University of Groningen
Iron Deficiency and Erythropoietin Excess: Two Sides of the Same Coin?
Eisenga, Michele Freerk
DOI:
10.33612/diss.98865528
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Eisenga, M. F. (2019). Iron Deficiency and Erythropoietin Excess: Two Sides of the Same Coin? studies in patients with chronic kidney disease and in the general population. Rijksuniversiteit Groningen.
https://doi.org/10.33612/diss.98865528
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Iron Deficiency and Erythropoietin Excess:
Two Sides of the Same Coin?
Studies in Patients with Chronic Kidney Disease and in the General Population
Michele Freerk Eisenga
Iron Defi ciency and Erythropoietin Excess: Two Sides of the Same Coin?
Financial support by the University of Groningen, University Medical Center Groningen and Graduate School of Medical Sciences for publication of this thesis is gratefully ac-knowledged.
Further, fi nancial support for the printing of this thesis was also kindly provided by:
2
Michele Freerk Eisenga
Iron Deficiency and Erythropoietin Excess: Two Sides of the Same Coin?
Financial support by the University of Groningen, University Medical Center Groningen and Graduate School of Medical Sciences for publication of this thesis is gratefully acknowledged.
Further, financial support for the printing of this thesis was also kindly provided by:
Copyright © 2019. Michele F. Eisenga
All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without the written permission from the author.
ISBN (printed): 978-94-6361-329-3 Cover design: Erwin Timmerman
Lay-out and printing: Optima Grafische Communicatie, Rotterdam, the Netherlands
Copyright © 2019. Michele F. Eisenga
All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without the written permission from the author.
ISBN (printed): 978-94-6361-329-3 Cover design: Erwin Timmerman
Iron Deficiency and Erythropoietin Excess:
Two Sides of the Same Coin?
Studies in Patients with Chronic Kidney Disease and in the General Population
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 30 oktober 2019 om 16.15 uur
door
Michele Freerk Eisenga
geboren op 8 juni 1988Promotores
Prof. dr. S.J.L. Bakker Prof. dr. C.A.J.M. Gaillard
Beoordelingscommissie
Prof. dr. I.C. Macdougall Prof. dr. D.W. Swinkels Prof. dr. A.A. Voors
Paranimfen
I. Minović, PharmD, PhD M.R. Postma, M.D.
TaBlE oF ConTEnTS
Chapter 1 Introduction 9
Iron
Chapter 2 Iron Deficiency, Anemia, and Mortality in Renal Transplant Recipients
Transplant International 2016; 29: 1176-1183
29
Chapter 3 C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and
Mortality in Renal Transplant Recipients
Journal of the American Society of Nephrology 2017;28:3639-3646
45
Chapter 4 Associations of Different Iron Deficiency Cutoffs with Adverse
Outcomes in Chronic Kidney Disease BMC Nephrology 2018; 19: 225
63
Chapter 5 Association of Hepcidin-25 with Survival after Kidney
Transplantation
European Journal of Clinical Investigation 2016; 46: 994-1001
89
Erythropoietin
Chapter 6 Effects of Erythropoietin on Fibroblast Growth Factor 23 in Mice and
Humans
Nephrology Dialysis Transplantation 2018: Epub ahead of print
105
Chapter 7 Erythropoietin, Fibroblast Growth Factor 23, and Mortality in Kidney
Transplant Recipients Submitted
139
Chapter 8 Epoetin Beta and C-Terminal Fibroblast Growth Factor 23 in Patients
with Chronic Heart Failure and Chronic Kidney Disease Journal of the American Heart Association 2019; 8(16):e011130
157
Iron and Erythropoietin beyond CKD
Chapter 9 Iron Deficiency, Elevated Erythropoietin, Fibroblast Growth Factor 23
and Mortality in the General Population of the Netherlands: a Cohort Study
PLOS Medicine 2019;16(6):e1002818
173
Chapter 10 Active Smoking and Hematocrit and Fasting Circulating
Erythropoietin Concentrations in the General Population Mayo Clinic Proceedings 2018; 93: 337-343
Chapter 11 Rationale and Design of TransplantLines: a Prospective Cohort Study
and Biobank of Solid Organ Transplant Recipients BMJ Open 2018; 8: e024502
207
Chapter 12 Summary, discussion, and future perspectives
Dutch summary / Nederlandse samenvatting Appendix (NtvG article)
Acknowledgements / Dankwoord Author Affiliations
About the author List of publications 235 249 259 273 283 291 295
