Cover Page

Cover Page

The handle http://hdl.handle.net/1887/135953

holds various files of this Leiden University

dissertation.

Author: Bos, M.

Colophon

© 2020 Manon Bos, Leiden, the Netherlands

On the nature of immunologically challenging pregnancies

All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, electronic or mechanical without prior permission of the author, or where appropriate, of the publisher of the articles

The research presented in this thesis was performed at:

The Department of Pathology, the Department of Obstetrics and Gynaecology and the De-partment of Immunohematology and Blood transfusion at Leiden University Medical Center Financial support for the research conducted was kindly provided by:

Nierstichting Nederland and Leiden University Medical Center Cover design by: Lars Minnes and Thomas Latjes

On the nature of immunologically

challenging pregnancies

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus Prof. Mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties

te verdedigen op donderdag 27 augustus 2020

klokke 11:15 uur

DOOR

Manon Bos

geboren te Woerden

Promotor:

Prof. Dr. J.A. Bruijn

Copromotoren:

Dr. M.L.P. van der Hoorn

Dr. J.J. Baelde

Leden promotiecommissie:

Prof. Dr. J.M.M. van Lith

Table of Contents

Chapter 1

Introduction

Chapter 2

Loss of placental thrombomodulin in oocyte donation pregnancies

Chapter 3

Thrombomodulin expression is increased in the kidney of women

with pre-eclampsia

Chapter 4

Reactive species interactome alterations in oocyte donation

pregnancies in the absence and presence of pre-eclampsia

Chapter 5

Towards standardized criteria for diagnosing chronic intervillositis

of unknown etiology: a systematic review

Chapter 6

Clinical outcomes in chronic intervillositis of unknown etiology

Chapter 7

Summary and general discussion