Spontaneous breathing and respiratory support of preterm infants at birth Pas, A.B. de

infants at birth

Pas, A.B. de

Citation

Pas, A. B. de. (2009, March 5). Spontaneous breathing and respiratory support of preterm infants at birth. Retrieved from

https://hdl.handle.net/1887/13595

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13595

Note: To cite this publication please use the final published version (if applicable).

Breathing patterns in preterm and term infants immediately after birth

Arjan B te Pas, Connie Wong, C Omar F Kamlin, Jennifer A Dawson, Colin J Morley, Peter G Davis

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Pediatr Res. 2009, in press

Abstract

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Introduction

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Data Analysis

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iZgb^c[Vcih#D[i]ZhZ&+gZXdgY^c\hlZgZZmXajYZY[gdbVcVanh^hWZXVjhZ/hZXgZi^dchXVjh^c\

Y^ginÅdlh^\cVa^cdcZiZgbVcYdcZegZiZgb^c[VciVcYV[jgi]Zg&)egZiZgb^c[VcihcZZYZY

kZci^aVidgnhjeedgi#I]jh!i]ZgZlZgZ'*gZXdgY^c\hVkV^aVWaZ[dgVcVanh^h!&'egZiZgbVcY&(

iZgb^c[Vcih#LZVcVanoZY,+.WgZVi]h^ci]ZegZiZgb^c[VcihVcY,).WgZVi]h^ci]ZiZgb

^c[Vcih#I]ZX]VgVXiZg^hi^Xhd[i]Z^c[VcihhijY^ZYVgZh]dlc^cIVWaZ&#

Patterns of breathing

I]Z^cX^YZcXZd[WgZVi]hd[ZVX]eViiZgc[dgWdi]\gdjehVgZh]dlc^cIVWaZ'VcYZmVbeaZh

d[ZVX]eViiZgcVgZh]dlc^cÄ\jgZh'",#

I]ZbZY^Vc>FGegdedgi^dcd[Zme^gVidgnWgV`^c\eViiZgchlVhkZgn]^\]^cWdi]\gdjeh!

^cegZiZgb^c[Vcih.%,)"..VcY^ciZgb^c[Vcih-,,)".)e2%#+#D[i]ZWgV`ZY

eViiZgch!Zme^gVidgn]daYeViiZgcdXXjggZYbdgZd[iZc^cegZiZgb^c[Vcih.)"&,kh#'%"

+0e2%#%'#I]ZbdhiXdbbdcWgZVi]^c\eViiZgc[dgWdi]\gdjehlVhi]ZXgn^c\eViiZgc

+'(+",,kh#+))+",.0e2%#)#I]Z^cX^YZcXZd[jcWgV`ZYeViiZgclVhadl^cWdi]

\gdjeh&%("',kh#&(+"'*0e2%#+#

Table 1. 8]VgVXiZg^hi^Xhd[i]ZiZgbVcYegZiZgb^c[Vcih#

Characteristics Preterm

C2&'

Term

C2&( P

<ZhiVi^dcVaV\Z!l`!bZVcH9 (''#' (-#.%#. 1%#%%&

7^gi]lZ^\]i!\!bZVcH9 '%%%*+% (()%*(% 1%#%%&

6e\VgVi*b^c!bZY^Vc>FG ..". .-". ch

I^bZhiVgigZXdgY^c\!h!bZVcH9 (%&* '.&) ch

8VZhVgZVcYZa^kZgn! (( *) ch

Respiratory parameters

I]ZgZlVhcdY^[[ZgZcXZ^ci]ZVkZgV\Zi^YVakdajbZbZVhjgZYWZilZZcegZiZgbVcYiZgb

^c[Vcih+#,(#.kh#+#*)#&ba$`\0e2%#*#I]ZWgZVi]h^cWdi]\gdjehlZgZX]VgVXiZg^oZY

WnV]^\]eZV`ÅdlYjg^c\^che^gVi^dc*#,(#-kh#-#%*ba$`\0e1%#%%&VcYVadlZgeZV`

ÅdlYjg^c\Zme^gVi^dc(#+'#)kh#)#-(#'ba$`\0e1%#%%&#I]ZVkZgV\Z^che^gVi^dci^bZ

lVhh]dgiVcYcdiY^[[ZgZciWZilZZci]Z\gdjeh%#(&%#&(kh#%#('%#&+h0e2%#*#I]Z

VkZgV\ZZme^gVi^dci^bZ^cWdi]\gdjehlVhadc\!Wji^cegZiZgb^c[Vcih^ilVhh]dgiZgi]Vc

^ciZgb^c[Vcih%#.(%#+)kh#&#&)%#-+h0e1%#%%&#

I]ZkVajZhd[i]ZgZhe^gVidgneVgVbZiZghd[Wdi]\gdjehl]ZcY^k^YZY^cidWgZVi]hl^i]

