University of Groningen
Modeling of MLL-AF9-rearranged pediatric leukemia Carretta, Marco
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Carretta, M. (2018). Modeling of MLL-AF9-rearranged pediatric leukemia: Identification of mechanisms and potential targets. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
!! ! ! ! ! ! ! ! ! !
Modeling of MLL-AF9-rearranged
pediatric leukemia
Identification of mechanisms and potential targets
!
The studies described in this thesis were financially supported by the grant: Marie Curie Euro Cancer Stem Cell Training Network FP7-PEOPLE-2010-ITN-264361. The publication of this thesis was financially supported by University of Groningen. Cover design: Oscar ‘Odd’ Diodoro, odd-house.com
Printed by: Ridderprint BV, www.ridderprint.nl ISBN 978-94-034-0440-0 (printed)
ISBN 978-94-034-0439-4 (e-book)
Copyright © 2018 by Marco Carretta. All rights reserved. No parts of this book may be reproduced or transmitted in any form or by any means without prior permission of the author.
Modeling of MLL-AF9-rearranged
pediatric leukemia
Identification of mechanisms and potential targets
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 5 February 2018 at 14.30 hours
by
Marco Carretta
born on 7 May 1985 in Mantova, Italië
! Supervisors Prof. J.J. Schuringa Prof. E. Vellenga Assessment Committee Prof. S. de Jong Prof. G. de Haan Prof. J. Jansen !
!
Paranymphs Vincenzo Terlizzi Bauke de Boer
TABLE OF CONTENTS
CHAPTER 1 9
General introduction and scope of the thesis
CHAPTER 2 45
Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model
Leukemia. 2016 Oct;30(10):2064-2073
CHAPTER 3 89
Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models
Exp Hematol. 2017 Jul;51:36-46.
CHAPTER 4 123
BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells
PLoS One. 2017 Dec 14;12(12):e0189102.
CHAPTER 5 159
The cell of maintenance in MLL-rearranged B-ALL is multipotent and retains myeloid potential while MLL-rearranged AML is maintained by myeloid restricted LSCs
Manuscript in preparation
CHAPTER 6 183
Summary, general discussion and future perspectives
CHAPTER 7 211
Nederlandse samenvatting Acknowledgements
Curriculum Vitae List of publications
