Spontaneous breathing and respiratory support of preterm infants at birth Pas, A.B. de

(1)

infants at birth

Pas, A.B. de

Citation

Pas, A. B. de. (2009, March 5). Spontaneous breathing and respiratory support of preterm infants at birth. Retrieved from

https://hdl.handle.net/1887/13595

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13595

Note: To cite this publication please use the final published version (if applicable).

(2)

Establishing functional residual capacity at birth:

the effect of sustained inﬂation and positive end expiratory pressure in a preterm rabbit model

Arjan B te Pas*^1,2, Melissa Siew³, Megan J Wallace³, Marcus J Kitchen⁴, Andreas Fouras⁶, Robert A Lewis⁵, Naoto Yagi⁷, Kentaro Uesugi⁷, Susan Donath⁸, Peter G Davis¹,

Colin J Morley¹, Stuart B Hooper³

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Pediatr. Res 2009, accepted for publication

(3)

Abstract

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(4)

Introduction

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Methods

Animal experiments

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(5)

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Plethysmography

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Mechanical ventilation

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Protocol

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(6)

Phase contrast X-ray imaging

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Analysis

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(7)

Results

Animal data

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0 0.5 1.0 1.5 0 0.5 1.0 1.5 A

B

C

D

Lung gas volume (mL)Lung gas volume (mL)Lung gas volume (mL)Lung gas volume (mL)

Time 2mins 0

0.5 1.0 1.5

0 0.5 1.0 1.5

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(8)

Table 1. BZVcH9;G8^ci^bZd[i]Z\gdjeh# ;G82;jcXi^dcVagZh^YjVaXVeVX^in

Group FRC (ml/kg)

20 seconds 1 minute 3 minutes 7 minutes

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FRC time-integral: Zero to seven minutes

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(9)

A B

C D

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egZhhjgZE::E*Xb=_'D062H> E::E!72cdH> E::E!82cdH>!cdE::E!92H>!cdE::E#

(10)

Time (secs)

CV between Quadrants (%)

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i]Zajc\lVhh^\c^ÄXVcianbdgZkVg^VWaZaZhhjc^[dgblî]djiVH>!XdbeVgZYlî]kZciâVi^dclî]VH>#6[iZg

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Inﬂation number from birth Expired tidal volume (mL/kg)

Figure 4.:[[ZXid[V'%hhjhiV^cZY^cÅVi^dcH>VcY*Xb=_'DE::Edci^YVakdajbZgZXgj^ibZciV[iZgW^gi]#

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gZXgj^iZYi^YVakdajbZ#KVajZhVgZbZVc£H:B#

(11)

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0 200 400 600 800

-2,000 0 2,000 4,000 6,000 8,000

A B C D

FRC area under curve 0-1 min (ml/kg.s)FRC area under curve 0-7 min (ml/kg.s)

5a

5b

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(12)

Discussion

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(13)

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(14)

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(15)

Reference List

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(17)