Cover Page
The handle http://hdl.handle.net/1887/29019 holds various files of this Leiden University dissertation.
Author: Ariotti, Silvia
Title: Function and behavior of CD8+ T cells in the skin
Issue Date: 2014-10-02
FUNCTION AND BEHAVIOR OF CD8
+T CELLS IN THE SKIN
Silvia Ariotti
Cover design: Silvia Ariotti and Nicole Nijhuis Printed by: Gildeprint
Lay-out: Nicole Nijhuis - Gildeprint
© 2014 by Silvia Ariotti. All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author and the publisher holding the copyright of the articles.
The research described in this thesis was performed at the Division of Immunology of the Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, the Netherlands.
The printing of this thesis was financially supported by the NKI-AvL.
FUNCTION AND BEHAVIOR OF CD8
+T CELLS IN THE SKIN
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 2 oktober 2014
klokke 11:15 uur
door
Silvia Ariotti Geboren te Torino, Italie
in 1974
PROMOTIECOMMISSIE
Promotoren: Prof. Dr. T.N.M. Schumacher Prof. Dr. J.B.A.G. Haanen Overige Leden: Prof. Dr. C.J.M. Melief
Prof. Dr. Peter Friedl (Radboud Universiteit Nijmegen) Prof. Dr. R.A.W. van Lier (Universiteit van Amsterdam) Prof. Dr. J. Borst (Universiteit van Amsterdam)
Prof. Dr. R.J. de Boer (Universiteit Utrecht)
TABLE OF CONTENTS
Chapter 1 9
Scope of the thesis
Chapter 2 19
Subtle, CXCR3-dependent, chemotaxis of cytotoxic T cells within infected tissue allows efficient target localization.
Manuscript under revision – Journal of Experimental Medicine
Chapter 3 53
Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.
Proc Natl Acad Sci U S A. 109: 19739-44 (2012)
Chapter 4 83
Behavior and function of tissue-resident memory T cells.
Adv Immunol 114: 203-16 (2012)
Chapter 5 99
Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert.
Manuscript accepted in Science
Chapter 6 123
Summary and general discussion Chapter 7 - Addenda
English summary 139
Dutch summary 143
Curriculum Vitae 147
Publications 149
To my parents, for teaching me curiosity
and sense of humour To Ruud
