Radiation-induced cardiac toxicity in breast cancer patients
van den Bogaard, Veerle
DOI:
10.33612/diss.144684776
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Publication date: 2020
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van den Bogaard, V. (2020). Radiation-induced cardiac toxicity in breast cancer patients. University of Groningen. https://doi.org/10.33612/diss.144684776
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RADIATION-INDUCED CARDIAC TOXICITY IN
BREAST CANCER PATIENTS
Financial support for printing this thesis was kindly provided by the department of radiation oncology at the University Medical Center Groningen, RaySearch Laboratories, the University of Groningen, Elekta, and the University Medical Center Groningen.
Cover and layout design: Off Page, Amsterdam Printing: Off Page, Amsterdam ISBN: 978-94-93197-31-2
© Copyright 2020 V.A.B. van den Bogaard, the Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of the publications included in this thesis.
RADIATION-INDUCED CARDIAC TOXICITY IN
BREAST CANCER PATIENTS
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 23 november 2020 om 11.00 uur
door
Veerle Anne Barbara van den Bogaard geboren op 13 december 1988
Dr. J.H. Maduro
BEOORDELINGSCOMMISSIE
Prof. dr. L.J. Boersma Prof. dr. ir. F.E. van Leeuwen Prof. dr. P. van der Meer
PARANIMFEN
Mw. S. Metselaar Mw. K.A. Bakker-Lie
TABLE OF CONTENTS
Chapter 1 General introduction and outline of the thesis 9 Chapter 2 Validation and modification of a prediction 19
model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose distributions to
cardiac substructures
Chapter 3 Cardiac function after radiation therapy for 49 breast cancer
Chapter 4 Is the coronary artery calcium score associated with 77 acute coronary events in breast cancer patients
treated with radiotherapy?
Chapter 5 Development and evaluation of an auto-segmentation 99 tool for the left anterior descending coronary artery of
breast cancer patients based on anatomical landmarks
Chapter 6 The importance of radiation dose to the atherosclerotic 115 plaque in the coronary artery for radiation-induced
cardiac toxicity of breast cancer patients
Chapter 7 Summarised discussion, future perspectives 145 and conclusions
Chapter 8 Nederlandse samenvatting 163
Addendum List of publications 171
Acknowledgments/Dankwoord 175
