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Antiretroviral therapy in Thai adults and children with HIV-1 infection - Chapter 13: Pharmacokinetics and 24-week efficacy/safety of dual boosted saquinavir/lopinavir/ritonavir in nucleoside-pretreated children

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(1)UvA-DARE (Digital Academic Repository). Antiretroviral therapy in Thai adults and children with HIV-1 infection Ananworanich, J. Publication date 2008. Link to publication Citation for published version (APA): Ananworanich, J. (2008). Antiretroviral therapy in Thai adults and children with HIV-1 infection.. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:21 Jun 2021.

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(94)  +85B5 G5B5 >? 49665B5>35C 9> 21C5<9>5 381B13D5B9CD93C ?6 D85 389<4B5> 1D D85 C9D5C #1=9FE49>5 EC5 494 >?D 16653D  - )% CE@@B5CC9?> ! 

(95)  &6 D85  389<4B5> G9D8  - )%  3?@95C =# 1D G55; 

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(98)  9>1<<I 1 D55>175B G9D8 1 89CD?BI ?6 @??B 1485B5>35 814 1>  - )% ?6  3?@95C =# 1D G55;  2ED 1 CE2C5AE5>D  - )% ?6  3?@95C =# 1D 1 6?<<?GE@ F9C9D &>5 389<4 814 1 C5B9?EC 14F5BC5 5F5>D 7B145  491BB851 F?=9D9>7 213; @19> 1>4 3?>FE<C9?>C G8938 G1C :E4754 2I D85 9>F5CD971D?B D? 25 1D <51CD @?CC92<I B5<1D54 D? CDE4I =54931D9?> +89C 9C D85 C53?>4 389<4 =5>D9?>54 12?F5 G9D8 $ >5@8B?@1D8I 1>4 C59JEB5 #?@9>1F9B 1>4 C1AE9>1F9B G5B5 2B95MI 9>D5BBE@D54 DG935 4EB9>7 85B 8?C@9D1<9J1D9?> 1>4 1D G55;

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(100)

(101)

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(106)  =7 4# D?

(107)  =7 4# ! 

(108)  +12<5

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(110)  G85B51C D85 @B?@?BD9?> G9D8 DB97<I35B945C 12?F5

(111)  =7 4# B?C5 6B?=  1D 21C5<9>5 D?   1D G55;  !  

(112)  <1>9>5 1=9>?DB1>C65B1C5 F1<E5C C8?G54 1 C97>9L31>D B54E3D9?> 4EB 9>7 D85 DB91< 6B?=  E>9DC # 1D 21C5<9>5 D?

(113)  E>9DC # 1D G55;  ! 

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(116)  389<4B5> &>5 389<4 G9D8 3?>3EBB5>D B961=@9> DB51D=5>D G1C 5H3<E454 6B?= 1>1<IC5C 3?BB5<1D9>7 @<1C=1 ' @81B=13?;9 >5D93C G9D8 56L313I 1>4 C165DI &F5B1<< D85 @81B=13?;9>5D93 =51CEB5=5>DC G5B5 G9D89> 1335@D54 B1>75C 6?B 1<< ' C &6  389<4B5> G9D8 C1AE9>1 F9B =9> 25<?G  =7 # 814  - )%  3?@95C =# 1D G55;  3?=@1B54 G9D8

(117) ?6

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(119) =7 # 2?D8 814  - )%  3?@95C =# 1D G55;  3?=@1B54 G9D8

(120) F9B?<?793 619<EB5 1=?>7

(121)  389<4B5> G9D8 <?@9>1F9B 3?>35>DB1D9?>C 12?F5

(122) =7 # ! 

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(142)  =7 #  45F5<?@54 D?D1< 38?<5C D5B?< 5<5F1D9?>C 3?=@1B54 G9D8 ?6

(143)  G9D8 <?@9>1F9B =9> 25<?G

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(145)  G9D8 <?@9>1F9B =9> 25<?G   =7 # !   ?BB5<1D9?>C 25DG55> C1AE9>1 F9B @81B=13?;9>5D93C 1>4 <9@94 5<5F1D9?>C 494 >?D B5138 CD1D9CD931< C97>9L31>35.  > D89C @9<?D CDE4I ?6 4E1< 2??CD54 <?@9>1F9B C1AE9>1 F9B B9D?>1F9B 9> %)+ @B5DB51D54 389<4B5>

(146)  ?6   @1D95>DC C8?G54 B54E3D9?>C 9>  - )% D?  3?@ 95C =# 16D5B  G55;C ?6 DB51D=5>D +89C B5C@?>C5 9C 3?=@1B12<5 G9D8 B5CE<DC 9> @B5F9?EC DB91<C ?6 ' DB51D=5>D G9D8 59D85B 2??CD54 ?B E>2??CD54 ' C  > 1449D9?> C97>9L31>D 9=@B?F5=5>DC 9>  G5978D 1>4 85978D ?33EBB54 +85 5<5F1D54 <9@94C C55> 1B5 3?>C9CD5>D G9D8 ?D85B CDE495C 9> 389<4B5> EC9>7 ' C

