induced hepatic cell death Biochim Biophys Acta Mol Basis Dis, 2020. 1866(3): p. 165621. CHAPTER 4 ... - 71 -
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes CHAPTER 5 ... - 89 -
Differential toxicity of oleate and palmitate on liver sinusoidal endothelial and vascular endothelial cells in vitro CHAPTER 6 ... - 111 -
Chemical Hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles Biochim Biophys Acta Mol Basis Dis, 2020. 1866(6): p. 165753. CHAPTER 7 ... - 143 -
Conditioned medium of hepatic stellate cells induces an inflammatory phenotype in Kupffer cells via the release of extracellular vesicles CHAPTER 8 ... - 163 -
Summary and perspectives APPENDIX ... - 171 -
Nederlandse samenvatting ... -172-
Acknowledgements ... -175-
List of publications ... -178-