WgV`ZYVcYjc"WgV`ZYZme^gVi^dcVgZh]dlc^cIVWaZ(#>cWdi]\gdjehWgZVi]hl^i]WgV`ZY

Zme^gVi^dclZgZX]VgVXiZg^oZYWnaVg\Zgi^YVakdajbZ!aVg\ZgeZV`^che^gVidgnÅdl!adc\Zg

Zme^gVi^dci^bZVcYhbVaaZggZhe^gVidgngViZIVWaZ(#

Table 2. I]Zegdedgi^dcd[WgZVi]hl^i]Y^[[ZgZciZme^gVidgneViiZgch[dgegZiZgbVcYiZgb^c[Vcih#

12 Preterm 13 Term P

C7gZVi]h *-)*"-' +'()",( %#*

7gV`ZYZme^gVi^dc

egdadc\ZY &'("&, &&("&- %#.

]daY .)"&, '%"+ %#%'

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JcWgV`ZYZme^gVi^dc

cdgbVa )%"&+ &&("&- %#.

eVci^c\ %%"& %%"&' %#*

Table 3#I]ZgZhe^gVidgneVgVbZiZghd[i]ZWgV`ZYVcYjc"WgV`ZYWgZVi]h[dgWdi]\gdjeh

Respiratory parameters, mean, (SD)

Braked expiration Unbraked expiration EgZiZgb

C2+*'

WgZVi]h

IZgb

C2*.-

WgZVi]h E

EgZiZgb

C2&&,

WgZVi]h

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C2&*&

WgZVi]h E

I^YVakdajbZba$`\ ,#'(#- +#-)#' ns (#,'#' *#*(#) < 0.001

>che^gVi^dci^bZh %#('%#&) %#((%#&+ ns %#(%%#%. %#(%%#&( ns :me^gVi^dci^bZh &#%(%#-) &#((&#%' < 0.001 %#)&%#&+ %#)(%#'+ ns EZV`Ådl^che^gVi^dcA$b^c +#'(#. -#)*#' < 0.001 '#.&#- +#*)#' < 0.001 EZV`ÅdlZme^gVi^dcA$b^c "(#-'#) ")#('#- < 0.001 "(#%'#) "+#()#% < 0.001 GZhe^gVi^dcgViZb^c^"& +%(% *%'( < 0.001 .%'+ .&(& ns

kVajZhd[WgV`ZYkhjcWgV`ZYeViiZgclZgZh^\c^ÄXVcianY^[[ZgZci^cWdi]\gdjehe1%#%%&#

Discussion

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Reference List

 &# @VgaWZg\ E! @dX] < &.+' GZhe^gVidgn hijY^Zh ^c cZlWdgc ^c[Vcih# >>># 9ZkZadebZci d[ bZX]Vc^Xh d[

WgZVi]^c\Yjg^c\i]ZÄghilZZ`d[a^[Z#6adc\^ijY^cVahijYn#6XiVEVZY^VigHjeea&(*/&'&"&'.

 '# @VgaWZg\E&.+%I]ZVYVei^kZX]Vc\Zh^ci]Z^bbZY^ViZedhicViVaeZg^dY!l^i]eVgi^XjaVggZ[ZgZcXZid

gZhe^gVi^dc#?EZY^Vig*+/*-*"+%)

 (# B^acZg69!HVjYZghG6&.,,EgZhhjgZVcYkdajbZX]Vc\ZhYjg^c\i]ZÄghiWgZVi]d[]jbVccZdcViZh#

6gX]9^h8]^aY*'/.&-".')

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dchZid[gZhe^gVi^dc^cWVW^ZhWdgcWnXZhVgZVchZXi^dcVcYWnkV\^cVaYZa^kZgn#?EZY^Vig../,-,",.&

 *# KnVh=!B^acZg69!=de`^c>:!;VaXdcZg69&.-(GdaZd[aVWdjg^ci]ZZhiVWa^h]bZcid[[jcXi^dcVagZh^YjVa

XVeVX^inViW^gi]#6gX]9^h8]^aY*-/*&'"*&,

 +# KnVh=!;^ZaY9!B^acZg69!=de`^c>:&.-+9ZiZgb^cVcihd[i]ZÄghi^che^gVidgnkdajbZVcY[jcXi^dcVa

gZh^YjVaXVeVX^inViW^gi]#EZY^VigEjabdcda'/&-."&.(

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XZhVgZVchZXi^dc#?6eeaE]nh^da*'/,&+",')

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VcYi]ZÄghiedhicViVaWgZVi]h^c]jbVchjW_ZXih#?EZY^Vig.(/++,"+,(

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