(147) 

(148)  +85 %1D9?>1< 8?<5CD5B?< 4E31D9?> 'B?7B1= B53?==5>4C CD5@G9C5 495D9>7 1>4 29<5 1394 C5AE5CDB1>DC 96 D85 6?B=5B 619<C

(149)  +85C5 =51CEB5C ?6D5> 1B5 9>145AE1D5 9> <?G5B9>7 <9@94C 9> 389<4B5> DB51D54 G9D8 ' &D85B <9@94<?G5B9>7 175>DC CE38 1C 1D?BF1CD1D9> 81F5 255> CE335CC6E<<I EC54 9> 1 C=1<< >E=25B ?6 389<4B5> G9D8 61=9<91< 8I@5B38?<5CD5B?<5=91 2ED D85C5 1B5 1@@B?F54 ?><I 6?B @?CD@E25C35>D 389<4B5>

(150)  1D1 ?> D85 =1>175 =5>D ?6 D89C @B?2<5= 9> ' DB51D54 389<4B5> 1B5 E>1F19<12<5 +85 B5<1D9F5 3?>DB92ED9?> ?6 2??CD54 C1AE9>1F9B 1>4 <?@9>1F9B ?> 1>D9B5DB?F9B1< 56L313I 31>>?D 25 45D5B=9>54 6B?= D89C DB91< +85B5 9C 9> F9DB? 5F945>35 6?B CI>5B7I 25DG55> C1AE9>1F9B 1>4 <?@9>1F9B

(151)

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(153) )1>4?=9J54 3<9>931< DB91<C 9> ' @B5DB51D54 14E<DC 81F5 C8?G> 9=@B?F54 3<9>931< 56L313I EC9>7 E>2??CD54 @B?D51C5 9>8929D?BC B5<1D9F5 D? EC9>7

(154) E>. 2??CD54 '

(155)  8?G5F5B D85 49665B5>35 9> 56L313I 6?B 4?E 2<5 F5BCEC C9>7<5 2??CD54 ' C 81C >?D 255> 5F1<E1D54 9> B1>4?=9J54 3<9>931< DB91<C ??CD54 C1AE9>1F9B 1>4 <?@9>1 F9B 81F5 1>D9B5DB?F9B1< 56653DC 9> C8?BD D5B= ' =?>?D85B1@I DB91<C 

(156) 2ED D85C5 51B<I DB5>4C 81F5 I5D D? 25 5F1<E1D54 9> <1B75 B1>4?=9J54 DB91<C *1AE9>1F9B @<1C=1 3?>35>DB1D9?>C G5B5 89785B 9> D89C DB91< D81> 6?B @B5F9?EC CDE495C ?6 E>2??CD54 C1AE9>1F9B 9> 389<4B5> +85 +819 389<4B5> 9> D89C DB91< 814 1 =5491> , N

(157) ?6   =7 #  8 G8938 9C C97>9L31>D<I 89785B D81> @B5F9?EC<I C55> 6?B 389<4B5> 79F5> E>2??CD54 C1AE9>1F9B  =7 ;7  D9=5C 1 41I G85B5 D85 , N  G1C   =7 #  8  +85 3?>35>DB1D9?>C 1<C? 1@@51B 89785B D81> 6?B 1E31C91> 14E<DC 9> G8?= D85

(158)

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(160)  =7 #  8

(161) ?G5F5B D85B5 =1I 25 1 B1391< 56653D ?> C1AE9>1F9B 3?>35>DB1D9?>C ?B

(162) +819 14E<DC DB51D54 G9D8 C1AE9>1F9B B9D?>1F9B

(163)

(164) =7 294 D85 =5491> , N  G1C   =7  8 =# G8938 9C 89785B D81> 6?B 1>I DB91< 9> 1E31C91> @1D95>DC +85 =5381>9C= ?6 D89C @?D5>D91< B1391< 3?BB5<1D9?> 9C E>;>?G> <?G5B 2?4I G5978D 6?B +819 14E<DC =1I @1BD<I 5H@<19> D89C 49665B5>35 #?@9>1F9B , 3?>35>DB1D9?>C 6B?= D89C DB91< 1<C? 1@ @51B54 D? 25 89785B D81> 6B?= @B5F9?EC DB91<C 9> 1E31C91> 389<4B5> +85 =5491> , 3?>35>DB1D9?> 6?B <?@9>1F9B 6B?= D89C DB91<

(165)

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(167) =19><I 1E31C91> 389<4B5> 79F5> <?@9>1F9B B9D?>1F9B 1D D85    =7 = 4?C175 G9D8?ED >5F9B1@9>5 1>4

(168)

(169)   =7 #  8 6?B

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