University of Groningen Melanoma Damude, Samantha

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University of Groningen

Melanoma

Damude, Samantha

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Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Damude, S. (2018). Melanoma: New Insights in Follow-up & Staging. Rijksuniversiteit Groningen.

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m e l a

n o m

a

S . Da m u d e

new insights

in follow-up

and staging

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colofon

Cover Design Robert Souhuwat Samantha Damude Layout

Support

The research described in this thesis was financially supported by a grant from the Groningen Melanoma Sarcoma Foundation.

Financial support for printing this thesis was kindly provided by the University Medical Center Groningen (UMCG) Department of Surgical Oncology, the Graduate School of Medical Sciences Groningen (GSMS), Maatschap Chirurgie Treant Zorggroep, Noord Negentig Accountants en Belastingadviseurs, Ekster Vintage, Bodyform Waterbedden & Tribrid Air Matrassen, Mediflow Orthopedische Waterkern Kussens.

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MELANOMA

New Insights in Follow-up & Staging

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 28 november 2018 om 12.45 uur

door

SAMANTHA DAMUDE

geboren op 16 maart 1986

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PROMOTOR

Prof. dr. H.J. Hoekstra

COPROMOTORES

Dr. J.E.H.M. Hoekstra-Weebers Dr. K.P. Wevers

BEOORDELINGSCOMMISSIE

Prof. dr. I.H.M. Borel Rinkes Prof. dr. H.B.M. van de Wiel Prof. dr. M.F. Jonkman

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Paranimfen

E.M. Coppen M. Faut

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General Introduction and Outline of the Thesis 9

PART I.

FOLLOW-UP IN AJCC STAGE I-II MELANOMA

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The MELFO-study: Prospective Randomized Clinical Trial for 27 the Evaluation of a Stage-adjusted Reduced Follow-up Schedule in Cutaneous Melanoma Patients - Results after One Year

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Melanoma Patients’ Disease-specific Knowledge, Information 47 Preference, and Appreciation of Educational YouTube Videos

for Self-inspection

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Practice Variation in Sentinel Lymph Node Biopsy for Melanoma 67 Patients in Different Geographical Regions in the Netherlands

PART II.

PREDICTION OF NODAL STATUS IN COMPLETION LYPMH NODE DISSECTION USING THE BIOMARKER S-100B

5.

The Predictive Power of Serum S-100B for Non-sentinel Node 89 Positivity in Melanoma Patients

6.

A Prediction Tool Incorporating the Biomarker S-100B for 107 Patient Selection for Completion Lymph Node Dissection

in Stage III Melanoma

PART III.

ACCURATE DETERMINATION OF THE BIOMARKER S-100B

7.

Adipocytes in Venipunctures Cause Falsely Elevated S-100B 129 Serum Values

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Double Venipuncture is not Required for Adequate S-100B 137 Determination in Melanoma Patients

9.

Summary & Dutch Summary 157

10.

Future Perspectives 171

A.

APPENDICES

List of Publications & Presentations 188

Authors & Affiliations 190

Acknowledgements - Dankwoord 192

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University of Groningen Melanoma Damude, Samantha