Spontaneous breathing and respiratory support of preterm infants at birth Pas, A.B. de

(1)

Pas, A.B. de

Citation

Pas, A. B. de. (2009, March 5). Spontaneous breathing and respiratory support of preterm infants at birth. Retrieved from

https://hdl.handle.net/1887/13595

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13595

Note: To cite this publication please use the final published version (if applicable).

(2)

Positive end expiratory pressure is required to develop a functional residual capacity in preterm

rabbits ventilated from birth

Melissa L. Siew ¹; Arjan B. te Pas²; Megan J. Wallace¹; Marcus J. Kitchen³; Robert A. Lewis^3,4; Andreas Fouras⁵; Colin J. Morley²; Peter G. Davis²; Naoto Yagi⁶;

Kentaro Uesugi⁶ and Stuart B. Hooper¹

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Submitted

(3)

Abstract

Objective. Id YZiZgb^cZ i]Z Z[[ZXi d[ E::E dc i]Z heVi^Va VcY iZbedgVa eViiZgc d[ ajc\

VZgVi^dc ^c egZiZgb gVWW^i ejeh bZX]Vc^XVaan kZci^aViZY [gdb W^gi] jh^c\ h^bjaiVcZdjh

e]VhZXdcigVhiM"gVn^bV\^c\VcYeaZi]nhbd\gVe]n#

Methods. EgZiZgb gVWW^i ejeh lZgZ YZa^kZgZY Wn XVZhVgZVc hZXi^dc Vi ',Y d[ \ZhiVi^dcVa

V\Z!^bbZY^ViZaneaVXZYl^i]^cVlViZg"ÄaaZYeaZi]nhbd\gVe]]ZVYdjiVcY^bV\ZYVh

i]ZnlZgZbZX]Vc^XVaankZciâViZY[gdbW^gi]lî]Zî]ZgVE::Ed[%Xb=_'Ddg*Xb=_'D#I]Z

eZV`^cÅVi^dcegZhhjgZlVh]ZaYXdchiVciVi(*Xb=_'D#

Results. L^i]djiE::E!\VhdcanZciZgZY^cidi]ZY^hiVaV^glVnhYjg^c\^cÅVi^dc#I]ZY^hiVa

V^glVnhXdaaVehZYYjg^c\Zme^gVi^dcVcYVhVgZhjai!i]Z[jcXi^dcVagZh^YjVaXVeVX^in;G8Y^Y

cdi^cXgZVhZVWdkZi]Zajc\¼hVcVidb^XVaYZVYheVXZkdajbZ'#*£%#-bA$`\#>cXdcigVhi!

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Conclusion. E::E ^h ZhhZci^Va [dg [VX^a^iVi^c\ VZgVi^dc d[ i]Z Y^hiVa V^glVnh! VXXjbjaVi^c\

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bZX]Vc^XVaankZci^aViZY[gdbW^gi]#

(4)

Introduction

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Methods

Experimental procedure

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(5)

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Plethysmography

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(6)

Data and statistical analysis

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(7)

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Results

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(8)

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(9)

Functional Residual Capacity (FRC)

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(10)

Breath Number

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Time above anatomical dead space volume (%) 0 20 40 60 80 100 120 (b)

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(11)

0 20 40 60 80 100 120

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0 10 20 30 40 50 60

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(a)

(b)

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(12)

Discussion

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Bdk^ZE::E"&dcY^hX!V^gdcaneZcZigViZYi]ZY^hiVa\VhZmX]Vc\ZgZ\^dchWg^ZÅnYjg^c\

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VecZ^XcZlWdgckZgnegZiZgb^c[Vcih#=dlZkZg!djggZhjaihbVnVahdegdk^YZVcVYY^i^dcVa

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Breath Number

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Lung gas volume integral (mL.sec/kg)

0 10 20 30 40 50 60

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(13)

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(14)

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(15)

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(16)

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(17)