University of Groningen Ageing and vaccination in transplant patients Wang, Lei

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University of Groningen

Ageing and vaccination in transplant patients

Wang, Lei

DOI:

10.33612/diss.160954435

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Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Wang, L. (2021). Ageing and vaccination in transplant patients. University of Groningen. https://doi.org/10.33612/diss.160954435

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556416-L-bw-Wang 556416-L-bw-Wang 556416-L-bw-Wang 556416-L-bw-Wang Processed on: 26-2-2021 Processed on: 26-2-2021 Processed on: 26-2-2021

Processed on: 26-2-2021 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

Ageing and vaccination in

transplant patients

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Cover image: ESO/B. Tafreshi (twanight.org) Bookmark image: A. Ghizzi Panizza / ESO

Cover & bookmark design: Lei Wang / Jingtong Gao Layout: Lei Wang

Printing: Ipskamp

ISBN: 978-94-6421-268-6

The research presented in this thesis was financially supported by: China

Scholarship Council, Jan Kornelis de Cock Stichting and the Graduate School of Medical Sciences of the University Medical Center Groningen. The printing of this thesis was financially supported by: University of Groningen and the

Graduate School of Medical Sciences of the University Medical Center Groningen.

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Ageing and vaccination in

transplant patients

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga and in accordance with

the decision by the College of Deans. This thesis will be defended in public on Wednesday 14 April 2021 at 11.00 hours

by

Lei Wang

born on 11 October 1990 in Shanxi, China

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Supervisor

Prof. N.A. Bos

Co-supervisors

Dr. J. Westra

Dr. E.A.M. Verschuuren

Assessment Committee

Prof. H.A.M. Kerstjens Prof. D. van Baarle Prof. C.A.C.M. van Els

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7 17 43 63 85 109 133 147 167 171 175 176

TABLE OF CONTENT

Chapter 1 Introduction

Chapter 2 Herpes Zoster and Immunogenicity and Safety of Zoster Vaccines

in Transplant Patients: a Narrative Review of the Literature

Front. Immunol. 2018;9:1632

Chapter 3 Prophylactic Vaccination with a Live-Attenuated Herpes Zoster

Vaccine in Lung Transplant Candidates

J Heart Lung Transplant. 2020 Dec;39(12):1445-1454

Chapter 4 Ageing of Immune System and Response to a Live-Attenuated

Herpes Zoster Vaccine in Lung Transplant Candidates

Vaccines.2021 (accepted for publication)

Chapter 5 Ageing of T- and B- cells in End-stage Renal Disease Patients

Before and After Kidney Transplantation

Submitted

Chapter 6 Immune Response to Varicella-Zoster Virus Before and After

Renal Transplantation

Antiviral Res. 2020 Nov;183:104938

Chapter 7 The Role of JNK and P38 MAPK Pathways during

Varicella-Zoster Virus Infection in the Ageing Cell Model

Work in progress

Chapter 8 Summary, Discussion and Future Perspectives Appendix Nederlandse samenvatting

Acknowledgements Curriculum Vitae List of publications

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